Final Scope of Risk Evaluation for Octamethylcyclotetra- siloxane (D4) Supplemental File: Data Extraction and Data Evaluation Tables for Physical and Chemical Property Studies CASRN: 556-67-2


vvEPA

February 2022

United States	Office of Chemical Safety and

Environmental Protection Agency	Pollution Prevention

Final Scope of Risk Evaluation for
Octamethylcyclotetra- siloxane (D4)

Supplemental File:

Data Extraction and Data Evaluation Tables
for Physical and Chemical Property Studies
CASRN: 556-67-2

CHo
H3^ I

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O

h3c

Si—,CH3
Si"—CH:

-Si

/ \ /
h3c O—Si

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h3c

o

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February 2022

-------
Table of Contents

Data Extraction Tables	6

Table 1. Physical State Study Summary for Octamethylcyclotetra- siloxane (D4)	6

Table 2. Physical Properties Study Summary for D4	6

Table 3. Melting Point Study Summary for D4	7

Table 4. Boiling Point Study Summary for D4	8

Table 5. Density Study Summary for D4	9

Table 6. Vapor Pressure Study Summary for D4	10

Table 7. Vapor Density Study Summary for D4	10

Table 8. Water Solubility Study Summary for D4	11

Table 9. Octanol Water Coefficient (logKow) Study Summary for D4	13

Table 10. Henry's Law Constant Study Summary for D4	15

Table 11. Flash Point Study Summary for D4	17

Table 12. Auto Flammability Study Summary for D4	17

Table 13. Viscosity Study Summary forD4	17

Table 14. Refractive Index Study Summary for D4	18

Table 15. Dielectric Constant Study Summary for D4	18

EPI Suite™ Model Outputs	19

Data Evaluation Tables	22

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	22

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	27

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	28

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	29

Fuller, J; White, D; Yi, H; Colley, J; Vickery, Z; Liu, S. (2020). Analysis of volatile compounds
causing undesirable odors in a polypropylene - high-density polyethylene recycled plastic resin

with solid-phase microextraction. Chemosphere 260: 127589. HERO ID:6834323	 30

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	 31

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry. The

Merck index: An encyclopedia for chemicals, drugs, and biologicals. HERO ID:6982970 	 32

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	33

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC

Press	34

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 35

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 36

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 37

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 38

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 39

RSC (2020). ChemSpider: D4. HERO ID:6982833 	40

RSC (2020). ChemSpider: D4. HERO ID:6982833 	41

RSC (2020). ChemSpider: D4. HERO ID:6982833 	42

Abbas, R., Schedemann, A., Ihmels, C., Enders, S., Gmehling, J. Measurement of Thermophysical
Pure Component Properties for a Few Siloxanes Used as Working Fluids for Organic Rankine

Cycles. Industrial and Engineering Chemistry Research. 2011. 50:9748. HERO ID:6835590	43

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	44

Page 2 of 134

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O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	45

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	46

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	47

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC

Press	48

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	49

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 50

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 51

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 52

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 53

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 54

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 55

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 56

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 57

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	58

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	59

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC

Press	60

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 61

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 62

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 63

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 64

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 65

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 66

Palczewska-Tulinska, M; Oracz, P. (2005). Selected physicochemical properties of

hexamethylcyclotrisiloxane, D4, and decamethylcyclopentasiloxane. Journal of Chemical and

Engineering Data 50: 1711-1719. HERO ID:3569075 	 67

Zhang, Y; Dong, H; Wu, C; Yu, L; Xu, J. (2015). The mixing properties of l,3,5-trimethyl-l,3,5-
tris(3,3,3-trifluoropropyl) cyclotrisiloxane with various organosilicon compounds at different

temperatures. The Journal of Chemical Thermodynamics 81: 16-25. HERO ID:4279677	 68

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	 69

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 70

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 71

Lei, YD; Wania, F; Mathers, D, an. (2010). Temperature-Dependent Vapor Pressure of Selected
Cyclic and Linear Polydimethylsiloxane Oligomers. Journal of Chemical and Engineering Data

55: 5868-5873	 72

Flaningam, O. L. (1986). Vapor pressures of poly(dimethylsiloxane) oligomers. Journal of

Chemical and Engineering Data 31(3): 266-272. HERO ID:6989156	 73

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	 74

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	75

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 76

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 77

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 78

Varaprath, S., et al. (1996). Aqueous solubility of permethylsiloxanes (silicones). Environmental
Toxicology and Chemistry 15(8): 1263-1265. HERO ID:6984031 	 79

Page 3 of 134

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Sousa, JV; Mcnamara, PC; Putt, AE; Machado, MW; Surprenant, DC; Hamelink, JL; Kent, DJ;
Silberhorn, EM; Hobson, JF. (1995). Effects of D4 (OMCTS) on freshwater and marine

organisms. Environ Toxicol Chem 14: 1639-1647. HERO ID:6834101 	 80

Sousa, JV; Mcnamara, PC; Putt, AE; Machado, MW; Surprenant, DC; Hamelink, JL; Kent, DJ;
Silberhorn, EM; Hobson, JF. (1995). Effects of D4 (OMCTS) on freshwater and marine

organisms. Environ Toxicol Chem 14: 1639-647. HERO ID:6834101 	 81

Gee, RP. (2015). Emulsion polymerization of dimethylcyclosiloxane in cationic emulsion:

Mechanism study utilizing two phase liquid-liquid reaction kinetics. Colloid Surface

Physicochem Eng Aspect 481: 297-306. HERO ID:6833841	 82

Gee, RP. (2015). Emulsion polymerization of dimethylcyclosiloxane in cationic emulsion:

Mechanism study utilizing two phase liquid-liquid reaction kinetics. Colloid Surface

Physicochem Eng Aspect 481: 297-306. HERO ID:6833841	 83

Springborn Laboratories, D4 - determination of the water solubility in synthetic seawater. 1989	 84

Springborn Laboratories, D4 - determination of the water solubility in freshwater. 1989	 85

Bayer AG, Contributions on assessment of the aquatic toxicity of OMCTS with cover letter. 1990. 86
Bayer AG, Contributions on assessment of the aquatic toxicity of OMCTS with cover letter. 1990. 87

Rhone-Poulenc Inc. Environmental fate of D4 with cover letter. 1990	 88

Rhone-Poulenc Inc, Environmental fate of D4 with cover letter. 1990	 89

Dow Corning. The n-octanol/water partition coefficient of D4 with attachment and cover letter

dated 092987. 1987. HERO ID:5905948	 90

Dow Corning, The water solubility of D4 with attachments and cover letter dated 092987. 1987	 91

Springborn, L. (1989). Octamethycyclotetrasiloxane - Determination of the water solubility in

freshwater. Washington, DC, Silicones Health Council. HERO ID:7006395	 92

Dow Corning, Aqueous solubility studies of D4. 1991. HERO ID:7310465	 93

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	 94

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	95

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 96

Xu, S. and B. Kropscott (2014). Evaluation of the three-phase equilibrium method for measuring
temperature dependence of internally consistent partition coefficients (KOW , KOA, and
KAW) for volatile methylsiloxanes and trimethylsilanol. Environmental Toxicology and

Chemistry 33(12): 2702-2710. HERO ID:2535012	 97

Xu, S. and B. Kropscott (2012). Method for simultaneous determination of partition coefficients
for cyclic volatile methylsiloxanes and dimethylsilanediol. Analytical Chemistry 84(4): 1948-

1955	 98

Dow Corning, The n-octanol/water partition coefficient of D4 with attachment and cover letter

dated 092987. 1987. HERO ID:5905948	 99

Dow Corning, Subject: Monthly summary 10/1982, octanol-water coefficients. 1982	 100

Kozerski, G., Shawl, H. Determination of the 1-octanol/water partition coefficient of D4 (D4) by

the slow-stirring method using gas chromatography. 2007. HERO ID:6987895	 101

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826	 102

Xu, S. and B. Kropscott (2014). Evaluation of the three-phase equilibrium method for measuring
temperature dependence of internally consistent partition coefficients (KOW , KOA, and
KAW) for volatile methylsiloxanes and trimethylsilanol. Environmental Toxicology and

Chemistry 33(12): 2702-2710. HERO ID: 2535012	 103

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 104

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 105

Hamelink, JL; Simon, PB; Silberhorn, EM. (1996). Henry's law constant, volatilization rate, and
aquatic half-life of D4. Environ Sci Technol 30: 1946-1952. HERO ID:2803124	 106

Page 4 of 134

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Xu, S. and B. Kropscott (2012). Method for simultaneous determination of partition coefficients
for cyclic volatile methylsiloxanes and dimethylsilanediol. Analytical Chemistry 84(4): 1948-

1955	 107

Xu, S. and B. Kropscott (2012). Method for simultaneous determination of partition coefficients
for cyclic volatile methylsiloxanes and dimethylsilanediol. Analytical Chemistry 84(4): 1948-

1955	 108

Ann Arbor Technical Services, Inc., Phase II studies of the Henry's law constant of OMCTS (D4).

2000	 109

Ann Arbor Technical Services, Inc., Phase II studies of the Henry's law constant of OMCTS (D4).

2000	 110

Ann Arbor Technical Services, Inc., Phase II studies of the Henry's law constant of OMCTS (D4).

2000	Ill

Ann Arbor Technical Services, Inc., Henry's law constant of OMCTS (D4) at 20 degrees. 1990.... 112
Kochetkov, A., et al. (2001). Air-water partition constants for volatile methyl siloxanes.

Environmental Toxicology and Chemistry 20(10): 2184-2188. HERO ID:7303416	 113

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 114

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 115

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 116

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 117

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 118

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 119

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	120

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 121

Palczewska-Tulinska, M; Oracz, P. (2005). Selected physicochemical properties of

hexamethylcyclotrisiloxane, D4, and decamethylcyclopentasiloxane. Journal of Chemical and

Engineering Data 50: 1711-1719. HERO ID:3569075 	 122

Liu F et al. 2013. Atomic force microscopy of confined liquids using the thermal bending

fluctuations of the cantilever. Phys Rev E 87: 62406. HERO ID:6835221 	 123

O'Neil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry	124

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	125

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC

Press	126

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 127

RSC (2020). ChemSpider: D4. HERO ID:6982833 	 128

NLM (2020). PubChem database: compound summary: D4. HERO ID:6982832	 129

Zhang, Y; Dong, H; Wu, C; Yu, L; Xu, J. (2015). The mixing properties of l,3,5-trimethyl-l,3,5-
tris(3,3,3-trifluoropropyl) cyclotrisiloxane with various organosilicon compounds at different

temperatures. The Journal of Chemical Thermodynamics 81: 16-25. HERO ID:4279677	 130

Elsevier (2019). Reaxys: physical-chemical property data for D4. CAS Registry Number: 556-67-

2	131

U.S. EPA. (2012). Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11

(Computer Program). Washington, DC. HERO ID:2347246 	 132

Page 5 of 134

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Data Extraction Tables

In each table, the value preliminarily selected for use in the risk evaluation is in bold.

Table 1, Physical State Study Summary for Octametfaylcyclotetra- siloxaee (1)4)

Study Type

Result

Comments

Affiliated Refcrcnee

Data Quality Evaluation
Results

Experimental

Oily liquid



fO'Neil. 2013)

High

Experimental

Colorless liquid



(RSC. 2020)

High

Experimental

Oily liquid



(NLM. 2020)

High

Experimental

Smooth, viscous liquid



(NLM. 2020)

High

Table 2, Physical Properties Study Summary for 1)4

Study Type

Result

Comments

Affiliated Refcrcnee

Data Quality Evaluation
Results

Experimental

Colorless liquid



(RSC. 2020)

High

Experimental

Oily liquid



(O'Neil. 2013)

High

Experimental

Dry powder; liquid



(NLM. 2020)

Unacceptable

Experimental

Colorless, oily liquid



(NLM. 2020)

High

Experimental

D4 does not have an odor; qualitative description that was not the
focus of the primary source



(Fulleret al.. 2020)

Medium

-------
Table 3, Melting Point Study Summary for 1)4

Study Type

Su bstanee
Purity

Result

Comments

Affiliated Refcrcnee

Data Quality
Evaluation Results

Experimental

NR

17.5-18.0 °C

17.6 °C average of 6 values

(U.S. EPA. 2020)

High

Experimental

NR

17.5 °C



(CTNeil. 2013)

High

Experimental

NR

17-18.5 °C

15 values were reported in Reaxys; 14 values were
in the range of 17-18.5 °C; 1 value was outside this
range.

(Elsevier. 2019)

High

Experimental

NR

17.10 °C



(Havnes. 2014)

High

Experimental

NR

17.5 °C



(NLM. 2020)

High

Experimental

NR

17.5 °C



(RSC. 2020)

High

Experimental

NR

17.5-18 °C



(RSC. 2020)

High

Experimental

NR

17-18 °C



(RSC. 2020)

High

Experimental

NR

17-18 °C



(RSC. 2020)

High

Experimental

NR

17-18 °C



(RSC. 2020)

High

Experimental

NR

17-18 °C



(RSC. 2020)

High

Experimental

NR

17-18 °C



(RSC. 2020)

High

Experimental;

differential

scanning

calorimeters

("DSC

Q100")

>99.8%

291.12 K

Experimental vapor pressures at 312.97-450.42 K
also reported in this study.

(Abbas et al.. 2011)

High

Page 7 of 134

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Table 4, Boiling Point Study Summary for 1)4

Study Type

Substanee
Purity

Result

Comments

Affiliated Refcrcnee

Data Quality
Evaluation
Results

Experimental

NR

176 °C

176 °C average of 4 values

(U.S. EPA. 2020)

High

Experimental

NR

175 °C

STP

fO'Neil. 2013)

High

Experimental

NR

74 °C

20 mmHg

(O'Neil. 2013)

High

Experimental

NR

170-176.4 °C

750-760 torr; 28 values were reported in Reaxys; 19 of these
values were reported in the range of 170-176.4 °C at 750-760
torr; 9 values were outside this range or measured at unreported
or non-standard pressures.

(Elsevier. 2019)

High

Experimental

NR

175.4 °C



(Havnes. 2014)

High

Experimental

NR

175.8 °C



(NLM. 2020)

High

Experimental

NR

74 °C

20 mmHg

(NLM. 2020)

High

Experimental

NR

175 °C



(NLM. 2020)

High

Experimental

NR

176 °C



(RSC. 2020)

High

Experimental

NR

175-176 °C



(RSC. 2020)

High

Experimental

NR

175-176 °C



(RSC. 2020)

High

Experimental

NR

175-176 °C



(RSC. 2020)

High

Experimental

NR

175-176 °C



(RSC. 2020)

High

Experimental

NR

175-176 °C



(RSC. 2020)

High

Page 8 of 134

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Table 5, Density Study Summary for 1)4

	j	ij	J	

Study Type

Study
Details

Refcrcnee
Substance

Temperatu
re

Result

(g/cm3)

Comments

Affiliated
Reference

Data Quality
Evaluation
Results

Experimental







0.9558

Units not given

(O'Neil. 2013)

High

Experimental





19.99-25°C

0.9497-
0.9568

47 values were reported in Reaxys; 21 values were
reported in the range of 0.9497-0.9568 g/cm3 at
19.99-25 °C; 26 values were outside this range or
measured at unreported or non-standard
temperatures.

(Elsevier. 2019)

High

Experimental





20 °C

0.9561



(Havnes. 2014)

High

Experimental







0.96

Relative density: water = 1

(NLM. 2020)

High

Experimental







0.9558

Units not given

(NLM. 2020)

High

Experimental







0.956

Reported as 0.956 g/mL

(RSC. 2020)

High

Experimental







0.956

Reported as 0.956 g/mL

(RSC. 2020)

High

Experimental







0.956

Reported as 0.956 g/mL

(RSC. 2020)

High

Experimental







0.956

Reported as 0.956 g/mL

(RSC. 2020)

High

Experimental





292.00 K

0.95755

Reported as 957.55 kg/m3 at 292.00 K; 957.55-
790.24 kg/m3 at 292.00-433.15 K

(Palczewska-
Tulinska and
Oracz. 2005)

High

Experimental





293.15 K

0.95603

Reported as 0.95603 g/cm3 measured at 293.15 K
and atmospheric pressure, 102.355 ± 0.020 kPa

fZhans et al..
2015)

High

Page 9 of 134

-------
Table 6, Vapor Pressure Study Summary for 1)4

Study Type

Substance
Purity

Temperature

Result

Comments

Affiliated
Reference

Data
Quality
Evaluation
Results

Experimental

NR

NR

1.05 torr

Reported as 1.05 mm Hg

(U.S. EPA.
2020)

High

Experimental

NR

25 °C

1.05 torr

Reported as 1.05 mm Hg

fNLM.
2020)

High

Experimental

NR

21.7 °C

133.3 Pa



fNLM.
2020)

High

Experimental

NR

298.15 K

92.8-24.5 Pa

Gas chromatographic retention time (GCRT) technique P(GC) and
Liquid state vapor pressure P(L). P(GC) = 92.8 ±0.9 Pa; P(L) 124.5
±6.2 Pa at 298.15 K. Std. dev. P(L) ± 6.2 Pa; P(GC) ±0.9.

Temperature ranges of retention time measurements 308.15-368.15 K.

(Lei et al..
2010)

High

Experimental

NR

361.71-
459.65 K

>5.36 to <
133.26 kPa

Non-guideline; vapor pressures measured in an ebulliometer over the
pressure range of 7-133 kPa; experimental data fit for Antoine
equation and constants A, B, and C. Temperature measurement
readings to the nearest 0.0IK

fFlanineam.
1986)

Medium

Table 7, Vapor Density Study Summary for 1)4
No Vapor Density data was identified for this chemical.

Page 10 of 134

-------
Table 8, Water Solubility Study Summary for 1)4

Study Type

Su bstance
Purity

Temperature

pH

Analytical
Method

Result

Comments

Affiliated
Reference

Data Quality
Evaluation Results

Experimental

NR

NR

NR



0.005 mg/L

Average of 2 values; 1.69E- 8
to 1.70E-8 mol/L

(U.S. EPA.
2020)

High

Experimental

NR

23 °C

NR





Reported as 189.86E6 mmol/L

(Elsevier. 2019)

Unacceptable

Experimental

NR

23°C

NR



0.056 mg/L



(NLM. 2020)

High

Experimental

NR

25 °C

NR



0.033 mg/L

Measured in synthetic seawater

(NLM. 2020)

High

Experimental

NR

NR

NR





Reported as "none"

(NLM. 2020)

Unacceptable

Experimental;
non-turbulent
method

NR

23 °C

NR

GC-MS

0.056 ppm

Reported as 56.0 ppb; also,
aqueous solubility = 189.86
nmol/L

(Varaorath et
al.. 1996)

High

Experimental;
Column generator

>99%

NR

NR



0.074 mg/L

Reported as 74 |ig/L in
freshwater

(Sousa et al..
1995)

High

Experimental;
Column generator

>99%

NR

NR



0.033 mg/L

Reported as 33 |ig/L in
saltwater

(Sousa et al..
1995)

High

Experimental

99.3%

40 °C

NR

GC-MS

0.161 mg/L

Reported as 544 nmol/L

(Gee. 2015)

High

Experimental

99.3%

60 °C

NR

GC-MS

0.4 mg/L

Reported as 1348 nmol/L

(Gee. 2015)

High

Experimental;
Generator Column
Method Following
TSCA Test
Standard 796.1860
and amendment #1

99%

25 °C

NR



29-38 |ig/L

Mean is 33 ng/L for 7
measurements; Mean recovery
from fresh and filtered
seawater was 96.5±3.99% and
97.3±12.2%; RSD was 8.8 and
1.1% at 5.00 and 20.0 ng/L,
respectively.

(Sorineborn

Laboratories.

1989c)

High

Experimental;
Generator Column
Method Following
TSCA Test
Standard 796.1860
and amendment #1

99%

25 °C

NR



60-94 |ig/L

Mean 74 |ig/L for 12
measurements; Mean recovery
103+/-12.6%. Likely the same
study as HERO ID 7006395

(Sorineborn

Laboratories.

1989b)

High

Page 11 of 134

-------
Study Type

Su bstancc
Purity

Temperature

pH

Analytical
Method

Result

Comments

Affiliated
Reference

Data Quality
Evaluation Results

Experimental

NR

NR

NR



39-47 (ig/L

Mean value 42+/-0.9 |ig/L

(Baver AG.
1990)

High

Experimental

NR

25 °C

NR



27-33 ng/L

Mean value 29.5 |ig/L

(Baver AG.
1990)

High

Experimental

NR

15-40 °C

NR



20-750 ppb

The large discrepancy between
the results cannot be explained
by either the duration of the 2
steps or the stirring
temperature. Detection of
microbubbles of D4 cannot be
checked.

(Rhone-Poulenc
Inc. 1990)

Medium

Experimental

NR

20 °C

NR



15-240 ppb

It is impossible to deduce a
precise value from the present
results.

(Rhone-Poulenc
Inc. 1990)

Medium

Experimental

>99.5%

NR

NR



50 ppb

Water solubility determined as
a result of log Kow
measurement.

First determination: 25 ppb in
water; second determination:
53 ppb in water

(Dow Cornine.
1987a)

High

Experimental

NR

NR

NR



40-80 ppb

Closed recirculating system:
76 ppb (unfiltered); 40
ppb (0.45-micron filter) Open
recirculating system: 27 ± 3
ppb (possible evaporative loss)
Separatory funnel: 8.1-2.9
ppm (unfiltered); 28-16 ppb
(0.20-micron filter) D4 is not
truly dispersed in water, may
be present in various particle
sizes.

(Dow Cornine.
1987b)

High

Experimental;
Non-Turbulent
Partitioning of D4

>99% Pure

23 °C

NR



56 ppb

WS ranged from 50-60 ppb

(Dow Cornine.
1991)

High

Page 12 of 134

-------
Study Type

Su bstancc
Purity

Temperature

pH

Analytical
Method

Result

Comments

Affiliated
Reference

Data Quality
Evaluation Results

Experimental;
Generator Column
Method Following
TSCA Test
Standard 796.1860
and amendment #1

99%

25 °C

NR



74 (ig/L

Likely the same study as
HERO ID 5889414

(Snrineborn

Laboratories.

1989a)

High

Table 9, Octaeol Water Coefficient (logKow) Study Summary for 1)4

Study Type

Substance
Purity

Temperature

pH

Other Study Details
(Amounts of substance
liquid phases)

Result

Comments

Affiliated
Reference

Data
Quality
Evaluation
Results

Experimental

NR

NR

NR

NR

6.74



(U.S. EPA.
2020)

High

Experimental

NR

21.6-21.7 °C

NR

NR

6.98

4 data points were
reported in Reaxys; 2 of
these values were reported
as 6.98 at 21.6-21.7°C; 2
data points were measured
at unreported
temperatures.

(Elsevier.
2019)

High

Experimental

NR

NR

NR

NR

6.74

Average of three
measurements

(NLM.
2020)

High

Experimental; double-
syringe method

>98%

5.7; 12.2;
21.7; 34.8 °C

NR

2 air-tight syringes with an
air sampling port and a
water sampling port;
concentration in water
(Hg/L): 1.4-2.0; 0.9-1.3;
0.8-1.5; 1.9—4.0

6.59-
7.13

Temperature has
substantial effects on
measured partition
coefficients; equilibrium
at 6 hrs

(Xu and

Krooscott.

2014)

High

Experimental; double-
syringe apparatus

98.1%

21.6; 21.7 °C

NR

2 air-tight syringes with an
air sampling port and a
water sampling port;
concentration in water
(mg/L): 1.53E-3; 1.84E-4

6.98

Equilibrium reached at 20
hrs; cryogenic cold trap,
dry ice acetone bath

(Xu and

Krooscott.

2012)

High

Page 13 of 134

-------
Study Type

Substance
Purity

Temperature

pH

Other Study Details
(Amounts of substance
liquid phases)

Result

Comments

Affiliated
Reference

Data
Quality
Evaluation
Results

Experimental; Draft
OECD Guideline -
Slow Stir Method

99.77; 2
area
percent
purity

25.1°C

NR

Slow-Stirring Method
Using Gas

Chromatography and
Mass Spectrometry

6.488

at equilibrium

(Kozerski
and Shawl.
2007)

High

Experimental

>99%

NR

NR

OECD classical partitioning
between 50 mL octanol and
250 mL water

4.0



(Dow

Cornine.

1982)

High

Experimental

>99.5%

NR

NR

100 nL (0.0956 g) D4 in 25
g (30.23 mL) octanol placed
in a 250 mL Wheaton bottle
with 150 mL distilled water.
The bottle was capped,
agitated for an hour on a
Burrell wrist-action shaker,
and allowed to settle
overnight.

5.10



(Dow

Cornine.

1987a)

High

Page 14 of 134

-------
Table 10, Henry's Law Constant Study Summary for D4

Study Type

Substance Purity

Temperature

Result

Comments

Affiliated
Reference

Data Quality
Evaluation
Results

Experimental

NR

NR

12.0 atm-m3/mol



(U.S. EPA. 2020)

High

Experimental

>98%

5.7±0.2,
12.2±0.1,
34.8±0.2 °C

1.79-3.09

log Kaw = 1.79±0.07, 2.17±0.08 and
3.09±0.14 at 5.7, 12.2 and 34.8 °C,
respectively; log Kaw = 2.74 at 25 °C
based on linear regression analysis of
data.

(Xu, 2014,
2535012)

High

Experimental

NR

NR

12.00 atm-m3/mol



(NLM. 2020)

High

Experimental

NR

25 °C

13.4 atm-m3/mol



(NLM. 2020)

High

Experimental

NR

20 °C

3.4

Undimensioned Henry's law constant
was 3.4 ±1.37 (grand mean over 5
experiments)

(Hamelink et al..
1996)

High

Experimental;
Not reported

98.1% radiochemical
purity

21.7 °C

2.70±0.14

log Kaw = 2.70± 0.14; Air = 0.417
mg/L; Water = 8.34xlO"4 mg/L

(Xu and

Krooscott. 2012)

High

Experimental;
Not reported

98.1% radiochemical
purity

21.6 °C

2.68

log Kaw = 2.68; ± 0.12; Air = 0.741;
mg/L Water = 1.53 x 10~3 mg/L

(Xu and

Krooscott. 2012)

High

Experimental

>99.9% (w/w)

10-25 °C

1.23-7.66

Mean He (undimensional) at
temperatures of 10, 15, 20, 25°C were
1.35, 2.38, 2.98, 4.78, respectively.
Mean recoveries were 79.8, 80.9, 79.8,
84.5% for respective temperatures.

(Ann Arbor
Technical
Services. 2000
5889409)

High

Experimental

>99.9% (w/w)

20 °C

0.98-4.10

Mean He (undimensional) at 4, 8, 16,
32 |ig/L starting concentration were
2.96, 3.53, 1.91, 2.98, respectively.
Mean recoveries were 82.0, 80.5, 82.9,
79.8% for respective starting
concentrations.

(Ann Arbor
Technical
Services. 2000
5889409)

High

Experimental

>99.9% (w/w)

20 °C

2.21-8.88

Mean He (undimensional) at 24, 48,
72, 96, 120 hours were 4.60, 5.62,
7.77, 5.04, 3.42, respectively. Mean
recoveries were 91.6, 101.9, 88.2,

(Ann Arbor
Technical
Services. 2000
5889409)

High

Page 15 of 134

-------
Study Type

Substance Purity

Temperature

Result

Comments

Affiliated
Reference

Data Quality
Evaluation
Results









79.0, 78.6% for respective
equilibration time.





Experimental

>99.9% (w/w)

20 °C

13.83-19.41

mean of 3 values 17.0; mean recovery
89.9±3.7%

(Ann Arbor
Technical
Services. 1990
5889489)

High

Experimental

99.9%

28 °C (30 IK)

>23 to <24

Static head space method and modified
batch air stripping method (vapor entry
loop method VEL) used for direct
measurement of Henry's law constant.

(Kochetkov et al..
2001)

High

Page 16 of 134

-------
Table 11, Flash Point Study Summary for D4

Study Type

Substanee Purity

Temperature

Result

Comments

Affiliated Refcrcnee

Data Quality Evaluation Results

Experimental

NR

131 °F

55 °C



(NLM. 2020)

High

Experimental

NR

NR

56 °C



(NLM. 2020)

High

Experimental

NR

NR

57 °C



(RSC. 2020)

High

Experimental

NR

NR

56 °C



(RSC. 2020)

High

Experimental

NR

NR

56 °C



(RSC. 2020)

High

Experimental

NR

NR

54 °C



(RSC. 2020)

High

Table 12, Auto Flammability Study Summary for 1)4
No Autoflammability data was identified for this chemical.

Table 13, Viscosity Study Summary for 1)4

Study Type

Apparatus

Temperature

Result

Comments

Affiliated
Refcrcnee

Data Quality
Evaluation
Results

Experimental



25-25.1°C

2.187-2.239 cP

13 values were reported in Reaxys; 4 values were
reported in the range of 2.187-2.239 cP at 25-25.1 °C;
9 values were outside this range or measured at
unreported or non-standard temperatures.

(Elsevier. 2019)

High

Experimental



25 °C

2.30 cP

Reported as 2.30 cSt

(NLM. 2020)

High

Experimental



293.15 K

2.45 mPa.s

Reported as 2.45 mPa-s at 293.15 K; ranged from 2.45-
0.41 mPa-s at 293.15-423.15 K.

(Palczewska-
Tulinska and Oracz.
2005)

High

Experimental



300 K

2.7 mPa.s



(Liuet al.. 2013)

High

Page 17 of 134

-------
Table 14. Refractive Index Study Summary for 1)4

Study Type

Apparatus

Result

Comments

Affiliated
Reference

Data Quality
Evaluation
Results

Experimental

20 °C/D

1.3968



(O'Neil.
2013)

High

Experimental

19.99-25
°C

1.3935-1.4013

22 values were reported in Reaxys; 15 values were reported in the range of
1.3935-1.4013 at 19.99-25 °C; 7 values were outside this range or measured
at unreported or non-standard temperatures.

(Elsevier.
2019)

High

Not specified

20 °C/D

1.3968



(Havnes.
2014)

High

Experimental

NR

1.396



(RSC. 2020)

High

Experimental

NR

1.396



(RSC. 2020)

High

Experimental

20 °C/D

1.3968



(NLM.
2020)

High

Experimental

293.15K

1.39674

Reported as 1.39674 at 293.15 K; also measured at 1.38925-1.37917 over
308.15-328.15 K, respectively.

fZhans et
al.. 2015)

High

Study Type

Apparatus

Result

Comments

Affiliated Reference

Data Quality Evaluation Results

Experimental

20 °C

2.4-2.405

Static Dielectric Constant

(Elsevier. 2019)

High

Page 18 of 134

-------
lite™ Model Outputs

(U.S. EPA. 2012)

SMILES: C[Si]l(C)0[Si](C)(C)0[Si](C)(C)0[Si](C)(C)01
CHEM: OCTAMETHYLTETRASILOXANE
MOL FOR: C8 H24 04 Si4
MOL WT: 296.62

	EPI SUMMARY (v4.11)	

Physical Property Inputs:

Log Kow (octanol-water): 6.49
Boiling Point (°C C): 175.80
Melting Point (°C): 17.50
Vapor Pressure (mm Hg): 1.05
Water Solubility (mg/L): 0.056
Henry LC (atm-m3/mole): 12

Log Octanol-Water Partition Coef (SRC):

Log Kow (KOWWIN vl.68 estimate) = 6.79
Log Kow (Exper. database match) = 6.74
Exper. Ref: SEHSC (2009); average

Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPVP vl.43):

Boiling Pt (°C): 159.41 (Adapted Stein & Brown method)

Melting Pt (°C): 1.78 (Mean or Weighted MP)

VP(mm Hg,25 °C): 1.18 (Mean VP of Antoine & Grain methods)

VP (Pa, 25 °C): 158 (Mean VP of Antoine & Grain methods)

MP (exp database): 17.5 °C

BP (exp database): 175.8 °C

VP (exp database): 1.05E+00 mm Hg (1.40E+002 Pa) at 25 °C

Water Solubility Estimate from Log Kow (WSKOW vl.42):

Water Solubility at 25 °C (mg/L): 0.1083
log Kow used: 6.49 (user entered)
melt pt used: 17.50 °C

Water Sol (Exper. database match) = 0.005 mg/L (25 °C)

Exper. Ref: DOW CORNING (1987)

Water Sol Estimate from Fragments:

Wat Sol (vl.01 est) = 0.17229 mg/L

ECOSAR Class Program (ECOSAR vl. 11):

Class(es) found:

Neutral Organics

Henry's Law Constant (25 °C) [HENRYWIN v3.20]:

Bond Method: 8.72E-002 atm-m3/mole (8.84E+003 Pa-m3/mole)

Group Method: Incomplete

Exper Database: 1.17E-01 atm-m3/mole (1.19E+004 Pa-m3/mole)

Page 19 of 134

-------
For Henry LC Comparison Purposes:

User-Entered Henry LC: 1.200E+001 atm-m3/mole (1.216E+006 Pa-m3/mole)
Henry's LC [via VP/WSol estimate using User-Entered or Estimated values]:
HLC: 7.318E+000 atm-m3/mole (7.415E+005 Pa-m3/mole)

VP: 1.05 mm Hg (source: User-Entered)

WS: 0.056 mg/L (source: User-Entered)

Log Octanol-Air Partition Coefficient (25 °C) [KOAWIN vl.10]:

Log Kow used: 6.49 (user entered)

Log Kaw used: 2.691 (user entered)

Log Koa (KOAWIN vl.10 estimate): 3.797

Log Koa (experimental database): None

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowinl (Linear Model): 0.6063

Biowin2 (Non-Linear Model): 0.2309

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model): 2.5437 (weeks-months)

Biowin4 (Primary Survey Model): 3.4198 (days-weeks )

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model): -0.1670

Biowin6 (MITI Non-Linear Model): 0.0028

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): 0.1995

Ready Biodegradability Prediction: NO

Hydrocarbon Biodegradation (BioHCwin vl.01):

Structure incompatible with current estimation method!

Sorption to aerosols (25 Dec C)[AEROWIN vl.00]:

Vapor pressure (liquid/subcooled): 140 Pa (1.05 mm Hg)

Log Koa (Koawin est): 3.797

Kp (particle/gas partition coef. (m3/ug)):

Mackay model: 2.14E-008

Octanol/air (Koa) model: 1.54E-009

Fraction sorbed to airborne particulates (phi):

Junge-Pankow model: 7.74E-007

Mackay model: 1.71E-006

Octanol/air (Koa) model: 1.23E-007

Atmospheric Oxidation (25 °C) [AopWin vl.92]:

Hydroxyl Radicals Reaction:

OVERALL OH Rate Constant = 1.1968 E-12 cm3/molecule-sec

Half-Life = 8.937 Days (12-hr day; 1.5E6 OH/cm3)

Half-Life = 107.246 Hrs

Ozone Reaction:

No Ozone Reaction Estimation

Fraction sorbed to airborne particulates (phi):

1.24E-006 (Junge-Pankow, Mackay avg)

Page 20 of 134

-------
1.23E-007 (Koa method)

Note: the sorbed fraction may be resistant to atmospheric oxidation

Soil Adsorption Coefficient (KOCWIN v2.00):

Koc: 1.444E+004L/kg (MCI method)

Log Koc: 4.159 (MCI method)

Koc: 4.271E+005 L/kg (Kow method)

Log Koc: 5.631 (Kow method)

Aqueous Base/Acid-Catalyzed Hydrolysis (25 °C) [HYDROWIN v2.00]:
Rate constants can NOT be estimated for this structure!

Bioaccumulation Estimates (BCFBAF v3.01):

Log BCF from regression-based method = 3.948 (BCF = 8867 L/kg wet-wt)
Log Biotransformation Half-life (HL) = 1.6572 days (HL = 45.41 days)
Log BCF Arnot-Gobas method (upper trophic) = 3.982 (BCF = 9592)
Log BAF Arnot-Gobas method (upper trophic) = 6.122 (BAF = 1,324e+006)
log Kow used: 6.49 (user entered)

Volatilization from Water:

Henry LC: 12 atm-m3/mole (entered by user)

Half-Life from Model River: 1.758 hours

Half-Life from Model Lake: 163.6 hours (6.816 days)

Removal in Wastewater Treatment (recommended maximum 95%):

Total removal: 99.91 percent

Total biodegradation: 0.18 percent

Total sludge adsorption: 59.87 percent

Total to Air: 39.86 percent

(using 10000 hr Bio P,A,S)

Level III Fugacity Model:

Mass Amount Half-Life Emissions

Air

Water

Soil

Sediment
Persistence

(percent)	(hr)	(kg/hr)

31	254	1000

39.2	900	1000

1.42	1.8e+003	1000

28.5	8.1e+003	0

Time: 214 hr

Page 21 of 134

-------
C ition Tables

Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the public
for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical State reported by this reference.

Page 22 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

Hi«h,
Medium, Low,
Unacceptable,
or Not Rated
[NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score



Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

1

1

1

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

1

1

1



Reliability /
Unbiased (Method
Objectivity)

Medium

There is no indication
that the methodology
for producing the
information was biased
towards a particular
product or outcome.

2

1

2

Test

Reliability

Reliability /
Analytical Method

Medium

Analytical method is
unknown but is likely
to be appropriate based
on the data's inclusion
in a peer-

reviewed/recognized
database or other
secondary source.

2

1

2

Other

Databases

High

Data is from a
secondary database
with a reference to the
peer-reviewed original
source.

1

1

1



Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

7

5

7

High

Medium

Low

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

>1 and
<1.7

>1.7 and <2.3

>2.3 and <3





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical State reported by this reference.
Cited reference: OU Chemical Safety Data.

Page 23 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features oi
other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the data's
inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the public
for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical State reported by this reference.

Cited reference: Lewis, R.J. Sr.; Hawley 's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New
York, NY 2007., p. 918

Page 24 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical State reported by this reference.

Cited reference: O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge,
UK: Royal Society of Chemistry, 2013., p. 1255.

Page 25 of 134

-------
Study
Reference:

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

(/.t'., Hi«h,
Medium, Low,
Unacceptable,
or Not Rated
[NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Test

Reliability

Reliability /
Unbiased (Method
Objectivity)

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

Reliability /
Analytical Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Other

Databases

High

Data is from a secondary
database with a reference
to the peer-reviewed
original source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

High

Medium

Low

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1.4

Overall
Score

(Rounded):

1.4

>1 and
<1.7

>1.7 and <2.3

>2.3 and <3

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical Properties reported by this reference.
Cited reference: OU Chemical Safety Data.

Page 26 of 134

-------
Study Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Qualitative

Determination

(Z.t'., High,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Medium, Low,
Unacceptable,
or Not Rated
INRI)

Comments

Weighting
Factor

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular
product or outcome.

Test Reliability

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

The information or data
is from a recognized
data collection/

Other

repository where data
are peer-reviewed by
experts in the field, are
broadly available to the
public for review and
use.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Mid.

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 III id 1

1 " and ^

: ^and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical Properties reported by this reference.

Page 27 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR[)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Test Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

Reliability / Analytical
Method

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

Other

Databases

High

The information or data
is from a recognized data
collection/ repository
where data are peer-
reviewed by experts in
the field, are broadly
available to the public for
review and use

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 ,o\\

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;nid 1 "

1 ~ and 2'

2 ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Physical Properties reported by this reference.
Cited reference: ILO International Chemical Safety Cards (ICSC).

Page 28 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(/.e., High,
Medium, Low,
Unacceptable,
or Not Rated
INR1)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

Unacceptable

Measured data are not
consistent with the subject
chemical substance
structural features or other
physical/chemical
properties or behaviors. It is
not likely to be a powder
with a melting point of 18
°C.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/ recognized
database or other secondary
source.

Other

Databases

High

The information or data is
from a recognized data
collection/ repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel l ie Weighting Factors:

Overall
Score

(Rounded):

1 and 1 "

1 ~ and

: ^ and ^

Overall
Quality
Level:

Unacceptable1

Physical state (dry powder) is inconsistent with subject chemical substance melting point of 18°C. Consistent with our
Application of Systematic Review in TSCA Risk Evaluation document, if a metric for a data source receives a score of
Unacceptable (score = 4), EPA will determine the study to be unacceptable. In this case, one of the metrics was rated as
unacceptable. As such, the study is considered unacceptable and the score is presented solely to increase transparency.
Cited reference: EPA Chemicals under the TSCA.

Page 29 of 134

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Study

Fuller, J; White, D; Yi, H; Colley, J; Vickery,

L; Liu, S. (2020). Analysis of volatile compounds causing

Reference:

undesirable odors in a polypropylene - high-density polyethylene recycled plastic resin with solid-phase

microcxtraction. Chcmosphcrc 260: 127589. HERO ID:6834323

Qualitative

Determination (i.e.,

Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium, Low,
Unacceptable, or Not
Rated [NR])

Comments

Weighting
Factor

Representativeness

High

Data are measured or
estimated for the

Substance

subject chemical
substance.

Appropriateness

Rating of this factor
is not applicable to
this kind of
information.

Reliability / Unbiased
(Method Objectivity)

Medium

The odor intensity
was determined
qualitatively by
pretrained people
based on a 1-10

Test

scale.

Reliability

Reliability / Analytical
Method

Low

Odor assessment was
not the focus of the
primary study, and
only qualitative
determination was
used.

Databases

Rating of this factor
is not applicable to
this kind of

Other

information.

Models

Rating of this factor
is not applicable to
this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score =
Sum of Weighted
Scores/Sum of
Metric Weighting
Factors:

Overall Score
(Rounded):

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality Level:

Medium

The reviewer agreed with the overall rating for the Physical Properties reported by this reference.

Page 30 of 134

-------
Study
Reference:

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology foi
producing the
information was biased
towards a particular
product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

Other

Databases

High

Data is from a
secondary database with
a reference to the peer-
reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall Score
(Rounded):

1.4

1 ;ind 1 "

1 ~ and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Data range determined from multiple primary sources in Chemistry Dashboard.

Page 31 of 134

-------
Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry. The Merck
index: An encyclopedia for chemicals, drugs, and biologicals. HERO ID:6982970

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel l ie Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1 " ;ind : ^

: ^ ;ind ^

Overall
Quality
Level:

High

1 lie iv\ icu or agreed u illi I lie o\ ci;ill inline lor I lie Moiling Point reported by this reference.

Page 32 of 134

-------
Study
Reference:

Elsevier (2019). Reaxvs: physical-chemical property data for D4. CAS Registry Number: 556-67-2.
HERO ID:6984075

Domain

Metric

Qualitative
Determination

(i.e., Hi«h,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 33 of 134

-------
Study
Reference:

Havncs, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC Press.
HERO ID:6982%9

Domain

Metric

Qualitative
Determination (i.e.,

High, Medium,
Low, Unacceptable,
or Not Rated |NR|)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the subject
chemical substance
structural features or other
physical/chemical properties
or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1 " ;ind : ^

: ^ ;md ^

Overall
Quality
Level:

High

1 lie iv\ icu or agreed u illi I lie o\ ci;ill inline lor I lie Moiling Point reported by this reference.

Page 34 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.

Cited reference: EPA DSSTox; Hazardous Substances Data Bank (HSDB); ILO International Chemical Safety Cards (ICSC)

Page 35 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination {i.e.,
High, Medium,

Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel l ie Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1 "and 2 ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Strem Product Catalog: https://www.strem.eom/catalog/v/14-5400/.

Page 36 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(Z.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database
with a reference to the

Other

peer-reviewed original

source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;ind 1 "

1 "and : ^

: ^and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Sigma-Aldrich.

Page 37 of 134

-------
Studv

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(i.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database
with a reference to the

Other

peer-reviewed original

source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ crall Score = Sum

of Weighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;ind 1 "

1 "and : ^

2 ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: LabNetwork.

Page 38 of 134

-------
Studv

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(i.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HW

()\ erall Score = Sum
of \\ eighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1

1 "and : ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Oakwood.

Page 39 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(Le., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

()\ erall Score = Sum
of \\ eighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1

1 "and 2 ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Alfa Aesar.

Page 40 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(Z.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database
with a reference to the

Other

peer-reviewed original

source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;ind 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: Jean-Claude Bradley Open Melting Point Dataset.

Page 41 of 134

-------
Studv

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(/.£., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication that

(Method Objectivity)

the methodology for
producing the information
was biased towards a
particular product or

Test

Reliability

outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other
secondary source.

Databases

High

Data is from a secondary
database with a reference
to the peer-reviewed

Other

original source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Midi

Medium

I.HM

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.4

Overall Score
(Rounded):

1.4

1 ;iih.I 1."

1 "and : ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.
Cited reference: OU Chemical Safety Data (no longer updated).

Page 42 of 134

-------
Study
Reference:

Abbas, R., Schcdcmann, A., Illinois, C., Endcrs, S., Gmchling, J. Measurement of Thcrmophysical Pure
Component Properties for a Few Siloxancs Used as Working Fluids for Organic Rankinc Cycles.
Industrial and Engineering Chcmistrv Research. 2011. 50:9748. HERO ID:6835590

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured for the
subject chemical
substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features (e.g., presence of
certain functional groups)
and/or other
physical/chemical
properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer- reviewed/recognize
d database or other
secondary source.

Other

Databases

Rating of this factor is not
applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Mid.

Medium

I.HW

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.5

Overall Score
(Rounded):

1.5

1 and 1

1 ~ and

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Melting Point reported by this reference.

Page 43 of 134

-------
Study
Reference:

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Domain

Metric

Qualitative
Determination (i.e.,
High, Medium,

Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel l ie Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1 "and 2 ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Data range determined from multiple primary sources in Chemistry Dashboard.

Page 44 of 134

-------
Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1." and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

Page 45 of 134

-------
Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1." and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

Page 46 of 134

-------
Studv

Elsevier (2019). Reaxvs: phvsical-chemical property data for D4. CAS Registry Number: 556-67-2.

Reference:

HERO ID:6984075

Qualitative

Determination

(/.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication that

(Method Objectivity)

the methodology for
producing the information
was biased towards a
particular product or

Test

Reliability

outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other
secondary source.

Databases

High

Data is from a secondary
database with a reference
to the peer-reviewed

Other

original source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 47 of 134

-------
Study
Reference:

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC Press.
HERO ID:6982969

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1." and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

Page 48 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable,
or Not Rated
INRI)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or estimated for
the subject chemical substance.

Appropriateness

High

Measured data are consistent with
the subject chemical substance
structural features or other
physical/chemical properties or
behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing the
information was biased towards a
particular product or outcome.

Reliability / Analytical
Method

Medium

The analytical method is unknown
but is likely to be appropriate
based on the data's inclusion in a
peer- reviewed/recognized
database or other secondary
source.

Other

Databases

High

The information or data is from a
recognized data

collection/repository where data
are peer-reviewed by experts in the
field, are broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

High

Medium

Low

Overall Score = Sum of
Weighted Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

>1 and <1.7

>1.7 and <2.3

>2.3 and <3

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

Cited reference: O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge,
UK: Royal Society of Chemistry, 2013., p. 1255.

Page 49 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

Cited reference: O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge,
UK: Royal Society of Chemistry, 2013., p. 1255.

Page 50 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: EPA DSSTox.

Page 51 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(/.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

Low

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1

1 "and : ^

: 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Strem Product Catalog: https://www.strem.eom/catalog/v/14-5400/.

Page 52 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

(i.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

1

1

1

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

2

1

2

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

1

1

1

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

7

5

7

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Sigma-Aldrich.

Page 53 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(Z.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database
with a reference to the

Other

peer-reviewed original

source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;ind 1 "

1 "and : ^

: ^and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: LabNetwork.

Page 54 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(Le., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a secondary
database with a reference
to the peer-reviewed

Other

original source.

Models

Rating of this factor is
not applicable to this kind
of information.

Sum of scores:

Midi

Medium

I.HM

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;iih.I 1."

1 " and 2. '

2.'Mild '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Oakwood.

Page 55 of 134

-------
Studv

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Reference:

Qualitative

Determination (/.£.,
Hidi, Medium,

Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

()\ erall Score = Sum
of \\ eighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1

1 "and 2 ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: Alfa Aesar.

Page 56 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833

Reference:

Qualitative

Determination

(i.t'., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

()\ erall Score = Sum
of \\ eighted
Scores/Sum of Metric
\\ eighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1

1 "and : ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Boiling Point reported by this reference.
Cited reference: OU Chemical Safety Data (no longer updated).

Page 57 of 134

-------
Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

2

1

2

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

1

1

1

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.

Page 58 of 134

-------
Studv

Elsevier (2019). Reaxvs: phvsical-chemical property data for D4. CAS Registry Number: 556-67-2.

Reference:

HERO ID:6984075

Qualitative

Determination

Metric
Weighting
Factor

Domain

Metric

(/.t'., High,
Medium, Low,

Comments

Metric
Score

Weighted Score

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject

Substance

chemical substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability /
Analytical Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a secondary
database with a reference
to the peer-reviewed

Other

original source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HW

()\ erall Score = Sum of
\\ eighted Scores/Sum
of Metric Weighting
Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1."

1 "and : ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 59 of 134

-------
Study
Reference:

Haynes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC Press.
HERO ID:6982969

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1." and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.

Page 60 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.

Cited reference: O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge,
UK: Royal Society of Chemistry, 2013., p. 1255.

Page 61 of 134

-------
Studv

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832



Reference:

















Qualitative













Determination





Metric
Weighting
Factor



Domain

Metric

(i.e., High,
Medium, Low,

Comments

Metric
Score

Weighted Score





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR



Reliability /

Medium

There is no indication that

2

1

2



Unbiased (Method
Objectivity)



the methodology for
producing the information
was biased towards a
particular product or







Test

Reliability





outcome.







Reliability /
Analytical Method

Medium

The analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/recognized
database or other
secondary source.

2

1

2



Databases

High

The information or data is
from a recognized data
collection/repository
where data are peer-

1

1

1

Other





reviewed by experts in the
field, are broadly
available to the public for
review and use.









Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;ind 1 "

1 ~ and

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: ILO International Chemical Safety Cards (ICSC).

Page 62 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833







Reference:

















Qualitative













Determination

(Le., High,
Medium, Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology
for producing the
information was biased
towards a particular
product or outcome.







Test

Reliability

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

2

1

2



Databases

High

Data is from a
secondary database with
a reference to the peer-

1

1

1

Other





reviewed original
source.









Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

Midi

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1."

1 " and 2. '

2.'Mild '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: Sigma-Aldrich.

Page 63 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833







Reference:

















Qualitative













Determination

(Le., High,
Medium, Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology
for producing the
information was biased
towards a particular
product or outcome.







Test

Reliability

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

2

1

2



Databases

High

Data is from a
secondary database with
a reference to the peer-

1

1

1

Other





reviewed original
source.









Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

Midi

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1."

1 " and 2. '

2.'Mild '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: Fluorochem.

Page 64 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833







Reference:

















Qualitative













Determination

(Le., High,
Medium, Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology
for producing the
information was biased
towards a particular
product or outcome.







Test

Reliability

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

2

1

2



Databases

High

Data is from a
secondary database with
a reference to the peer-

1

1

1

Other





reviewed original
source.









Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

Midi

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1."

1 " and 2. '

2.'Mild '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: Oakwood.

Page 65 of 134

-------
Studv

RSC (2020). ChcmSpider: D4. HERO ID:6982833







Reference:

















Qualitative













Determination

(Le., High,
Medium, Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology
for producing the
information was biased
towards a particular







Test

Reliability





product or outcome.







Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

2

1

2



Databases

High

Data is from a
secondary database with
a reference to the peer-

1

1

1

Other





reviewed original
source.









Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

hind 1."

1 "and

:.^md ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.
Cited reference: Alfa Aesar.

Page 66 of 134

-------
Study
Reference:

Palczcwska-Tulinska, M; Oracz, P. (2005). Selected physicochcmical properties of
hcxamcthylcyclotrisiloxanc, D4, and dccamcthylcyclopcntasiloxanc. Journal of Chemical and
Engineering Data 50: 1711-1719. HERO ID:3569075

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific
question, and the
methodology's objective
is clear.

1

1

1

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for physical-
chemical properties or
another developed
standard.

1

1

1

Other

Databases

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

3

3

3

Midi

Medium

l.nw

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1

Overall Score
(Rounded):

1

1 and 1

1 "and : ^

2 'and '





Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.

Page 67 of 134

-------
Study
Reference:

Zhang, Y; Dong, H; Wu, C; Yu, L; Xu, J. (2015). The mixing properties of l,3,5-trimcthyl-l,3,5-
tris(3,3,3-trifluoropropyl) cyclotrisiloxanc with various organosilicon compounds at different
temperatures. The Journal of Chemical Thermodynamics 81: 16-25. HERO ID:427%77

Qualitative

Determination

Metric
Weighting
Factor

Domain

Metric

(/.e., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score

Unacceptable, or
Not Rated [NR])

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific
question, and the
methodology's objective
is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for physical-
chemical properties or
another developed
standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

Overall Score
(Rounded):

1 ;ind 1 "

1 "and : ^

2 ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Density reported by this reference.

Page 68 of 134

-------
Study
Reference:

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Domain

Metric

Qualitative
Determination (i.e.,
High, Medium,

Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

Data is from a recognized,
peer- reviewed data
collection.

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

0\erall Score = Sum of
\\ eighted Scores/Sum of
Mel lie Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference.
Cited reference: Physprop.

Page 69 of 134

-------
Studv

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Reference:

Qualitative

Determination

(i.t'., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical substance
structural features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

Medium

There is no indication that

(Method Objectivity)

the methodology for
producing the information
was biased towards a
particular product or

Test

Reliability

outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer- reviewed/recognized
database or other
secondary source.

Databases

High

The information or data is
from a recognized data
collection/repository
where data are peer-

Other

reviewed by experts in the
field, are broadly available
to the public for review
and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting
l-aclors:

1.4

Overall Score
(Rounded):

1.4

1 ;nid 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference.
Cited reference: EPA DSSTox; Hazardous Substances Data Bank (HSDB).

Page 70 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(/.£., High,
Medium, Low,
Unacceptable,
or Not Rated
fNR})

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the public
for review and use or includes
references to the original
sources.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 ,o\\

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 ~ and

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference.
Cited reference: ILO International Chemical Safety Cards (ICSC).

Page 71 of 134

-------
Study
Reference:

Lei, YD; Wania, F; Mathers, D, an. (2010). Temperature-Dependent Vapor Pressure of Selected Cyclic
and Linear Polydimcthylsiloxanc Oligomers. Journal of Chemical and Engineering Data 55: 5868-5873.
HERO ID:2629388

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured for
the subject chemical
substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific
question, and the
methodology's objective
is clear.

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for physical-
chemical properties or
another developed
standard.

Other

Databases

Rating of this factor is
not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

Overall Score
(Rounded):

1 ;nid 1 "

1 "and : ^

:.^nid ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference.

Page 72 of 134

-------
Studv

Flaningam, O. L. (1986). Vapor pressures of poly(dimcthylsiloxanc) oligomers. Journal of Chemical

Reference:

and Engineering Data 31(3): 266-272. HERO ID:6989156

Qualitative

Determination

(i.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured for
the subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Low

Data are obtained by
accepted standard
analytical methods.
Score reduced because
all measurements were
outside of

environmental range.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 .o\\

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

1.75

Overall
Score

(Rounded):

1.8

hind 1."

1 ~ ;md

l^md ^

Overall
Quality
Level:

Medium

The re\ ie\\ or;

igreed w ilh I he o\ em II rnlnig lor I he \ ;ipoi Pressure reported by this reference.

Page 73 of 134

-------
Study
Reference:

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Domain

Metric

Qualitative
Determination

(Le., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.
Cited reference: Physprop; Kovdienko, et. al. Molecular informatics 29.5 (2010): 394-406.

Page 74 of 134

-------
Study
Reference:

Elsevier (2019). Rcaxvs: physical-chemical property data for D4. CAS Registry Number: 556-67-2.
HERO ID:6984075

Domain

Metric

Qualitative
Determination

(Z.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Unacceptable

Data measured for the
subject chemical substance
are not consistent with the
subject chemical substance
structural properties,
features or behaviors.

Test

Reliability

Reliability /
Unbiased (Method
Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability /
Analytical Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use or
includes references to the
original sources.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

Overall
Score

(Rounded):

1 ;i ikI 1 "

1 ~ and

: ^ and ^

Overall
Quality
Level:

Unacceptable"

"The value was determined to be misreported in the secondary source when compared to the primary source. Consistent with
our Application of Systematic Review in TSCA Risk Evaluation document, if a metric for a data source receives a score of
Unacceptable (score = 4), EPA will determine the study to be unacceptable. In this case, one of the metrics was rated as
unacceptable. As such, the study is considered unacceptable and the score is presented solely to increase transparency.

Cited reference: Varaprath S et al; Environ Toxicol Chem 15(8): 1263-1265 (1996).

Page 75 of 134

-------
Studv

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Reference:

Qualitative

Determination

(/.t'., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NRj)

Representativeness

Unacceptable

Source reports as none
which may indicate the
compound was not tested.

Substance

Appropriateness

Low

Data measured for the
subject chemical substance
are not consistent with the
subject chemical substance
structural properties,
features or behaviors.

Reliability / Unbiased

Medium

There is no indication that

(Method Objectivity)

the methodology for
producing the information
was biased towards a
particular product or

Test

Reliability

outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other
secondary source.

Databases

High

Data is from a recognized,
peer- reviewed data

Other

collection.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Midi

Medium

Low

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

2.4

Overall
Score

(Rounded):

1 ;iih.I 1."

1 "and : ^

2.' and '

Overall
Quality
Level:

Unacceptable"

" Consistent with our Application of Systematic Review in TSCA Risk Evaluation document, if a metric for a data source

receives a score of Unacceptable (score = 4), EPA will determine the study to be unacceptable. In this case, one of the
metrics was rated as unacceptable. As such, the study is considered unacceptable and the score is presented solely to increase

transparency.

Cited reference: ILO International Chemical Safety Cards (ICSC).

Page 76 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Cited reference: ECHA; Search for Chemicals. D4 (CAS 556-67-2) Registered Substances Dossier. European Chemical
Agency. Available from, as of Aug 17, 2015: http://echa.europa.eu/.

Page 77 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(/.£., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features
or other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1and : ^

2 ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.
Cited reference: Varaprath S et al; Environ Toxicol Chem 15(8): 1263-1265 (1996)

Page 78 of 134

-------
Studv

Varaprath, S., ct al. (1996). Aqueous solubility of pcrmcthylsiloxancs (silicones). Environmental

Reference:

Toxicology and Chcmistrv 15(8): 1263-1265. HERO ID:6984031

Qualitative

Determination

(i.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Mid.

Medium

I.HM

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

Overall
Score

(Rounded):

1 III id 1

1 "and 2 ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 79 of 134

-------
Study
Reference:

Sousa, JV; Mcnamara,

PC; Putt, AE; Machado, MW; Surprcnant, DC; Hamclink, JL; Kent,

DJ;

Silbcrhorn, EM; Hobson, JF. (1995). Effects of D4 (OMCTS) on freshwater and marine organisms.
Environ Toxicol Chem 14: 1639-1647. HERO ID:6834101





Qualitative













Determination





Metric
Weighting
Factor



Domain

Metric

(i.t'., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

1

1

1



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology for
producing the
information was biased







Test





towards a particular







Reliability





product or outcome.







Reliability / Analytical
Method

Medium

The analytical method is
described in limited
detail but is expected to
be appropriate.

2

1

2



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;i ikI 1 "

1 ~ and

: ^ ;ind ^





Overall
Quality
Level:

High

1 lie re\ icw or

igreed \x nli I lie n\ ei.ill nil

nig lor ilie Waler Solubility reported by this reference.





Page 80 of 134

-------
Study
Reference:

Sousa, JV; Mcnamara, PC; Putt, AE; Machado, MW; Surprcnant, DC; Hamclink, JL; Kent

DJ;

Silbcrhorn, EM; Hobson, JF. (1995). Effects of D4 (OIV1CTS) on freshwater and marine organisms.
Environ Toxicol Chcm 14: 1639-647. HERO ID:6834101





Qualitative













Determination





Metric
Weighting
Factor



Domain

Metric

(i.e., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

1

1

1



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology for
producing the
information was biased







Test





towards a particular







Reliability





product or outcome.







Reliability / Analytical
Method

Medium

The analytical method is
described in limited
detail but is expected to
be appropriate.

2

1

2



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.5

Overall
Score

(Rounded):

1.5

hind 1."

1 ~;nid : ^

: ^ ;ind ^





Overall
Quality
Level:

High

The re\ ie\\er

igreed u illi ihe n\ ei.ill r;il

mi; lor ilie \\';iler Solubility reported by this reference.





Page 81 of 134

-------
Study
Reference:

Gee, RP. (2015). Emulsion polymerization of dimcthylcyclosiloxanc in cationic emulsion: Mechanism
study utilizing two phase liquid-liquid reaction kinetics. Colloid Surface Physicochcm Eng Aspect 481:
297-306. HERO ID:6833841

Qualitative

Determination (/.t'.j

Metric
Weighting
Factor

Domain

Metric

High, Medium,

Low,

Comments

Metric
Score

Weighted
Score

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific

Test

Reliability

question, and the
methodology's objective
is clear.

Reliability /
Analytical Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not limited
to OECD guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this kind
of information.

Models

Rating of this factor is
not applicable to this kind
of information.

Sum of scores:

Mid.

Medium

I.HM

0\erall Score = Sum of
\\ eighted Scores/Sum of
Mel lie Weighting
l-aclors:

Overall
Score

(Rounded):

1 and 1

1 "and : ^

2.'Mild '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 82 of 134

-------
Study
Reference:

Domain

Metric

Qualitative
Determination (/.£.,
High, Medium, Low,
Unacceptable, or Not
Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or estimated
for the subject chemical
substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features or
other physical/chemical
properties or behaviors.

Test

Reliability

Reliability /
Unbiased (Method
Objectivity)

High

The methodology for producing
the information is designed to
answer a specific question, and
the methodology's objective is
clear.

Reliability /
Analytical Method

High

Data are obtained by accepted
standard analytical methods,
including, but not limited to
OECD guidelines for physical-
chemical properties or another
developed standard.

Other

Databases

Rating of this factor is not
applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

Overall
Score

(Rounded):

1 and 1 "

1 . ~ ;md 2'

2 ^ ;md ^

Overall
Quality
Level:

High

1 lie re\ icu or agreed u illi I lie o\ ci;ill inline I'm' I lie \\ aler Solubility reported by this reference.

Page 83 of 134

-------
Studv

Springborn Laboratories, D4 - determination of the water solubility in synthetic scawatcr. 1989.

Reference:

HERO ID:5889412

Qualitative

Determination

Metric
Weighting
Factor

Domain

Metric

(i.t'., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical substance
structural features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the information
is designed to answer a
specific question, and the
methodology's objective is
clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not limited
to OECD guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is not

Other

applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

Overall
Score

(Rounded):

1 ;ind 1 "

1 " and ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 84 of 134

-------
Studv

Springborn Laboratories, D4 - determination of the water solubility in freshwater. 1989.

Reference:

HERO ID:5889414

Qualitative

Determination

(i.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical substance
structural features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the information
is designed to answer a
specific question, and the
methodology's objective is
clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not limited
to OECD guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is not

Other

applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Midi

Medium

I.HM

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

Overall
Score

(Rounded):

1 and 1

1 " and ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 85 of 134

-------
Studv

Bavcr AG, Contributions on assessment of the aquatic toxicity of OMCTS with cover letter.

1990.

Reference:

HERO ID:5899898

Qualitative

Determination (i.e.,
High, Medium,

Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated fNRl)

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased

Test

towards a particular

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

The analytical method
is non- standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 huh

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1.5

Overall Score
(Rounded):

1.5

1 III id 1 "

1 "and : ^

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 86 of 134

-------
Studv

Bayer AG, Contributions on assessment of the aquatic toxicity of OMCTS with cover letter.

1990.

Reference:

HERO 10:5899898

Qualitative

Determination

(i.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased

Test

towards a particular

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

The analytical method
is non- standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1

1 ~ and

2.'Mild '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 87 of 134

-------
Study
Reference:

Rhone-Poulenc Inc. Environmental fate of D4 with cover letter. 1990.
HERO ID:5899916

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

1

1

1

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

1

1

1

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Low

The methodology
indicates that method
bias is likely.

3

1

3

Reliability / Analytical
Method

Low

The analytical method
described is not
appropriate.

3

1

3

Other

Databases

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

8

4

8

1 hull

Medium

1 A»\X

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

2

Overall Score
(Rounded):

2

1 III id 1 "

1 ~;md : ^

: ^ ;md ^





Overall
Quality
Level:

Medium

1 lie re\ icw or agreed u nil I lie o\ emll i;il inii I'm' I lie \\ aler Solubility reported by this reference.

Page 88 of 134

-------
Studv

Rhone-Poulenc Inc, Env

ironmental fate of D4 with cover letter. 1990.





Reference:

HERO ID:5899916















Qualitative













Determination (i.t'.j





Metric
Weighting
Factor



Domain

Metric

High, Medium,

Low,

Comments

Metric
Score

Weighted
Score





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

1

1

1

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

1

1

1

Test

Reliability / Unbiased
(Method Objectivity)

Low

The methodology
indicates that method
bias is likely.

3

1

3

Reliability

Reliability / Analytical
Method

Low

The analytical method
described is not
appropriate.

3

1

3



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

8

4

8

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

2

Overall Score
(Rounded):

2

1 III id 1 "

1 " and ^

: ^ and ^





Overall
Quality Level:

Medium

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 89 of 134

-------
Studv

Dow Corning. The n-octanol/watcr partition coefficient of D4 with attachment and cover letter dated

Reference:

092987. 1987. HERO ID:5905948

Qualitative

Determination (/.£.,

Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium,
Low, Unacceptable,
or Not Rated |NR|)

Comments

Weighting
Factor

Representativeness

High

Data are measured for
the subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features (e.g.,
presence of certain
functional groups).

Reliability / Unbiased
(Method Objectivity)

High

Methodology for
producing the
information is

Test

Reliability

designed to answer a
specific question, and
the methodology's
objective is clear.

Reliability / Analytical
Method

Medium

Analytic method is
non-standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of
Metric Weighting
Factors:

1.25

Overall Score
(Rounded):

1.3

1 and 1

1 "and : ^

2 'and '

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 90 of 134

-------
Studv

Dow Corning, The water solubility of D4 with attachments and cover letter dated 092987. 1987.

Reference:

HERO ID:5905954















Qualitative













Determination (/.e.,



Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium,
Low, Unacceptable,
or Not Rated |NR|)

Comments

Weighting
Factor



Representativeness

High

Data are measured for
the subject chemical
substance.

1

1

1

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features (e.g.,
presence of certain
functional groups).

1

1

1



Reliability / Unbiased
(Method Objectivity)

High

Methodology for
producing the
information is

1

1

1

Test

Reliability





designed to answer a
specific question, and
the methodology's
objective is clear.









Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytic methods.

1

1

1



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

4

4

4

1 hull

Medium

1 ,o\\

Overall Score = Sum
of Weighted
Scores/Sum of
Metric Weighting
Factors:

1

Overall Score
(Rounded):

1

1 ;nid 1 "

1 "and : ^

2 ^ and ^





Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 91 of 134

-------
Studv

Springborn, L. (1989). Octamcthycyclotctrasiloxanc- Determination of the water solubility in

Reference:

freshwater. Washington, DC, Silicones Health Council. HERO ID:7006395

Qualitative

Determination

(i.t'., High,
Medium. Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured for
the subject chemical
substance.

Appropriateness

High

Measured data are
consistent with the

Substance

subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

Overall Score
(Rounded):

1 ;nid 1 "

1 ~ and 2'

2.' and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 92 of 134

-------
Study
Reference:

Dow Corning, Aqueous solubility studies of D4. 1991. HERO ID:7310465

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific
question, and the
methodology's objective
is clear.

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for physical-
chemical properties or
another developed
standard.

Other

Databases

Rating of this factor is
not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

Overall Score
(Rounded):

1 ;nid 1 "

1 "and : ^

:.^nid ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

Page 93 of 134

-------
Study
Reference:

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Domain

Metric

Qualitative
Determination (/.e.,
High, Medium, Low,
Unacceptable, or Not
Rated |NR|)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or estimated
for the subject chemical
substance.

Appropriateness

High

Measured data are consistent
with the subject chemical's
physical/chemical properties.

Test

Reliability

Reliability /
Unbiased (Method
Objectivity)

Medium

There is no indication that the
methodology for producing the
information was biased towards
a particular product or outcome.

Reliability /
Analytical Method

Medium

Analytical method is unknown
but is likely to be appropriate
based on the data's inclusion in a
peer- reviewed/recognized
database or other secondary
source.

Other

Databases

High

Data is from a secondary
database with a reference to the
peer-reviewed original source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 ;ind 1."

1 "and 2 ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.
Cited reference: Physprop.

Page 94 of 134

-------
Study
Reference:

Elsevier (2019). Rcaxvs: physical-chemical property data for D4. CAS Registry Number: 556-67-2.
HERO ID:6984075

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

Other

Databases

High

Data is from a
secondary database with
a reference to the peer-
reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.4

Overall Score
(Rounded):

1.4

1 ;ind 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 95 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are consistent
with the subject chemical
substance structural features oi
other physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the data's
inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.4

Overall
Score

(Rounded):

1.4

1 and 1 "

1and 2 "!

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.
Cited reference: Xu S et al; Environ Sci Technol 48: 11748-11759 (2014).

Page 96 of 134

-------
Study
Reference:

Xu, S. and B. Kropscott (2014). Evaluation of the three-phase equilibrium method for measuring
temperature dependence of internally consistent partition coefficients (KOW , KOA , and KAW) for
volatile mcthylsiloxancs and trimcthylsilanol. Environmental Toxicology and Chemistry 33(12): 2702-
2710. HERO ID:2535012

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium. Low,
Unacceptable, or
Not Rated |NR|)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Other

Databases

Rating of this factor is
not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

Overall Score
(Rounded):

1 III id 1 "

1 "and 2 ^

: ^ and ^

Overall
Quality
Level:

High

The iv\ icu or agreed u illi I lie o\ ci;ill inline I'm' I lie ()cl;nml Water Coefficient (logKow) reported by this reference.

Page 97 of 134

-------
Study
Reference:

Xu, S. and B. Kropscott (2012). Method for simultaneous determination of partition coefficients for
cyclic volatile mcthylsiloxancs and dimcthylsilancdiol. Analytical Chemistry 84(4): 1948-1955.
HERO ID:2188633

Qualitative

Determination

Metric
Weighting
Factor

Domain

Metric

(Z.e., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Mid.

Medium

I.HM

0\erall Score = Sum
of \\ eighted
Scores/Sum of Metric
\\ eighting Factors:

Overall Score
(Rounded):

1 III id 1

1 "and 2 ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.

Page 98 of 134

-------
Study
Reference:

Dow Corning, The n-octanol/watcr partition coefficient of D4 with attachment and cover letter dated
092987. 1987. HERO ID:5905948

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium. Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured for
the subject chemical
substance.

1

1

1

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features (e.g., presence
of certain functional
groups).

1

1

1

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

Methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

1

1

1

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytic methods.

1

1

1

Other

Databases

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

4

4

4

Midi

Medium

l.nw

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

1

Overall Score
(Rounded):

1

1 ;iih.I 1."

1 ~ and

2 'and '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.

Page 99 of 134

-------
Studv

Dow Corning, Subject: Monthly summary 10/1982, octanol-watcr coefficients. 1982.



Reference:

HERO ID:7310176















Qualitative













Determination

(i.e., High,
Medium. Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

NR

Data are measured for
the subject chemical
substance.

NR

NR

NR

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features.

1

1

1



Reliability / Unbiased

Medium

There is no indication

2

1

2



(Method Objectivity)



that the methodology
for producing the
information was







Test





biased towards a







Reliability





particular product or
outcome.









Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods.

1

1

1



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

4

3

4

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of
Metric Weighting
Factors:

1.3

Overall Score
(Rounded):

1.3

1 ;nid 1 "

1 ~;md : ^

:.^;nid ^





Overall
Quality Level:

High

1 lie re\ ie\xer;

Hived u illi I lie o\ ei.ill r;ii 11112 lor 1 lie ()el;nml Waier Coefficient (logKow) reported by this reference.

Page 100 of 134

-------
Studv

Ko/crski, G., Shawl, H. Determination of the 1-octanol/watcr partition coefficient of D4 (D4) by the

Reference:

slow-stirring method using gas chromatography. 2007. HERO ID:6987895

Qualitative

Determination (/.£.,

Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium,
Low, Unacceptable,
or Not Rated |NR|)

Comments

Weighting
Factor

Representativeness

High

Data are measured for
the subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is

Test

Reliability

designed to answer a
specific question, and
the methodology's
objective is clear.

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods.

Databases

Rating of this factor
is not applicable to
this kind of

Other

information.

Models

Rating of this factor
is not applicable to
this kind of
information.

Sum of scores:

Mid.

Medium

l.nw

Overall Score = Sum
of Weighted
Scores/Sum of
Metric Weighting
Factors:

Overall Score
(Rounded):

1 ;nid 1 "

l."aiid 2"

2 'and '

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.

Page 101 of 134

-------
Study

U.S. EPA (2020). Chemistry dashboard information for D4. HERO ID:6982826

Reference:

Qualitative

Determination

(i.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical's
physical/chemical
properties.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.4

Overall Score
(Rounded):

1.4

1 and 1

1 "and : ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.
Cited reference: Physprop.

Page 102 of 134

-------

Xu, S. and B. Kropscott (2014). Evaluation of the three-phase equilibrium method for measuring

Studv

temperature dependence of internally consistent partition coefficients (KOW

, KOA , and KAW) for

Reference:

volatile mcthylsiloxancs and trimcthylsilanol. Environmental Toxicology and Chemistry 33(12): 2702-

2710. HERO ID: 2535012

Qualitative

Determination

(i.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated |NR|)

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features (e.g., presence
of certain functional
groups).

Reliability / Unbiased
(Method Objectivity)

High

Methodology for
producing the
information is

Test

Reliability

designed to answer a
specific question, and
the methodology's
objective is clear.

Reliability / Analytical
Method

High

Analytic method is
non-standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.25

Overall Score
(Rounded):

1.3

1 ;ind 1 "

1 "and : '

: ' ;md ^

Overall
Quality
Level:

High

1 lie re\ ie\\er

igreed \\ nli ilie n\ ei.ill nil

uig liir ilie 1 leiiis s

-aw reported by this reference.

Page 103 of 134

-------
Study

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Reference:

Qualitative

Determination

(i.t'., Hi«h,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular
product or outcome.

Test

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is the

Reliability

analytical method is
unknown but is likely to
be appropriate likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other
secondary source.

Databases

High

The information or data is
from a recognized data
collection/repository
where data are peer-

Other

reviewed by experts in
the field, are broadly
available to the public for
review and use.

Models

Rating of this factor is
not applicable to this kind
of information.

Sum of scores:

Mid.

Medium

I.HM

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.4

Overall
Score

(Rounded):

1.4

1 III id 1

1 " and ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.
Cited reference: Xu S, Kropscott B; Environ Toxicol Chem 33(12): 2702-10 (2014).

Page 104 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(/.£., High,
Medium, Low,
Unacceptable, or
Not rated)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology
for producing the
information was biased
towards a particular
product or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Other

Databases

High

The information or data
is from a recognized
data collection/
repository where data
are peer-reviewed by
experts in the field, are
broadly available to the
public for review and
use.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Mid.

Medium

I.HW

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.4

Overall Score
(Rounded):

1.4

1 III id 1

1 "and : ^

2 'and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.
Cited reference: EPA DSSTox.

Page 105 of 134

-------
Studv

Hamclink, JL; Simon, PB; Silbcrhorn, EM. (19%). Hcnrv's law constant, volatilization rate.

and

Reference:

aquatic half-life of D4. Environ Sci Tcchnol 30: 1946-1952. HERO ID:2803124

Qualitative

Determination

(i.e., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is designed
to answer a specific
question, and the
methodology's objective
is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for physical-
chemical properties or
another developed
standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 ,o\\

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

Overall Score
(Rounded):

1 ;nid 1 "

1 ~ and

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.

Page 106 of 134

-------
Study
Reference:

Domain

Metric

Qualitative
Determination (/.£.,

High, Medium,
Low, Unacceptable,
or Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

High

Measured data are
consistent with the subject
chemical substance's other
physical/chemical
properties or behaviors.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the information
is designed to answer a
specific question, and the
methodology's objective is
clear.

Reliability / Analytical
Method

Medium

The analytical method is
non- standard but is
expected to be appropriate.

Other

Databases

Rating of this factor is not
applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Mid.

Medium

I.HM

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1.25

Overall Score
(Rounded):

1.3

1 III id 1

1 "and : ^

: ^and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.

Page 107 of 134

-------
Study
Reference:

Xu, S. and B. Kropscott (2012). Method for simultaneous determination of partition coefficients for

cyclic volatile mcthylsiloxancs and dimcthylsilancdiol. Analytical Chemistry 84(4): 1948-1955.
HERO ID:2188633

Qualitative

Determination

Metric
Weighting
Factor

Domain

Metric

(i.e., High,
Medium, Low,

Comments

Metric
Score

Weighted
Score

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the subject
chemical substance's other
physical/chemical
properties or behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the information

Test

Reliability

is designed to answer a
specific question, and the
methodology's objective
is clear.

Reliability / Analytical
Method

Medium

The analytical method is
non- standard but is
expected to be
appropriate.

Databases

Rating of this factor is not

Other

applicable to this kind of
information.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

Mid.

Medium

I.HW

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting
l-actors:

1.25

Overall
Score

(Rounded):

1.3

1 III id 1

1 "and : ^

2 ' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.

Page 108 of 134

-------
Studv

Ann Arbor Technical Services, Inc., Phase II studies of the Hcnrv's law constant of OMCTS (D4). 2000.

Reference:

HERO ID:5889409

Qualitative

Determination (/.e.,
High, Medium.

Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

High

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased

Test

towards a particular

Reliability

product or outcome.

Reliability / Analytical
Method

High

The analytical method
is non-standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

Overall Score
(Rounded):

hind 1."

1 "and : ^

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.

Page 109 of 134

-------
Study
Reference:

Ann Arbor Technical Services, Inc., Phase II studies of the Henry's law constant of OMCTS (D4). 2000.
HERO ID:5889409

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

High

Measured data are
consistent with the subject
chemical substance
structural features or other
physical/chemical
properties or behaviors.

1

1

1

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

High

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

1

1

1

Reliability / Analytical
Method

High

The analytical method is
non- standard but is
expected to be appropriate.

1

1

1

Other

Databases

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

4

4

4

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting
Factors:

1

Overall Score
(Rounded):

1

1 mid 1."

1 " mul : '

: ^ mill '





Overall
Quality
Level:

High

The ie\ icu or ;ii2ivcil u illi I lie o\ emll i ;il inii I'm' I he 1 leiii s s Law reported by this reference.

Page 110 of 134

-------
Studv

Ann Arbor Technical Services, Inc., Phase II studies of the Henrv's law constant of OMCTS (D4). 2000.

Reference:

HERO ID:5889409

Qualitative

Determination (i.e.,
High, Medium,

Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features or other
physical/chemical
properties or behaviors.

Reliability / Unbiased

High

There is no indication

(Method Objectivity)

that the methodology
for producing the
information was biased

Test

towards a particular

Reliability

product or outcome.

Reliability / Analytical
Method

High

The analytical method
is non- standard but is
expected to be
appropriate.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

Overall Score
(Rounded):

1 ;i ikI 1 "

1 ~ and

: ^ and ^

Overall
Quality
Level:

High

1 lie re\ icw or

agreed \x illi 1 lie n\ ei.ill r;il iiiii I'm' I lie 1 leni's s 1

aw reported by this reference.

Page 111 of 134

-------
Studv

Ann Arbor Technical Services, Inc., Hcnrv's law constant of OMCTS (D4) at 20 decrees. 1990.

Reference:

HERO ID:5889489

Qualitative

Determination

(/.e„ High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured for
the subject chemical
substance.

Appropriateness

High

Measured data are
consistent with the

Substance

subject chemical
substance structural
features or other
physical/chemical
properties or
behaviors.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 ,o\\

()\ erall Score = Sum
of Weighted
Scores/Sum of Metric
\\ eighting Factors:

Overall Score
(Rounded):

1 ;nid 1 "

1 ~ ;ind

: ^ ;ind ^

Overall
Quality
Level:

High

1 lie re\ ie\xer;

igreed u illi I lie n\ ei.ill r;ii

iii2 liir I lie 11 e11r\ s 1

.aw reported by this reference.

Page 112 of 134

-------
Study

Kochctkov, A., ct al. (2001). Air-water partition constants for volatile mcthvl siloxancs. Environmental

Reference:

Toxicology and Chcmistrv 20(10): 2184-2188. HERO ID:7303416

Qualitative

Determination (i.e.,

Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium, Low,
Unacceptable, or
Not Rated |NR|)

Comments

Weighting
Factor

Representativeness

High

Data are measured
for the subject
chemical substance.

Substance

Appropriateness

High

Measured data are
consistent with the
subject chemical
substance structural
features.

Reliability / Unbiased

Medium

There is no

(Method Objectivity)

indication that the
methodology for
producing the
information was

Test

Reliability

biased towards a

particular product or
outcome.

Reliability / Analytical
Method

Medium

The analytical
method is non-
standard but is
expected to be
appropriate.

Databases

Rating of this factor
is not applicable to
this kind of

Other

information.

Models

Rating of this factor
is not applicable to
this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score =
Sum of Weighted
Scores/Sum of
Metric Weighting
Factors:

1.5

Overall Score
(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Henry's Law reported by this reference.

Page 113 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Qualitative

Determination

(/.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject

Substance

chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Reliability / Unbiased

Medium

There is no indication that

(Method Objectivity)

the methodology for
producing the information
was biased towards a
particular product or

Test

Reliability

outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Databases

High

The information or data is

Other

from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.5

Overall Score
(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.
Cited reference: ILO International Chemical Safety Cards (ICSC).

Page 114 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.

Cited reference: Sigma-Aldrich; Safety Data Sheet for D4. Product Number: 235695, Version 3.14 (Revision Date
02/28/2015). Available from, as of September 30, 2015: http://www.sigmaaldrich.com/safety- center.html.

Page 115 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Qualitative

Determination

(/.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject

Substance

chemical substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.5

Overall Score
(Rounded):

1.5

hind 1."

1 ~ and

:.^nid ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.
Cited reference: LabNetwork.

Page 116 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not rated)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

2

1

2

Other

Databases

High

Data is from a
secondary database with
a reference to the peer-
reviewed original
source.

1

1

1

Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

Midi

Medium

I.HM

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.5

Overall Score
(Rounded):

1.5

1 ;iih.I 1."

1 ~ and

2.'iind '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.
Cited reference: Oakwood.

Page 117 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Qualitative

Determination

(/.t'., High,
Medium, Low,

Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject

Substance

chemical substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

Data is from a
secondary database with
a reference to the peer-

Other

reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.5

Overall Score
(Rounded):

1.5

hind 1."

1 ~ and

:.^nid ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.
Cited reference: Alfa Aesar.

Page 118 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology for
producing the
information was biased
towards a particular
product or outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-

reviewed/recognized
database or other
secondary source.

2

1

2

Other

Databases

High

Data is from a
secondary database with
a reference to the peer-
reviewed original
source.

1

1

1

Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

6

4

6

Midi

Medium

I.HM

()\ erall Score = Sum ol
\\ eighted Scores/Sum
of Metric Weighting
l-aclors:

1.5

Overall Score
(Rounded):

1.5

1 ;iih.I 1."

1 ~ and

2.' and '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Flash Point reported by this reference.
Cited reference: OU Chemical Safety Data (no longer updated).

Page 119 of 134

-------
Studv

Elsevier (2019). Rcaxvs: phvsical-chemical property data for D4. CAS Registry Number: 556-67-2.

Reference:

HERO ID:6984075

Qualitative

Determination

(/.e., High,
Medium, Low,

Metric

Weighted
Score

Domain

Metric

Comments

Metric Score

Weighting
Factor

Unacceptable, or
Not Rated [NR])

Representativeness

High

Data are measured or
estimated for the subject

Substance

chemical substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased

Medium

There is no indication

(Method Objectivity)

that the methodology for
producing the
information was biased
towards a particular

Test

Reliability

product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Databases

High

The information or data
is from a recognized data
collection/repository
where data are peer-

Other

reviewed by experts in
the field, are broadly
available to the public for
review and use.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum
of Metric Weighting
Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;ind 1 "

1 "and : '

:.^;iiid ^

Overall
Quality
Level:

High

1 lie re\ ie\\ei

agreed \x nli I lie n\ ei.ill i

almg lor ihe \ isensity reported by this reference.

Page 120 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

2

1

2

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

2

1

2

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

1

1

1

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1 "and : ^

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Viscosity reported by this reference.
Cited reference: Hazardous Substances Data Bank (HSDB).

Page 121 of 134

-------
Study
Reference:

Palczcwska-Tulinska, M; Oracz, P. (2005). Selected phvsicochcmical properties of
hevamethylcvclotrisiloxane, D4, and dccamcthylcyclopcntasiloxanc. Journal of Chemical and
Engineering Data 50: 1711-1719. HERO ID:3569075





Qualitative













Determination





Metric
Weighting
Factor



Domain

Metric

(i.t'., High,
Medium. Low,

Comments

Metric
Score

Weighted
Score





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the

1

1

1

Substance





subject chemical
substance.









Appropriateness

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR



Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

1

1

1

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

1

1

1



Databases

NR

Rating of this factor is

NR

NR

NR

Other





not applicable to this
kind of information.







Models

NR

Rating of this factor is
not applicable to this
kind of information.

NR

NR

NR

Sum of scores:

3

3

3

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1

Overall Score
(Rounded):

1

1 ;ind 1 "

1 "and

2.' and ^





Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Viscosity reported by this reference.

Page 122 of 134

-------
Studv

Liu F ct al. 2013. Atomic force microscopy of confined liquids using

the thermal bending fluctuations of

Reference:

the cantilever. Phvs Rev E 87: 62406. HERO ID:6835221











Qualitative













Determination

(Z.e., High,
Medium, Low,



Metric
Score

Metric

Weighted
Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated [NR])









Representativeness

High

Data are measured or
estimated for the subject

1

1

1

Substance





chemical substance.







Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR



Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the information
is designed to answer a
specific question, and the
methodology's objective
is clear.

1

1

1

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not limited
to OECD guidelines for
physical-chemical
properties or another
developed standard.

1

1

1



Databases

NR

Rating of this factor is not

NR

NR

NR

Other





applicable to this kind of
information.







Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

3

3

3

Midi

Medium

I.HM

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel lie Weighting
Faclors:

1

Overall Score
(Rounded):

1

1 ;iih.I 1

1 "and : ^

2 ' and '





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Viscosity reported by this reference.

Page 123 of 134

-------
Study
Reference:

O'Ncil, M. J. (2013). The Merck Index D4. Cambridge, UK, The Royal Society of Chemistry.
HERO ID:6982970

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium. Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.

Page 124 of 134

-------
Study
Reference:

Elsevier (2019). Rcaxvs: physical-chemical property data for D4. CAS Registry Number: 556-67-2.
HERO ID:6984075

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted Score

Substance

Representativeness

High

Data are measured or
estimated for the
subject chemical
substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication
that the methodology
for producing the
information was biased
towards a particular
product or outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to
be appropriate based on
the data's inclusion in a
peer-reviewed/
recognized database or
other secondary source.

Other

Databases

High

Data is from a
secondary database with
a reference to the peer-
reviewed original
source.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

Midi

Medium

I.HM

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;iih.I 1

1 ~ and

2.' and '

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 125 of 134

-------
Study
Reference:

Havnes, W. M. (2014). CRC Handbook of Chemistry and Physics D4. Boca Raton, FL, CRC Press.
HERO ID:6982969

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated |NR|)

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1 "and : ^

: ^and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.

Page 126 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination (i.e.,
High, Medium,

Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

2

1

2

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

1

1

1

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel l ie Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 and 1 "

1 "and 2 ^

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.
Cited reference: Sigma-Aldrich.

Page 127 of 134

-------
Study
Reference:

RSC (2020). ChcmSpidcr: D4. HERO ID:6982833

Domain

Metric

Qualitative
Determination

(/.t'., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

1

1

1

Appropriateness

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

2

1

2

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

2

1

2

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

1

1

1

Models

NR

Rating of this factor is not
applicable to this kind of
information.

NR

NR

NR

Sum of scores:

6

4

6

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^





Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.
Cited reference: Alfa Aesar.

Page 128 of 134

-------
Study
Reference:

NLM (2020). PubChcm database: compound summary: D4. HERO ID:6982832

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that the
methodology for producing
the information was biased
towards a particular product
or outcome.

Reliability / Analytical
Method

Medium

The analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized database
or other secondary source.

Other

Databases

High

The information or data is
from a recognized data
collection/repository where
data are peer-reviewed by
experts in the field, are
broadly available to the
public for review and use.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

()\ erall Score = Sum of
\\ eighted Scores/Sum of
Mel ric Weighting Factors:

1.5

Overall
Score

(Rounded):

1.5

kind 1."

1 "and : ^

: ^ and ^

Overall
Quality
Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.
Cited reference: Hazardous Substances Data Bank (HSDB).

Page 129 of 134

-------
Study
Reference:

Qualitative

Determination {i.e.,

Metric
Score

Metric

Weighted
Score

Domain

Metric

High, Medium,
Low, Unacceptable,
or Not Rated [NR])

Comments

Weighting
Factor

Representativeness

High

Data are measured or
estimated for the

Substance

subject chemical
substance.

Appropriateness

Rating of this factor is
not applicable to this
kind of information.

Reliability / Unbiased
(Method Objectivity)

High

The methodology for
producing the
information is
designed to answer a
specific question, and
the methodology's
objective is clear.

Test

Reliability

Reliability / Analytical
Method

High

Data are obtained by
accepted standard
analytical methods,
including, but not
limited to OECD
guidelines for
physical-chemical
properties or another
developed standard.

Databases

Rating of this factor is

Other

not applicable to this
kind of information.

Models

Rating of this factor is
not applicable to this
kind of information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum
of Weighted
Scores/Sum of Metric
Weighting Factors:

Overall Score
(Rounded):

1 ;ind 1 "

1 "and : ^

2 ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Refractive Index reported by this reference.

Page 130 of 134

-------
Study
Reference:

Elsevier (2019). Rcaxvs: physical-chemical property data for D4. CAS Registry Number: 556-67-2.
HERO ID:6984075

Domain

Metric

Qualitative
Determination

(i.e., High,
Medium, Low,
Unacceptable, or
Not Rated [NR])

Comments

Metric
Score

Metric
Weighting
Factor

Weighted
Score

Substance

Representativeness

High

Data are measured or
estimated for the subject
chemical substance.

Appropriateness

Rating of this factor is not
applicable to this kind of
information.

Test

Reliability

Reliability / Unbiased
(Method Objectivity)

Medium

There is no indication that
the methodology for
producing the information
was biased towards a
particular product or
outcome.

Reliability / Analytical
Method

Medium

Analytical method is
unknown but is likely to be
appropriate based on the
data's inclusion in a peer-
reviewed/recognized
database or other secondary
source.

Other

Databases

High

Data is from a secondary
database with a reference to
the peer-reviewed original
source.

Models

Rating of this factor is not
applicable to this kind of
information.

Sum of scores:

1 hull

Medium

1 A»\X

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1.5

Overall Score
(Rounded):

1.5

1 ;i ikI 1 "

1 "and : ^

: ^ and ^

Overall
Quality Level:

High

The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference.
Cited reference: Data range determined from multiple primary sources in REAXYS.

Page 131 of 134

-------
Studv

U.S. EPA. (2012). Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11 (Comi)utcr

Reference:

Program). Washington, DC. HERO ID:2347246











Qualitative













Determination (i.e.,
High, Medium,

Low,



Metric
Score

Metric

Weighted

Score

Domain

Metric

Comments

Weighting
Factor





Unacceptable, or
Not Rated NRJ)







Substance

Representativeness

NR

The metric is not applicable
to this study type (SAR).

NR

1

NR

Appropriateness

NR

The metric is not applicable
to this study type (SAR).

NR

1

NR

Test

Reliability

Reliability /
Unbiased (Method
Objectivity)

NR

The metric is not applicable
to this study type (SAR).

NR

1

NR

Reliability /
Analytical Method

NR

The metric is not applicable
to this study type (SAR).

NR

1

NR



Databases

NR

The metric is not applicable
to this study type (SAR).

NR

1

NR



Models

High

The models in EPI Suite™
have defined endpoints.
Chemical domain and
performance statistics for
each model are known, and
unambiguous algorithms are
available in the EPI Suite™
documentation and/or cited
references to establish their
scientific validity. Many EPI
Suite™ models have

1

1

1

Other





correlation coefficients >0.7,











cross-validated correlation
coefficients >0.5, and
standard error values <0.3;
however, correlation
coefficients (r2, q2) for the
regressions of some
environmental fate models
(i.e., BIOWIN) are lower, as
expected, compared to
regressions which have
specific experimental values
such as water solubility or
log Kow (octanol-water
partition coefficient).







Sum of scores:

1

1

1

1 hull

Medium

1 ,o\\

Overall Score = Sum of
Weighted Scores/Sum of
Metric Weighting Factors:

1

Overall
Score

(Rounded):

1

1 and 1 "

1 "and : ^

: ^ and ^





Overall
Quality
Level:

High

Page 132 of 134

-------
References

Abbas. R: Schedemann. A: Ihmels. C: Enders. S: Gmehling. J. (2011). Measurement of thermophysical pure component

properties for a few siloxanes used as working fluids for organic rankine cycles. Ind Eng Chem Res 50: 9748-9757.
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Ann Arbor Technical Services. I. (1990). Henry's law constant of OMCTS (D4) at 20 degrees [TSCA Submission],
(OTS0557020. 86940000610. TSCATS/442490). Silicones Health Co.

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Ann Arbor Technical Services. I. (2000). Phase II studies of the Henry's law constant of OMCTS (D4) [TSCA Submission],
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Baver AG. (1990). Contributions on assessment of the aquatic toxicity of OMCTS with cover letter [TSCA Submission],
(OTS0530075. 86-910000021. TSCATS/414455). Mobay Corp.

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Dow Corning (Dow Corning Corporation). (1982). Subject: Monthly summary 10/1982, octanol-water coefficients [TSCA
Submission], In Letter from Dow Corning Corp to US EPA commenting on ITC report nominating D4 for testing
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Dow Corning (Dow Corning Corporation). (1987a). The n-octanol/water partition coefficient of D4 with attachment and
cover letter dated 092987 [TSCA Submission], (OTS0513955. 86-880000065. TSCATS/304944).
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Dow Corning (Dow Corning Corporation). (1987b). The water solubility of D4 with attachments and cover letter dated
092987 [TSCA Submission], (OTS0513956. 86-880000065A. TSCATS/304946).
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Dow Corning (Dow Corning Corporation). (1991). Aqueous solubility studies of D4 [TSCA Submission], In Letter from

Dow Corning Corporation to USEPA submitting enclosed submissions of list and copies of health and safety studies
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Flaningam. OL. (1986). Vapor pressures of poly(dimethylsiloxane) oligomers. Journal of Chemical and Engineering Data 31:

266-272. https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/6989156C3 - 2976
Fuller. J: White. D: Yi. H: Collev. J: Vickerv. Z: Liu. S. (2020). Analysis of volatile compounds causing undesirable odors in
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Gee. RP. (2015). Emulsion polymerization of dimethylcyclosiloxane in cationic emulsion: Mechanism study utilizing two
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Hamelink. JL: Simon. PB: Silberhora EM. (1996). Henry's law constant, volatilization rate, and aquatic half-life of D4.
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https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/2803124C3 -
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Havnes. W. ,M. (2014). D4. In CRC Handbook of Chemistry and Physics (95 ed.). Boca Raton, FL: CRC Press.

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Kochetkov. A: Smith. JS: Ravikrishna. R: Valsarai. KT: Thibodeaux. LJ. (2001). Air-water partition constants for volatile
methyl siloxanes. Environ Toxicol Chem 20: 2184-2188.

https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/7303416C3 - 2976
Kozerski. G: Shawl. H. (2007). Determination of the 1-octanol/water partition coefficient of D4 (D4) by the slow-stirring

method using gas chromatography. (HES study no. 10198-102). Auburn, MI: Dow Corning Corporation, Health and
Environmental Sciences.

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Lei. YD: Wania. F: Mathers. D. an. (2010). Temperature-Dependent Vapor Pressure of Selected Cyclic and Linear
Polydimethylsiloxane Oligomers. Journal of Chemical and Engineering Data 55: 5868-5873.
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Liu. F: de Beer. S: van den Ende. D: Mugele. F. (2013). Atomic force microscopy of confined liquids using the thermal
bending fluctuations of the cantilever. Phys Rev E Stat Nonlinear Soft Matter Phys 87: 062406.
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NLM (National Library of Medicine). (2020). PubChem database: compound summary: D4. Available online at

https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/6982832C3 - 2976
O'Neil. MJ. (2013). D4. In MJ O'Neil (Ed.), The Merck index: An encyclopedia for chemicals, drugs, and biologicals (15th
ed., pp. 1255). Cambridge, UK: Royal Society of Chemistry.

https://HEROnet.epa.gov/HEROnet/index.cfiWreference/download/reference id/6982970C3 - 2976
Palczewska-Tulinska. M: Oracz. P. (2005). Selected physicochemical properties of hexamethylcyclotrisiloxane, D4, and
decamethylcyclopentasiloxane. Journal of Chemical and Engineering Data 50: 1711-1719.
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2531,2553,2554,2555,2976

Rhone-Poulenc Inc. (1990). Environmental fate of D4 with cover letter [TSCA Submission], (OTS0530015. 86-900000476.
TSCATS/414395). https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/5899916C3 -
2876,2976

RSC (Royal Society of Chemistry). (2020). ChemSpider: D4. Available online at

https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/6982833C3 - 2976
Sousa. JV: Mcnamara. PC: Putt. AE: Machado. MW: Surprenant. DC: Hamelink. JL: Kent. DJ: Silberhorn. EM: Hobson. JF.
(1995). Effects of D4 (OMCTS) on freshwater and marine organisms. Environ Toxicol Chem 14: 1639-1647.
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Springborn Laboratories. (1989a). Octamethycyclotetrasiloxane - Determination of the water solubility in freshwater. (EPA
#86940000619; SLI Report #89-10-3116). Washington, DC: Silicones Health Council.
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Springborn Laboratories. (1989b). D4 - determination of the water solubility in freshwater [TSCA Submission], (89-10-3116.
12023-1288-6101-700. OTS0557029. 86940000619. TSCATS/442499). Silicones Health Co.
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Springborn Laboratories. (1989c). D4 - determination of the water solubility in synthetic seawater [TSCA Submission], (89-
9-3104. 12023-1288-6101-700. OTS0557030. 86940000620. TSCATS/442500). Silicones Health Co.
https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/5889412C3 - 2876,2976
U.S. EPA (U.S. Environmental Protection Agency). (2012). Estimation Programs Interface Suite™ for Microsoft® Windows,
v 4.11 [Computer Program], Washington, DC. Retrieved from https://www.epa.gov/tsca-screening-tools/epi-
suitetm-estimation-pro gram-interface
U.S. EPA (U.S. Environmental Protection Agency). (2020). Chemistry dashboard information for D4. Available online at

https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/6982826C3 - 2976
Varaprath. S: Frve. CL: Hamelink. J. (1996). Aqueous solubility of permethylsiloxanes (silicones). Environ Toxicol Chem

15: 1263-1265. https://HEROnet.epa.gov/HEROnet/index.cfm/reference/download/reference id/6984031C3 - 2976
Xu. S: Kropscott. B. (2012). Method for simultaneous determination of partition coefficients for cyclic volatile
methylsiloxanes and dimethylsilanediol. Anal Chem 84: 1948-1955.

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