Invitation for Comment on the Short List Candidates for the
Clean Air Scientific Advisory Committee (CASAC)
Carbon Monoxide Review Panel
5 February 2008

The EPA Science Advisory Board (SAB) Staff Office is forming the Clean Air
Scientific Advisory Committee (CASAC) Carbon Monoxide Review Panel (Panel). The
Panel will provide advice to the EPA Administrator regarding the primary national
ambient air quality standards (NAAQS) for carbon monoxide (CO). Nominations for
technical experts to augment the chartered CASAC were requested in a 12 October 2007
Federal Register Notice (72 FR 58078). Individuals with expertise regarding carbon
monoxide in one or more of the following areas were sought: atmospheric science;
exposure modeling; risk assessment modeling; dosimetry; toxicology; controlled human
exposure; epidemiology; and biostatistics.

Biosketches of the seven members of CASAC are available at:
http://vosemite.epa.gov/sab/sabpeople.nsfAVebCommittees/CASAC. Below are the
biosketches for the fifteen candidates under consideration. We hereby invite comments
from members of the public for relevant information, analysis or other documentation for
the consideration of the SAB Staff Office in making the final decision about the CASAC
CO Panel.

Information furnished by the public in response to this Web site posting will be
combined with information provided by the nominee and information gathered
independently by the SAB Staff Office. For the SAB Staff Office, a balanced
subcommittee or review panel includes nominees with the necessary domains of
knowledge, the relevant scientific perspectives (which, among other factors, can be
influenced by work history and affiliation), and the collective breadth of experience to
adequately address the charge. Specific criteria to be used in evaluating an individual
Panel member include: (a) scientific and/or technical expertise, knowledge, and
experience; (b) availability and willingness to serve; (c) absence of financial conflicts of
interest; (d) absence of an appearance of a lack of impartiality; and (e) skills working in
committees, subcommittees and advisory panels; and, for the Panel as a whole, (f)
diversity of, and balance among, scientific expertise, viewpoints, etc. The SAB Staff
Office Director makes the final decision concerning who will serve on the CASAC CO
Review Panel.

Please provide any comments no later than 26 February 2008. Please make your
comments to the attention of Ms. Kyndall Barry, Designated Federal Officer (DFO), at:
barrv.kyndall@epa.gov.

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CASAC Carbon Monoxide NAAQS Review Panel

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Dahms,Thomas

Thomas E. Dahms, Ph.D., is a professor in the Department of Anesthesiology and Critical Care at St. Louis University Medical School. He holds secondary appointments in the Department of Internal
Medicine (Division of Pulmonology, Critical Care and Sleep Medicine) and in the Department of Surgery. He has been actively involved in Carbon Monoxide research for nearly 40 years. He served as
corresponding author for publications relating to the health effects of low levels of CO on individuals with cardiovascular disease. Dr. Dahms has expertise in the measurement of endogenous levels of CO
in blood. Dr. Dahms served as a consultant to the EPA in 1990-91 and again in 1998-99 for the purposes of drafting the documents relating to the Air Quality Criteria for Carbon Monoxide. Additional
research interests of Dr. Dahms focus on the impact of inflammation in the pulmonary circulation and air ways on gas transfer in the lung.

Dickerson,Russell R.	

The University of Maryland, College Park

Russell R. Dickerson received his AB in 1975 from the University of Chicago and his Ph.D. in 1980 from The University of Michigan, where he studied the interaction of radiation and trace gases in the
atmosphere. After graduation, he worked with Nobel Laureate Paul Crutzen in the Air Chemistry Division at NCAR and in the Abteilung Luftchemie at the Max Planck Institute in Mainz, Germany. Professor
Dickerson began working in the Department of Meteorology as an Assistant Professor in 1983 as the sole atmospheric chemist. He built the program in atmospheric chemistry and air pollution to include six
faculty, several post docs and more than a dozen graduate students. His research has expanded to include the interactions of weather phenomena such as thunderstorms and atmospheric chemistry,
ocean-atmosphere interactions, air pollution, the links between particulate and gaseous chemistry and global biogeochemical cycles. His research group, composed of meteorologists, engineers, and
chemists, develops analytical instruments (for species such as NOx, CO, NH3, aerosols, and for photolysis rate measurements), employs these instruments in the laboratory, field, and on ships and aircraft,
and interprets the results in terms of photochemistry, heterogeneous processes, and atmospheric physics with the aid of numerical chemical transport and cloud models. He has won external funding
awards in excess of $10M from MDE, NSF, NOAA, EPA, DOE, NASA and private industry. More recently, remote sensing from satellites has been added to better extrapolate from in situ observations to
large-scale processes and climate impacts. Among the more exciting recent discoveries are smoke pall from South Asia, rapid ozone destruction in the marine boundary layer, the impact of aerosol radiative
forcing on air quality, and the dry convection as a major mechanism in inter-hemispheric transport of air pollution form China. He has helped define, plan, and execute the Atmosphere Ocean Chemistry
Experiment (AEROCE), and the Indian Ocean Experiment (INDOEX), and served as the Chief Scientist on the R/V Ronald Brown. He served on the steering committees of Center for Clouds Chemistry and
Climate (C4), INDOEX, NARSTO, and BASE-ASIA. Professor Dickerson was a member of the National Academy of Sciences National Research Council Committee on Animal Feeding Operations and has
helped write a NRC Report on the impact of agriculture on air pollution in the US. He has been a coauthor of the EPA Criteria Documents for CO, 03 and PM, contributing the sections on analytical
techniques and interpretation of results from field experiments. He serves on the Maryland Climate Change Commission. In teaching, Professor Dickerson developed courses in Air Pollution (AOSC 434),
Atmospheric Chemistry (AOSC/CHEM 637) and Air Sampling and Analysis (AOSC/CHPH 634). He has directed research for 14 B.S., 13 M.S., and 19 Ph.D. degrees in METO(AOSC), CHEM and CHPH. The
Regional Atmospheric Measurement, Modeling and Prediction Program (RAMMPP) that he heads acts as the scientific arm of the Maryland Department of the Environment and Department of Natural
Resources concerning air quality issues in the Mid-Atlantic region. RAMMPP makes air quality forecasts, emissions estimates, aircraft measurements, and helps develop plans for compliance with the Clean
Air Act such as State Implementation Plans (SIPS). He is co-director of EAST-AIRE, East Asian Study of Tropospheric Aerosol: International Regional Experiment where the first aircraft measurements of air
pollutants over China were made. Dickerson serves on various committees including the Science Advisory Committee of the Texas Environmental Research Consortium. The Chronicle of Higher Education
ranked AOSC as the 4th best program in the US in 2007, the last year in which Prof. Dickerson chaired the Department; see:
http://chronicle.com/stats/productivity/page.php?year=2007&primary=4&secondary=130&bycat=Go.

F echter,Laurence

Dr. Laurence Fechter has been a Research Scientist at the Jerry L. Pettis Memorial VA Medical Center in Loma Linda, CA since 2002 and holds a Research Professorship in the Department of Surgery at the
Loma Linda University School of Medicine. Prior to taking these positions, Dr. Fechter was the Mosier Centennial Professor of Toxicology and Director of the Oklahoma Center for Toxicology at the
University of Oklahoma Health Sciences Center (1993-2002). His first academic position was in the Department of Environmental Health Sciences at the Johns Hopkins School of Hygiene and Public Health
(1976-1993) where he attained the rank of Professor of Environmental Toxicology. Dr. Fechter obtained his Ph.D. from the University of Rochester (1973) in the fields of Neurosciences/Biopsychology and
undertook post-doctoral training in the Medical Pharmacology Institute at the University of Uppsala (Sweden) Biomedical Center and in the Environmental Toxicology Division at Hopkins School of Hygiene.
Dr. Fechter's research career has focused on two principal areas of neurotoxicology; susceptibility of the developing organism to toxicants and on the potentiation of neurotoxicology by multiple agents.
These two foci have resulted in over 25 peer reviewed manuscripts related to carbon monoxide toxicity (out of approximately 80 total peer-reviewed papers) as well as to multiple review articles and
chapters. He maintains an active research program in neurotoxicology where his focus has been predominantly in the areas of metabolic stress and complex environmental exposures that yield potentiation
of toxicity. This work has entailed studies of carbon monoxide, hydrogen cyanide, and acrylonitrile neurotoxicity focused predominantly on auditory system function. This work has included benchmark dose
calculations and consideration of risk assessment. He has also studied the neurotoxicity of complex hydrocarbon mixtures (aviation fuels) His research is currently funded by a VA Rehabilitation Service
grant recently renewed until 2011. He also holds a Senior Research Scientist Career Award from the VA which is funded from 2007-2014. Additional research support has been provided by the American
Petroleum Institute for research on fuel. Until he took a position at the VA, Dr. Fechter's research had been funded by NIH-NIEHS, NIH-NIDCD, NIOSH, the US EPA, and the Health Effects Institute among

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others. Dr. Fechter has played an active consulting role in grant and manuscript review processes and in government policy review. He has served on review panels for NIEHS Superfund Research Center
grants and has served as an ad hoc member or chair for multiple NIH and NIOSH P30, P40, P01, ROl, R03, and R29 grants. He has served as a consultant on the Carbon Monoxide Criteria Document on
two occasions (1979, 1984) and as a contributing author (1987- 1992) to that document. He has also been a consultant to the National Commission on Air Quality with regard to Carbon Monoxide at High
Altitude, and to the US EPA SAC for a Developmental Toxicology Guideline. Dr. Fechter has also served as a consultant to the Ontario (Canada) Labour Relations Board on issues relating to occupational
exposures, and the World Health Organization. He is an active member of the Society of Toxicology, the International Neurotoxicology Association (of which he has held multiple offices including that of
President), and the Association for Research in Otolaryngology. He has served on the editorial boards of Toxicological Sciences, Neurotoxicology, and Neurotoxicology & Teratology and reviews widely for
toxicology and hearing research journals. Dr. Fechter is currently serving as a scientific consultant on a review of the trichloroethylene literature for the US EPA.

Guensler, Randall

Randall Guensler is a Professor in the School of Civil and Environmental Engineering at the Georgia Institute of Technology. After working for the California Air Resources Board for seven years, and
completing his Ph.D. in Civil Engineering at the University of California at Davis, Dr. Guensler joined Georgia Tech in 1994. During his years with the State of California, Dr. Guensler worked for four years
in Compliance Assistance and for three years in the Executive Office, evaluating the design and implementation of transportation control measures by regional air quality management agencies. Since
arriving at Georgia Tech, Dr. Guensler's main research focus has been the development of new monitoring and modeling tools to assess the air quality impacts of transportation policies. Dr. Guensler was
the Chairman of the Transportation Research Board committee on Transportation and Air Quality from 1997 to 2002. From 1995 to 2001, Dr. Guensler served on the Environmental Protection Agency's
Mobile Source Technical Advisory Subcommittee. Over the past ten years, he has served on various National Academy of Sciences committees and panels charged with the assessment of vehicle emissions
impacts and identification of research needs. Dr. Guensler is the director of Commute Atlanta, a $2.3 million joint value pricing initiative sponsored by the Federal Highway Administration and Georgia
Department of Transportation. Commute Atlanta includes the collection and analysis of second-by-second vehicle speed, position, and engine operating data from 470 vehicles in representative Atlanta
households. The researchers have monitored more than 1.4 million vehicle trips (more than 350,000 vehicle-miles per month). In 2005, the Commute Atlanta households began participating in road pricing
experiments (cent/mile pricing, as well as real-time congestion pricing). Dr. Guensler's research team is assessing consumer response to these pricing mechanisms. A secondary focus of the research is the
enhancement of monitoring technologies and services to support future transportation planning, safety, and operations policy initiatives. Development of tools for data management, data analysis, and
privacy protection became major research activities. Secondary research has also included analysis of speeding, journey to work route choice, trip chaining, activity-based demand, household tripmaking
variability, household and vehicle range of travel, long-distance travel, freeway operations, engine load, start and soak distributions, transit bus operations, etc.

Hazucha, Milan

University of North Carolina - Chapel Hill

Dr. Milan J. Hazucha is a Professor of Medicine in the Department of Medicine, School of Medicine and a Senior Research Scientist in the Center for Environmental Medicine, Asthma and Lung Biology,
University of North Carolina at Chapel Hill. He received his M.D. in 1962 from the Comenius' University, Bratislava, Slovakia and his Ph.D. (Physiology, 1974) from McGill University, Montreal, Canada. As a
Professor in The Graduate School and in the Curriculum in Toxicology, University of North Carolina he has been actively involved in teaching and directs a course on the health effects of air pollutants. He is
a member of multiple professional organizations and over the years he has served on many professional committees. Dr. Hazucha has a longstanding experience and published expertise in the pulmonary
and cardiovascular health effects of air pollutants (Ozone, CO, NOx) in healthy and at-risk population such as children, asthmatics and individuals with chronic lung disease. His specific expertise is in the
area of physiologic assessment of effects and mechanisms of action. Over the past 30 years he has been either a Principal Investigator or a Co-Investigator in numerous collaborative laboratory and field
exposure studies with the EPA HSD investigators. He has also participated in many EPA-organized workshops and contributed periodically in writing sections and reviewing NAAQS for ozone, CO and NOx.
More recently his work has focused on studying the mechanisms involved in production and release of NO in patients with primary ciliary dyskinesia (PCD).

Kleinman,Michael T.

University of California, Irvine

Michael T. Kleinman is a Professor of Community and Environmental Medicine at the University of California, Irvine. He is an inhalation toxicologist and has been studying the health effects of exposures to
environmental contaminants found in ambient air for more than 30 years. He holds a MS in Chemistry (Biochemistry) from the Polytechnic Institute of Brooklyn and a Ph.D. in Environmental Health
Sciences from New York University. He is a Professor and Co-Director of the Air Pollution Health Effects Laboratory in the Department of Community and Environmental Medicine at University of California,
Irvine. Prior to joining the faculty at U.C.I, in 1982, he directed the Aerosol Exposure and Analytical Laboratory at Rancho Los Amigos Hospital in Downey, CA. He has published more than 95 articles in
peer-reviewed journals dealing with environmental contaminants and their effects on cardiopulmonary and immunological systems. He has directed more than 50 controlled exposure studies of human
volunteers and laboratory animals to ozone and other photochemical oxidants, carbon monoxide, ambient particulate matter and laboratory-generated aerosols containing chemically or biologically reactive
metals such as lead, cadmium, iron and manganese. He recently served on two National Academy committees to examine issues in protecting deployed US Forces from the effects of chemical and
biological weapons. Dr. Kleinman's current studies focus on neurological and cardiopulmonary effects of inhaled particles, including nanomaterials and ultrafine, fine and coarse ambient particles in humans
and laboratory animals. His current studies have demonstrated that inhalation of combustion-generated particles can promote airway allergies and accelerate the development of cardiovascular disease and
that these effects may be associated with organic and elemental carbon components of the ultrafine fraction of the ambient aerosol. His studies have also demonstrated that inhalation of ambient particles
is associated with persistent inflammation in the brain and that particles associated with manganese can alter dopamine and serotonin levels in the brain and can cause changes in nerve structure during

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University of Colorado - Boulder

Dr. Roger A. Pielke Sr. is currently a Senior Research Scientist in CIRES and a Senior Research Associate at the University of Colorado-Boulder in the Program in Atmospheric and Oceanic Sciences (PAOS)
at the University of Colorado in Boulder (Nov. 2005 -present). He is also an Emeritus Professor of Atmospheric Science at Colorado State University and has a five-year appointment (April 2007 - March
2012) on the Graduate Faculty of Purdue University in West Lafayette, Indiana. He received a B.A. in Mathematics from Towson State College in 1968 and an M.S. and Ph.D. in Meteorology from
Pennsylvania State University in 1969 and 1973, respectively. Pielke has studied terrain-induced mesoscale systems, including the development of a three-dimensional mesoscale model of the sea breeze,
for which he received the NOAA Distinguished Authorship Award for 1974. Dr. Pielke has worked for NOAA's Experimental Meteorology Lab (1971-1974), The University of Virginia (1974-1981), and
Colorado State University (1981-2006). He served as Colorado State Climatologist from 1999-2006. He was an adjunct faculty member in the Department of Civil and Environmental Engineering at Duke
University in Durham, North Carolina (July 2003-2006) and a visiting Professor in the Department of Atmospheric Sciences at the University of Arizona from October to December 2004.He has served as
Chairman and Member of the AMS Committee on Weather Forecasting and Analysis, and was Chief Editor for the Monthly Weather Review for 5 years from 1981 to 1985. In 1977, he received the AMS
Leroy Meisinger Award for "fundamental contributions to mesoscale meteorology through numerical modeling of the sea breeze and interaction among the mountains, oceans, boundary layer, and the free
atmosphere." Dr. Pielke received the 1984 Abell New Faculty Research and Graduate Program Award, and also received the 1987/1988 Abell Research Faculty Award. He was declared "Researcher of the
Year" by the Colorado State University Research Foundation in 1993. In 2000 he received the Engineering Dean's Council Award from Colorado State University. He has authored a book published by
Academic Press entitled Mesoscale Meteorological Modeling (1984) with a 2nd edition in 2002, a book for Routledge Press entitled The Hurricane (1990), a book (co-authored with W.R. Cotton) for
Cambridge Press entitled Human Impacts on Weather and Climate (1995; 2nd Edition 2006), a book (co-authored with R.A. Pielke, Jr.) entitled Hurricanes: Their Nature and Impacts on Society published
in 1997 by John Wiley and Sons, and was Co-Chief Editor (with R.A. Pielke, Jr.) of a book entitled Storms, published by Routledge Press in 1999.Dr. Pielke was elected a Fellow of the AMS in 1982 and a
Fellow of the American Geophysical Union in 2004. From 1993-1996, he served as Editor-in-Chief of the US National Science Report to the IUGG (1991-1994) for the American Geophysical Union. From
January 1996 to December 2000, he served as Co-Chief Editor of the Journal of Atmospheric Science. In 1998, he received NOAA's ERL Outstanding Scientific Paper (with Conrad Ziegler and Tsengdar Lee)
for a modeling study of the convective dryline. He was designated a Pennsylvania State Centennial Fellow in 1996, and named the Pennsylvania State College of Earth and Mineral Sciences Alumni of the
year for 1999 (with Bill Cotton). He is among one of three faculty and one of four members listed by ISI HighlyCited in Geosciences at Colorado State University and the University of Colorado at Boulder,
respectively. Professor Pielke has published over 300 papers in peer-reviewed journals, 50 chapters in books, and co-edited 9 books. A listing of papers can be viewed at the project website:
http://cires.colorado.edu/science/groups/pielke/pubs/.

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Ritz,Beate

UCLA

Beate Ritz, MD, Ph.D., is Professor and Vice Chair the Department of Epidemiology with co-appointments in the department of Environmental Health at the UCLA School of Public Health and the
department of Neurology UCLA School of Medicine; she is a member of the Center for Occupational and Environmental Health, the NIEHS-UCLA-USC Environmental Health Science Center, and co-director
of the NIEHS-funded UCLA Center for Gene-Environment Studies of Parkinson's disease. Her primary research interests are the effects of occupational and environmental toxins such as pesticides, ionizing
radiation, and air pollution on chronic diseases including neurodegenerative disorders (Parkinson's disease), cancers, and adverse birth outcomes including birth defects and asthma. She currently studies
the effects of air pollution on adverse birth outcomes and asthma in children in Southern California and investigates the long-term effects of pesticide exposures on Parkinson's disease and cancers. Her
research involves extensive geographic information system (GIS) modeling of environmental exposures including pesticide use and traffic related air pollution in California and the application of hierarchical
modeling procedure of longitudinal data in cohort studies. She is directing or collaborating in a large number of federally (NIEHS), state (California Air Resources Board), and foundation (Micheal J Fox
Foundation) funded research projects.

Roberts,Paul

Sonoma Technology, Inc.

Dr. Paul T. Roberts is Executive Vice President and Chief Scientific Officer of Sonoma Technology, Inc. At STI since 1986, Dr. Roberts' work focuses on the design and management of air quality field, data
management, and data analysis projects. Dr. Roberts earned his Ph.D. degree in Environmental Engineering Science at the California Institute of Technology in 1975 working for Professor Sheldon K.
Friedlander on formation of secondary aerosols in the Los Angeles basin. His B.S. and M.Ch.E degrees in Chemical Engineering are from Rice University (1969 and 1970).Dr. Roberts served on the EPA
External Peer-Review Panel for the Air Quality Criteria Document for Carbon Monoxide in 1998-1999. He has also served on numerous STAR-grant and similar peer-review panels for EPA and HEI. Dr.
Roberts was a member of the California Inspection and Maintenance Review Committee in 1994-1995.Most of Dr. Roberts' projects involve the use of field data and analysis methods to understand
important meteorological, air quality, and exposure phenomena; to support the development, application, and evaluation of meteorological, photochemical, and exposure models; and to evaluate the
effectiveness of ambient air quality and meteorological networks in meeting various regulatory requirements. Dr. Roberts has expertise in the atmospheric science, exposure assessment, and measurement
of ozone and particulate matter (PM) and their precursors, and of carbon monoxide (CO), toxics, and visibility. He has led and performed air quality projects throughout the western, central, mid-western,
mid-Atlantic, and northeastern United States; and in Juarez, Mexico, and Cairo, Egypt. Recently, his work has focused on near-roadway and other near-source exposures to PM and toxics, as well as CO
and nitrogen dioxide (N02). Dr. Roberts is a member of the Air and Waste Management Association and the American Associate for Aerosol Research.

Thom,Stephen

University of Pennsylvania

Stephen R. Thom, MD, Ph.D., is Chief of Hyperbaric Medicine for the University of Pennsylvania's Institute for Environmental Medicine and Medical Director of the Pennstar Flight Program. He is also
Professor of Emergency Medicine and Emergency Medicine in Pediatrics at the University of Pennsylvania and Children's Hospital of Philadelphia, respectively. With published papers involving studies with
cell cultures, animal models and clinical trials; his lab has had an interest in carbon monoxide (CO) pathophysiology for some years. Our work has shown that there are biochemical/physiological responses
to CO that depend on both the concentration and duration of exposure. In cell cultures, biochemical evidence of oxidative stress responses occur with exposures to just 20 ppm CO. Intravascular effects in
humans were demonstrated following exposures lasting less than 1 hour and COHb levels on the order of 19 %. We have shown that neuropathology results from a relatively complex cascade of
intravascular and perivascular events.

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