Toxics Release Inventory (TRI) and Pollution Prevention (P2)

Summary of Solvent Substitution Information
Overview of Solvent Use and Substitution

Solvents are chemicals used to dissolve other substances. At industrial
facilities, this means solvents are often used as cleaners, degreasers,
reaction media, extraction aids, and ingredients in products. However,
exposure to solvent chemicals released into the air, water, and land has the
potential to harm humans and the environment. The best way to prevent
these chemicals from entering the environment is to eliminate or reduce
their use in facility operations—a process known as source reduction.

Learn about the benefits of source reduction.

Substituting a solvent with a less hazardous alternative is one approach to
source reduction. Identifying suitable substitutions requires a holistic
evaluation of the process(es) in question, including material inputs, energy requirements, and necessary solvent
properties. The hazard profiles of potential replacement solvents must be well characterized to avoid replacing one
hazardous solvent with another that is just as harmful or worse. Additionally, efficacy, cost, government regulations,
and product standards may be important factors for solvent substitution. Learn more in the solvent, substitution
resources listed below.

TRI Pollution Prevention Data Analysis

The Toxics Release Inventory (TRI) includes several chemicals commonly used as solvents. Each year, facilities subject
to TRI requirements must report any newly implemented pollution prevention activities and may provide optional
comments describing efforts to reduce the use of TRI chemicals. Between 2005 and 2020, facilities submitted
1,926 comments related to substitutions of TRI-listed solvent chemicals. A subset of 391 comments describe specific
substitutions (e.g., name the alternative chemical or process), reported by facilities in 16 industry sectors. These
comments represent 116 distinct substitution combinations for TRI-listed solvent chemicals.

The reported solvent substitution comments are mainly associated with modifications to cleaning or coating materials
and processes. Facilities most commonly replaced xylene (mixed isomers), toluene, and methanol. The most common
substitutes were aqueous products and powder coatings, followed by high solids. Based on comments with specific
substitutions, the chart below shows the top 10 TRI-listed solvent chemicals and the top five substitutes.

Original TRI-Listed
Solvent Chemical
refers to the starting
chemical replaced
which is often the
TRI chemical on the
Form R.

While most reported
substitutes are not
on the TRI list, some
facilities transition
from one TRI-listed
chemical to another
(e.g., from xylene
(mixed isomers) to
o xylene).

Learn more about TRI's P2 Information at www.epa.gov/p2



Quick Stats

•	Facilities in 16 industry sectors reported
391 comments about specific solvent
substitutions from 2005-2020

•	Comments cover 11© distinct solvent
substitutions for TRI-listed chemicals

•	Substitutions are typically associated
with modifications to cleaning or coating
materials

Top Reported TRI Solvent Chemicals and their Substitutes

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Aqueous product

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Powder

Original TRI-Listed Solvent Chemical
High Solids	Acetone	Propylene glycol	Other substitutes


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£ CPA Toxics Release Inventory (TRI) and Pollution Prevention (P2)

Summary of Solvent Substitution Information

Examples of Solvent Substitutions Reported by Facilities

Below are examples of optional comments describing solvent substitutions. This information provides insight into how
businesses are transitioning to other chemicals and processes. In general, facilities report substituting for chemicals
not on the TRI list.

•	A motor vehicle body manufacturer in Indiana reduced toluene releases by replacing a toluene-based purge
solvent used in paint processes with one that is primarily acetone and isopropyl alcohol.

•	A fabricated structural metal manufacturing facility in Michigan stopped spray painting and instead switched to
powder coating of some products, which eliminated xylene.

•	A commercial lithographic printer in Maine eliminated methanol by converting from methanol-to acetone-based
ink for catalog address labeling.

Note that EPA does not conduct comparative toxicity assessments of substitutions reported to TRI. To learn about
other limitations of TRI, refer to Factors to Consider When Using TRI.

Inventory of Specific Chemical Substitutions

The chemicals sector submitted the most solvent substitution comments, followed by metal manufacturing and
fabrication and transportation equipment sectors. The table below summarizes the reported substitutes for TRI-Iisted
chemicals by industry sectors, covering most of EPA's National Emphasis Areas.

Sector

Summary

Most Common Original TRI-
Listed Solvent Chemical

Most Common Substitutes

Chemicals, 325

79 specific comments
13 TRI original solvents
24 substitutes

Toiuene

Aqueous product, Xylene (mixed isomers), Acetone

Xylene (mixed isomers)

Aqueous product, Toluene, o-Xylene

Methanol

Isopropanol, High solids, Aqueous product, Ethanol

Metal Manufacturing
and Fabrication, 331
and 332

61 specific comments
15 TRI original solvents
14 substitutes

Xylene (mixed isomers)

Powder, Acetone

Toluene

Aqueous product, Powder

Trichloroethylene

1-Bromopropane, Aqueous product

Transportation
Equipment, 336*

49 specific comments
14 TRI original solvents
16 substitutes

Xylene (mixed isomers)

o-Xylene, Aqueous product

Toluene

Acetone, Aqueous product

Tetrachloroethyiene

p-Chlorobenzotrifluoride

Other Sectors**

202 specific comments
18 TRI original solvents
34 substitutes

Toluene

Aqueous product, Ethyl acetate

Xylene (mixed isomers)

Aqueous product, Powder

Methanol

Aqueous product, High solids

^Transportation Equipment includes Automotive Manufacturing (3361-3363) and Aerospace Product and Parts Manufacturing (3364).
** Other Sectors includes other TRI sectors, including the Food and Beverage Manufacturing National Emphasis Area (311 and 312).

Solvent Substitution Resources

There are numerous resources available to help identify substitutes for hazardous solvents.

•	Solvent Selection Guide from the American Chemical Society's Green Chemistry Institute

•	CHEM 21 selection guide from the Innovative Medicine Initiative

To explore the solvent substitution data compiled over the last 15 years, visit TRI's Solvent Substitution webpage. You
can filter by TRI chemical, substitute, or industry sector, or you can export all available data.


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