Cost Estimates of Studies Required for Pesticide Registration
	April 2022	

Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021

810.1000

0.0000

Overview, Definitions, and General Considerations

$139,100

810.1550

0.0000

Product Identity and Disclosure of Ingredients (Composition) (Chemical Identity)

$300

810.2100

0.0000

Products for hard surfaces -EPA Disinfectant test

$9,200

810.2100

0.0000

Products for hard surfaces - AOAC Fungicide test

$2,200

810.2100

(b)&(i)

Chemical Analysis

$6,900

810.2100

(f)

Products for hard surfaces - Fungicidal test

$2,200

810.2100

(g)

Products for hard surfaces - Virucidal activity method

$5,600

810.2100

(g)

Products for hard surfaces -AOAC Tuberculocidal test

$4,500

810.2100

(j)

Products for hard surfaces -Sanitizer test non food

$5,600

810.2100

(i)

Products for hard surfaces - Hard inanimate surface non food

$5,600

810.2100

(m)(2)

Products for hard surfaces - AOAC Germicidal, detergent sanitizers

$4,900

810.2100

b,c,d or i

Products for hard surfaces -AOAC use dilution test, germicidal

$8,300

810.2100

c,d,e

Products for hard surfaces -AOAC Use dilution/germicidal spray/carrier

$8,300

810.2200



Products for hard surfaces - AVG

$8,100

810.2200

- itemized

Limited disinfectant

$5,500

810.2200

- itemized

Broad spectrum disinfectant

$7,500

810.2200

- itemized

Hospital disinfectant

$7,800

810.2200

- itemized

Fungicidal disinfectant

$5,500

810.2200

- itemized

Virucidal disinfectant

$17,000

810.2200

- itemized

Tuberculocidal disinfectant

$6,100

810.2200

- itemized

Additional bacteria

$5,300

810.2200

- itemized

Non-food contact

$6,800

810.2200

- itemized

Food contact - Halide products

$5,800

810.2200

- itemized

Food contact - Non-halide products

$7,900

810.2200

- itemized

Sanitizers for urinal and toilet bowl water and in-tank sanitizers

$7,400

810.2200

- itemized

Residual self-sanitizing - wet surfaces

$6,800

810.2200

- itemized

Sterilants

$15,400

810.2300

b

Products for fabrics/textiles -EPA Carpet Sanitizer

$4,500

810.2400



Products for air sanitizers

$7,200

810.2400

(b)(j)

Chemical Analysis

$200

810.2400

(b)(1)

Chemical Analysis

$5,600

810.2600



Products for microbial pests associated with human and animal waste

$7,400

810.2700

(d)

Products for treating water systems AOAC- water disinfectants pools

$10,400

810.3000



General considerations for Efficacy of invertebrate control agents

$800

810.3100



Soil treatments for imported fire ants

$20,100

810.3200



Livestock, poultry,fur and wool bearing animal treatments

$209,500

810.3300



Treatments to control pests of human and pets

$298,000

810.3400



Mosquito,blackfly and biting midge treatments

$58,600

810.3500



Premises Treatments

$19,500

810.3600



Structural Treatments

$37,700

810.3700



Insect repellants for human skin and outdoor premises

$106,000

810.3700

-

temized

Cage studies with mosquitoes

$25,500

810.3700

-

temized

Cage studies with biting flies

$28,300

810.3700

-

temized

Lab studies with ticks

$37,500

810.3700

-

temized

Field studies with mosquitoes

$86,100

810.3700

-

temized

Field studies with biting flies

$86,100

810.3800

0.0000

Methods for efficacy testing of termite baits

$78,100

830.1550



Product identity and composition

$300

830.1600



Description of materials used to produce the product

$400

830.1620



Description of production process

$500

830.1650



Description of formulation process

$500

830.1670



Discussion of formulation of impurities

$500

830.1700



Preliminary analysis

$41,000

830.1750



Certified limits

$300

830.1800



Enforcement analytical method

$21,500

830.1900



Submittal of samples

$700

830.6302



Color

$1,000

830.6303



Physical state

$1,000

830.6304



Odor

$1,000

830.6313



Stability to normal and elevated temperatures, metals, and metal ions

$11,500

830.6314



Oxidation/reduction: chemical incompatibility

$3,900

830.6315



Flammability

$2,800

830.6316



Explodability

$5,400


-------
Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021

830.6317



Storage stability

$16,000

830.6319



Miscibility

$1,500

830.6320



Corrosion characteristics

$3,800

830.6321



Dielectric breakdown voltage

$3,300

830.7000



PH

$1,000

830.7050



UV/visible light absorption

$2,800

830.7100



Viscosity

$1,900

830.7200



Melting point/melting range

$1,700

830.7220



Boiling point/boiling range

$2,100

830.7300



Density/relative density/bulk density

$1,900

830.7370



Dissociation constants in water

$6,300

830.7520



Particle size, fiber length, and diameter distribution

$1,900

830.7550



Partition coefficient (n-octanol/water) - shake flask method

$8,700

830.7560



Partition coefficient (n-octanol/water) -generator column

$9,300

830.7570



Partition coefficient (n-octanol/water) -estimation chromatography

$6,100

830.7840



Water Solubility: column elution/shake flask

$12,500

830.7860



Water solubility

$12,500

830.7950



Vapor pressure

$20,900

835.1110



Activated Sludge Sorption Isotherm

$24,000

835.1230



Sediment and soil adsorption/desorption

$52,000

835.1240



Leaching and adsorption/desorption

$71,000

835.1410



Laboratory volatility

$34,100

835.2120



Hydrolysis

$51,000

835.2210



Direct Photolysis

$47,800

835.2240



Photodegradation in water

$62,300

835.2370



Photodegradation in air

$166,900

835.2410



Soil photolysis

$89,900

835.3110



Ready Biodegradability

$10,500

835.3180



Freshwater and marine or estuarine environmental expression testing

$157,000

835.3220



Porous Pot Test

$40,100

835.3300



Soil Persistance and Degradation

$156,200

835.4100



Aerobic soil metabolism

$131,300

835.4200



Anaerobic soil metabolism

$182,600

835.4300



Aerobic aquatic metabolism

$124,300

835.4400



Anaerobic aquatic metabolism

$707,400

835.6100



Terrestrial field dissipation

$442,000

835.6200



Aquatic field dissipation

$371,800

835.6300



Forestry dissipation

$383,200

835.6400



Combination and tank mixes

$598,700

835.7100



Groundwater Monitoring

$1,858,600

835.8100



Field volatility

$630,600

840.1100



Spray droplet size spectrum

$336,800

840.1200



Spray drift field deposition

$21,100

850.1000



Use Profile

$300

850.1010



Aquatic invertebrate acute toxicity, freshwater daphnids

$23,600

850.1020



Gammarid acute toxicity test

NA

850.1025



Oyster acute toxicity test

$28,000

850.1035



Mysid acute toxicity test

$28,000

850.1045



Penaeid acute toxicity test

$28,000

850.1055



Bivalve acute tox larval (embryo/larval)

$28,000

850.1075



Fish acute toxicity (freshwater)

$15,600

850.1075



Fish acute toxicity test (estaurine/marine)

$15,100

850.1300



Daphnid chronic toxicity test

$164,200

850.1350



Mysid chronic tox - aquatic invertebrate life-cycle (saltwater)

$50,500

850.1400



Fish early-life stage toxicity test (freshwater)

$51,900

850.1450



Fish early-life stage toxicity test (saltwater)

NA

850.1500



Fish life-cycle toxicity

$712,900

850.1710



Aquatic Bioavailability/Biomagnification: Oyster BCF

$161,300

850.1730



Aquatic Bioavailability/Biomagnification: Fish BCF

$182,800

850.1735



Whole sediment acute toxicity invertebrates (freshwater)

$26,600

850.1740



Whole sediment acute toxicity invertebrates (marine)

$56,900

850.1790



Chironomid sediment toxicity test

$112,300

850.1800



Tadpole/sediment subchronic toxicity test

$265,000

850.1850



Aquatic food chain transfer - Bioavailability

$423,000

850.1900



Generic freshwater microscosm test (laboratory)

$399,200

850.1925



Site-specific aquatic microcosm test (laboratory)

$338,300


-------
Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021

850.1950



Simulated or actual field testing - field animal

$712,900

850.1950



Simulated or actual field testing - aquatic

$834,600

850.1950



Simulated or actual field testing - insect predators

$121,700

850.1950



Simulated or actual field testing - plants

$86,900

850.2100



Avian acute oral toxicity test

$14,000

850.2200



Avian dietary toxicity test

$9,000

850.2300



Avian reproduction test

$234,000

850.2400



Wild mammal acute toxicity

$58,600

850.2500



Simulated or actual field testing terrestrial wildlife

$733,100

850.2500



Simulated or actual field testing - birds

$834,600

850.3020



Honey bee acute contact toxicity

$4,400

850.3030



Honey bee toxicity of residues on foliage

$17,400

850.3040



Field testing for pollinators

$66,100

850.4000



Background - Nontarget plant testing

NA

850.4025



Target area phytotoxicity

NA

850.4100



Terrestrial plant toxicity (seedling emergence, Tier I)

$22,200

850.4150



Terrestrial plant toxicity (vegetative vigor, Tier I)

$22,600

850.4200



Seed germination/root elongation toxicity test

$15,600

850.4200



Seed germination

$38,800

850.4225



Seedling emergence, Tier II

$28,300

850.4230



Early seed growth toxicity test

NA

850.4250



Vegetative vigor, Tier II

$44,900

850.4300



Terrestrial plants field study, Tier III

$53,500

850.4400



Aquatic plant toxicology test using Lemna spp., Tier I

$44,200

850.4400



Aquatic plant toxicology test using Lemna spp., Tier II

$45,800

850.4450



Aquatic plants field study, Tier III

$34,700

850.5100



Soil microbial community toxicity test

$17,300

850.5400



Algal Toxicity Tier I and Tier II

$17,500

850.6800



Modified activated sludge, respiration inhibition test

$5,200

860.1100



Chemical identity

$1,700

860.1200



Directions for use

$5,600

860.1300



Nature of the residue in plants

$139,100

860.1300



Nature of the residue in livestock

$147,200

860.1340



Residue analytical method - plants

$17,700

860.1340



Residue analytical method - livestock

$91,100

860.1360



Multiresidue method

$33,400

860.1380



Storage stability data

$24,100

860.1400



Water

$74,800

860.1400



Irrigated crops (one-crop)

$106,400

860.1400



Fish

$144,700

860.1460



Food handling

$285,200

860.1480



Meat/m ilk/poult ry/eg g s

$207,300

860.1500



Crop field trials

$101,700

860.1520



Processed food/feed

$109,300

860.1540



Reduction of Residues

$20,900

860.1550



Proposed tolerance

$7,500

860.1560



Reasonable grounds in support of the petition

$13,900

860.1650



Submittal of analytical reference standards

$400

860.1850



Confined accumulation in rotational crops

$325,200

860.1900



Field accumulation in rotational crops

$208,600

870.1100



Acute oral toxicity (rat)

$4,800

870.1200



Acute dermal toxicity

$7,100

870.1300



Acute inhalation toxicity (rat)

$34,200

870.1300



Acute inhalation tox (microbials)

$16,700

870.2400



Acute eye irritation (rabbit)

$2,800

870.2500



Acute dermal irritation

$2,800

870.2600



Skin (dermal) sensitization

$9,900

870.3100



90-day oral toxicity in rodents

$192,100

870.3150



90-day oral toxicity in non-rodents

$287,700

870.3200



21/28-day dermal toxicity

$126,300

870.3250



90-day dermal toxicity

$160,700

870.3355



Combined Chronic Toxicity/Carcinogenicity Testing of Respirable Fibrous Particles (inhalation route)

$4,506,600

870.3465



90-day inhalation toxicity (rat)

$637,600

870.3700



Prenatal developmental toxicity study (rat)

$142,300

870.3700



Prenatal developmental toxicity study (rabbit)

$202,600

870.3800



Reproduction and fertility effects (multigeneration) - rat

$478,200


-------
Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021

870.4100



Chronic oral toxicity - dog

$921,500

870.4200



Carcinogenicity (microbials)

$1,401,900

870.4200



Carcinogenicity (rat and mouse, preferred)

$1,963,100

870.5100



Bacterial reverse mutation assay

$6,500

870.5300



In vitro mammalian cell gene mutation test

$29,100

870.5375



In vitro mammalian chromosomal aberration test

$35,000

870.5380



Mammalian spermatogonia! chromosomal aberration test

$27,000

870.5385



Mammalian bone marrow chromosomal aberration test

$41,700

870.5395



Mammalian erthrocyte micronucleus test

$28,600

870.5450



Rodent dominant lethal assay

NA

870.5500



Bacterial DNA damage or repair tests

NA

870.5550



Unscheduled DNA synthesis in mammalian cells in culture

$31,300

870.6100



Acute and 28 day delayed neurotoxicity organophosphorus substances (hen)

$120,400

870.6200



90-day Neurotoxicity (rat)

$279,200

870.6200



Acute neurotoxicity (rat)

$189,200

870.6300



Developmental neurotoxicity study

$854,100

870.6500



Schedule-controlled operant behavior

$248,800

870.6850



Peripheral nerve function

$166,900

870.6855



Neurophysiology: sensory evoked potentials

$166,900

870.7200



Companion animal safety

$236,700

870.7485



Metabolism and pharmacokinetics

$237,800

870.7600



Dermal penetration

$192,000

870.7800



Immunotoxicity

$78,800

875.1100



Dermal outdoor exposure

$233,500

875.1200



Dermal indoor exposure

$175,900

875.1300



Inhalation outdoor exposure (HRSB costs not included)

$547,100

875.1400



Inhalation indoor exposure

$175,900

875.1500



Biological monitoring

$262,000

875.1600



Application exposure data reporting and calculations

$11,400

875.1700



Product use information

$4,200

875.2100



Dislodgeable foliar residue dissipation and turf transferable residues

$83,600

875.2200



Soil residue dissipation

$308,500

875.2300



Indoor surface residue dissipation

$91,700

875.2400



Dermal exposure

$190,400

875.2500



Inhalation exposure

$110,800

875.2600



Biological monitoring (HRSB costs not included)

$455,900

875.2700



Product use information

$4,600

875.2800



Description of human activity

$4,600

875.2900



Data reporting and calculations

$4,600

875.3000



Nondietary ingestion exposure

$113,800

880.1100



Product identity

$300

880.1200



Description materials, production, formulation

$1,300

880.1400



Discussion of formation of impurities

$500

880.3800



Immune Response

$118,200

880.4350



Non-target insect testing

$20,900

880.4425



Dispenser - water leaching

$34,800

885.1100



Product Identity

$7,000

885.1200

a

Manufacturing process

$4,900

885.1200

b

Deposition of samples

$4,900

885.1300



Discussion of formulation of unintentional ingredients

$4,900

885.1400



Analysis of samples

$103,600

885.1500



Certification of limits

$500

885.2000



Background for residue analysis of microbial pest control agents

NA

885.2100



Chemical identity

$900

885.2200



Nature of the residue in plants

$150,700

885.2250



Nature of the residue in animals

$163,000

885.2300



Analytical method - plants

$36,900

885.2350



Analytical method - animals

$61,100

885.2400



Storage stability, plants

$43,100

885.2500



Magnitude of residue in plants

$190,800

885.2550



Magnitude of residue in meat/milk/poultry

$219,300

885.2600



Magnitude of residue in potable water, fish, and irrigated crops

$308,000

885.3000



Background Mammalian Infectivity/pathogenicity analysis

$347,800

885.3050



Acute oral toxicity/pathogenicity

$45,900

885.3150



Acute pulmonary toxicity/pathogenicity

$52,200

885.3200



Acute injection toxicity/pathogenicity (intravenous)

$52,200


-------
Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021

885.3200



Acute injection toxicity/pathogenicity (intraperitoneal)

$17,400

885.3400



Hypersensitivity incidents

$1,100

885.3500



Cell Culture

$41,700

885.3550



Acute toxicity, Tl

$29,900

885.3600



Subchronic toxicity/pathogenicity

$208,700

885.3650



Reproductive/fertility effects

$100,900

885.4050



Avian Oral, Tl

$20,900

885.4100



Avian Inhalation toxicity/pathogenicity, Tl

$22,300

885.4150



Wild mammal toxicity/pathogenicity,Tl

$90,400

885.4200



Freshwater fish toxicity/pathogenicity,Tl

$52,200

885.4240



Freshwater invertebrate toxicity/pathogenicity,Tl

$52,200

885.4280



Estuarine/marine animal testing, Tl

$55,600

885.4280



Estuarine/marine invertebrate testing,Tl

$55,600

885.4300



Nontarget plant studies, Tl

$46,500

885.4340



Nontarget insect testing, Tier I

$14,600

885.4340



Non-target Lepidoptera

$46,900

885.4350



Beneficial soil invertebrate testing - Collembola

$16,000

885.4380



Honey bee testing

$15,100

885.4600



Avian chronic pathogenicity and reproduction, Till

$243,400

885.4650



Aquatic invertebrate range testing,Till

$35,500

885.4700



Fish life cycle studies,Till

$347,800

885.4750



Aquatic ecosystem test

$486,900

885.5200



Terrestrial environmental expression tests

$132,100

885.5300



Freshwater environmental expression test

NA

885.5400



Marine or estaurine environmental expression tests

$132,100



NA

OECD unique identifier for transformation event

$400



NA

Appropriate identifier for active and inert ingredient(s) (e.g., name or designation )

$300



NA

Identification of transformation event and PIP ingredients (combination of OECD unique identifier for transformation event
and Appropriate identifier for active and inert inqredient(s))

$700



NA

Biology of the plant

$3,900



NA

Biology of the plant

$20,500



NA

Description of the intended trait

$300



NA

Expression level in plant

$387,200



NA

Characterization of protein (active/inert)

$97,700



NA

• Spectrum of pesticidal activity • Mode of action • Characterization of expressed substance(s) (molecular characterization
data) (combination of Description of the intended trait, Expression level in plant, and Characterization of protein
(active/inert))

$161,800



NA

Transformation system

$1,100



NA

Certification of limits

$300



NA

Analytical detection method

$80,500



NA

Submittal of samples

$600



NA

Characterization of inserted DNA

$2,300



NA

Inheritance and stability

$300



NA

Characterization of inserted DNA (combination of Characterization of inserted DNA & Inheritance and stability)

$2,600



NA

Surrogate protein production

$27,900



NA

Acute oral toxicity

$55,300



NA

Toxicity of substances other than proteins

NA



NA

Protein Digestion via Kinetic Enzyme

$153,700



NA

Quantified concentration of protein produced in various tissues, e.g., leaf, seed, fruit, pollen, and whole plant by Western
blot or ELISA

$68,800



NA

Laboratory and/or greenhouse testing to determine sexual compatibility/ability to form a viable hybrid between the modified
crop plant and wild or weedy relatives in the United States. Testing would begin with the most closely related species in the
same family that occur in the area of cultivation.

$101,500



NA

Description of propensity of the crop plant to naturalize, including extent of existing feral populations (In most cases,
sufficient information can be obtained from literature searches and/or consultations with breeders. Field surveys may be
required in some instances.)

$20,300



NA

Outcrossing potential - information on potential outcrossing with all wild or weedy relatives with which the transformed plant
can form viable hybrids in nature, e.g., degree of sexual compatibility, degree of overlap in the geographic distribution of
relatives and crop cultivation areas, phenology assessment. (Information can be based upon literature, field experts,
breeders, etc.)

$4,700



NA

Reproductive timing and output, e.g., timing of flowering and seed set and amount of seed produced; for root crops
including also size, mass, and shape of tubers at harvest time. Stability of the acquired transgene in the hybrids and their
proqenv.

$28,100



NA

Studies to evaluate the potential impact of transgene introgression, for example:

•	plant community dynamics modeling (with hybrids and plants expected in the communities in which the hybrids exist).

•	plant competition growth chamber studies, e.g., series replacement under controlled conditions.

•	plant competition mesocosm studies (with hybrids and plants expected in the communities in which the hybrids exist).

•	field studies, e.q., to investiqate impact of virus infection on wild or weedv relatives of the modified plant.

$2,029,800



NA

Bioinformatic amino acid sequence comparison of short contiguous amino acid segments using an allergen database to
identify anv allerqens containinq identical short sequences.

$10,100



NA

Bioinformatic amino acid sequence search for overall similarity with known toxins and allergens.

$8,100


-------
Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021



NA

Bioinformatic amino acid sequence analysis (comparison to toxins) (also called a global amino acide sequence comparison

$4,300



NA

In vitro digestibility in simulated gastric fluid and simulated intestinal fluid (as defined in the U.S. Pharmacopeia).

$47,400



NA

Assessment of heat stability/lability.

$37,200



NA

Allergenicity Information: specific serum-binding study

$143,200



NA

Allergencity Info: in vitro digestibility in SGF

$43,000



NA

Allergenicity Info: Assessment of heat stability/lability

$33,800



NA

Allergenicity Info: Bioinformatic amino acid sequence analysis (comparison to allergens)

$4,400



NA

Toxicity and Allergenicity info: in vitro digestibility in SIF

$43,000



NA

Allergenicity analysis (combination of in vitro digestibility in SGF, Assessment of heat stability/lability, Bioinformatic amino
acid sequence analysis (comparison to allergens), and in vitro digestibility in SIF)

$124,200



NA

90-day oral toxicity

$169,800



NA

Specific serum binding test

$135,200



NA

Hypersensitivity incidents

$1,000



NA

Wild mammal oral toxicity

$55,300



NA

Avian single-dose oral LD50

$12,400



NA

Avian oral toxicity (note: the cost of this is equivalent to two avian single-dose LD50s)

$24,800



NA

Avian dietary toxicity

$8,000



NA

Freshwater fish oral toxicity

$14,700



NA

Freshwater invertebrate testing (aka Freshwater invertebrate - toxicity)

$46,100



NA

Estuarine and marine animal toxicity

$49,200



NA

Honey bee testing - Apis mellifera (larvae)

$35,700



NA

Honey bee testing - Apis mellifera (adult)

$14,300



NA

Nontarget insect testing- Ladybird beetles

$18,300



NA

Nontarget insect testing- Parasitic Hymenoptera

$18,300



NA

Nontarget insect testing- Predaceous Neuropteran

$18,300



NA

Nontarget insect testing - Lepidoptera

$18,300



NA

Nontarget insect testing - Predaceous Hemiptera

$18,300



NA

Non-Target Hemiptera Study

$49,200



NA

Non-target insect testing - Coleoptera

$18,300



NA

Arthropod - toxicity (combination of all nontarget insect testing tests)

$55,000



NA

Non-target Arthropod Study (3 species)

$147,500



NA

Beneficial soil invertebrate testing- Collembola

$15,100



NA

Beneficial soil invertebrate testing- Earthworm

$15,100



NA

Nonarthropod invertebrate - toxicity (for a single species) (combination of Beneficial soil invertebrate testing for
Collembola and Earthworms)

$15,100



NA

Nontarget plant studies (aka plant studies)

$44,000



NA

Soil microbial community toxicity test

$16,300



NA

Tritrophic testing of selected beneficial insects

$112,500



NA

Tritrophic Testing of Selected Beneficial Insects

$364,800



NA

Protein synthesis inhibition study

$157,000



NA

Lack of association of proteins in solution

$4,400



NA

Plant tissue testing

$5,200



NA

Plant tissue testing (reflected in NTO data costs)

$31,800



NA

Endangered species exposure determination

$80,800



NA

Semi-field studies

$409,000



NA

Semi-field Study on Honey Bees

$141,300



NA

Degradation rate in the environment

$418,000



NA

Field persistence

$115,800



NA

Environmental Fate - Field Persistence

$1,519,800



NA

Field studies

$260,300



NA

Additive effects - synergy study

$29,900



NA

Potential for vertical gene flow

$68,300



NA

Potential for horizontal gene transfer

$44,000



NA

Potential for horizontal gene transfer (lab estimate)

$6,800



NA

Evaluation of environmental impacts of gene flow between sexually compatible plants

$123,500



NA

Potential for weediness

$235,900



NA

Evaluation of potential weediness

$0



NA

Target pest biology and ecology

$16,900



NA

Target organism biology and ecology

$494,800



NA

Target organism susceptibility - above ground target

$400,800



NA

Target organism susceptibility - below ground target

$290,400



NA

Dose expression for the target pests

$462,300



NA

Potential for cross resistance

$25,100



NA

Potential for cross resistance

$307,900



NA

Simulation models to predict PIP durability and evaluate resistance management options

$91,100



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field

$94,200


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Test
Guideline

Guideline
Section
or NA*

Test Name

Average Test Cost
Adjusted for Inflation
to 2021



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field

$1,239,000



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field - Plan
Development Cost

$696,800



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field -
Implementation Monitoring, Reporting

$95,700



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field -
Bioassavs

$399,300



NA

Development and implementation of a resistance monitoring plan to detect potential resistance to the PIP in the field -
Annual Reporting

$70,700



NA

Resistance monitoring plan

$1,847,700



NA

Development of a remedial action plan to mitigate potential resistance to the PIP in the field

$12,600



NA

Development of a refuge compliance plan

$5,000



NA

Development of a grower education program

$520,600



NA

Annual reporting

$81,600



NA

Independent lab validation of an analytical method

$20,900



NA

If an analytical method for residue exists - analytical method for soil and/or water

$18,400



NA

If an analytical method for residue exists - independent lab validation of the completed analytical methods

$20,900



NA

Human Subjects Review Board Costs

$32,300

Source: EPA Estimates, adjusted for inflation using the BLS May 2018 National Occupational Employment and Wage Estimates wage rate for occupation code 19-0000


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