^tD sr^ US Environmental Protection Agency
Office of Pesticide Programs
DEEM User's Manual
October 21, 2011
-------
\JULA
DEEM-FCID
TM
Food translations based on
EPA/USDA FCID lecipe set
as of Maich 2011
.TM
Dietary Exposure Evaluation Model
Based on NHANES 2-day food consumption data for 2003-2006
Licensed by:
Duiango Software LLC,
Crownsville. MD 21032
240-461 -2341
Licensed for use only by:
Limited Use Evaluation Copy Only - Not foi Submissions
Use the menu bar at top to run this program.
Developed by Durango Software, LLC
Copyright 2011. Durango Software LLC
General Overview of DEEM-FCID™ Dietary Exposure Analysis
DEEM-FCID™ is a dietary exposure analysis system that is used to estimate exposure to
pesticides in foods in the diets of the U.S. population, including population subgroups.
DEEM employs a deterministic (single value) and/or Monte Carlo Analysis (MCA)
technique to provide probabilistic assessments of dietary pesticide exposures when
residue data for targeted foods. The software was developed by Durango Software, LLC
and contains food consumption data from the National Health and Nutrition Examination
Survey (NHANES) conducted in 2003-2006.
The main DEEM-FCID™ module is used to launch the residue file editor to create and
edit residue files for specific chemical or cumulative applications, and to launch the
DEEM-FCID™, Acute, Chronic, and RDFgen™ analysis modules. The DEEM-FCID™
software itself is also integrated with CALENDEX™, an aggregate exposure assessment
software application used when combining dietary and residential (non-dietary)
exposures. To conduct either acute, chronic and/or cancer risk analyses using DEEM-
FCID™ software, the user must provide three types of information: (1) the residue
concentrations in the foods and/or food forms which can be a theoretical level (such as
the tolerance or MRL (maximum residue limit)) or a level of residue anticipated to be
present in the food of interest; (2) the pesticide's toxicological data that are directly
relevant to both the length of time or duration of interest and the evaluation of the
significance of estimates of exposure by the oral route. These data should include a
toxicology endpoint based on chronic (long-term) exposure such as the cancer potency
factor (Qi*), the No Observed Adverse Effect Level (NOAEL), Reference Dose (RfD),
Population Adjusted Dose (PAD), or Margin of Exposure (MOE); and (3) any adjustment
factors directly relevant to potential constituent levels in the diet to more accurately
reflect likely exposures (e.g. processing factors or percent of the crop treated).
The acute and chronic analysis of DEEM-FCID™ can be used to estimate total exposure
for both the U. S. population as a whole and subgroups of the population. Subgroups are
1
-------
divided by regions of the country, seasons of the year, age, gender, or ethnicity. The
Commodity Contribution Analysis can be used to identify the contribution of residues in
individual foods (and foodforms) to the overall estimate of dietary exposure.
Getting Started
lEEM Main Menu
M- ||n|M
File Analysis RDFgen RDFdoc Help
TM Vei. 3.04
^ Mm MM m I I ^ Food translations based on
UCClvrrLrlU —set
Dietary Exposure Evaluation Model™
Based on NHANES 2-day food consumption data for 2003-2006
r Setup variables:
(Use full path name, e.g. c:\deem96\J
Residue file path: I'CS'A!D)|5|^"d]Dj'i,
Food Consumption File path:
Lines per page for reports [50-70]: ir;Ti
Include pg numbers and pg breaks in reports (Y/N)?
¦
Print comments in residue listing (Y/N)?
Acute Percentiles: Ascending or Descending (A/DJ?
m ™®
Copyright 2011, Durango Software LLC
1) Go to "File" and select "Set Up" from the main menu screen. If the DEEM-
FCID™ defaults are correct, click the "OK" button.
[iOtherwise, enter the name of the directory where you would like the residue files that
you will be creating to be saved; next, enter the name of the directory where the food
consumption files are located. Also, indicate the number of lines per page that will
accommodate your printer, page breaks in reports that are generated by DEEM-
FCID™, identification of printer port, displaying the acute exposure percentiles in
ascending or descending order and identifying the path for RDFgen].
2
-------
2) Go to File and select "Residue File Editor" from the main menu screen. Next,
click on "File" and select "New" to create a new file. You then will be prompted
to enter the name of the file. This is your R2D file. For this example, save the file
as "Training." Once you have saved the data, click on "Save" to close the screen.
[Note: When naming a file do not include any symbols, spaces, or special
characters, such as commas, parenthesis, etc. this will prevent DEEM-FCID™
from recognizing your R2D file\
File Add/Edit Header Add/Edit Comnnodities/Foodforrins Crop Group Actions Help
1 New,,,
Open.,.
Save,,,
Save As...
Print File with all commodities... ~
Print File with included commodities only... ~
Close
Exit to Main Menu
3) Click on "Add/Edit Header" from the main screen then "Open Header." Add the
chemical name, NOAEL, Reference Dose (RfD) or the Population Adjusted Dose,
and Qi* if applicable. You may also add comments, which will appear on all
subsequent DEEM-FCID™ analyses. Once you have completed entering the
data, click on "Finished" to close the screen. [You may move from field to field
with either the key or the mouse\
sidue File Header Data
Chemical Name:
Chemical X
You must enter the chemical
name to be evaluated.
Reference Dose (Chronic): | 040000
Reference Dose (Acute): .002500
mg/kg body-wt/day
mg/kg body-wt/dav
Finished (Exit)
Noel (Chronic): 4.000000
Noel (Acute): .250000
|.0000
mg/kg body-wt/day
mg/kg body-wt/day
Cancel (Exit)
Comment: j raining
3
-------
4) Click on "Add/Edit Foods/Foodforms" option from the menu bar. You may sort
foods by food code or alphabetic order. Select "View/Select All" and by
Alphabetic order.
Creating new file: C:\Deemfcid\Training.r2d
File Add/Edit Header
Add/Edit Commodities/Foodforms 1
View/Select All,,, ~
Food Code order
View Included Only,,, ~
Alphabetic order
for selected Crop Croups only
5) In the "Default Residue" column, enter the residue value in ppm for each
commodity in your assessment. For this example, use 5 ppm for all apple
commodities, except apple juice use 0.05 ppm.
\DEEM-FCID™ permits entry of values of0.000001 ppm to 999.999999 ppm. Note
that data entry is restricted to 6 decimals]
4
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^ Residue Assignment Grid: Residue file = C:\Deemfcid\Training.r2d
100010000 « Quick
commodity code find
.Quick Save
Help
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Resort to Code
Order
Turn CropGrps
On
Show RDL Close (Exit)
EPA Code
Ciop
Gip
Commodity Name
NFF
Default
Residue
(ppm)
Adjust
Factor
#1
Adjust
Factor
#2
RDL
Pntr
#1
Comment (documentation)
9500000500
~
Acai berry
0
1
1
9500001000
0
Acerola
0
1
1
9500001500
O
Agave
0
1
1800002000
18
Alfalfa, seed
1
1
1
1400003000
14
Almond
8
1
1
1400004000
14
Almond, oil
1
1
1400004001
14
Almond, oil-babyfood
0
1
1
1400003001
14
Almond-babyfood
0
1
1
9500006000
0
Amaranth, grain
2
1
1
0401005000
4A
Amaranth, leafy
1
1
1
1100009000
11
Apple, dried
4
5
1
1
1100009001
11
Apple, dried-babyfood
1
5
1
1
1100007000
11
Apple, fruit with peel
4
5
1
1
1100010000
11
Apple, juice
8
.05
1
1
1100010001
11
Apple, juice-babyfood
2
.05
1
1100000000
11
Apple, peeled fruit
8
1
1
1100000001
11
Apple, peeled fruit-babyfood
1
5
1
1
1100011000
11
Apple, sauce
5
5
1
1
1100011001
11
Apple, sauce-babyfood
1
5
1
1
1202012000
12B
Apricot
6
1
1202013000
12B
Apricot, dried
2
1
1
1202014000
12B
Apricot, juice
4
1
1
1202014001
12B
Apricot, juice-babyfood
1
1
1
1202012001
12B
Apricot-babyfood
1
1
1
0103015000
1CD
Arrowroot, flour
1
1
1
-
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* Residue Assignment Grid: Residue file = C:\Deemfcid\Training.r2d
For almond, there are 8 food forms. To view these food forms, highlight the
default residue value (10 ppm) and right click the mouse. The prompt will ask to
include foodforms for almonds, select "Yes."
Si Residue Assignment Grid: Residue file = C:\Deemfcid\Training.r2d
1400003000 « Quick
commodity code find
£uick Save
Help
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Resort to Code
Order
Turn CropGrps
On
ShowRDL Close (Exit)
EPA Code
Crop
Grp
Commodity Name
NFF
Default
Residue
(ppm)
Adjust
Factor
#1
Adjust
Factor
«2
RDL
Pntr
#1
Comment (documentation)
1800002000
18
Alfalfa, seed
1
1
1
1400003000
14
Almond
8 !
1
1
110-Uncooked; Fresh or N/S; Cook Meth N/S
10
1
1
120-Uncooked; Frozen; Cook Meth N/S
10
1
1
210-Cooked; Fresh or N/S; Cook Meth N/S
10
1
1
211-Cooked; Fresh or N/S; Baked
10
10
10
1
1
212-Cooked; Fresh or N/S; Boiled
1
1
220-Cooked; Frozen; Cook Meth N/S
1
1
221-Cooked; Frozen; Baked
10
1
1
230-Cooked; Dried; Cook Meth N/S
10
1
1
1400004000
14
Almond, oil
1
10
1
1
1400004001
14
Almond, oil-babyfood
0
10
1
1
i4nono3nm
14
Almnnri-hahufnnrl
n
10
1
1
"31
J
5b) Adjustment Factors. Typically, the first adjustment factor in the DEEM-FCID™
software is used for reductions or concentrations from processing a commodity, and the
second adjustment factor is used to incorporate pesticide usage estimates. The program
multiplies the residue value by each of the adjustment factors. The default values for
processing factors are located on TIED's Dietary Exposure Science Advisory Council
(DESAC) database.
6
-------
5c) For this example, the default processing factor for apples dried is 8.0 and apple juice
is 1.3 and entered in as adjustment factor # 1. The percent crop treated estimate for apples
is 50% and is entered as 0.50 in the adjustment factor #2 column. [Make sure to include
the same value for the baby food commodities]
§ Residue Assignment Grid: Residue file = C:\Deemfcid\Training.r2d
11100011001 << Quick
commodity code find
Quick Save
Help
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Resort to Code
Order
T urn CropGrps
fin
Show .RDL Close (Exit)
EPA Code
Crop
Grp
Commodity Name
NFF
Default
Residue
(ppm)
Adjust
Factor
#1
Adjust
Factor
#2
RDL
Pntr
#1
Comment (documentation)
1800002000
18
Alfalfa, seed
1
1
1
1400003000
14
Almond
8
10
1
1
110-Uncooked; Fresh or N/S; Cook Meth N/S
10
1
1
120-Uncooked; Frozen; Cook Meth N/S
10
10
1
1
210-Cooked; Fresh or N/S; Cook Meth N/S
1
1
211-Cooked; Fresh or N/S; Baked
10
1
1
212-Cooked; Fresh or N/S; Boiled
10
1
1
220-Cooked; Frozen; Cook Meth N/S
10
1
1
221-Cooked; Frozen; Baked
10
10
1
1
230-Cooked; Dried; Cook Meth N/S
1
1
1400004000
14
Almond, oil
1
10
1
1
1400004001
14
Almond, oil-babyfood
0
10
1
1
1400003001
14
Almond-babyfood
0
10
1
1
9500006000
0
Amaranth, grain
2
1
1
0401005000
4A
Amaranth, leafy
1
1
1
1100009000
11
Apple, dried
4
5
8
.50
1100009001
11
Apple, dried-babyfood
1
5
8
0 5
1100007000
11
Apple, fruit with peel
4
5
1
0.5
1100010000
11
Apple, juice
8
.05
1.3
0.5
1100010001
11
Apple, juice-babyfood
2
.05
1.3
0.5
1100008000
11
Apple, peeled fruit
8
5
5
1
0.5
1100008001
11
Apple, peeled fruit-babyfood
1
1
0.5
1100011000
11
Apple, sauce
5
5
1
0.5
1100011001
11
Apple, sauce-babyfood
1
5
1
¦ncv
1202012000
12B
Apricot
6
1
1
<1 I
_lI
_l
Max RDL Pointers JjQ j Quick RDL pointer find ]
Quick commodity name find I
The following commodity counts are only valid when the grid is
T otal w/o ff | j 2
Total commod-
ities included
updated.
Total w/ ff
5d) Adding Crop Groups. The latest EPA Health Effects Division (HED) crop groups
are included in DEEM-FCID. All foods in a specified food group can be added
simply by clicking the "Turn CropGrps On" display button or using the "add crop
group" from the main menu.
For example, assume that the tree nuts have a tolerance of 10 ppm. Click the "Turn
CropGrps On" and select "Tree Nuts" and select the "Display" button.
7
-------
Creating new file: C:\Deemfcid\Training.r2d
File Add/Edit Header Add/Edit Commodities/Foodforrns Crop Group Actions Help
Check the Crop Group(s) to be viewed/selected:
(Press Display button to display residue data grid) Display
-Crop Groups:
r
All crop groups
r
(0) Other
r
(9A) Melons
r
(19B)S pices
r
(1) Root and Tuber Vegetables
r
(9B) Squash/Cucumbers
r
(28) Oilseeds
r
(1A) Root Vegetables
r
(10) Citrus Fruits
r
(28A) Rapeseed
r
[IB] Root Vegetables (exc sugar beet) subgroup
r
(10A) Orange subgroup
r
(28B) Sunflower
r
(1C) Tuberous and Corm Vegetables
r
(10B) Lemon/Lime subgroup
r
(28C) Cottonseed
r
(1D) T uberous/Corm Vegetables (exc sugar beet)
r
(10C) Grapefruit subgroup
r
(21) Mushroom
r
(2) Leaves of Root and Tuber Vegetables
r
(11) Pome Fruits
r
(31) Beef
r
(3) Bulb Vegetables
r
(12) Stone Fruits
r
(32) Goat
r
(3A) Garlic/Onion
r
(12A) Cherry
r
(33) Horse
r
(3B) Other Bulb Veg
r
(12B) Apricot/Peach
r
(34) Pork
r
(4) Leafy Vegetables (except Brassica)
r
(12C) Plum
r
(35) Sheep
r
(4A) Leafy Greens
r
(13) Berries
r
(3G) Milk
r
(4B) Leaf Petioles
r
(13A) Berries: Caneberry subgroup
r
(38) Game
r
(5) Brassica (Cole) Leafy Vegetables
r
(13B) Berries: Bushberry subgroup
r
(39) Rabbit
r
(5A) Brassica: Head and Stem
r
(13C) Berries: Large Shrub/tree berry subgroup
r
(48) Chicken
r
(5B) Brassica: Leafy Greens
r
(13D) Berries: Small fruit vine climbing subgroup
r
(58) T urkey
r
(6) Legume Vegetables (Succulent or Dried)
r
(13E) Berries: Small fruit vine climbing (except grape)
r
(G8) Poultry (other)
r
(GA) Edible-pod Legume Vegetables
r
(13F) Berries: Small fruit vine climbing (except kiwi)
r
(78) Egg
r
(GB) Succulent shelled peas and beans
r
(13G) Berries: Low growing berry subgroup
r
(88) Fish
r
(GC) Dried Shelled Pea/Bean (exc Soybean)
r
(13H) Berries: Low growing berry (except strawberry]
r
(8G) Water
r
(8) Fruiting Vegetables
w
!|14i Tree Nutsj
r
(8GA) Direct Water
r
(BA) T omato
r
(15) Cereal Grains
r
(8GB) Indirect Water
r
(8B) Bell Pepper
r
(18) Non-grass animal feeds
r
(8C) Other Fruiting Veg
r
(19) Herbs and Spices
r
(9) Curcurbit Vegetables
r
(19A)Herbs
Add the value 10 to almonds in the "Default Residue" column. You can enter the
same residue "10" value in a number of contiguous residue cells by clicking on the
first cell with the left mouse button, and then, while holding the left mouse button
down, dragging the highlighted area down to the last cell that you would like to
replace. Select "Yes" when the following the screen appears "Do you want to set the
values for the entire highlighted area with the same value?"
Then select the "Turn CropGrps Off button to go back to the residue assignment grid.
-------
<< Quick
commodity code find
Quick Save
Help
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Turn CropGrps
Off
Show RDL Close (Exit)
EPA Code
Crop
Grp
Commodity Name
NFF
Default
Residue
[ppm]
Adjust
Factor
Adjust
Factor
tt2
RDL
Pntr
#1
Comment (documentation)
1400003000
14
Almond
IIQ-Uncooked; Fresh or N/S; Cook Meth N/S
120-Uncooked; Frozen; Cook Meth N/S
210-Cooked; Fresh or N/S; Cook Meth N/S
211-Cooked; Fresh or N/S; Baked
212-Cooked
220-Cooked
Fresh or N/S; Boiled
Frozen; Cook Meth N/S
221-Cooked; Frozen; Baked
230-Cooked; Dried; Cook Meth N/S
1400004000
1400004001
1400003001
1400059000
1400068000
1400081000
1400092000
1400155000
1400156000
1400185000
1400213000
1400269000
1400278000
1400282000
1400391000
Almond, oil
Almond, oil-babyfood
Almond-babyfood
Brazil nut
Butternut
Cashew
Chestnut
Hazelnut
Hazelnut, oil
Hickory nut
Macadamia nut
Pecan
Pine nut
Pistachio
Walnut
Confirmation!
Max RDL Pointers Quick RDL pointer find
Quick commodity name find
5e) Additional Features. The "Quick Save" button is an easy way to save your
information and the "Help" button will give you additional information on how to
run DEEM-FCID.
Residue Assignment Grid: Commodity codes by Crop Group. Residue file = C:\Deemfcid\Training.r2d
1400391000 « Quick
commodity code find
EPA Code
1400003000
1400004000
1400004001
1400003001
Crop
Grp
14
14
14
14
'? Quick Save Help
A A
Comr 'i Name j/Bk
Almond
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Resort to Code
Order
Turn CropGrps
Off
Show RDL
Close (Exit)
110-Uncooked; Fresh oi N/S; Cook Meth N/J
120-Uncooked; Frozen; Cook Meth N/S
210-Cooked
211-Cooked
212-Cooked
220-Cooked
221-Cooked
230-Cooked
Fresh or N/S; Cook Meth N/S
Fresh or N/S; Baked
Fresh or N/S; Boiled
Frozen; Cook Meth N/S
Frozen; Baked
Dried; Cook Meth N/S
Almond, oil
Almond, oil-babyfood
Almond-babyfood
g Residue Data Entry... (-
Select help topic, then press 'Show'
(• Command button^
C 'Quick' Input boxes
C Cell Entries
C Navigating through grid
C Column headings
C Food counts
C Misc. Info
10
10
10
10
Show
Comment (documentation)
9
-------
Also, the two buttons, "Quick Commodity Code Find" and "Quick Commodity
Name Find" may be used to move to a specific raw agricultural commodity
(RAC) code or food.
01032960 << Quick
commodity code finds
Help
Commodities with NFF=0 are not
consumed in CSFII 1994-98.
Resort to Code
Order
Turn CropGrps
~n
Show RDL Close (Exit)
EPA Code
Crop
Grp
Commodity Name
NFF
Default
Residue
(ppm)
Adjust
Factor
#1
Adjust
Factor
#2
RDL
Pntr
#1
Comment (documentation)
25002950
M
Pork, liver
3
1
1
01032960
1C
Potato, chips
2
1
1
1
1
1
1
01032970
1C
Potato, dry (granules/ flakes)
7
01032971
1C
Potato, dry (granules/ flakes)-babyfood
1
01032980
1C
Potato, flour
23
1
1
01032981
1C
Potato, flour-babyfood
3
1
01032990
1C
Potato, tuber, w/peel
4
1
1
01032991
1C
Potato, tuber, w/peel-babyfood
0
1
1
01033000
1C
Potato, tuber, w/o peel
13
1
1
1
1
1
1
01033001
1C
Potato, tuber, w/o peel-babyfood
1
60003010
P
Poultry, other, meat
5
60003020
P
Poultry, other, liver
1
1
1
60003030
P
Poultry, other, meat byproducts
3
1
1
60003040
P
Poultry, other, fat
5
1
60003050
P
Poultry, other, skin
3
1
1
95003060
O
Psyllium, seed
1
1
1
10003070
10
Pummelo
0
1
1
09023080
98
Pumpkin
6
1
1
1
1
09023090
98
Pumpkin, seed
3
11003100
11
Quince
0
1
1
95003110
~
Quinoa, grain
0
1
29003120
M
Rabbit, meat
3
1
1
1
04013130
4A
Radicchio
1
01013140
1AB
Radish, roots
2
1
1
02003150
2
Radish, tops
0
1
1
«l I
~
Max RDL Pointers IT3 Quick RDL pointer find
Quick commodity name find [potato
The following commodity counts are only valid when the grid is updated.
Total commod- J24 Total w/o ff J22 Total w/ ff J2
ities included
6) Select the "Close (Exit)" button when you are finished. To save your file for use
in the chronic or acute analysis, click "File" and "Save." For this example, save
the file as "Training." Click "file" and "Exit to Main Menu."
10
-------
Running DEEM-FCID™
Chronic Dietary Analysis
1) To run a DEEM-FCID™ chronic dietary assessment, go to the DEEM-FCID
main menu screen, click on "Analysis" then "Run Chronic."
DEEM Main Menu
File
Help
DEEM-FCID
TM Ver. 3.04
Food translations based on
EPA/USDA FCID recipe set
as of March 2011
TM
Dietary Exposure Evaluation Model
Based on NHANES 2-day food consumption data for 2003-2006
2) Select the file to be analyzed by clicking on "File" from the main menu then
"Open Residue File." Note: All future run analyses (results files, commodity
contribution files) will be saved in the same location as your selected R2D file.
File Run Analysis Help
Close Residue File
Exit
¦a residue file or a batch file.
Commodity Analysis
I Complete Commodity Contribution Analysis
| Critical Commodity Contribution Analysis
Analysis Parameters:
I [Use second adjustment factor]
T oxicology endpoints (chronic):
Use: Value:
M ~ E L || | mg/kg bw/day
RfD | | mg/kg bw/day
Q" f~ |
pad r~
Save Reports
to File
Run Comment:
Clear Form
Show Last Chronic Rpt
Show Last Commodity Rpt
3) Double click the file you want to run. For this example, open "Training.R2D."
The toxicology endpoints should automatically appear (if you added them in the
Edit Header option shown in section 3 of Getting Started). At this point, you will
have the option of changing any of the toxicological endpoints identified in the
file. You also will be given the option of comparing the exposure results
(expressed as mg chemical/kg bw/day) to the chronic RfD, NOAEL, both, or to
the Qi*. Exposure estimates will be expressed as a percent of the RfD; selecting
the NOEL will produce Margins of Exposure. The chronic exposure value for the
11
-------
general U.S. population will be multiplied by the Qi* to yield the lifetime cancer
risk estimate. Click on the toxicology endpoints (e.g. NOAEL, RfD).
Residue File:
Residue file: Training.R2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: ChemicaCK
Working Folder: C:\Documents and
Chronic Analysis Parameters
| [Use second adjustment factod
T oxicology endpoints (chronic):
Use: Value:
NOELf [4 mg/kg bw/day
RfD
Q* I- fo
pad r~
Save Reports
to File
Run Comment:
T raining
|0 4 mg/kg bw/day
4) Click on the "Second Adjustment Factor" (if you added a percent crop treated
value in the current analysis). To save the chronic analysis report to a file, select
"Save Reports to File" option and name the file.
Residue File:
R esidue file: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: Chemical
Working Folder: C:\Docurnents and
Chronic Analysis Parameters
Use second adjustment factor
T oxicology endpoints (chronic):
Use: Value:
NOEL | [4 mg/kg bw/day
RfD |q 4 mg/kg bw/day
QT [0
PADT
Report
r-r Save Reports File Name|T--
W to File (w/0 M raining
extension)
Run Comment:
T raining
12
-------
5) Under the Commodity Analysis, select the "Complete Commodity Contribution
Analysis" option and under the Standard Subpopulations for Commodity Analysis
select the subpopulations of interest.//^'; If you click Total US Population, the
results will automatically show the results for all the subpopulations]
Residue File:
R esidue file: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: ChemicaK
Working Folder: C:\Documents and
Chronic Analysis Parameters
Use second adjustment factor
T oxicology endpoints (chronic):
Use: Value:
NOELF [4
mg/kg bw/day
RfD Jo 4 mg/kg bw/day
Q T [o~
padt
Report
Save Reports FtoN-na^~
to File
extension)
Run Comment:
T raining
Commodity Analysis
p Complete Commodity Contribution Analysis
Critical Commodity Contribution Analysis
Standard Subpopulations for Commodity Analysis
1?
Total US Population
r
Female 13-50
r
Hispanic
r
Children 1-2
r
Non-Hisp-White
r
Children 3-5
r
Non-Hisp-Black
r
Children 6-12
r
Non-Hisp-Other
r
Youth 13-19
r
Nursing Infants
r
Adults 20-49
r
Non-Nursing Infants
r
Adults 50-99
r
Female 13+ PR EG
r
Female 13-49
r
Children 1 -G
r
Children 7-12
r
Male 13-19
r
Female 13-19/NP
r
Male 20+
r
Female 20+/NP
r
Seniors 55+
r
All Infants
6 To run a DEEM-FCID chronic dietary assessment, click on "Run Analysis," from
the main menu, then select "Chronic Analysis." The chronic analysis will run
automatically.
File Run Analysis Help
Chronic Analysis
Commodity Analysis
Date last saved: 1/10/2008 3:33:49 PM
Chemical Name: Chemical X
Working Folder: C:\DEEMFCID\
Commodity Analysis
Is? Complete Commodity Contribution Analysis
Critical Commodity Contribution Analysis
Chronic Analysis Parameters
jUse second adjustment factor!
Standard Subpopulations for Commodity Analysis
7) You may view or obtain a hard copy of the residue data used in your analysis by
clicking the "Show Res File" button. You will then be prompted to display the
report to screen, save to disk, or send directly to printer.
13
-------
Deem FCID Chronic Analysis NHANES 2003-2006 2 d • Current Residue File
Run Analysis Help
Residue File:
Residue file: Training.R2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: ChemicatK
Working Folder: C:\Documents and
Chronic Analysis Parameters
p" Use second adjustment factor
T oxicology endpoints (chronic):
Use: Value:
NOEL I- [4 " mg/kg bw/day
RfD [7 [0^4 mg/kg bw/day
-------
9) Critical Commodity Analysis: The Critical Commodity Analysis reports the
exposure from those foods that contribute a user-specified proportion of the
overall exposure, e.g. 1% of total exposure. The critical commodity listing is
expressed as both a percent of the RfD (or PAD, or lifetime cancer risk, or MOE)
and as a percent of total exposure. Enter the desired critical value for your
analysis and under Standard Subpopulation for Commodity Analysis select the
subpopulation of interest.
9a) Note: The criteria for including foods and crop groups in the critical
commodity analysis may be different. For example, include those foods or food
forms that contribute at least 1% of exposure but only those crop groups which
contribute at least 5% of exposure and for which no individual food contributes at
least 1% of total exposure.
r Residue File:
R esidue file: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: ChemicaK
Working Folder: C:\Documents and
Commodity Analysis
Complete Commodity Contribution Analysis
W Critical Commodity Contribution Analysis
Chronic Analysis Parameters
17 U se second adjustment factor
T oxicology endpoints (chronic):
L
Critical value for Foods/Foodforms F
Critical value for Crop Groups
X of total exposure (.1 to 99)
Standard Subpopulations for Commodity Analysis
|7 Total US Population
f~ Hispanic
r Female 13-50
r~ Children 1 -2
10) To run a DEEM-FCID Critical Commodity Contribution Analysis, click on "Run
Analysis," then click "Commodity Analysis." The commodity analysis will run
automatically and you will then be prompted to display the report to screen, save
to disk, or send directly to printer.
:ile Help
FJ
Chronic Analysis
Commodity Analysis
Date last saved: 9/25/2011 1:45:52 PI
Chemical Name: Chemical
Working Folder: C:\Documentsand
Commodity Analysis
Complete Commodity Contribution Analysis
Critical Commodity Contribution Analysis
U
Chronic Analysis Parameters
Use second adjustment factor
T oxicology endpoints (chronic):
Critical value for Foods/Foodforms Ff
Critical value for Crop Groups
W~
% of total exposure (.1 to 99)
Standard Subpopulations for Commodity Analysis
[7 Total US Population Female 13-50
r~ Hispanic
Children 1 -2
11) The "Show Last Commodity Rpt" button permits the user to display, save or
print the analysis report. The user may save the report to file by selecting Save
Reports to disk file.
15
-------
Residue File:
Residue file: Training.R2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: Chemical
Working Folder: C:\Documents and
Chronic Analysis Parameters
I/ Use second adjustment factor
Toxicology endpoints (chronic):
Use: Value:
N 0 E L p [4 mg/kg b w/day
RfD |y* [q4 mg/kg bw/day
IT (0
PADf
Report
r, Save Reports FileNamej. ¦ ¦
" to File (w/o I ^
Run Comment:
Training
Commodity Analysis
r Complete Commodity Contribution Analysis
|7 Critical Commodity Contribution Analysis
L
Critical value for Foods/Foodforms |-|
Critical value for Crop Groups [5
Standard Subpopulations for Commodity Analy
r Female
W Total US Population
r Hispanic
r Non-Hisp-White
r Non-Hisp-Black
r Non-Hisp-Other
r Nursing Infants
r Non-Nursing Infants
f Female 13+PREG
r Children 1-6
r Children 7-12
r Male 13-19
r Female 13-19/NP
f Male 20+
Female 20+/NP
r Seniors 55+
r All Infants
r Children
r Children
r Children
f Youth 1
r Adults 2
f Adults 5
r Female
Clear Form Show Res File Show Last Chronic Rpt I Show Last Commodity Rpt
Evaluation Copy Only Ver. 3.04
DEEM-FCID Chronic analysis for CHEHICALX NHANES 2003-2006 2-day
Residue file name: C:\Documents and Settings\spiper\Desktop\wweia_deem\Training.R2D
Adjustment factor $2 used.
Analysis Date 09-25-2011/14:28:20 Residue file dated: 09-25-2011/13:45:52/0
Reference dose (RfD, Chronic) = .4 mg/kg bw/day
COMMENT 1: Training
Critical Commodity Contribution Analysis for
Total US Population
Total Exposure =.0038904 mg/kg bw/day
Crop groups with total exposure contribution > 5%
Foods/Foodforms with exposure contribution > II
Crop group
Food
Foodform
Exposure Analysis
mg/kg I of Total Percent
body wt/day Exposure of RfD
:Crop Group = (11) Pome Fruits
Apple, fruit with peel (1100007000):
FoodForm N/S
Apple, juice (1100010000):
FoodForm N/S
Apple, juice-babyfood (1100010001):
FoodForm N/S
Apple, sauce (1100011000):
FoodForm N/S
Apple, sauce-babyfood (1100011001):
FoodForm N/S
0.0007244
0.0023299
0.0001633
0.0001979
0.0000594
18.624
59.894
4.204
5.094
1.534
0.184
0.584
0.044
0.054
0.014
Total for crop group
0.0035453 91.134
0.894
12) When you have completed your chronic assessment, you may exit the window by
clicking 011 "File" then "Exit."
16
-------
Running DEEM-FCID™
Acute Dietary Analysis (Tier 1 & 2)
1) To run a DEEM-FCID™ acute dietary assessment, go to the DEEM-FCID main
menu screen, click on "Analysis" then "Run Acute." Select the file to be
analyzed by clicking on "File" then "Open Residue File." For this example,
open "Training."
Run Analysis
Acute Analysis
DWLOC Analysis
Set Report Specs Help
:ile
Res|
Filer
Date k
Chemical Name: ChemicatK
Working Folder: C:\Documents and Settings\spiper\Desktop\
Acute Analysis Parameters
I Use second adjustment factor
W [Divide by body weight!
I Two Day Average
T oxicology endpoints:
Foods/Foodforms i
(T Dai, Total N°EL ^
C Eating Occasion
aRfD
mg/kg bw/day
10.0025 mg/kg bw/day
\~ Save Acute Rpt
r Save DWLOC Rpt
CEC File Generator
r Save CEC File
Standard Populations
| U.S. Population
r~ Hispanic
| Non-Hisp-White
| Non-Hisp-Black
Non-Hisp-Other
I Nursing Infants
| Non-Nursing Infants
Female 13+ PR EG
Children 1 -6
Children 7-12
Male 13-19
Female 13-1S/NP
Male 20+
Female 20+/NP
Seniors 55+
All Infants
| Female 13-50
I Children 1 -2
I Children 3-5
r Children 6-12
r Youth 13-19
r Adults 20-49
r Adults 50-99
r Female 13-49
Custom Subpopulations (Enter name, then click on number to open)
Name Name
m r
t2) r
(3)
[«) r
t5) p
(6)
T raining
ihow Residue File
Show Last Acute
Show Last Acute
Show Last CEC
1 Show Last .DWLOC
Show Last DWLOC
Report
Plot File
Report
Report
Plot File
2) The toxicology endpoints should automatically appear (if you added them in the
Edit Header option shown in section 3 of Getting Started). At this point, you will
have the option of changing any of the toxicological endpoints identified in the
file.
3) To compare exposure to an acute Population Adjusted Dose (aPAD), select "Edit
PADs" button. A window will appear with a list of population subgroups. [For
an acute analysis, we may have a different toxicology endpoint for females 13-49
yrs]. For this example, the aPAD= 0.0002 mg/kg/day for females 13-49 yrs]
Save and Click Exit
17
-------
File Run Analysis Set Report Specs Help
Residue File:
Filename: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: Chemical
Working Folder: CADocuments and Settings\spiper\Desktop\
Acute Analysis Parameters
T~ Use second adjustment factor
Divide by body weight
f~ Two Day Average
T oxicology endpoints:
_ _ , NOEL
Daily Total
Eating Occasion
aRfD
10.25
10.0025
mg/kg bw/day
mg/kg bw/day
W Use PAD
Edit PADs
f~~ Save Acute Rpt
r Save DWLOC Rpt
CEC File Generator
I- Save CEC File
§ Acute PAD Values
Nursing Infants
Non-Nursing Infants
Female 13+ PR EG
Children 1 -G
Children 7-12
Male 13-19
Female 13-19/NP
Male 20+
Female 20+/NP
Seniors 55+
All Infants
Female 13-50
Children 1 -2
Children 3-5
Children 6-12
Youth 13-19
Adults 20-49
Adults 50-99
Female 13-49
m
mg/kg-bw-day
Populations with blank PAD or PAD = 0
will use the current RfD endpoint.
Clear
Exit/Save
4) Under the Standard Populations, select the subpopulations of interest. Save the
acute analysis by selecting "Save Acute Rpt" and entering a file name.
Residue File:
Filename: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: Chemical
Working Folder: CADocuments and Settings\spiper\Desktop\
Acute Analysis Parameters
r Use second adjustment factor
fv* Divide by body weight
f~ T wo Day Average
T oxicology endpoints:
NOEL
(* Daily Total
C Eating Occasion
Standard Populations '
Foods/Foodforms
aRfD
0.25
0.0025
mg/kg bw/day
mg/kg bw/day
W Use PAD
Edit PADs
I*? Save Acute Rpt File Name (X.AC7) jTraining.AC7
Save DWLOC Rpt
r Save Plot File
CEC File Generator
Save CEC File
IV
U.S. Population
r
Female 13-50
r
Hispanic
17
Children 1 -2
r
Non-Hisp-White
17
Children 3-5
r
Non-Hisp-Black
I?
Children 6-12
r
Non-Hisp-Other
17
Youth 13-19
r
Nursing Infants
17
Adults 20-43
r
Non-Nursing Infants
17
Adults 50-93
r
Female 13+ PREG
17
Female 13-49
r
Children 1 -6
r
Children 7-12
r
Male 13-19
r
Female 13-19/NP
r
Male 20+
r
Female 20+/NP
r
Seniors 55+
W jAH Infants!
Custom Subpopulations (Enter name, then click on number to open)
Name Name
in
(2)
(3)
Run Comment
T raining
(4)
(5)
(G)
18
-------
5) Critical Exposure Commodity (CEC) Analysis: The acute CEC analysis is
analogous to the chronic critical commodity contribution analysis. This feature
permits the user to identify commodities that are contributing a user-specified
percentage of exposure with intervals between the 95th percentile of exposure
and the maximum exposure estimate.
5a) To run a DEEM-FCID acute CEC analysis, select "Save CEC File." You will
then be prompted to enter a CEC file name and the desired number of records,
minimum exposure contribution, and exposure intervals.
5b) Note: Maximum CEC records (1-500): This is the maximum number of
individual exposure records that can be saved to a CEC file.
Minimum Contribution (1-50%): Only foods/food forms that contribute more than
this percentage amount to an individual's total exposure will be included in the
CEC file.
Low/High Percentiles: User-specified to determine commodities contributing to
exposure between these percentiles.
Residue File:
Filename: T raining. R 2D
Date last saved: 9/25/2011 1:45:52 PM
Chemical Name: ChernicaK
Working Folder: C:\Documents and Settings\spiper\Desktop\
Acute Analysis Parameters
| Use second adjustment factor
15? Divide by body weight
T wo D ay Average
T oxicology endpoints:
(i Daily Total N°EL
C Eating Occasion
aRfD
0.25
0.0025
mg/kg bw/day
mg/kg bw/day
W Use PAD
Edit PADs
Save Acute Rpt File Name (XAC7) |Training.AC7
|~ Save DWLOC Rpt
I Save Plot File
CEC File Generator
\>/ Save CEC File File Name (X.CEC) |training.CEC
Man number of printed rjfj
records f1 -400001 1
Minimum Individual Exposure
Contribution by Food (%, 1 -50) P 0
CEC Boundary Basis:
(* Percentile Amounts
C Exposure Amounts
Low Percentile
l~~ Excel Format
Show Residue File
95%
96%
97%
97.5%
98%
99.5%
99.9%
s CEC warning |
1100% Cumul.
CEC
Cumulative CEC |-|e|p
Show Last Acute
Report
19
-------
6) Once you have identified the parameters for conducting the analyses and the
population groups of interest, click on "Run Analysis" at the top of the Acute
Analysis screen. A progress window will appear displaying the status of the
analysis.
nc r\ui i hi iaiy&i&
Residue File:
Filename: T raining
Date last saved: 1/3/2008 9:55:51 AM
Chemical Name: Chemical X
Working Folder: C:\DEEMFCID\
Acute Analysis Parameters
P/ Use second adjustment factor
Is? Divide by body weight
Foods/Foodforms
(* Daily Total
C Eating Occasion
T oxicology endpoints:
NOEL | o.25 mg/kg bw/day
aRfD 10.0025 rng/kg bw/day
I? Use PA
Standard Populations
fy* U.S. Population
[~~ U.S. Population (spring season)
f~ U.S. Population (summer season)
J- U.S. Population (autumn season)
f~ U.S. Population (winter season)
f~ Northeast region
F Midwest region
f~~ Southern region
T~ Western region
r Hispanics
Non-hisDanic whites
Acute Analysis Progress Report
File Name (X.AC7)
Is? S ave Acute Rpt
r Save DWLOC Rpt
F/ Save Plot File
r CE C File G enerator
Save CEC File File Name (X.CEC) |trainingacut
File Name (X.PLT)
Max number of printed pjTT
records (1-400001 |IU
Min Expos Contribution [Jo
by Food \%, 1 -501:
Low Percentile \S3Z ^ High Percentile |100%
f" Excel Format f Suppress CEC warning f~
T raining
f" Children 1 -6 yrs
F" Children 7-12 yrs
I- Females 13+ (preg/not nursing)
I- Females 13+ (nursing)
f~ Females 13-19 (not preg or nursing)
r Females 20+ (not preg or nursing)
f~~ Females 13-50 yrs
P Males 13-19 yrs
Males 20+yrs
Seniors 55+
Children 1 -2 yrs
5 yrs
12 yrs
|9 yrs
•9 yrs
yrs
49 yrs
m number to open)
Show Res File
Clear Form
Redo Last CEC
Last Acute Rpt
Last Acute Plot Fl
Last CEC Rpt
Last DWLOC Rpt
Last DWLOC Plot Fl
7) Once the analysis is completed, you will have the option of viewing the results
on the screen, saving to a disk, or printing the results by clicking on the "Last
Acute Rpt" button. You also have options of viewing the Residue File, Plot File,
and/or CEC Report.
20
-------
Ujjj
File Run Analysis Help
Residue File:
Filename: T raining
cuie Analysis
afiiiiHi
Date last saved: 1/3/2008 9:55:51 AM
Chemical Name: Chemical X
Working Folder: CADEEMFCID\
Acute Analysis Parameters
Use second adjustment factor
p Divide by body weight
r Foods/Foodforrns —
(* Daily Total
C Eating Occasion
Toxic
NOEl
aRfD
S ave Acute Rpt
r Save DWLQC Rpt
(7 Save Plot File
r CEC File Generator
[~ Save CEC File
File Name (x„d
File Name (X.F
File Name (X.CE
Maw number of printed rrpj
records fl -400001 1
Min Expos Contribution Hq
by Food \%, 1 -501: 1
Low Percentile |99%
V Excel Format V Suppress CEC
U.S. Environmental Protection Agency Ver. 2.02
DEEH-FCID ACUTE Analysis for CHEMICAL X (1994-98 data)
Residue file: Training 2008.R98 Adjustment factor #2 used.
Analysis Date: 01-03-2008/11:40:18 Residue file dated: 01-03-2008/09:55:51/8
NOEL (Acute) = 0.250000 mg/kg body-wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports
Daily totals for food and foodform consumption used.
Run Comment: "Training "
Summary calculations (per capita):
95th. Percentile
Exposure % aPAD
99th Percentile
Exposure % aPAD
99.9th Percentile
Exposure % aPAD HOE
U.S. P opulat i on:
0.014368 574.73
All infants:
0.069742 2789.67
Children 1-2 yrs:
0.053136 2125.45
Children 3-5 yrs:
0.046087 1843.49
Children 6-12 yrs:
0.027544 1101.76
Youth 13-19 yrs:
0.010321 412.85
Adults 20-49 yrs:
0.009484 379.37
Adults 50+ yrs:
0.010961 438.43
Females 13-49 yrs:
0.010655 5327.41
0.040298 1611.92
0.129044 5161.75
4
5
9
24
26
22
23
086372 3454.88
078170 3126.81
048758 1950.33
019886 795.42
016955 678.21
021087 843.47
019018 9508.87
2
3
5
12
14
11
13
0.094161 3766.45
0.209896 8395.83
0.128181 5127.24
0.152443 6097.74
0.106215 4248.60
0.032318 1292.71
0.035968 1438.71
0.038251 1530.03
0.046676 >10000
1 |
Ilear Form
Redo Last CEC
Show Res File
Last Acute Rpt
Last Acute Plot Fl
Last CEC Rpt
Last DWL0C Rpt
Last DWL0C Plot Fl 1
8) Additional Features: Custom Population Groups allow you to select from 6
custom populations for any single analysis based on sex, age, season, ethnicity,
etc. Enter the name of a population group in the "Custom Subpopulations"
section and click on the number to the left of the box. This will prompt the
Custom Subpopulation menu to appear and you may then select your preferences
for the indicated population. Once the population group has been identified, click
on the Definition Complete button and you will be returned to the DEEM-FCID
acute analysis screen.
21
-------
Custom Subpopulation: (1) testl
r Sex
Male
I Female
Age
_ All Ages
nr
from pj~
to fi
C months
(* years
S
easons
All Seasons
W Spring
W Summer
W Fall
W Winter
Race
| All Races
W Hispanic
) NonHispanic White
I NonHispanic Black
Other
r
months
f?
years
Pregnant/Nursing Status (Female) —
All
I Not Pregnant/Not Nursing
I Pregnant
I Nursing
Nursing Status (<3 years)
I Nursing and Non-Nursing
| Non-Nursing
I Nursing
Regions
All regions
North East
p" North Central
South
West
aPAD
Definition Complete
Cancel
Help
Note: At least one box in each frame
must be checked to complete this
screen (except for males only, do not
check any box in the Pregnant/Nursing
Status frame, and for ages above 3
years you do not need to check Nursing
Status).
mg\kg-bw-day
9) The Plot File consists of the entire per-user exposure distribution. The plot file
includes information about the actual (unweighted) and weighted number of
people-days and user-days in the populations considered. It can be imported in a
spreadsheet program for statistical manipulation or to produce graphs. The plot
file runs automatically with the acute analysis. Once the analysis is completed,
you will have the option of viewing the results on the screen, saving to a disk, or
printing the results by clicking on the "Last Acute Plot Fl" button.
10) Acute Report Specifications allows you to report features (per user, per capita,
and/or percentile for exposure) that you want to see.
Jl Acute Report Specifications
This is a new feature in DEEM Acute. In past versions of DEEM Acute both per capita and user means and
distributions were reported, along with summary statistics for the 95th, 99th, and 99.9th percentiles. Now you can
specify more precisely the reporting features that you wish to see. Your specifications will be saved and used for all of
your DEEM Acute reports until you change them here.
[Report User Distribution!
1^ Report Per Capita Distribution
Header and page numbers on report
»— Specify Minimum Percent
Contribution in CEC Report (0-50%)
More Info
Select 3 Percentiles for Exposure Summary
F 90% r 99-5%
W 95% |T~ 99.75
97.5% W 99.9%
W 99%
Save/Exit
Cancel
22
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