United States Environmental Protection Agency	Office of Research and Development

National Exposure Research Laboratory
Research Abstract

Government Performance Results Act (GPRA) Goal 4.5
Annual Performance Measure 228

Significant Research Findings:

Workshop on Exposure Research Needs for Addressing Cumulative Risk

Scientific	Humans and other living things are exposed to a multitude of chemicals, physical

Problem and	agents, and other stressors through multiple pathways, routes, and sources. To

Policy Issues	address this problem, the U.S. EPA's Office of Research and Development (ORD)

has identified cumulative-risk assessment as a priority research area. In order to
assess cumulative risk, one must shift from the traditional paradigm of assessing
risk on an individual chemical or facility basis, to a person-oriented community
(population) basis. Typically, when estimating population exposures, risk
assessors do not simultaneously track an individual's exposure to multiple
chemicals and do not consider factors other than chemical exposure that can
contribute to adverse health effects. These other factors include
individual-specific factors (e.g., compromised health), exposure to non-chemical
stressors, and exposures accumulated over time. Many different types of data are
required and these data need to be collected, interpreted, and presented in new
ways to classify populations and characterize exposures.

EPA's National Exposure Research Laboratory (NERL) conducted an internal
workshop to examine exposure research needs for addressing cumulative risk.
Workshop participants from NERL and the Lawrence Berkeley National
Laboratory (LBNL) reviewed and evaluated recent cumulative-risk research
documents. Participants then identified research needs relevant to exposure and
dose modeling and proposed future research areas.

Results and	This workshop was an important first step towards formulating a comprehensive

Impact	research strategy for exposure and dose modeling to address cumulative risk.

Research	The workshop and its output is the result of a collaboration between EPA's NERL

Collaboration and and one of its university partners, LBNL. Discussions from the workshop were

Research	summarized and prepared as an internal report (NERL-RTP-HEASD-04-120).


Future Research NERL will identify specific exposure and dose modeling research in consultation
with EPA's ORD, Program Offices, and Regional representatives. In addition to
extending internal collaborative efforts, expert solicitation outside of the Agency is
warranted due to the importance, breadth, and depth of cumulative-risk research.
NERL will summarize the research needs, identify available tools and gaps, and
propose a new research framework and conceptual model in a draft research plan.
NERL will then conduct another workshop consisting of experts in cumulative risk
and exposure modeling to evaluate each component of the draft research plan. A


final research plan will be developed based on the workshop recommendations.

Contacts for	Questions and inquiries can be directed to:


Information	Stephen E. Graham, Ph.D.

U.S. EPA, Office of Research and Development
National Exposure Research Laboratory
109 TW Alexander Drive
Phone: 919/541-4344
E-mail: graham.stephen@epa.gov

Elaine Cohen-Hubal, Ph.D.

U.S. EPA, Office of Research and Development
National Exposure Research Laboratory
109 TW Alexander Drive
Phone: 919/541-4077
E-mail: hubal.elaine@epa.gov

Partial Federal funding for this research was administered under EPA Interagency
Agreement DW-8993-0582 to Lawrence Berkeley National Laboratory,
Environmental Energy Technologies Division, Indoor Environment Department.