^£D sr^ • A prO^ Status of Conditional Registrations under FIFRA sec.3(c)(7)(C) from 2000 through 2022 (September 2022) ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Ammonium Carbamate AD 2/24/2014 1. Green Algae Toxicity Study 11/24/2014 49496201 Satisfied 10/24/2014 Bethoxazin AD 6/6/2006 1. Fish Acute Toxicity Test, Freshwater 9/30/2006 46939003 Cancelled 9/20/2006 Cancelled July 2011 and Marine Bethoxazin AD 6/6/2006 2. Daphnid Chronic Toxicity Test 9/30/2006 46969001 Cancelled 9/20/2006 Cancelled July 2011 Bethoxazin AD 6/6/2006 3. 90-Day Inhalation Toxicity 4/30/2007 Waiver requested Cancelled N/A Cancelled July 2011 Boric Acid AD 9/27/2007 1. Seedling Emergence, Tier II 6/1/2008 47675201 Satisfied 2/13/2009 Boric Acid AD 9/27/2007 2. Vegetative Vigor, Tier II 6/1/2008 47675201 Satisfied 2/13/2009 Boric Acid AD 9/27/2007 3. Duckweed Study 6/1/2008 47675202 Satisfied 2/13/2009 Boric Acid AD 9/27/2007 4. Algal Toxicity, Tiers 1 and II 6/1/2008 47675203 Satisfied 2/13/2009 Boric Acid AD 9/27/2007 5. Fish Acute Toxicity Test, Freshwater 9/28/2008 47425202 Satisfied 5/15/2008 and Marine Boric Acid AD 9/27/2007 6. Mysid Acute Toxicity Test 9/28/2008 47425204 Satisfied 5/15/2008 Boric Acid AD 9/27/2007 7. Acute Embryo larvae 9/28/2008 47425201 Satisfied 5/15/2008 Boric Acid AD 9/27/2007 8. Green Algae Study 6/1/2008 47425203 Satisfied 5/15/2008 Boric Acid AD 9/27/2007 9. Whole Sediment Freshwater 9/28/2008 Waiver requested Waived N/A Boric Acid AD 9/27/2007 10. Whole Sediment Marine 9/28/2008 Waiver requested Waived N/A Boric Acid AD 9/27/2007 11. Leaching Study 11/28/2008 Waiver requested Waived N/A Cetyl pyridinium AD 3/5/2009 1. Ready Biodegradability 3/6/2010 49233702 Satisfied 9/26/2013 chloride Cetyl pyridinium AD 3/5/2009 2. Sediment and Soil 3/6/2010 48012103 Satisfied 3/5/2010 chloride Adsorption/Desorption Isotherm Cetyl pyridinium AD 3/5/2009 3. Activated Sludge Sorption Isotherm 3/6/2010 49233701 Satisfied 9/26/2013 chloride Cetyl pyridinium AD 3/5/2009 4. Aerobic Degradation 3/6/2010 48012105 Satisfied 3/5/2010 chloride Cetyl pyridinium AD 3/5/2009 5. Algal Toxicity, Tiers 1 and II 3/6/2010 48012106 Satisfied 3/5/2010 chloride Cetyl pyridinium AD 3/5/2009 6. Activated Sludge Sorption Isotherm 3/6/2010 48012107 Satisfied 3/5/2010 chloride Cetyl pyridinium AD 3/5/2009 7. Bacterial Reverse Mutation Test 3/6/2010 48012108 Satisfied 3/5/2010 chloride Copper Carbonate, AD 10/31/2006 1. Mouse Carcinogenicity Study 10/31/2009 47667001 Satisfied 2/9/2009 basic (Polymeric Betaine) Copper Carbonate, AD 10/31/2006 2. Skin Sensitization 10/31/2007 Waiver requested Waived N/A basic (Polymeric Betaine) 1 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Copper Carbonate, AD 10/31/2006 3. Hydrolysis 47348101 Satisfied 2/15/2008 basic (Polymeric Betaine) Copper Carbonate, AD 10/31/2006 4. Aerobic Soil Metabolism 10/31/2007 47757601 Satisfied 5/22/2009 basic (Polymeric Betaine) Copper Carbonate, AD 10/31/2006 5. Avian Acute Oral 10/31/2007 46768502 Satisfied 2/24/2006 basic (Polymeric Betaine) Copper Carbonate, AD 10/31/2006 6. Fish Acute Toxicity Test, Freshwater 10/31/2007 Waiver requested Waived N/A basic (Polymeric and Marine Betaine) Copper Carbonate, AD 10/31/2006 7. Aquatic Invetebrate Acute Toxicity, 10/31/2007 Waiver requested Waived N/A basic (Polymeric Test, Freshwater Daphnids Betaine) Copper Carbonate, AD 10/31/2006 8. Other (fixation) 47484102, 47484101, 47497001 Satisfied 7/22/2008 basic (Polymeric and 8/5/2208 Betaine) DDAC AD 5/14/2003 1. 21/28-Day Dermal Toxicity 5/14/2004 47045101 Satisfied 2/1/2007 DDAC AD 5/14/2003 2. Surface residue wipe study 5/14/2004 46764002 Satisfied 2/21/2006 DDAC AD 5/14/2003 3. Fish Early-Life Stage Toxicity Test 5/14/2004 46914401 Satisfied 8/18/2006 DDAC AD 5/14/2003 4. Fish BCF 5/14/2004 45834101 Satisfied 1/9/2003 DDAC AD 5/14/2003 5. Whole Sediment Acute Toxicity Invertebrates, Freshwater 5/14/2004 45821701 Satisfied 12/20/2002 DDAC AD 5/14/2003 6. Whole Sediment Acute Toxicity Invertebrates, Marine 5/14/2004 45821702 Satisfied 12/20/2002 DDAC AD 5/14/2003 7. Honey bee toxicity study 5/14/2004 Waiver requested Waived N/A DDAC AD 5/14/2003 8. Seedling Emergence, Tier II 5/14/2004 46375401 Satisfied 10/1/2004 DDAC AD 5/14/2003 9. Vegetative Vigor, Tier II 5/14/2004 46414501 Satisfied 12/1/2004 DDAC AD 5/14/2003 10. Aquatic Plant Toxicity Test using Lemna spp. Tiers 1 and II 5/14/2004 46295804 Satisfied 6/16/2004 DDAC AD 5/14/2003 11. Anaerobic Aquatic Metabolism 5/14/2004 46124303 Satisfied 11/18/2003 DDAC AD 5/14/2003 12. Algal Toxicity, Tiers 1 and II 5/14/2004 46295801 Satisfied 6/16/2004 DDAC AD 5/14/2003 13. Environmental monitoring study 5/14/2004 46934201 Satisfied 9/14/2006 Fenpropimorph AD 9/27/2007 1. Seedling Emergence using rice (Oryza sativa), TEP 6/1/2008 47675201 Satisfied 2/13/2009 Fenpropimorph AD 9/27/2007 2. Tier II Vegative Vigor using rice (Oryza sativa) TEO 6/1/2008 47675201 Satisfied 2/13/2009 Fenpropimorph AD 9/27/2007 3. Lemna gibba (duckweed) using TEP 6/1/2008 47675202 Satisfied 2/13/2009 2 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fenpropimorph AD 9/27/2007 4. Algal toxicity studies using TEP 6/1/2008 47675203, 47675204 Satisfied 2/13/2009 Anabaena flos-aquae (blue-green cyanobacteria) Noavicula pelliculosa (freshwater diatom) Skeletonema cosatum (marine diatom) Fenpropimorph AD 9/27/2007 5. Acute estuarine/marine fish 9/28/2008 47425202 Satisfied 5/15/2008 Fenpropimorph AD 9/27/2007 6. Acute Mysid shrimp 9/28/2008 47425204 Satisfied 5/15/2008 Fenpropimorph AD 9/27/2007 7. Acute embryo larvae using E. oyster 9/28/2008 47425201 Satisfied 5/15/2008 Fenpropimorph AD 9/27/2007 8. Selenastrum capricornutum (green 6/1/2008 47425203 Satisfied 5/15/2008 algae) using TEP Fenpropimorph AD 9/27/2007 9. Whole sediment acute freshwater 9/28/2008 47425201 Satisfied 5/15/2008 invertabrates using fenpropimorphic acid Fenpropimorph AD 9/27/2007 10. Whole sediment acute marine 9/28/2008 47425201 Satisfied 5/15/2008 invertabrates using fenpropimorphic acid Fenpropimorph AD 9/27/2007 11. Leachability of Wood Preservatives 11/28/2008 Waiver requested Waived N/A Glycolic Acid AD 6/29/2011 1. Registered conditionally but no data N/A N/A N/A required Listeria specific AD 6/18/2008 1. Additional efficacy data (Monitoring 47242001 Satisfied 9/28/2007 bacteriophage Plan) Lonzabec AD 5/20/2006 1. Storage Stability /Corrosion 12/1/2006 46309707, 46309706 Satisfied 7/8/2004 Characteristics Lonzabec AD 5/20/2006 2. Analytical Method 12/1/2006 46309707 Satisfied 7/8/2004 Potassium AD 3/28/2014 1. Registered conditionally but no data N/A N/A N/A Hypochlorite required Silver chloride AD 3/28/2006 1. Enforcement Analytical Method 6/28/2006 46914401 Satisfied 8/18/2006 Silver Nanoparticles AD 12/1/2011 1. Particle Size Distribution 3/31/2012 48854401 Satisfied 6/6/2012 (HeiQ) Silver Nanoparticles AD 12/1/2011 2. Surface Area 3/31/2012 48821601, 48957801 Satisfied 5/4/2012, (HeiQ) 10/25/2012 Silver Nanoparticles AD 12/1/2011 3. Stability 3/31/2012 Waiver requested 48788001 Satisfied 4/2/2012 (HeiQ) Silver Nanoparticles AD 12/1/2011 4. Storage Stability 3/31/2012 48788002 Satisfied 4/2/2012 (HeiQ) Silver Nanoparticles AD 12/1/2011 5. Corrosion Characteristics 3/31/2012 48788002 Satisfied 4/2/2012 (HeiQ) Silver Nanoparticles AD 12/1/2011 6. UV-Vis 3/31/2012 48878801 Satisfied 6/29/2012 (HeiQ) 3 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (HeiQ) AD 12/1/2011 7. Solubility 3/31/2012 48788003 Satisfied 4/2/2012 Silver Nanoparticles (Heidi AD 12/1/2011 8. Dissolution Kinetics 6/28/2013 49141001 Satisfied 6/3/2013 Silver Nanoparticles (HeiQ) AD 12/1/2011 9. Leaching Test of Textile 5/31/2013 49165501 Satisfied 7/2/2013 Silver Nanoparticles (HeiQ) AD 12/1/2011 10. Dermal Exposure-Indoor No longer required Formulation change negated need for study. (10/22/2013) Silver Nanoparticles (HeiQ) AD 12/1/2011 11. Inhalation Exposure-Indoor No longer required Formulation change negated need for study. (10/22/2013) Silver Nanoparticles (HeiQ) AD 12/1/2011 12. Attrition Test - Laundry Drying No longer required No longer required based on the results from lower- tiered studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 13. 90-Day Inhalation No longer required Formulation change negated need for study. (10/22/2013) Silver Nanoparticles (HeiQ) AD 12/1/2011 14. 90-Day Dermal Toxicity 49740301 - Waiver requested No longer required 9/30/2015 Reviewed under DP430750 and found acceptable. Silver Nanoparticles (HeiQ) AD 12/1/2011 15. Reproduction/Developmental Toxicity Screening Test 8/31/2019 49740302 - Waiver requested (denied) New waiver request submitted In review 1/15/2020 Waiver request reviewed under DP430750 and not accepted. New study required. Silver Nanoparticles (HeiQ) AD 12/1/2011 16. In vitro micronucleus (MN) assay 9/30/2016, 2/22/2018 49740303 - Waiver requested (denied); Protocol submitted (rated unacceptable) Required 9/30/2015, 2/22/2018 New study protocol required. Silver Nanoparticles (HeiQ) AD 12/1/2011 17. Avian Acute Oral Toxicity On hold Requirement on hold pending results of aquatic invertebrate and aquatic plant studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 18. Aquatic Invertebrate Acute Toxicity, Freshwater Daphnids 2/29/2016, 5/22/2018, 01/15/2020 49710101 In review 8/31/2020 Reviewed under DP 429650 and found unacceptable. New study required. Waiver requested. 4 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (HeiQ) AD 12/1/2011 19. Fish Acute Toxicity Test, Freshwater and Marine On hold Requirement on hold pending results of aquatic invertebrate and aquatic Dlant studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 20. UV Vis 11/30/2015 49710102 - Waiver requested (denied); 50534302 In review waiver 8/31/2015; new submision 02/26/2018 Waiver request reviewed underDP429651- unacceptable. New submission under review. Silver Nanoparticles (HeiQ) AD 12/1/2011 21. Particle Size Distribution 11/30/2015 49710102 - Waiver requested (denied); new submission 50534302 In review waiver 8/31/2015; new submision 02/26/2018 Waiver request reviewed underDP429651- unacceptable. New submission under review. Silver Nanoparticles (HeiQ) AD 12/1/2011 22. Surface Area 11/30/2015 49710102 - Waiver requested (denied); 50534302 In review waiver 8/31/2015; new submision 02/26/2018 Waiver request reviewed underDP429651- unacceptable. New submission under review. Silver Nanoparticles (HeiQ) AD 12/1/2011 23. Solubility 11/30/2015 49710102 - Waiver requested (denied); 50534302 In review waiver 8/31/2015; new submision 02/26/2018 Waiver request reviewed underDP429651- unacceptable. New submission under review. Silver Nanoparticles (HeiQ) AD 12/1/2011 24. Zeta-potential 11/30/2015 49710102 - Waiver requested (denied); 50534302 In review waiver 8/31/2015; new submision 02/26/2018 Waiver request reviewed underDP429651- unacceptable. New submission under review. Silver Nanoparticles (HeiQ) AD 12/1/2011 25. 90-Day Oral Toxicity No longer required No longer required No longer required based on the results from lower- tiered studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 26. 90-Day Dermal Toxicity No longer required No longer required No longer required based on the results from lower- tiered studies. 5 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (HeiQ) AD 12/1/2011 27. Modified Reproduction/Developmental Toxicity Screening Test No longer required No longer required No longer required based on the results from lower- tiered studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 28. In vitro micronucleus (MN) assay No longer required No longer required No longer required based on the results from lower- tiered studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 29. Modified Aquatic Food Chain Transfer 49710102 - Waiver requested (denied) On hold 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement dependent on results from aquatic invertebrate and aquatic plant studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 30. Terrestrial Plant Toxicity, Seedling Emergence 8/31/2017 49710102 - Waiver requested (denied) On hold 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement dependent on results from aquatic invertebrate and aquatic plant studies. Silver Nanoparticles (HeiQ) AD 12/1/2011 31. Aquatic Plant Toxicity, Tier II 49710102 - Waiver requested (denied) On hold 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement dependent on results from green alga study. Silver Nanoparticles (HeiQ) AD 12/1/2011 32. Algal Toxicity, Tier II 5/31/2016 49710102 - Waiver requested (denied) Required 8/31/2015 Reviewed under DP 429651 - unacceptable. New green algal study required. Silver Nanoparticles (HeiQ) AD 12/1/2011 33. Measuring the Chronic Effects of Freshwater Sediment-Associated Contaminants on Chironomus dilutes 49710102 - Waiver requested (denied) On hold 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement for new study dependent on results from hyalella study. Silver Nanoparticles (HeiQ) AD 12/1/2011 34. Measuring the Chronic Effects of Freshwater Sediment-Associated Contaminants on Hya lei la azteca 8/31/2020 49710102 - Waiver requested (denied) New waiver request submitted In review 1/15/2020 Reviewed under DP 429651 - unacceptable. New hyalella study required. 6 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (HeiQ) AD 12/1/2011 35. Measuring the Chronic Effects of Marine and Estuarine Sediment- Associated Contaminants on Leptocheirus plumulosus 49710102 - Waiver requested (denied) On hold 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement for new study dependent on results from hyalella study. Silver Nanoparticles (HeiQ) AD 12/1/2011 36. Rate of Aggregation 5/31/2016 49710102 - Waiver requested (denied) Required 8/31/2015 Reviewed under DP 429651 - unacceptable. New study now required. Silver Nanoparticles (HeiQ) AD 12/1/2011 37. Activated Sludge Sorption Isotherm 8/31/2020 49710102 - Waiver requested (denied) Required 8/31/2015 Reviewed under DP 429651 - unacceptable. New study now required. Silver Nanoparticles (HeiQ) AD 12/1/2011 38. Adsorption/Desorption 5/31/2016 49710102 - Waiver requested (denied) Required 8/31/2015 Reviewed under DP 429651 - unacceptable. New study now required. Silver Nanoparticles (HeiQ) AD 12/1/2011 39. Leaching Studies (Soil Column Tests) 49710102 - Waiver requested (denied) No longer required 8/31/2015 Reviewed under DP429651 - unacceptable. Requirement can be addressed with acceptable absorption/desorption study. Silver Nanoparticles (HeiQ) AD 12/1/2011 40. Modified Activated Sludge, Respiration Inhibition Test for Sparingly Soluble Chemicals 8/31/2020 49710102 - waiver requested (denied) Required 8/31/2015 Reviewed under DP 429651 - unacceptable. New study now required. Silver Nanoparticles (NanoSilva) AD 5/15/2015 1. Particle Size Distribution 5/31/2016 Vacated This registration was vacated by a court decision on May 30, 2017. Silver Nanoparticles (NanoSilva) AD 5/15/2015 2. Surface Area 5/31/2016 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 3. Particulate Stability 5/31/2016 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 4. Dissolution Kinetics 8/31/2016 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 5. Leaching Test of Plastic 8/31/2016 Vacated 7 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (NanoSilva) AD 5/15/2015 6. 90-Day Inhalation modified to include a functional observational battery, motor activity and detailed neuropathology 1/31/2018 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 7. Modified Reproduction/Developmental Toxicity Screening Test via the inhalation route 1/31/2018 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 8. Aquatic Invertebrate Acute Toxicity, Freshwater Daphnids 11/30/2016 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 9. Plasmon Resonance 5/31/2017 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 10. Particle Size Distribution 5/31/2017 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 11. Surface Area 5/31/2017 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 12. Solubility 5/31/2017 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 13. Zeta-potential 5/31/2017 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 14. Peri- and post-natal exposure to NSPW-L30SS 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 15. Dermal Penetration 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 16. Modified Aquatic Food Chain Transfer 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 17. Terrestrial Plant Toxicity, Seedling Emergence 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 18. Aquatic Plant Toxicity, Tier II (Definitive) Test 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 19. Algal Toxicity, Tier II (Definitive) Test 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 20. Cyanobacteria Toxicity, Tier II (Definitive) Test 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 21. Measuring the Chronic Effects of Freshwater Sediment-Associated Contaminants on Chironomus dilutes 2/15/2019 Vacated 8 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Silver Nanoparticles (NanoSilva) AD 5/15/2015 22. Measuring the Chronic Effects of Freshwater Sediment-Associated Contaminants on Hya lei la azteca 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 23. Measuring the Chronic Effects of Marine and Estuarine Sediment- Associated Contaminants on Leptocheirus plumulosus 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 24. Acute Toxicity Test with Freshwater and Marine Fish 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 25. Daphnid Chronic Toxicity Test 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 26. Early-Life Stage Toxicity Test for Freshwater, Estuarine, and Marine Fish 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 27. Rate of Deposition/Aggregation 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 28. Activated Sludge Sorption Isotherm 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 29. Adsorption/Desorption (Soil/Sediment) modified to include leaching component 2/15/2019 Vacated Silver Nanoparticles (NanoSilva) AD 5/15/2015 30. Activated Sludge, Respiration Inhibition Test for Sparingly Soluble Chemicals 2/15/2019 Vacated Tolylfluanid AD 12/30/2007 1. Monitoring Study 3/1/2008 48071901 Waived 4/22/2010 No data required. Study not acceptable but requirement waived Trimethoxysilyl quat AD 11/22/2006 1. Developmental Toxicity Study (to remove production cap of 10,000lbs) 1/31/2008 47449001 Satisfied 6/17/2008 Trimethoxysilyl quat AD 11/22/2006 2. Enforcement Analytical Method 6/21/2007 47148601 Satisfied 6/7/2007 (Z,E)-9, 12 Tetradecadien-l-yl acetate BPPD 3/13/2006 1. Storage stability 9/13/2007 48830401 Satisfied 5/17/2012 The conditions of registration are satisfied. Aspergillus flavus AF36 BPPD 6/24/2003 1. Efficacy (Texas) 46859502 Satisfied 6/15/2006 Aspergillus flavus AF36 BPPD 6/24/2003 2. 5-batch analysis 46859501 Satisfied 6/14/2006 9 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Aspergillus flavus NRRL 21882 BPPD 5/28/2004 1. Analysis and certified limits 11/28/2006 47008702, 47189202, 47349302, 47364501 Satisfied 12/18/2006, 7/26/2007, 2/19/2008, 3/6/2008 Aspergillus flavus NRRL21882 BPPD 5/28/2004 2. Product identity and composition 11/28/2006 47008702, 47364501 Satisfied 12/18/2006, 3/6/2008 Aspergillus flavus NRRL21882 BPPD 5/28/2004 3. Storage stability 11/28/2006 47364501, 47349302 Satisfied 2/19/2008 Aspergillus flavus NRRL21882 BPPD 5/28/2004 4. Efficacy 47008701, 47189201, 47299401 Satisfied 12/18/2006, 7/26/2007, 12/6/2007 Bacillus subtilis QST 713 BPPD 6/20/2000 1. Manufacturing process (upgrade submitted study; includes 5-batch analyses and quality control to limit microbial impurities) 6/20/2001 45206101 Satisfied 9/11/2000 Bacillus subtilis QST 713 BPPD 6/20/2000 2. Freshwater fish toxicity/pathogenicity 6/20/2001 45455202 Satisfied 7/17/2001 Bacillus subtilis QST 713 BPPD 6/20/2000 3. Freshwater aquatic invertebrate toxicity/pathogenicity 6/20/2001 45455203 Satisfied 7/17/2001 Bacillus subtilis QST 713 BPPD 6/20/2000 4. 30-day toxicity/pathogenicity in grass shrimp 6/20/2001 45455204 Satisfied 7/17/2001 Bacillus subtilis QST 713 BPPD 6/20/2000 5. Non-target insect - parasitic Hymenoptera 6/20/2001 45455205 Satisfied 7/17/2001 Bacillus subtilis QST 713 BPPD 6/20/2000 6. Honeybee study 6/20/2001 46172901, 46172902 Satisfied 1/14/2004 Bacillus subtilis QST 713 BPPD 6/20/2000 7. Storage stability 6/20/2002 45188101 Satisfied 9/11/2000 Beauveria bassiana strain 447 BPPD 9/27/2002 1. 5-batch analysis 6/30/2004 46480601 Satisfied 8/29/2005 Beauveria bassiana strain HF23 BPPD 12/27/2006 1. 5-batch analysis 6/27/2008 47345701 Satisfied 2/14/2008 Beauveria bassiana strain HF23 BPPD 12/27/2006 2. Certification of limits 6/27/2008 47345701 Satisfied 2/14/2008 Beauveria bassiana strain HF23 BPPD 12/27/2006 3. Unintentional ingredients 6/27/2008 47345701 Satisfied 2/14/2008 Beauveria bassiana strain HF23 BPPD 12/27/2006 4. Human pathogens 6/27/2008 47345701 Satisfied 2/14/2008 10 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Beauveria bassiana strain HF23 BPPD 12/27/2006 5. Storage stability 6/27/2008 47779201 Satisfied 6/16/2009 Beauveria bassiana strain HF23 BPPD 12/27/2006 6. Viability data 6/27/2008 47345701 Satisfied 2/14/2008 Calcium lactate BPPD 2/15/2008 1. Efficacy 2/15/2009 N/A Cancelled N/A Registration of product with this active ingredient was cancelled on 9/3/2010. Chenopodium ambrosoides var. ambrosoides BPPD 6/30/2010 1. Storage stability 6/30/2015 49331901 Not Required Chenopodium ambrosoides var. ambrosoides BPPD 6/30/2010 2. 5-batch preliminary analysis 6/30/2011 49061001, 49061002 Satisfied 2/21/2013 Chondrostereum purpureum BPPD 9/23/2004 1. 5-batch analysis 46702401 Satisfied 12/5/2005 Coat Protein Gene of Plum Pox Virus BPPD 5/7/2010 1. Independent laboratory validation of analytical method 5/7/2011 4828401 Satisfied 11/3/2010 Coddling moth virus BPPD 6/20/2001 1. Cell culture study 6/30/2003 45650901 Satisfied 4/11/2002 Corn gluten meal BPPD 9/4/2002 1. Storage stability 3/4/2003 45870101 Satisfied 3/4/2003 COT102 x COT67B (Vip3Aal9 x FLCrylAb) BPPD 6/26/2008 1. Independent laboratory validation of analytical method 5/1/2009 47743201 Satisfied 5/1/2009 COT102 x COT67B (Vip3Aal9x FLCrylAb) BPPD 6/26/2008 2. 7-14 day Daphnia or aquatic invertebrate dietary study 5/1/2009 47779101, 47779102 Satisfied 6/16/2009 COT102 x COT67B (Vip3Aal9x FLCrylAb) BPPD 6/26/2008 3. Baseline susceptibility and diagnostic concentration determinations for major cotton pests 1/31/2009 47662801 Satisfied 2/2/2009 CrylF (Event 281) and CrylAc (Event 3006) Bt in co BPPD 9/30/2004 1. Data supporting natural refuge as alternate host to Cotton Bollworm (CBW) 7/31/2005 46610301, 46909901, 47019301 Satisfied 8/1/2005, 8/10/2006, 12/29/2006 CrylF (Event 281) and CrylAc (Event 3006) Bt in co BPPD 9/30/2004 2. Baseline susceptibility data and discriminating dose of toxins forTobacco Budworm (TBW) and CBW 9/1/2005 46938701, 47223501 Satisfied 1/31/2005, 9/21/2006, 9/5/2007 CrylF (Event 281) and CrylAc (Event 3006) Bt in co BPPD 9/30/2004 3. Avian chronic exposure study 9/30/2008 Waiver requested Waived 4/7/2006 11 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received CrylF (Event 281) and CrylAc (Event 3006) Bt in co BPPD 9/30/2004 4. Non-target insect study (minute pirate bug) 9/30/2008 47462301 Satisfied 7/1/2008 CrylF (Event 281) and CrylAc (Event 3006) Bt in co BPPD 9/30/2004 5. Soil fate/terrestrial expression studies for long range soil persistence 47214501 Satisfied 8/27/2007 CrylF in corn BPPD 5/18/2001 1. Soil degradation study (field) 47120701 Satisfied 5/2/2007 CrylF in corn BPPD 5/18/2001 2. Confirmatory Monarch butterfly data 45759701 Satisfied 9/18/2002 Cry2Ab2 in cotton BPPD 6/14/2002 1. Heat stability study 6/30/2003 45086303 Satisfied 4/7/2000 Cry2Ab2 in cotton BPPD 6/14/2002 2. Confirmatory soil degradation study 6/30/2003 45806601 Satisfied 11/25/2002 Cry2Ab2 in cotton BPPD 6/14/2002 3. Avian oral toxicity 6/30/2003 45086316, 45086317 Satisfied 4/7/2000 Cry2Ab2 in cotton BPPD 6/14/2002 4. Ladybeetle larval data 6/30/2003 45086311 Satisfied 4/7/2000 Cry34Abl and Cry35Abl (Cry34/35Abl) BPPD 8/31/2005 1. Laboratory toxicity data for 2 species of non-target beetles 8/31/2007 46714101, 47436701 Satisfied 12/20/2005, 6/3/2008 This registration expired 9/30/2015. Cry34Abl and Cry35Abl (Cry34/35Abl) BPPD 8/31/2005 2. 3-year full-scale field or semi-field studies - non-target invertebrates 9/30/2009 47870301 Satisfied 9/28/2009 This registration expired 9/30/2015. Cry34Abl and Cry35Abl (Cry34/35Abl) BPPD 8/31/2005 3. 3-year field degradation study 1/31/2010 47959501 Satisfied 1/21/2010 This registration expired 9/30/2015. Cry3Bbl (Event MON 863) BPPD 2/24/2003 1. Insect resistance management/pest biology research data 2/13/2005 45943801, 46186501, 46262701, 46725901, 46949101 Satisfied 5/29/2003, 2/4/2004, 5/4/2004, 12/12/2005, 10/4/2006 Cry3Bbl (Event MON 863) BPPD 2/24/2003 2. Expression data 2/24/2005 46479902 Satisfied 2/25/2005 Cry3Bbl (Event MON 863) BPPD 2/24/2003 3. Field degradataion studies 2/24/2005 46510301 Satisfied 3/31/2005 Cry3Bbl (Event MON 863) BPPD 2/24/2003 4. Laboratory toxicity data for 2 species of non-target beetles 46479904, 46479905 Satisfied 2/25/2005 Cry3Bbl (Event MON 863) BPPD 2/24/2003 5. 3-year full-scale or semi-field studies - non-target invertebrates 46262702, 46262703, 46394202 Satisfied 5/4/2004, 11/1/2004 Cry3Bbl (Event MON 863) BPPD 2/24/2003 6. 6-week broiler dietary study 45941501 Satisfied 5/23/2003 12 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Cry3Bbl (Event MON 88017) BPPD 12/13/2005 1. Insect resistance management/pest biology research data 45943801, 46186501, 46262701, 46725901, 46949101 Satisfied 5/29/2003, 2/4/2004, 5/4/2004, 12/12/2005, 10/4/2006 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cry3Bbl (Event MON 88017) BPPD 12/13/2005 2. Expression data 46479902 Satisfied 2/25/2005 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cry3Bbl (Event MON 88017) BPPD 12/13/2005 3. Field degradataion studies 46510301 Satisfied 3/31/2005 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cry3Bbl (Event MON 88017) BPPD 12/13/2005 4. Laboratory toxicity data for 2 species of non-target beetles 46479904, 46479905 Satisfied 2/25/2005 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cry3Bbl (Event MON 88017) BPPD 12/13/2005 5. 3-year full-scale or semi-field studies - non-target invertebrates 46262702, 46262703 Satisfied 5/4/2004 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cry3Bbl (Event MON 88017) BPPD 12/13/2005 6. 6-week broiler dietary study 45941501 Satisfied 5/23/2003 The registration of this active ingredient required that the conditional data requirements for Cry3Bbl (Event MON 863) must be satisfied. Cydia pomonella Granulosis Virus BPPD 7/17/2000 1. Manufacturing process 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. 13 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Cydia pomonella Granulosis Virus BPPD 7/17/2000 2. Analysis of Samples 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. Cydia pomonella Granulosis Virus BPPD 7/17/2000 3. Product identity 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. Cydia pomonella Granulosis Virus BPPD 7/17/2000 4. Certification of limits 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. Cydia pomonella Granulosis Virus BPPD 7/17/2000 5. Acute Intraperitoneal toxicity/pathogenicity study 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. eCry3.1Ab (Event 5307) BPPD 7/31/2012 1. Plant-based diagnostic assay report 49048901, 49049001 Satisfied 1/31/2013 eCry3.1Ab (Event 5307) BPPD 7/31/2012 2. Corn rootworm baseline susceptibility data 7/31/2014 49559102 Satisfied 1/30/2015 eCry3.1Ab (Event 5307) BPPD 7/31/2012 3. Data to address cross-resistance potential with Cry3Bbl and Cry34/35Abl 7/31/2014 49492501 Satisfied 10/20/2014 German Cockroach Pheromone BPPD 9/23/2004 1. 5-batch analysis 46469401, 46539801 Satisfied 2/14/2005, 5/4/2005 Harpin proteins BPPD 4/19/2000 1. Freshwater invertebrate pathogenicity 4/19/2001 45380401 Satisfied 4/17/2001 Harpin proteins BPPD 4/19/2000 2. 5-batch analysis for survival of Harpin- producing E. coli in end-prodct and quatitation of human pathogens 4/19/2001 45380402 Satisfied 4/17/2001 Harpin proteins BPPD 4/19/2000 3. Sample media without antibiotics to detect bacterial contamination 4/19/2001 45380402 Satisfied 4/17/2001 Harpin proteins BPPD 4/19/2000 4. PCR-based amplification to detect/estimate residual plasmid in end- product 4/19/2001 45380403 Satisfied 4/17/2001 Metarhizium anisopliae F52 BPPD 6/6/2003 1. Manufacturing process - upgrade 48058801 Satisfied 4/12/2010 Metarhizium anisopliae F52 BPPD 6/6/2003 2. Formation of unintentional ingredients - upgrade 47880601, 48177001 Satisfied 10/9/2009, 8/6/2010 14 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Metarhizium anisopliae F52 BPPD 6/6/2003 3. Freshwater Fish Testing - repeat Waiver requested Waived 12/9/2004, 1/14/2008 Metarhizium anisopliae F52 BPPD 6/6/2003 4. Product identity - upgrade 47123901 Satisfied 5/4/2007 MIR 604 (mCry3A) BPPD 10/3/2006 1. 3-year field degradation study 1/31/2011 Waiver requested Waived N/A MIR 604 (m Cry3A) BPPD 10/3/2006 2. 3-year full-scale field or semi-field studies - non-target invertebrates 1/31/2011 48285801 Satisfied 11/4/2010 MIR162 (Vip3Aa20) BPPD 11/26/2008 1. Analytical method validation 11/1/2009 N/A Satisfied 6/15/2009 MIR162 (Vip3Aa20) BPPD 11/26/2008 2. 7-14 day Daphnia study or aquatic invertebrate dietary study 11/1/2009 47779102 Satisfied 5/1/2009 MOCrylF (Event DAS- 06275-8) BPPD 5/27/2005 1. Independent laboratory validation of analytical method 46656101 Satisfied 10/3/2005 Registration of products containing this active ingredient expired 9/30/2015. MOCrylF (Event DAS- 06275-8) BPPD 5/27/2005 2. Confirm moCrylF protein levels in soil under range of conditions typical for Bt corn cultivation. 3/15/2008 47120702 Satisfied 5/7/2007 Registration of products containing this active ingredient expired 9/30/2015. MOCrylF (Event DAS- 06275-8) BPPD 5/27/2005 3. Confirmatory non-target insect field data 3/15/2008 46784601 Satisfied 3/15/2006 Registration of products containing this active ingredient expired 9/30/2015. MON 89034 (CrylA.105 and Cry2Ab2) BPPD 6/10/2008 1. 7-14 day daphnia study or aquatic invertebrate dietary study 4/1/2009 47838801 Satisfied 8/27/2009 MON 89034 (CrylA.105 and Cry2Ab2) BPPD 6/10/2008 2. Info on cross-resistance of CrylA.105, CrylF and CrylAc fortarget pests, and impact on the durability of MON 89034 4/1/2009 47838801 Satisfied 8/27/2009 MON 89034 (CrylA.105 and Cry2Ab2) BPPD 6/10/2008 3. Sweet Corn: baseline susceptibility studies of major pests 4/1/2009 47791201, 47791202, 47791203 Satisfied 7/14/2008, 6/30/2009, 6/30/2009 MON 89034 (CrylA.105 and Cry2Ab2) BPPD 6/10/2008 4. Sweet corn: baseline Fall Army Worm susceptibility studies to the 2 proteins 4/1/2009 48588801, 48588802, 48588803 Satisfied 8/30/2011 MON 89034 (CrylA.105 and Cry2Ab2) BPPD 6/10/2008 5. Analytical method validation, including reagents/methodology 4/1/2010 47731601 Satisfied 4/22/2009 15 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Muscador albus BPPD 9/22/2005 1. 5-batch analysis 47526001 Cancelled 9/2/2008 Registrations of products with this active ingredient were cancelled on 10/4/2010. Muscador albus BPPD 9/22/2005 2. Storage stability 47526002 Cancelled 9/2/2008 Registrations of products with this active ingredient were cancelled on 10/4/2010. Muscador albus BPPD 9/22/2005 3. Acute inhalation toxicity 1/31/2007 47043801 Cancelled 1/31/2007 Registrations of products with this active ingredient were cancelled on 10/4/2010. Nuclear Polyhedrosis Virus of Anagrapha falcifera BPPD 8/9/2002 1. Analysis of samples 1/8/2003 46228201 Satisfied 3/22/2004 Oil of Black Pepper and Piperine BPPD 3/18/2004 1. Storage stability 12/1/2005 46717901 Satisfied 12/27/2005 Paecilomyces lilacinus strain 251 BPPD 3/30/2005 1. Acute intraperitoneal toxicity pathogenicity study 9/30/2006 46950401 47197501 Satisfied 8/6/2007 Pasteuria usgae BPPD 6/2/2009 1. Analysis of Samples 5/1/2011 48453101 Satisfied 4/14/2011 Pasteuria usgae BPPD 6/2/2009 2. Manufacturing process 10/1/2009 47885301 Satisfied 10/16/2009 Pasteuria usgae BPPD 6/2/2009 3. Storage Stability 6/1/2010 48196201 Satisfied 8/17/2010 Pasteuria usgae BPPD 6/2/2009 4. Product Identity N/A No longer Required N/A 6-21: Product identity requirement will be satisfied when the microorganism classification is determined by the International Committee for Systematic Bacteriology. Pseudomonas chloroaphis strain 63- 28 BPPD 9/28/2001 1. Data demonstrating production of siderophores 46615902, 46766902 Cancelled 8/4/2005, 2/23/2006 This registration containing this active ingredient was cancelled on 7/22/2013. Pseudomonas chloroaphis strain 63- 28 BPPD 9/28/2001 2. Growth and survival of microbe at 10- 25°C 6/28/2004 46615901, 46615901 Cancelled 8/4/2005, 2/23/2006 This registration containing this active ingredient was cancelled on 7/22/2013. 16 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Pseudozyma flocculosa strain PF-A22 BPPD 9/20/2002 1. Confirmatory pulmonary toxicity/pathogenicity study N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/15/2011. Pseudozyma flocculosa strain PF-A22 BPPD 9/20/2002 2. Storage stability N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/15/2011. Pseudozyma flocculosa strain PF-A22 BPPD 9/20/2002 3. Certificates of Analysis N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/15/2011. Quillaja saponaria extract BPPD 7/14/2007 1. Product performance (efficacy) 7/15/2010 47645201 to 47645212, 48151401 to 48151413 Satisfied 1/15/2009, 7/15/2012 Trichoderma harzianum strain T-39 BPPD 5/25/2000 1. Efficacy of PCR-RAPD protocol for strain identity 8/25/2000 N/A Cancelled Not submitted All products cancelled on 7/21/2005. Trichoderma harzianum strain T-39 BPPD 5/25/2000 2. 5-batch analysis 5/25/2001 N/A Cancelled Not submitted Registrations of products with this active ingredient were cancelled on 7/21/2005. Trichoderma harzianum strain T-39 BPPD 5/25/2000 3. Freshwater invertebrate study verification 44890101 Cancelled 8/23/2000 Registrations of products with this active ingredient were cancelled on 7/21/2005. Trichoderma harzianum strain T-39 BPPD 5/25/2000 4. Plant-pathogenicity N/A Cancelled Not submitted Registrations of products with this active ingredient were cancelled on 7/21/2005. Trichoderma harzianum strain T-39 BPPD 5/25/2000 5. Non-target insect (Ladybird beetle) N/A Cancelled Not submitted Registrations of products with this active ingredient were cancelled on 7/21/2005. Trichoderma harzianum strain T-39 BPPD 5/25/2000 6. Upgrade honeybee study 5/25/2001 45244001 Cancelled 9/22/2000 Registrations of products with this active ingredient were cancelled on 7/21/2005. Trypsin modulating oostatic factor (TMOF) BPPD 5/24/2004 1. Storage Stability 5/24/2006 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/21/2005. 17 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Xanthomonas campestris pv vesicatoria and Pseuodom BPPD 12/9/2005 1. PCR-based screen maintain/report QA/QC 6/9/2006 46887301 Satisfied 6/12/2006 Products registered with this active ingredient require ongoing QA/QC data to be submitted to EPA whenever requested. All other conditions of registration are satisfied. (Z,E)-9, 12 Tetradecadien-l-yl acetate BPPD 3/13/2006 1. Storage Stability 10/20/2007 2/28/2014 49313401 Satisfied 5/17/2012 Conditions of registration are satisfied. (Z,E)-9, 12 Tetradecadien-l-yl acetate BPPD 3/13/2006 2.Corrosion characteristics 10/20/2007 2/28/2014 49313401 Satisfied 5/17/2012 Conditions of registration are satisfied. Z,Z-3, 13-Octadecadien- l-o 1 and E,Z-3, 13- Octadecadien-l-ol and E,Z-3, 13-Octadecadien- BPPD 4/20/2006 1. Storage stability 49313401 Satisfied 2/6/2014 Z,Z-3, 13-Octadecadien- l-ol and E,Z-3, 13- Octadecadien-l-ol and E,Z-3, 13-Octadecadien- BPPD 4/20/2006 2. Corrosion characteristics 49313401 Satisfied 2/6/2014 Acequinocyl RD 9/26/2003 1. Storage stability and corrosion characteristics 9/26/2005 46372101 Satisfied 8/5/2005 Acequinocyl RD 9/26/2003 2. Freshwater invertebrate (Daphnia) study 9/26/2004 46372101 Satisfied 9/29/2004 Acequinocyl RD 9/26/2003 3. Acute sediment toxicity test for freshwater invertebrates for the major metabolite, deacetylated acequinocyl; pending results on freshwater invertebrates, the test for sediment dwelling estaurine/marine invertebrates may be required. If required, it is to be submitted within 1 year of the date of the Agency's notification to company 9/26/2004 46372101 Satisfied 9/24/2004 Acequinocyl RD 9/26/2003 4. Acute toxicity study for the deacetylated acequinocyl using fish (rainbow trout; or bluegill sunfish) 9/26/2004 46370502 Satisfied 9/24/2004 18 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Acequinocyl RD 9/26/2003 5. Acute toxicity study for the deacetylated acequinocyl using an aquatic invertebrate using daphnids or mysids as the test species 9/26/2004 46372101 Satisfied 9/24/2004 Acetaminophen RD 3/21/2003 1. Conditionally registered but no data requirements N/A N/A N/A Acetamiprid RD 3/5/2002 1. Storage Stability Data for Rotational Crops 3/5/2004 46729102 Satisfied 1/12/2006 Acetamiprid RD 3/5/2002 2. Radio validation data for IM-2_1 amide in ruminant muscle 8/5/2002 Waiver requested Waived 12/17/2002 Waiver requested on 12/17/02. Data indicate that residues of IM-2-1 amide in ruminant muscle can be estimated by applying a 10-fold factor to residues of IM-2-1 in muscle. Acetamiprid RD 3/5/2002 3. Avian Reproduction 3/5/2003 46369201, 46555601 Satisfied 6/16/2003 Acetamiprid RD 3/5/2002 4. Acute Aquatic Invertebrate 3/5/2003 45932501, 45916201, 49034202 Satisfied 5/14/2003, 01/09/2013 Acetamiprid RD 3/5/2002 5. Freshwater Fish Early Life-Stage 8/5/2002 N/A Satisfied N/A No further data are required. Acetamiprid RD 3/5/2002 6. Toxicity of Foliar Residue to the Honey Bee 3/5/2003 45932505, 45932504 Satisfied 5/14/2003 Acetamiprid RD 3/5/2002 7. Tier II Phytotoxicity, Vegetative Vigor - Lettuce 3/5/2003 46229602, 46229601 Satisfied 2/10/2004 Acibenzolar-s-methyl RD 8/11/2000 1. Developmental neurotoxicity study in rats 8/11/2002 46046401 Satisfied 7/3/2003 Acibenzolar-s-methyl RD 8/11/2000 2. Subchronic neurotoxicity study in rats 8/11/2002 45713601 Satisfied 7/11/2002 Acibenzolar-s-methyl RD 8/11/2000 3. Mutagenicity study (Ames assay) with technical-grade acibenzolar-s-methyl (prepared by a new "thiazole" production process) 8/11/2002 48490001, 48490002, 48490003 Satisfied 5/24/2011 19 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Acibenzolar-s-methyl RD 8/11/2000 4. Soil photolysis study 8/11/2001 45434103, 45434104 Satisfied 6/20/2001 No additional (supplemental) data/information is required after assessing the studies and completing reviews for the Interim Registration Review Decision. Acibenzolar-s-methyl RD 8/11/2000 5. Aerobic soil metabolism study 8/11/2001 45434103, 45434104 Satisfied 6/20/2001 No additional (Supplemental) data/information is required after assessing the studies and completing reviews for the Interim Registration Review Decision. Acibenzolar-s-methyl RD 8/11/2000 6. Aerobic aquatic metabolism study 8/11/2001 45434103, 45434104 Satisfied 6/20/2001 No additional (supplemental) data/information is required after assessing the studies and completing reviews for the Interim Registration Review Decision. Acibenzolar-s-methyl RD 8/11/2000 7. One of two batch equilibrium study 8/11/2001 45434103, 45434104 Satisfied 6/20/2001 No additional (supplemental) data/information is required after assessing the studies and completing reviews for the Interim Registration Review Decision. Alpha-Chlorohydrin RD 12/7/2006 1. Registered conditionally but no data N/A N/A N/A required Amicarbazone RD 10/4/2005 1. Nature of the residue-Plants 49133501 Satisfied 5/23/2013 Amicarbazone RD 10/4/2005 2. Nature of the residue-Livestock 48237521 Satisfied 10/5/2010 Amicarbazone RD 10/4/2005 3. Residue Analytical Methods 48237521 Satisfied 10/5/2010 Amicarbazone RD 10/4/2005 4. Storage stability 48612001 Satisfied 9/29/2011 Amicarbazone RD 10/4/2005 5. Meat, poultry and eggs - poultry 49133508 Satisfied 5/23/2013 feeding study Amicarbazone RD 10/4/2005 6. Crop field trials 49133502, 49133503 Satisfied 5/23/2013 Amicarbazone RD 10/4/2005 7. Field accumulation in rotational crops 49135504-07 Satisfied 5/23/2013 Amicarbazone RD 10/4/2005 8. Acute Avian Dietary (Quail) 48237511 Satisfied 10/5/2010 20 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Amicarbazone RD 10/4/2005 9. Avian reproduction 12/15/2016 48237512, 48237513, 48237514, 48237515, 50738101 Satisfied/ Supplemetal 10/5/2010; 12/3/2018 (50738101) MRIDs 48237512, 48237514, 48237515 (acceptable); 48237513 (supplemental) needed to be repeated. New study MRID 50738101 (supplemental). Amicarbazone RD 10/4/2005 10. Aquatic Invertebrate Life Cycle - Saltwater 48407503 Satisfied 3/8/2011 Amicarbazone RD 10/4/2005 11. Aquatic invertebrate life cycle 48071501 Satisfied 4/22/2010 Amicarbazone RD 10/4/2005 12. Tier II vegetative vigor 48237518, 48237519, 48237520 Satisfied 10/5/2010 Amicarbazone RD 10/4/2005 13. Tier II seedling emergence and vegetative vigor 48237516, 48237517 Satisfied 10/5/2010 Amicarbazone RD 10/4/2005 14. Aerobic soil metabolism 48237507 Satisfied 10/5/2010 Amicarbazone RD 10/4/2005 15. Aerobic water and sediment metabolism 6/1/2018 50456601 (water); 48237507 (sediment) Satisfied/ Supplemetal 10/5/2010, 12/7/17 Amicarbazone RD 10/4/2005 16. Hydrolysis for degradates 48073601, 48237506 Satisfied 4/26/2010, 10/5/2010 Amicarbazone RD 10/4/2005 17. Aerobic soil metabolism fro Des- amino, N-methyl des-amino. 48407501, 48407502 Satisfied 3/8/2011 Amicarbazone RD 10/4/2005 18. Analytical reference standards to the EPA National Pesticide Standards Repository: DA amicarbazone, iPr-2-OH DA Amicarbazone, aminocarbazone-d9, iPr-2-OH DA amicarbazone-d6. 12/15/2016 N/A Satisfied 3/23/2015 Amicarbazone RD 10/4/2005 19. Fish early life stage 48237510 Satisfied 10/5/2010 Aminocyclopyrachlor RD 8/30/2010 1. Storage Stability 8/30/2011 48372401 Satisfied 2/1/2011 Aminocyclopyrachlor RD 8/30/2010 2. Corrosion Characteristics 8/30/2011 48372401 Satisfied 2/1/2011 Aminocyclopyrachlor RD 8/30/2010 3. 5-batch analysis from commercial- scale production of product, 8/30/2011 48720201, 48720202 Satisfied 1/18/2012 Aminocyclopyrachlor RD 8/30/2010 4. Repeated dose in sensitive species to address chronic exposure 8/30/2012 48830801 Satisfied 5/17/2012 21 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Aminocyclopyrachlor RD 8/30/2010 5. Avian Reproduction 8/30/2012 48333632, 48333633, 49909801 Satisfied 1/25/2011, 4/28/2016 DER upgraded. Requirement satisfied. Aminocyclopyrachlor RD 8/30/2010 6. Freshwater Invertebrate Life Cycle Toxicity Study 8/30/2012 48576201 Satisfied 8/11/2011 Aminopyralid RD 8/10/2005 1. Completed enforcement method of analysis to show that the analytical method differentiates between aminoyralid, picloram and clopyralid 46729001 Satisfied 1/12/2006 Aminopyralid RD 8/10/2005 2. The completed enforcement method to EPA Fort Meade Laboratory for validation 46729000 Satisfied 1/12/2006 Aminopyralid RD 8/10/2005 3. Storage stability data for grass forage and hay reflecting up to approximately 15 months of frozen storage 46661301 Satisfied 10/11/2005 Aminopyralid RD 8/10/2005 4. Repeated Aerobic Soil Metabolism Study 47911201 Satisfied 11/13/2009 Aminopyralid RD 8/10/2005 5. Repeated Avian Reproduction study in bobwhite quail 47109901 Satisfied 4/20/2007 Aminopyralid RD 8/10/2005 6. Repeated Tier II Aquatic Plant Growth: Blue-green algae, Anabaena flos aquae 47109902 Satisfied 4/20/2007 Benzovindiflupyr RD 8/28/2015 1. Bee data - acute oral tox larval - protocol 10/28/2015 49712301 Waived 11/24/2015 Waiver, acceptable 5/5/2016 Benzovindiflupyr RD 8/28/2015 2. Bee data - chronic oral tox adult honeybee - protocol 10/28/2015 49712302 Waived 11/24/2015 Waiver, acceptable 4/5/2016 Benzovindiflupyr RD 8/28/2015 3. Bee data - chronic oral tox larval - protocol 10/28/2015 N/A Satisfied 11/24/2015 Protocol reviewed. Comments provided to registrant, recommend use of OECD draft guidance documents. Benzovindiflupyr RD 8/28/2015 4. Controlled water monitoring study - protocol 11/28/2015 N/A Satisfied 11/24/2015 Protocol acceptable. Comments provided to registrant 4/5/16. Benzovindiflupyr RD 8/28/2015 5. Vegetative Filter Strips field study - protocol 11/28/2015 NA Satisfied 11/24/2015 Protocol acceptable. Comments provided to registrant 4/5/16 (memo dated 3/29/16) 22 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Rea u ire menus') Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Benzovindiflupyr RD 8/28/2015 6. Sediment toxicity study with Hyalella azteca - protocol 11/29/2015 N/A Satisfied 11/25/2015 Protocol acceptable. Comments provided to registrant 4/5/16. Benzovindiflupyr RD 8/28/2015 7. Vegetative Filter Strips - educational plans 12/28/2015 N/A Satisfied Condition satisfied although EFED does not support VFS as feasible method to control runoff (letter dated 4/5/16) Benzovindiflupyr RD 8/28/2015 8. Controlled water monitoring study - preliminary report 12/31/2016, 12/31/2020 51176402, 51176101 In review 12/16/2016 Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further submissions. Benzovindiflupyr RD 8/28/2015 9. Vegetative Filter Strips field study - preliminary report 12/31/2016, 12/31/2020 In review 12/16/2016 Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further submissions. Benzovindiflupyr RD 8/28/2015 10. Sediment toxicity study with Hyalella Azteca - study 9/1/2017 50337301 In review 12/16/2016 Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further submissions. Benzovindiflupyr RD 8/28/2015 11. Controlled water monitoring study - updated report (based on results of study, it may be extended) 12/31/2017 In review 12/31/2017 Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further submissions. Benzovindiflupyr RD 8/28/2015 12. Bee data - chronic oral tox larval - study 9/1/2018 49712303 In review 11/24/2015 Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further submissions. Benzovindiflupyr RD 8/28/2015 13. Bee data - chronic oral tox adult honeybee - study 9/1/2018 49712302 Satisfied 11/24/2015 Study waiver granted (5/5/16 memo) 23 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Rea u ire menus') Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Benzovindiflupyr RD 8/28/2015 14. Vegetative Filter Strips field study (based on results of study, it may be extended) 12/31/2020 51176401 thru 51176414 In Review Final reports submitted for all conditional data and in review. Additional raw data requested by EFED in 2022. Partial data submitted. Awaiting further registrant submissions. Bicyclopyrone RD 3/8/2000 1. Bee data - acute and chronic larval and chronic adult - study 4/21/2018 50490601, 50490602, 50490603 Satisfied 9/1/2018 Bispyribac-Sodium RD 9/24/2001 1. Storage stability data for the benzene- labeled rate rice metabolism study 9/24/2003 46076600 Satisfied 9/22/2003 Bispyribac-Sodium RD 9/24/2001 2. Poultry feeding study 9/24/2003 48060601, Waiver requested Waived 4/13/2010 Waiver; DP 377208; acceptable Bispyribac-Sodium RD 9/24/2001 3. 28-day inhalation 9/24/2003 48578001, Waiver requested Waived 8/22/2011 Waiver; DP 394228; acceptable Bispyribac-Sodium RD 9/24/2001 4. In vitro mammalian cell gene mutation assay 9/24/2003 46076601 Satisfied 9/22/2003 Bispyribac-Sodium RD 9/24/2001 5. Residue data generated for the vegetative vigor of terrestrial plants 9/24/2003 Waiver requested Waived 9/30/2002 Waiver; DP 287947; acceptable Bispyribac-Sodium RD 9/24/2001 6. Residue data generated for the seedling emergence of terrestrial plants 9/24/2003 Waiver requested Waived 9/30/2002 Waiver; DP 287947; acceptable Bispyribac-Sodium RD 9/24/2001 7. Toxicity study to green algae 9/24/2003 46076602 Satisfied 9/22/2003 Boscalid RD 7/21/2003 1. Radiovalidation study to support the adequacy of the proposed tolerance 12/31/2002 46220001 Satisfied 3/11/2004 Boscalid RD 7/21/2003 1. for sunflower seed (from Region 5) 8/31/2004 46512003 Satisfied 3/31/2005 Boscalid RD 7/21/2003 2. Radiovalidation data demonstrating the efficiency of the microwave hydrolysis step in Method 476/0 12/31/2003 46220002 Satisfied 3/11/2004 Boscalid RD 7/21/2003 2. for cucumber (one each from Regions 2 and 10) 8/31/2004 46512002 Satisfied 3/31/2005 Boscalid RD 7/21/2003 3. All proposed data collection and tolerance methods, revised to state that solutions of analytical standards should not be stored longer than 2 months before replacement 8/30/2004 46351401, 46351402, 46351403 Satisfied 8/31/2004 24 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Boscalid RD 7/21/2003 3a. Residues in mustard greens (one each from Regions 2,3, and 10) 8/31/2004 46512001 Satisfied 3/31/2005 Boscalid RD 7/21/2003 4. Final Report of the storage stability study in plant matrices with description of the fortification solutions (solvent) used in the study and a full description of the analytical method (445/0) 8/30/2004 46351404, 46351405 Satisfied 8/31/2004 Boscalid RD 7/21/2003 5. Data demonstrating the frozen storage stability of BAS 510 F residues in processed grape juice (2 months) and tomato paste (5 months) 12/31/2003 46160103, 45405126, 45405109, 47584402 Satisfied 12/23/2003, 4/3/2001, 4/3/2001, 2/3/2009 Boscalid RD 7/21/2003 6. Additional field trials, conducted per their respective proposed use pattern by 8/31/2004 8/31/2004 46655106 Satisfied 10/11/2005 Boscalid RD 7/21/2003 7. Limited field accumulation study which provides data on beet tops (sugar or garden) and turnip tops, from beets and turnips planted as rotational crops into treated soil 14 days following the last of 3 applications of BAS 510 F totaling ~1.8 lbs ai/A 8/31/2004 46210606 Satisfied 3/2/2004 Boscalid RD 7/21/2003 8. Limited field accumulation study which provides residue data on spinach and celery, planted as rotational crops into treated soil 14 days following the last of 3 applications of BAS 510 F totaling ~1.8 lbs ai/A (alternatively, the petitioner may submit a full set of crop field trials data for spinach (6) and celery (6), via a use pattern similar/identical to that for lettuce, and request a direct use tolerance on all of crop group 4 8/31/2004 46145101, 46145102 Satisfied 12/1/2003 25 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Boscalid RD 7/21/2003 9. Demonstration that pH, water hardness, and the use of dechlorinated tap water do not affect the toxicity of Boscalid and if it can be demonstrated that mean measured concentrations accurately reflect the amount of chemical in solution, so aquatic toxicity tests using fish and invertebrates may be upgraded to core studies. 8/31/2004 Waiver requested Waived 11/18/2004 Boscalid RD 7/21/2003 10. Provide data on growth (length and weight) of Daphnia magna in the freshwater invertebrate life cycle study. 8/31/2004 46351406, 45405005 Satisfied 8/31/2004 Boscalid RD 7/21/2003 11. Provide data for freshwater mollusc such as Corbicula spp., given the persisitence of Boscalid and its tendency to partition onto sediments. 8/31/2004 Waiver requested Waived Boscalid RD 7/21/2003 12. 21/28 day inhalation study 8/31/2004, 1/11/2018 Waiver requested (denied 3/7/13); 50485703 (acceptable study) Satisfied 1/11/2018 Boscalid RD 7/21/2003 13. Dermal sensitization 8/31/2004 46270102 Satisfied 5/13/2004 Buprofezin RD 8/31/2000 1. Developmental neurotoxicity study in rats 12/31/2003 45819101 Satisfied 12/10/2002 Buprofezin RD 8/31/2000 2. Storage stability data validating the following intervals for buprofezin, BF 9, and BF 12: cucumber (26 months); summer squash (12 months); lettuce (31 months); wheat forage, hay and straw (29 months); wheat grain (21 months); sugar beet top and root (24 months); mustard greens (28 months); turnip tops and roots (29 months); carrot (26 months). 12/31/2003 44576916, 46804701 Satisfied 1/30/2001, 4/6/2006 Buprofezin RD 8/31/2000 3. Frozen storage intervals for cantaloupe (10 months); summer squash (12 months); cucumber (26 months) are to be validated. 12/31/2003 48488201, 48488202, 8488203 Satisfied 5/20/2011, 6/13/2011 Buprofezin RD 8/31/2000 4. Cantaloupe field trials in Regions 2 and 10. 12/31/2003 48488202 Satisfied 6/13/2011 26 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Buprofezin RD 8/31/2000 5. Frozen sample interval for lettuce samples (28 months) to be validated. 12/31/2003 46804701 Satisfied 4/6/2006 Buprofezin RD 8/31/2000 6. Leaf lettuce field trials in Regions 1 and 10. 12/31/2003 47112003 Satisfied 4/20/2007 Buprofezin RD 8/31/2000 7. Data needed to upgrade the terrestrial field trial storage stability from upgradable to acceptable. 12/31/2003 44576915 Satisfied 6/5/1998 Buprofezin RD 8/31/2000 8. Freshwater Fish Full Life Cycle 10/8/2015 49738503 Satisfied 4/1/2015 Butafenacil RD 9/29/2003 1. Ruminant feeding study 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 2. Repeat of the 21-day chronic toxicity test with freshwater invertebrates 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 3. Repeat of the acute toxicity study on plants with a plant species that can provide a better representation of the toxicity of parent butafenacil to vascular plants 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 4. Chronic toxicity test with an estuarine/marine invertebrate species. 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 5. Repeat of the tier II seedling emergence 123-l(a) 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 6. Repeat of the vegetative vigor 123-l(b) 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 7. Acute fish study with parent butafenacil in the presence of natural sunlight or an equivalent source 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 8. Frozen storage stability data 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Butafenacil RD 9/29/2003 9. Ruminant validation method 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 Clodinafop-propargyl RD 6/6/2000 1. Acute neurotoxicity study in rats 6/1/2003 46012992, 46012947 Satisfied Clodinafop-propargyl RD 6/6/2000 2. Subchronic neurotoxicity study in rats 6/1/2003 46012921, 46012946 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 3. Developmental neurotoxicity study in rats 6/1/2003 46012925 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 4. In vitro cytogenetic assay 6/1/2003 46012919 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 5. Nature of the residue in plants 6/1/2003 46012908, 46012909 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 6. Residue analytical methods 6/1/2003 46012912, 46012914 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 7. Storage stability data 6/1/2003 46012916, 46012917 Satisfied 6/3/2003 27 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Clodinafop-propargyl RD 6/6/2000 8. Magnitude of the residue in plants 6/1/2003 46012918 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 9. Hydrolysis 6/1/2003 46012926 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 10. Photolysis in water 6/1/2003 46012927, 46012928 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 11. Anaerobic soil metabolism on degradate 6/1/2003 Not submitted Waived 6/3/2003 Requirement withdrawn Clodinafop-propargyl RD 6/6/2000 12. Adsorption/desorption 6/1/2003 46012934, 46012935, 46012936, 46012937 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 13. Field dissipation 6/1/2003 46012939 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 14. Aerobic soil metabolism 6/1/2003 46012930, 46012931 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 15. Avian reproduction 6/1/2003 46012945 Satisfied 6/3/2003 Clodinafop-propargyl RD 6/6/2000 16. Seedling emergence/vegetative vigor 6/1/2003 46012902, 46012901 Satisfied 6/3/2003 Clothianidin RD 5/30/2003 1. Developmental immunotoxicity study 5/30/2006 46536502, 46536501 Satisfied 4/29/2005, 2008 Clothianidin RD 5/30/2003 2. Additional analysis of test materials used in mutagenicity studies 5/30/2006 46339001, 46339002, 46339003, 46339004 Satisfied 8/10/2004 Clothianidin RD 5/30/2003 3. Rotational crop residue field trials with mature soybeans 5/30/2006 46826901 Satisfied 5/15/2006 Clothianidin RD 5/30/2003 4. Aerobic aquatic metabolism 5/30/2006 46826903 Satisfied 5/15/2006 Clothianidin RD 5/30/2003 5. Seed leaching study 5/30/2006 46826904 Satisfied 5/15/2006 Clothianidin RD 5/30/2003 6. Whole sediment acute toxicity to freshwater invertebrates 5/30/2006 46826902 Satisfied 5/15/2006 Clothianidin RD 5/30/2003 7. Field test for pollinators 5/30/2006 46907801, 46907802 Satisfied 8/9/2006 Cyazofamid RD 11/9/2004 1. All the submitted fate and transport studies were classified either supplemental or unacceptable. Therefore, the registrant is required to respond to notes present in all of the EFED DERs. The identified data gaps must be resolved by submitting additional details about the methods or results. If the studies cannot be upgraded, new studies may be required 3/31/2005 446537701, 46537702, 46537703, 46537704, 46537705, 46537706, 46537707, 46537709, 46537710, 46537711, 46537712, 46537713, 46537714, 46537715, 46537716, 46537717, 46537719, 46537720, 46537722, 46537723 46537724, 46784201, 46784202 Satisfied 5/2/05, 3/15/06, (last 2) 28 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Cyazofamid RD 11/9/2004 2. Hydrolysis/aerobic soil on the degradate CCTS to look into the fate of this degradate and to confirm that the degradates HTID, CDTS and p-Toluamide were only photolytic degradates resulting from long exposure to light 11/30/2006 46537725 (Waiver requested) Waived 5/2/2005 Cyazofamid RD 11/9/2004 3. Replacement avian reproduction study using bobwhite quail to establish valid NOAECs for parent cyazofamid and the CCIM degradate 11/30/2006 45638515, 47716308 Satisfied 3/28/02, 3/31/09 Cyazofamid RD 11/9/2004 4. Freshwater Invertebrate Life Cycle Test using the parent 11/30/2006 46702708, 47716307 Satisfied 12/5/05, 3/31/09 Cyazofamid RD 11/9/2004 5. Photodegradation on Soil 11/30/2005 46702704 Satisfied 12/5/2005 Cyazofamid RD 11/9/2004 6. Aerobic Soil Metabolism (Two relevant U.S. soils) 11/30/2005 47716301 (Waiver requested) Waived 3/31/2009 Cyazofamid RD 11/9/2004 7. Aerobic Aquatic Metabolism (One water sediment system) 11/30/2005 47716303 Satisfied 3/31/2009 Cyazofamid RD 11/9/2004 8. Anaerobic Aquatic Metabolism (One water sediment system) 11/30/2005 47716302 Satisfied 3/31/2009 Cyazofamid RD 11/9/2004 9. Bio-accumulation in Fish Study 11/30/2005 47716305 Satisfied 3/31/2009 Cyazofamid RD 11/9/2004 10. Nature of Residue: Information pertaining to dates of sample collection, extraction, final analysis. Representative chromatograms of the radiolabeled residues taken before and after storage under frozen conditions 3/31/2005 46537726, 46537727, 46537728 Satisfied 5/2/2005 Cyazofamid RD 11/9/2004 11. Storage Stability data for 18 months on the representative commodities of the cucurbit required to support the storage intervals and conditions of the croc field trials 11/30/2006 46989701 Satisfied 11/21/2006 Cyazofamid RD 11/9/2004 12. Confined Accumulation in Rotational Crops: Data to confirm the actual sample storage interval storage stability data indicate that the parent and its metabolites CCIM and CCBA are stable in fortified samples of carrot roots, lettuce, and wheat forage stored frozen for at least 4 months 11/30/2006 46537726, 46537727, 46537728 Satisfied 5/2/2005 Provided additional information around times of the confined rotational crop study -Status: Canada reviewed the study and HED has confirmed 29 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Cyflufenamid RD 6/27/2012 1. Acute neurotoxicity study 6/27/2013 49128101 Satisfied 5/16/2013 Cyflufenamid RD 6/27/2012 2. Sample storage stability associated with the apple metabolism study must be 6/27/2014 49023501 Satisfied Waiver submitted 12/2012 Cyflufenamid RD 6/27/2012 3. Nature of the residue in plants 49023500 Satisfied 12/19/2012 Data was only required when a future new use was submitted and this was done with MRIDs 50032701 and 50644700 Cyhalofop-butyl RD 5/23/2002 1. 28-day inhalation toxicity study 6/1/2006 46471101 Satisfied 2/15/2005 Cyhalofop-butyl RD 5/23/2002 2. Carcinogenicity study in rats 6/1/2006 46471101, 46471102, 46471103 Satisfied 2/15/2005 Cyhalofop-butyl RD 5/23/2002 3. Carcinogenicity study in mice 6/1/2006 46471101, 46471102, 46471103 Satisfied 2/15/2005 Diclosulam RD 3/8/2000 1. New Ames mutagenicity test conducted at adequate dose levels 2/28/2001 45225501 Satisfied 10/2/2000 Diclosulam RD 3/8/2000 2. Additional information concerning the metabolism study for poultry and eggs and the rotational crop study. The storage time between sampling and analysis for poultry, eggs, and rotational crops must be reported. If the storage time was longer than 6 months, adequate data concerning the stability of residues during the storage period between collection and final analysis. 2/28/2001 45225500 Satisfied 10/2/2000 Diclosulam RD 3/8/2000 3. Analysis of plant metabolism or field trial samples of peanut and soybean for 2,6-DCA using a validated method at the parts per billion level. The storage time b/t sampling and analysis for 2,6-DCA must be reported. If the storage time was longer than 6 mo., adequate data concerning the stability of residues during the storage period b/t collection and final analysis must be provided 2/28/2001 45225500 Satisfied 10/2/2000 Diclosulam RD 3/8/2000 4. Additional positive control data and untransformed motor activity data for the acute neurotoxicity study and the 1- year neurotoxicity study 2/28/2001 45225502, 45225503, 45225504, 45225505, 45225506 Satisfied 10/2/2000 30 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Rea u ire menus') Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Difenacoum RD 9/28/2007 1. Registered conditionally but no data required N/A N/A N/A Dimethyl disulfide RD 7/9/2010 1. Field Volatility from Soil study 49461201 Satisfied 7/13/2012 Dimethyl disulfide RD 7/9/2010 2. Estimation of inhalation exposure, outdoor sites 49461201 Satisfied 7/13/2012 Dimethyl disulfide RD 7/9/2010 3. Environmental Chemistry Methods and Independent Laboratory Validations for Soil, Water, and Air 6/30/2011 48128201, 48535303, 48575201, 49173201 Air- Satisfied; Soil and Water ILV replacements are now in review. 6/21/10, 8/15/11, 8/2021 Environmental chemistry methods submitted. In 2021, the registrant submitted ILV replacements for soil and water which are now in review. Dimethyl disulfide RD 7/9/2010 4. Aerobic Aquatic Metabolism study 9/30/2011 48662501 Satisfied 3/5/2012 Dimethyl disulfide RD 7/9/2010 5. Anaerobic Aquatic Metabolism study 9/30/2011 48662502 Satisfied 3/5/2012 Dimethyl disulfide RD 7/9/2010 6. Vegetative Vigor study 9/30/2011 47471202 Satisfied 5/29/2014 Acceptable per DP# 355006 Dimethyl disulfide RD 7/9/2010 7. Aquatic Freshwater Invertebrate Life- Cycle Toxicity study 9/30/2011 48662504 Satisfied 3/5/2012 Dimethyl disulfide RD 7/9/2010 8. Aquatic Saltwater invertebrate Life- Cycle Toxicity study 9/30/2011 48662506 Satisfied 3/5/2012 Dimethyl disulfide RD 7/9/2010 9. Freshwater Fish Early Life-Stage Toxicity study 9/30/2011 48662503 Satisfied 3/5/2012 Dimethyl disulfide RD 7/9/2010 10. Saltwater Fish Early Life-Stage Toxicity study 9/30/2011 48662505 Satisfied 3/5/2012 Dinotefuran RD 9/17/2004 1. Stability to metals and metal ions 46403801 Satisfied 11/12/2004 Dinotefuran RD 9/17/2004 2. Confirm sample extraction and analysis dates for MRID 45639822. 12/17/2004 No MRID assigned Satisfied 2/3/2005 Information submitted in conjunction with a new use application. 120 Day plant back interval retained. Dinotefuran RD 9/17/2004 3. Confirmatory dermal absorption study in the rat 9/17/2005 47013401 Satisfied 12/22/2006 31 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Dinotefuran RD 9/17/2004 4. Developmental neurotoxicity study in the rat 9/17/2006 47677502, 48291601 Satisfied 2/17/2009 Dinotefuran RD 9/17/2004 5. Developmental immunotoxicity study in the rat with comparative measures between pups and the parents. 9/17/2006 47677501 Satisfied 2/17/2009 Dinotefuran RD 9/17/2004 6. Photodegradation in soil 9/17/2005 45640109 Satisfied 8/24/2010 Dinotefuran RD 9/17/2004 7. New aerobic soil metabolism or upgrade 2nd study (MRID 45640112) by addressing the characterization of the major degradates at various sampling intervals. 9/17/2005 46711201, 46711202 Satisfied 12/16/2005 Dinotefuran RD 9/17/2004 8. Anaerobic Aquatic/soil metabolism study needs to be upgraded if direct application to water is proposed. 48680002 Satisfied 12/6/2011 Dinotefuran RD 9/17/2004 9. Aerobic aquatic metabolism study needed for any future aquatic uses. 48680002 Satisfied 12/6/2011 Dinotefuran RD 9/17/2004 10. Repeated fish early life stage toxicity test 9/17/2005 45639719 Satisfied 8/24/2010 Dinotefuran RD 9/17/2004 11. Avian acute oral test using bobwhite quail or mallard duck 9/17/2005 47353601 Satisfied 2/25/2008 Dinotefuran RD 9/17/2004 12. Aquatic invertebrate life cycle test is needed for any future aquatic uses. 45639718 Satisfied 8/24/2010 Eco2Fume RD 12/20/1999 1. Conditionally registered under 3(c )(7)(c ) but no data requirements N/A N/A Ethametsulfuron Methyl RD 4/23/2001 1. Product chem. Data partially satisfied and needed: product identity and discussion of ingredients, beginning materials and manufacturing process, formation of impurities, prelim analysis, analytical methods to verify cert limits, and stability. NOT satisfied: oxidizing or reducing action, explodability, storage stability, corrosion characteristics. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 Ethametsulfuron Methyl RD 4/23/2001 2. Hydrolysis study needs the % of phenyl- ring transformation products that are present after 30 days 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 32 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Ethametsulfuron RD 4/23/2001 3. Photodegradation in water: electronic 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl absorption spectra of ethametsulfuron methyl at ph5 and 9. 2/20/13 Ethametsulfuron RD 4/23/2001 4. Aerobic soil metabolism: triazine 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl radiolabeled study to address comments in study review. 2/20/13 Ethametsulfuron RD 4/23/2001 5. Terrestrial field dissipation study: 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl Analytical method for identifying and quantifying residues of "cold" ethametsulfuron methyl must be evaluated 2/20/13 Ethametsulfuron RD 4/23/2001 6. Freshwater fish full life-cycle 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl 2/20/13 Ethametsulfuron RD 4/23/2001 7. Tier II seed germination/seed 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl emergence 2/20/13 Ethametsulfuron RD 4/23/2001 8. Tier II vegetative vigor 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl 2/20/13 Ethametsulfuron RD 4/23/2001 9. Tier II Lemma gibba, Skeletonma 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl costatum, blue green algae 2/20/13 Ethametsulfuron RD 4/23/2001 10. Batch equilibrium 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl adsorption/desorption study were conducted with acidic soils taken from eastern states. At least 2 alkaline soils should be included. Soil TLC studies only provide ancillary data. 2/20/13 Ethametsulfuron RD 4/23/2001 11. Additional information required for 4/23/2005 N/A Cancelled N/A All products cancelled on Methyl acute inhalation and dermal sensitization studies. Refer to review. 2/20/13 Etofenprox RD 9/14/2001 1. Acute and subchronic neurotoxicity 3/1/2003 45932301, 45925701 Satisfied 4/22/2003 Etofenprox RD 9/14/2001 2. Development neurotoxicity 9/1/2003 46062301 Satisfied 8/28/2003 Etofenprox RD 9/14/2001 3. Residential "Indoor Surface Residue Dissipation Study following Total Release Product Use" 9/1/2003 46075002 Satisfied 9/3/2006 Etofenprox RD 9/14/2001 4. Residential "Indoor Air Concentration Measurements following Total Release Product Use" 9/1/2003 46075003 Satisfied 9/3/2006 Etofenprox RD 9/14/2001 5. Product Performance Data for cockroaches, fleas, ticks, and mosquitoes 9/1/2002 46066506 Satisfied 9/5/2003 33 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Etoxazole RD 8/22/2002 1. Core freshwater fish acute toxicity studies 46059001, 46059002 Satisfied 8/25/2003 Etoxazole RD 8/22/2002 2. 90-day subchronic inhalation study on rats 48134301 Waiver requested Waived 6/28/2010 Famoxadone RD 7/17/2003 1. Leaching/Adsorption/Desorption study (one additional soil type which should be finer-grained than those previously tested-which were sand, sandy/loam, and sandy/clay/loam) 8/31/2004 46350401 Satisfied 8/30/2004 Study Supplemental, requirement satisfied Famoxadone RD 7/17/2003 2. Acute freshwater fish (Rainbow trout) guideline study using the end-use product 8/31/2004 46144801 Satisfied 12/4/2003 Famoxadone RD 7/17/2003 3. Whole sediment acute toxicity invertebrates, freshwater chironomids, the 28-day test 44946308, 49663601 Satisfied 12/31/2014 Famoxadone RD 7/17/2003 4. Honey-bee acute contact with the end- use product by 8/31/2004 46350402 Satisfied 8/30/2004 Famoxadone RD 7/17/2003 5. Honey-bee toxicity of residues on foliage with the end-use product 8/31/2004 46350403 Satisfied 8/30/2004 Fenamidone RD 9/30/2002 1. Honey bee acute contact LD50 12/1/2003 45802901 Satisfied 11/19/2002 Fenamidone RD 9/30/2002 2. Mallard duck reproduction 12/1/2004 46418601 Satisfied 12/6/2004 Fenamidone RD 9/30/2002 3. Freshwater fish early life-stage or fish full life cycle 12/1/2004 47332201 - Waiver requested (denied), 48389201 study (acceptable) Satisfied 12/6/2004; 02/16/2011 Waiver denied; study satisfied requirement. Fenamidone RD 9/30/2002 4. Aerobic soil metabolism 12/1/2004 45385819 Satisfied 11/21/2002 Fenamidone RD 9/30/2002 5. Residue analytical methods-plants any modification or revisions recommended by the Agency 6/1/2003 No modifications requested Satisfied 11/21/2002 Fenamidone RD 9/30/2002 6. Confined accumulation in rotational crops- fenamidone labeled in the N- phenyl ring (aniline and substituted aniline standards should be included) 12/1/2003 Waiver requested Waived 11/21/2002 Fenamidone RD 9/30/2002 7. Confined accumulation in rotational crop study 12/1/2003 46440805, 47514101, 47514102, 47514103 Satisfied 1/2/2005, 8/12/2008, 8/12/2008, 8/12/2008 34 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fenamidone RD 9/30/2002 8. Storage stability data for the confined accumulation in rotational crop study 12/1/2003 47817002 Satisfied 7/30/2009 Fenamidone RD 9/30/2002 9. Developmental neurotoxicity study 12/1/2003 46501102, 46590001 Satisfied 3/18/04, 7/12/05 Fenamidone RD 9/30/2002 10. 28-day inhalation toxicity study 12/1/2003 47465801,Waiver requested Waived 7/2/2008 Fenamidone RD 9/30/2002 11. Storage Stability 3/1/2004 47120801 Satisfied 5/2/2007 DP 454776 Fenamidone RD 9/30/2002 12. Corrosion Characteristics 3/1/2004 46152101 Satisfied 12/15/2003 Fenpyroximate RD 9/29/2000 1. Confirmatory data must be submitted for the existing rat developmental study including additional historical control data. 9/27/2003 45323301 Satisfied 2/6/2001 Fenpyroximate RD 9/29/2000 2. 28-day inhalation study 9/27/2003 45323302 Satisfied 2/6/2001 Fenpyroximate RD 9/29/2000 3. Aerobic soil metabolism and adsorption/desorption (batch equilibrium) study. 9/27/2003 45649708 Satisfied 4/1/2002 Flazasulfuron RD 5/14/2007 1. One-year storage stability and corrosion characteristics 11/14/2008 46220905 Satisfied 3/2/2004 Agency letter, dated 11/20/08, states that the study submitted with the application satisfies the requirement. Flazasulfuron RD 5/14/2007 2. Acute neurotoxicity study including historical positive control data, analytical data verifying homogeneity, and stability of formulated test materials for this study. 6/30/2009 47785301 Satisfied 6/23/2009 DP366699, DP404895, DP408778 Flazasulfuron RD 5/14/2007 3. Aerobic aquatic metabolism 6/30/2009 47785302 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement Flazasulfuron RD 5/14/2007 4. Aerobic soil metabolism 6/30/2009 47785303 Satisfied 6/23/2009 DP366710, acceptable Flazasulfuron RD 5/14/2007 5. Anaerobic aquatic metabolism 6/30/2009 47785304 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement Flazasulfuron RD 5/14/2007 6. Soil Mobility: Adsorption/desorption (parent) 6/30/2009 47030002 Satisfied 1/2/2013 Flazasulfuron RD 5/14/2007 7. Freshwater fish early life-stage 6/30/2009 47785305 Satisfied 6/23/2009 DP366710, acceptable Flazasulfuron RD 5/14/2007 8. Aquatic invertebrate life-cycle (freshwater) 6/30/2009 47785306 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement Flazasulfuron RD 5/14/2007 9. Aquatic vascular plant (duckweed) study 6/30/2009 47785307 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement 35 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Flazasulfuron RD 5/14/2007 10. Seedling emergence (Tier II) 6/30/2009 47785308 Satisfied 6/23/2009 DP366710, DP372895 acceptable Flazasulfuron RD 5/14/2007 11. Studies need to be conducted on the hydrolysis degradates DTPU and DTPP at the pH(s) at which they are most stable to hydrolysis 47785309 Satisfied 6/23/2009 DP366710, acceptable Flonicamid RD 9/25/2003 1. 90-day inhalation study to address concerns for repeated exposure via the inhalation route as a result of greenhouse use 9/25/2005 Waiver requested Waived waiver granted 5/9/2005 Flonicamid RD 9/25/2003 2. Storage stability/corrosion characteristics and UV/Visible absorption data 9/25/2005 46370701 Satisfied 10/26/2007 Flonicamid RD 9/25/2003 3. UV/Visible absorption data 9/25/2005 45911601 Satisfied 4/17/2003 Florasulam RD 9/28/2007 1. Seedling emergence study 9/28/2008 48651302 Satisfied 11/8/2011 Florasulam RD 9/28/2007 2. Independent laboratory validation study for the Florasulam method in soil and the 5-Hydroxy Florasulam Degradate in Soil by Capillary Gas chromatography with mass Selective Detector 9/28/2008 48651303 Satisfied 11/21/2008 Florasulam RD 9/28/2007 3. 5-batch analysis on the samples produced on commercial scale and based on the analytical results, a revised CSF 9/28/2008 47595601 Satisfied 11/13/2008 Florasulam RD 9/28/2007 4. One-year storage stability and corrosion characteristics studies 9/28/2008 48902101 Satisfied 4/3/2009 Fluazinam RD 3/5/2003 1. 28-day inhalation toxicity study in rats 12/1/2003 48571410 Satisfied 9/8/2011 Waiver request submitted in 2002 was deemed acceptable due to label mitigation (inclusion of respirator). Full study was submitted in 2011 as part of registration review Fluazinam RD 3/5/2003 2. Developmental neurotoxicity study in rats (Submit protocol for Agency approval and submit the study 2 years after approval 4654401, 47018301, 47037001 Satisfied 4/28/2005 36 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fluazinam RD 3/5/2003 3. Subchronic neurotoxicity screening battery in rats, required based on results of the developmental neurotoxicity study (must by submitted 2 years after notification by the Agency N/A Waived N/A Data not requested based on results of developmental neurotoxicity studies. Fluazinam RD 3/5/2003 4. Processed commodity study on potatoes at a higher treatment level, 5x 12/3/2003 Waiver requested and granted Satisfied 1/17/2002 Fluazinam RD 3/5/2003 5. Photodegration in soil 12/1/2003 45584205 Waiver requested Waived 10/28/2008 Fluazinam RD 3/5/2003 6. Terrestrial Field Dissipation and concurrent storage stability study 12/1/2004 48631521, 48631522, 48631523 Satisfied 10/28/2008 Fluazinam RD 3/5/2003 7. Tier 1 or Tier II Terrestrial Plant Growth, seedling emergence and vegetative vigor by 12/2003 12/1/2003 46172801, 46172802 Satisfied 1/15/2004 Flubendiamide RD 8/1/2008 1. Vegetative Filter Strip Study 7/31/2010 48175602, 48175604, 48175606 Satisfied 11/8/2010 Flubendiamide RD 8/1/2008 2. Protocol for Farm Pond Watering Program Study 8/3/2010 48535201, 48535201 (approval of NC monitoring site), 48644901 (approval of GA monitoring site Satisfied 11/8/2010 Flubendiamide RD 8/1/2008 3. Farm Pond Water Monitoring Program Study 1/31/2012 49415301, 49415302, 49415303 Satisfied 2/20/2015 Flucarbazone RD 9/29/2000 1. Refined analytical methods for the quantification of flucarbazone-sodium and its degradates in both soil and water (analytes of concern: flucarbazone- sodium, its sulfonamide and sulfonic acid degradates, O-desmethyl flucarbazone, N, O-dimethyltriazolin 10/1/2001 46926101, 46926102, 46926103 Satisfied 9/5/2006 Flucarbazone RD 9/29/2000 2. 28-day rat inhalation study 10/1/2001 46168501 Satisfied 1/12/2004 Flucarbazone RD 9/29/2000 3. A revised plant enforcement method which measures all residues of toxicological concern: flucarbazone- sodium; its N-desmethyl metabolite; and flucarbazone sulfonamide and its conjugates. Also submit an independent laboratory validation and radiovalidation of the method 10/1/2001 46223700 Waived 3/18/2004 37 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Flucarbazone RD 9/29/2000 4. Additional residue field trial data on the sulfonamide metabolite and its conjugates. If the company can provide adequate storage stability data from the previously conducted field trials, the samples from these field trials may be analyzed for sulfonamide and its conjugates 10/1/2001 46223700 Waived 3/18/2004 Flucarbazone RD 9/29/2000 5. Additional data on the sulfonamide metabolite and its conjugates in grain samples from the submitted processed food/feed study, should re-analyze grain samples from this study for flucarbazone sulfonamide and its conjugates. If quantifiable residues are found in the grain, then you must conduct a processing study 10/1/2001 46223700 Waived 3/18/2004 Flucarbazone RD 9/29/2000 6. Additional storage stability data from the submitted rotational crop studies for turnip tops and kale 10/1/2001 46103702 Satisfied 10/1/2003 Flucarbazone RD 9/29/2000 7. Field rotational crop studies supporting the 11-month plant back interval for canola, barley and field peas 10/1/2001 46083802 Satisfied 10/1/2003 Flucarbazone RD 9/29/2000 8. Seedling emergence and vegetative vigor data for sulfonamide degradate (test plant species should include lentil, canola, oat, onion, sugarbeet and buckwheat) 10/1/2001 46103701 Satisfied 10/27/2003 Flucarbazone RD 9/29/2000 9. Three field dissipation studies conducted on bare ground 10/1/2001 46223703, 46223704 Satisfied 3/18/2004 Flufenpyr-ethyl RD 9/30/2003 1. Additional storage stability data for the metabolite S-3153 acid-4-OH in field corn and stover 9/30/2004 46028601 Satisfied 7/10/2003 38 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Flufenpyr-ethyl RD 9/30/2003 2. Confirmatory method for residues of flufenpyr-ethyl in/or on corn, soybeans, sugarcane raw agricultural commoditities (RACs) by 9/30/2004. If the confirmatory method does not utilize a mass-selective detector (MSD), then an interference study will be required. 9/30/2004 46028602 Satisfied 7/10/2003 Flumioxazin RD 4/12/2001 1. Confirmatory residue analytical method for plants 4/12/2003 45914603 Satisfied 4/22/2003 Flumioxazin RD 4/12/2001 2. Aqueous photolysis 4/12/2003 45914601 Satisfied 4/22/2003 Flumioxazin RD 4/12/2001 3. Anaerobic soil/aqueous soil metabolism 4/12/2003 45914602 Satisfied 4/22/2003 Flumioxazin RD 4/12/2001 4. Field dissipation 4/12/2003 46163701 Satisfied 4/22/2003 Fluopicolide RD 1/28/2008 1. Additional storage stability data are needed for celery and spinach relfecting a storage interval of 38 months. One study should be conducted on any representative leafy vegetable. 1/31/2009 49054401, 49054402, 49054403, 49054404 Satisfied 2/6/2013 Fluopicolide RD 1/28/2008 2. Provide sample history of cow metabolism study (46708514). 1/31/2009 47689304 Satisfied 2/24/2009 Fluopicolide RD 1/28/2008 3. Provide storage stability, clarify identification of peaks, correct flowchart for fat, recalculate the radioactivity levels forthe cow metabolism study (46708518). 1/31/2009 47689305 Satisfied 2/24/2009 Fluopicolide RD 1/28/2008 4. Provide sample history of the hen metabolism study (46708515). 1/31/2009 47689303 Satisfied 2/24/2009 Fluopicolide RD 1/28/2008 5. Provide stability data forthe duration of the storage period forthe hen metabolism study (46708519). 1/31/2009 47689306 Satisfied 2/24/2009 Fluopyram RD 2/2/2012 1. Field accumulation in rotational crops;cotton, canola, cereal grains (except rice), and soybean 12/1/2015 49006009, 49006008, 49006010 Satisfied 5/31/2013 Fluopyram RD 2/2/2012 2. 90 day inhalation 4/30/2012 48828300, Waiver requested Waived 6/19/2012 39 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fluopyram RD 2/2/2012 3. Seedling emergence, tier II for buckwheat. 12/1/2012 48934301 Satisfied 9/13/2012 This study fulfills the guideline requirements when combined with the previously submitted seedling emergence study 47372349. Fluoxastrobin RD 9/20/2005 1. Additional information (definitive identification of the test substance, spleen weights at necropsy, and competence of the laboratory to perform this type of assay) that will potentially allow upgrade of the assessment of the mouse subacute immunotoxicity study 6/30/2006 48692105 Satisfied 12/14/2011 Fluoxastrobin RD 9/20/2005 2. Additional data concerning the chromatograms and chromatography from the goat metabolism study 6/30/2006 46925801 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 3. Proposed enforcement method, including instructions for the analysis of all crops and their associated processed commodities for which the petitioner is requesting tolerances 6/30/2006 46486101, 46925803, 46486102 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 4. Residue enforcement method livestock 6/30/2006 46486101, 46486102, 46925803 Satisfied 3/3/2005, 09/01/2006 Fluoxastrobin RD 9/20/2005 5. Additional information and confirmatory raw data for the residue storage stability study 6/30/2006 46925801 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 6. Summary information concerning the weather conditions for the growing season for each croD field residue trial 6/30/2006 46925801 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 7. New peanut processing study 9/20/2007 47588901 Satisfied 11/6/2008 Fluoxastrobin RD 9/20/2005 8. Analytical reference standards for Fluoxastrobin, its Z-isomer, a metabolite, several deuterated molecules 6/30/2006 analytical reference standards are available Satisfied N/A Fluoxastrobin RD 9/20/2005 9. Summary information concerning the weather conditions for the growing season for each field rotational crop residue study 6/30/2006 46925801 Satisfied 9/1/2006 40 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fluoxastrobin RD 9/20/2005 10. Soil characteristics data for each field rotational crop trial from which samples were analyzed 6/30/2006 46925801 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 11. Explanation of why samples from one of the grass forage and hay rotational crop field trials appears to have been harvested more than one year after planting of the grass crop 6/30/2006 46925801 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 12. One acute (10-day) sediment toxicity test 6/30/2006 49317701 Satisfied 2/4/2003, 9/1/2006 Fluoxastrobin RD 9/20/2005 13. One chronic (28-day) sediment toxicity test 6/30/2006 49317702 Satisfied 2/4/2003, 11/16/2004, 9/1/2006 Fluoxastrobin RD 9/20/2005 14. Upgrade for anaerobic aquatic metabolism and one of the aerobic aquatic metabolism studies 6/30/2006 46925806 Satisfied N/A Fluoxastrobin RD 9/20/2005 15. Upgrade for the 96-hour rainbow trout acute toxicity study of degradate HEC 7180 9/30/2006 46925805 Satisfied 9/1/2006 Fluoxastrobin RD 9/20/2005 16. Upgrade for the 96-hour sheepshead minnow acute toxicity study 9/30/2006 45865417, 46925805 Satisfied 2/4/2003, 9/1/2006 Flutriafol RD 4/29/2010 1. Immunotoxicity study 4/29/2015 48360301, 48360302, 48360303 Satisfied 1/21/2011 Flutriafol RD 4/29/2010 2. Storage stability data for flutriafol and/or its metabolites in/on livestock and soybean commoditites 4/29/2015 47959201, 47606601, 46568301 Satisfied 9/4/2012, 7/17/2013 Flutriafol RD 4/29/2010 3. A confined rotation crop study conducted with [triazole-3,5-14C] flutriafol and [carbinoll4C] flutriafol 4/29/2015 47732601, 47675601, 47659101 Satisfied 4/22/2009, 2/13/2009, 1/30/2009 Flutriafol RD 4/29/2010 4. small scale prospective ground water monitoring study 4/29/2015 48735801, 48769301, 48838501 Satisfied 2/2/2012, 3/13/2012, 4/4/2012, 7/31/2015 Protocol review completed Flutriafol RD 4/29/2010 5. Avian acute oral LD50 study with passerine birds 7/31/2015 48586401, waiver denied. New study 49674201 acceptable. Satisfied 7/17/2015 Foramsulfuron RD 3/27/2002 1. Fish early life stage study 3/27/2004 46241301 Satisfied 4/5/2004 Foramsulfuron RD 3/27/2002 2. Seed germination/seedling emergence study conducted using the end-use product 3/27/2004 45483801 Satisfied 8/24/2001 41 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Foramsulfuron RD 3/27/2002 3. Vegetative vigar study conducted using the end-use product 3/27/2004 45483802 Satisfied 8/24/2001 Foramsulfuron RD 3/27/2002 4. Tier II aquatic plant growth study conducted using the end-use product 3/27/2004 45109911 Satisfied 4/3/2000 Foramsulfuron RD 3/27/2002 5. Submit an acceptable study to complete the data requirement as specified in the Confidential Attachment to the Registration Notice. 3/27/2004 45554701, 45562501, 45562501, 45562502 Satisfied 4/8/2002 Forchlorfenuron RD 9/30/2004, 2/2/2005 1. Aquatic Algal Species 12/31/2006 46753501, 46753502, 46753503, 46753504 Satisfied 2/8/2006 Forchlorfenuron RD 9/30/2004, 2/2/2005 2. Vegetative Vigor Study 1/15/2007 46753505 (supplemental), 49862501 Satisfied 2/8/2006, 3/16/2016 Acceptable per DP# 432820 Forchlorfenuron RD 9/30/2004, 2/2/2005 3. Field Dissipation Study 1/15/2007 Waiver requested Waived 4/5/2005 Forchlorfenuron RD 9/30/2004, 2/2/2005 4. Avian Chronic Study 1/15/2007 49350901 (supplemental), 50905201 Satisfied 3/28/2014, 7/26/2019 Upgraded to acceptable per DP# 420428 dated 12/12/2017 Fosthiazate RD 3/30/2004 1. The final report of the 3 year storage stability data for tomato 12/30/2008 45866701 Satisfied 8/24/2009 Fosthiazate RD 3/30/2004 2. Tobacco storage stability study (data depicting frozen storage stability of foshiazate and ASC-67131 in a representative foliage commodity 12/30/2008 45866701(tomato) and 45866705 (tobacco) Satisfied 2/27/2003 Registrant submitted the studies prior to registration in response to the Agency's residue chemistry review of 8/27/2002. Fosthiazate RD 3/30/2004 3. Analytical grade reference standards forthe foshiazate metabolite ASC-67131 must be submitted to the EPA standards repository 12/30/2008 No MRID number. Satisfied N/A Sample shipped to EPA's standards repository on 12/6/2004 Fosthiazate RD 3/30/2004 4. Additional data to characterize insoluble residues in 30 days after treatment (DAT) rotated wheat commodities 12/30/2008 Waived 8/24/2010 Required only for a pending use that was not registered. Fosthiazate RD 3/30/2004 5. Storage stability data to support the additional analyses required on the 30- DAT wheat forage, straw, and grain 12/30/2008 Waived 8/24/2010 Required only for pending use that was not registered. Fosthiazate RD 3/30/2004 6. 28-day inhalation study in rats with foshiazate 12/30/2008 46744901 Satisfied 1/30/2006 42 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Fosthiazate RD 3/30/2004 7. Developmental neurotoxicity (DNT) study in rats with comparative ChE measurements in adults and pups 12/30/2008 46784301, waiver requested and granted Waived 5/15/2006 Fosthiazate RD 3/30/2004 8. A worker study for activities involving contact ith treated soil conducted concurrently with a soil residue dissipation study. 12/30/2008 47098901, waiver request Waived 4/2/2007 Agency did additional risk assessments and concluded MOEs are adequate. Requirement withdrawn. Furfural RD 10/5/2006 1. 28-day dermal toxicity study 46917201 Satisfied 8/21/2006 Furfural RD 10/5/2006 2. Guideline 28- or 90-day inhalation study 46917202, 47419101, 46426505 Satisfied 8/21/2006, 5/19/2008 Furfural RD 10/5/2006 3. Field/greenhouse volatility study for each major application method 47253701 Satisfied 10/11/2007 Furfural RD 10/5/2006 4. Dislodgeable foliar residue study 47146202 Satisfied 6/19/2007 Halauxifen-methyl RD 7/29/2016 1. Bee studies (Acute oral, Chronic oral adult and larval, Toxicity of residues on foliage) 12/31/2018 50747601 (supplemental); 50747602 (acceptable), 50978601 (waiver granted) Satisfied studies - chronic oral adult and larval: toxicity of residues on foliage. Waived study-acute oral. 12/20/2018, 12/20/2018, 1/20/2020 Imazosulfuron RD 12/14/2010 1. immunotoxicity study 12/14/2012 48691003 Satisfied 12/12/2011 Imazosulfuron RD 12/14/2010 2. Multiresidue Methods 12/14/2012 49019000 Satisfied 12/17/2012 Imazosulfuron RD 12/14/2010 3. Storage stability for rice, grain, peppers, tomatoes. 49114902 Satisfied 4/30/2013 Imazosulfuron RD 12/14/2010 4. Confined Accumulation in Rotational Crops 12/14/2012 48691001 Satisfied 12/12/2011 Imazosulfuron RD 12/14/2010 5. Field Accumulation in Rotational Crops extension granted until 6/30/2014 N/A No longer required 12/17/2012 Not required unless the registrant wishes to shorten the 1 year plant- back interval on the label. Imazosulfuron RD 12/14/2010 6. Acute toxicity study addressing effects of degradate, ISPN, to fish, quatic invertebrates, and aquatic non-vascular plants. 12/14/2012 49019001, 49019002, 49019003, 49019004, 49019005, 49019006, 49485201 Satisfied 12/17/2012 With the review of 49485201, the requirement has been satisfied. Imazosulfuron RD 12/14/2010 7. Acute Avian Oral Toxicity Study 12/14/2012 48691002 Satisfied / supplemental 12/12/2011 No new study required. Indaziflam RD 7/26/2010 1. Estuarine/Marine Invertebrate Life Cycle 7/26/2012 49073301 Satisfied 7/1/2013 43 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Indaziflam RD 7/26/2010 2. Avian reproduction study on Mallard duck 7/26/2012 48892801 Satisfied 7/30/2012 Indoxaca rb RD 9/29/2000 1. Product identity and composition 1/30/2002 45591501 Satisfied 1/30/2002 Indoxacarb RD 9/29/2000 2. Description of materials used to produce the product 1/30/2002 45591501 Satisfied 1/30/2002 Indoxacarb RD 9/29/2000 3. Description of production process 1/30/2002 45591501 Satisfied 1/30/2002 Indoxacarb RD 9/29/2000 4. Description of formulation process 1/30/2002 45591501 Satisfied 1/30/2002 Indoxacarb RD 9/29/2000 5. Discussion of formation of impurities 10/30/2002 46749001, 46749002, 46749003 Satisfied 2/2/2006 Indoxacarb RD 9/29/2000 6. 90-day inhalation toxicity study in the rat 10/30/2002 45354001 Satisfied 2/2/2006 Indoxacarb RD 9/29/2000 7. Poultry feeding study 10/30/2002 46114302 Satisfied 11/6/2003 Indoxacarb RD 9/29/2000 8. Confirmatory method for plants 10/30/2002 45795818 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 9. Specificity testing for analytical methods for plants 10/30/2002 45795818 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 10. Storage stabiliry data reflecting the maximum frozen storage intervals of cotton processed samples 10/30/2002 45795819 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 11. Photodegradation in water 10/30/2002 45795802 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 12. Hydrolysis 10/30/2002 45795801 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 13. Aerobic soil metabolism 10/30/2002 45795803, 45906701 Satisfied 11/4/02, 4/11/03 Indoxacarb RD 9/29/2000 14. Anaerobic aquatic metabolism 10/30/2002 45795804 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 15. Aerobic aquatic metabolism 10/30/2002 45793301 Satisfied 10/31/2002 Indoxacarb RD 9/29/2000 16. Leaching-adsorption/desorption 10/30/2002 45795805, 45795806, 45795807, 45795808, 45906702 Satisfied 11/4/02, 4/11/03 Indoxacarb RD 9/29/2000 17. Terrestrial field dissipation 10/30/2002 45795810, 45795811 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 18. Accumulation in fish 10/30/2002 45805301 Satisfied 11/22/2002 lodomethane RD 10/5/2007 1. Agency does not request any additional conditional data in reg. notice N/A N/A N/A lodosulfuron-methyl- sodium RD 10/26/2002 1. Avian reproduction studies 12/31/2004 46431803 Satisfied 12/27/2004 lodosulfuron-methyl- sodium RD 10/26/2002 2. Freshwater fish early-life stage studies 12/31/2004 46431804 Satisfied 12/27/2004 lodosulfuron-methyl- sodium RD 10/26/2002 3. Estuarine invertebrate life-stage studies 12/31/2004 48288301 Satisfied 11/5/2010 lodosulfuron-methyl- sodium RD 10/26/2002 4. Carcinogenicity study in mice 12/31/2004 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) 44 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received lodosulfuron-methyl- sodium RD 10/26/2002 5. Developmental toxicity study in rabbits 12/31/2004 Waiver Requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) lodosulfuron-methyl- sodium RD 10/26/2002 6. 28-day inhalation study 12/31/2003 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) lodosulfuron-methyl- sodium RD 10/26/2002 7. 21-day dermal study 12/31/2003 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) lodosulfuron-methyl- sodium RD 10/26/2002 8. Analytical methods in plants, soil, and water. 12/31/2004 N/A N/A N/A For this requirement, the regsitrant understood in a meeting with the Agency on 4/9/2003 that the requirement was placed in reserve pending consultation with industry working groups on ways to address the requirement. This chemical is currently in registration review and this requirement is included in the DCI. Ipconazole RD 9/10/2004 1. 28-day dermal toxicity study in rats 4/30/2006 47048916 Satisfied 5/15/2006 Ipconazole RD 9/10/2004 2. 90-day inhalation toxicity study in rats 4/30/2006 47048915 Satisfied 4/19/2005 Ipconazole RD 9/10/2004 3. Additional soil adsorption/desorption study conducted in a low organic matter (OM) soil 4/30/2006 46827503 Satisfied 5/15/2006 Ipconazole RD 9/10/2004 4. In vivo cytogenic assay 4/30/2006 46827502 Satisfied 5/15/2006 Isofetamid RD 7/21/2015 1. Bee data (acute and chronic larval and chronic adult) 7/21/2016 49819601, 49819602 Satisfied 1/22/2016 Macleaya Extract RD 9/19/2002 1. 90-day dermal study in the rabbit 3/31/2004 46273804 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived. 45 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Macleaya Extract RD 9/19/2002 2. 90-day inhalation in rats 3/31/2004 46273806 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived. Macleaya Extract RD 9/19/2002 3. Developmental study in the rabbit 3/31/2004 46273807 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived. Macleaya Extract RD 9/19/2002 4. Mutagenicity battery (gene mutation in bacteria) and mammamalian cells, and an in vivo cytogenetics assay 3/31/2004 46273814, 46273811, 46273812 Satisfied 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived. Mammalian Gonadotropin Releasing Hormone RD 9/29/2009 1. Guideline 830.1700 Preliminary analysis and validation of the method of analysis of the formulation 9/29/2010 48623801 Satisfied 9/29/2011 Mammalian Gonadotropin Releasing Hormone RD 9/29/2009 2. Guideline 830.1750 Certified Limits (basic and alternate CSFs) 9/29/2010 48959701 Satisfied 10/1/2012 Mandestrobin RD 9/30/2016 1. Bee studies (Chronic oral adult and larval) 9/30/2019 50710101, 50710102 and 50710103 Satisfied 3/28/2019 Mandipropamid RD 1/9/2008 1. New chronic daphnia study 1/9/2009 47802601 Satisfied 7/14/2009 Mandipropamid RD 1/9/2008 2. Storage stability data for SYN 500003 which covers the entire 32 months of storage (interim storage stability data for six months were submitted) 1/9/2009 47642303 Satisfied 1/12/2009 Mesosulfuron-methyl RD 3/31/2004 1. One-year storage stability and corrosion characteristics 10/1/2005 46647101 Satisfied 9/19/2005 Mesosulfuron-methyl RD 3/31/2004 2. Independent laboratory validation of the livestock enforcement method for mesosulfuron-methyl in ruminant liver 10/1/2004 48080501 Satisfied 4/30/2010 46 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Mesosulfuron-methyl RD 3/31/2004 3. Storage stability data to demonstrate the stability of mesosulfuron-methyl residues in/on wheat forage stored frozen for up to 26 months and in/on wheat grain and straw stored frozen for up to 25 months 10/1/2005 46229001, 46229002, 46229003, 46229004 Satisfied 5/22/2004 Mesosulfuron-methyl RD 3/31/2004 4. Tier II vegetative vigor study with Osprey herbicide 10/1/2005 46688201 Satisfied 11/14/2005 Mesosulfuron-methyl RD 3/31/2004 5. Terrestrial field dissipation study with Silverado Wild Oat herbicide in a spring wheat area such as North Dakota. 10/1/2006 46948901 Satisfied 10/3/2006 Mesosulfuron-methyl RD 3/31/2004 6. Avian-reproduction study (mallard duck) 4/2/2006 Waiver requested Waived 3/30/01, 10/28/04 Mesosulfuron-methyl RD 3/31/2004 7. Independently validated analytical chemistry methods to identify and quantify residues of mesosulfuron- methyl and its degradates in water (must be sufficiently sensitive to adequately determine and characterize mesosulfuron-methyl residues in water resources down to levels of ecotoxicological importance) 4/2/2005 46451701, 46451702 Satisfied / Supplemental 1/24/2005 Addressed in Reg Review DCI Mesotrione RD 6/4/2001 1. Developmental neurotoxicity study in the mouse. 6/4/2005 45651812 Waived 3/28/2002 Mesotrione RD 6/4/2001 2. Adequate storage stability data in the plant and livestock metabolism studies 6/4/2005 45651814 Waived 3/28/2002 Mesotrione RD 6/4/2001 3. Revised interference study 6/4/2005 45651816 Waived 3/28/2002 Mesotrione RD 6/4/2001 4. 28-day Inhalation study 6/4/2005 46562908, Waiver requested Waived 6/27/2005 Mesotrione RD 6/4/2001 5. Phytotoxicity studies 6/4/2005 47093501 Satisfied 3/20/2007 Mesotrione RD 6/4/2001 6. Improvement in the extraction method in the soil analytical method 6/4/2005 45651815 Satisfied Mesotrione RD 6/4/2001 7. A prospective groundwater monitoring study at a vulnerable site in the southern US. 6/4/2005 47418901 Satisfied 5/7/2008 Metaflumizone RD 4/30/2007 1. Storage and corrosion characteristics 10/30/2008 47267901 Satisfied 10/30/2007 47 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Methoxyfenozide RD 7/5/2000 1. Bi-valve mussel bioaccumulation study 6/30/2002 45702704 Satisfied Methoxyfenozide RD 7/5/2000 2. Frog embryo teratogenesis assay using Xenopus laevis 6/30/2002 48661701, 48938701 Satisfied 9/14/2012 Methoxyfenozide RD 7/5/2000 3. Sub-acute sediment study using Hexagenia 6/30/2002 45702703 (supplemental) Satisfied 2/4/2013 No additional data/information is required after assessing this study and completing reviews for the Interim Registration Review Methoxyfenozide RD 7/5/2000 4. Chronic Sediment Study using Chironomus riparius 6/30/2002 45032801 (supplemental) Satisfied 2/3/2000 No additional data/information is required after assessing this study and completing reviews for the Interim Registration Review Decision. Methoxyfenozide RD 7/5/2000 5. Honey Bee Brood Studies 6/30/2002 45065501, 48350501, 48962201 (sopplemental, non-guideline) No further data required at this time. At this time, pollinator policy considerations have not determined that additional data will be necessary. Methoxyfenozide RD 7/5/2000 6. Residue in Almond Orchards Investigating Honey Bee and Bee products 6/30/2002 48962202 Satisfied 10/3/2012 Supplemental - At this time, pollinator policy considerations have not determined that additional data will be necessary. Metofl uthrin RD 9/29/2006 1. Fish toxicity bluegill study 9/29/2008 47414002 Satisfied 4/30/2008 Metofluthrin RD 9/29/2006 2. Honey bee acute contact 9/29/2008 47046301, 47414001 Satisfied 2/2/07, 4/30/08 Metrafenone RD 11/24/2010 1. Immunotoxicity study needed for future uses 11/30/2012 48981302 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 2. Method validation data must be submitted for Method FAMS 105-01 reflecting fortifications at 4.5 ppm for grapes, and at both the LOQ (0.05 ppm) and 17 ppm for raisins. 11/30/2012 48981303, 48981304 Satisfied 11/13/2012 48 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Metrafenone RD 11/24/2010 3. Radiovalidation for method FAMS 105- 11/30/2012 48981305-48981308 Satisfied 11/13/2012 01 to demonstrate recovery of weathered residues of metrafenone from grapes. Cucumber data may be submitted in lieu of grapes if the data show adequate extractibility by 9:2 n- heptane/acetone. Metrafenone RD 11/24/2010 4. Radiovalidation data are required to 11/30/2012 48981305-48981308 Satisfied 11/13/2012 support the data collection method, BASF Method 535/0. Samples from the cucumber metabolism study currently in progress may also be used to generate these data. Metrafenone RD 11/24/2010 5. Avian acute oral with passerine birds 11/30/2012 48981309 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 6. Acute tox freshwater fish 11/30/2012 48981310 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 7. Chronic freshwater fish early-life stage 11/30/2012 48981311 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 8. Chronic aquatic freshwater 11/30/2012 48981312 Satisfied 11/13/2012 invertebrate life-cycle Metrafenone RD 11/24/2010 9. Acute marine/estuarine invertebrate 11/30/2012 48981313 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 10. Aquatic vascular plant growth Tier II 11/30/2012 48981314 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 11. Aquatic non-vascular Tier II 11/30/2012 48981315-21 Satisfied 11/13/2012 Metrafenone RD 11/24/2010 12. Chronic freshwater invertebrate 11/30/2012 48981320-22 Satisfied 11/13/2012 whole sediment on TGAI for Chironomus dilutus Metrafenone RD 11/24/2010 13. Storage stability and corrosion 11/30/2012 48981301 Satisfied 11/14/2012 characteristics Milbemectin RD 9/29/2003 1. Acute inhalation toxicity (technical)- 5/29/2004 N/A Cancelled N/A Voluntarily cancelled. rat (not upgradable-must be repeated) Milbemectin RD 9/29/2003 2. 28-day dermal toxicity-rabbit (not 9/29/2005 N/A Cancelled N/A Voluntarily cancelled. upgradable-must be repeated) Milbemectin RD 9/29/2003 3. Prenatal developmental toxicity-rabbit 9/29/2005 N/A Cancelled N/A Voluntarily cancelled. (possibly upgradable) Milbemectin RD 9/29/2003 4. Prenatal development toxicity- rat 9/29/2005 N/A Cancelled N/A Voluntarily cancelled. (possibly upgradable) Milbemectin RD 9/29/2003 5. Multigeneration reproductive toxicity- 9/29/2007 N/A Cancelled N/A Voluntarily cancelled. rat (possibly upgradable) 49 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Milbemectin RD 9/29/2003 6. Estuarine fish early life-stage- sheepshead minnow 9/29/2004 N/A Cancelled N/A Voluntarily cancelled. Milbemectin RD 9/29/2003 7. Estuarine invertebrate life-stage- mysid 9/29/2004 N/A Cancelled N/A Voluntarily cancelled. Milbemectin RD 9/29/2003 8. Aquatic acute sediment toxicity testing 9/29/2004 N/A Cancelled N/A Voluntarily cancelled. Milbemectin RD 9/29/2003 9. Anaerobic aquatic metabolism (possibly upgradable) 9/29/2005 N/A Cancelled N/A Voluntarily cancelled. Milbemectin RD 9/29/2003 10. Bioconcentration in fish (possibly upgradable) 9/29/2005 N/A Cancelled N/A Voluntarily cancelled. Nica rbazin RD 11/23/2005 1. Storage stability and corrosion characteristics studies 11/23/2006 46416408 Satisfied 1/12/2005 Novaluron RD 9/25/2001 1. 90-day inhalation toxicity study in rats 9/25/2003 Waiver requested Waived N/A Novaluron RD 9/25/2001 2. Two mutagenicity studies: In vitro mammalian cell gene mutation and in vivo cytogenetics assay 9/25/2003 45638321, 45638222 Satisfied 3/22/2002 Orthosulfamuron RD 2/22/2007 1. Results of one year storage stability and corrosion characteristics 46712101 Satisfied 12/16/2005 Satisfied with MRID 49649200. Orthosulfamuron RD 2/22/2007 2. Analytical reference standard to the National Pesticide Standards Repository Sample(s) received on 6/25/08 Satisfied Sample(s) received on 6/25/08 Orthosulfamuron RD 2/22/2007 3. Dates of sample extraction, initial TLC analysis, and metabolite identification analyses in order to determine sample storage intervals for the submitted goat metabolism study. (If the initial quantitative TLC analyses were conducted within 6 months of sample collection. Information provided in letter dated 9/27/07 Satisfied Information provided in letter dated 9/27/07 Orthosulfamuron RD 2/22/2007 4. Radiovalidation data (using samples from the rice metabolism study) for the method chosen for tolerance enforcement purposes. 47030001 Satisfied 1/16/2007 Orthosulfamuron RD 2/22/2007 5. Recovery data using specific directions for each multiresidue method used by FDA 47674201 Satisfied 2/12/2009 50 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Penoxsulam RD 9/27/2004 1. Seed germination/seeding emergence 46758301, Exhibit A in 46758300 Satisfied 2/13/2006 studies, vegetative vigor studies, and an aquatic plant growth study using Duckweed with the degradates, BSA, 2- amino-TP, TPSA, BSTCA methyl, BSTCA, 2- amino-TCA, 5-OH-penoxsulam, SFA, sulfonamide, 5, 8-di-OH and 5-OH 2 amino TP Penoxsulam RD 9/27/2004 2. Test terrestrial plants using the liquid 46930301, 46930302 Satisfied 2/13/2003 and end-use products of penoxsulam. Penoxsulam RD 9/27/2004 3. Enforcement method revised as 46389701 Satisfied 10/26/2004 recommended in the Analytical Chemistry laboratory memo dated 9/17/2004 Penoxsulam RD 9/27/2004 4. One year storage stability and 46433901, 46433902, 46449901 Satisfied 12/28/04, corrosion characteristics 12/28/04, 1/24/05 Penthiopyrad RD 2/29/2012 1. Estuarine/marine invert acute tox Satisfied 1/26/2012 Penthiopyrad RD 2/29/2012 2. Estuarine/marine fish acute tox Satisfied 1/26/2012 Penthiopyrad RD 2/29/2012 3.Tier II Seedling emergence study 49316402 Satisfied 2/11/1014 Penthiopyrad RD 2/29/2012 4. Tier II vegetative vigor study 49316403 Satisfied 2/11/1014 Picaridin RD 12/7/2000 1. 5 week oral toxicity study in rats 4/15/2001 45387901 Satisfied 12/1/2002 Picaridin RD 12/7/2000 2.14 week oral toxicity study in rats. 4/15/2001 45387902 Satisfied 12/1/2002 Picaridin RD 12/7/2000 3. Submit the protocol and locations for 3/1/2001 Correspondence - no MRID Satisfied 2/28/2001 conduct of the 2001 market test for 2000 assigned human subjects. Picaridin RD 12/7/2000 4. Submit the results of the marketing 12/1/2001 Correspondence - no MRID Satisfied 9/27/2001 test with up to 2000 subjects. assigned Pinoxaden RD 7/27/2005 1. Additional validation data for 47293207 Satisfied 11/30/2007 pinoxaden and M2 residues in livestock commodities. Pinoxaden RD 7/27/2005 2. Storage Stability Data for Rotational 47293208 Satisfied 11/30/2007 Crops in barley for 15 months and wheat for 6 months. Pinoxaden RD 7/27/2005 3. Fish acute toxicity tests required for 47293202 Satisfied 11/30/2007 parent pinoxaden to replace supplemental studies. 51 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Pinoxaden RD 7/27/2005 4. Freshwater invertebrate acute toxicity study for parent pinoxaden to replace an unacceptable study. 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 5. Estuarine/marine fish acute toxicity test using parent pinoxaden to replace a supplemental study. 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 6. Estuarine/marine shrimp acute toxicity test is required using parent pinoxaden to replace a supplemental study. 47293201 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 7. Freshwater fish early life-stage study using parent pinoxaden 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 8. Freshwater invertebrate life-stage study required using pinoxaden 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 9. Avian dietary studies in mallard duck and bobwhite quail for the formulated product with adjuvant. 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 10. Acute fish toxicity for the degradate NOA-407854 on warm water species only, for the degradate NOA-447204 on warm water and cold water species, and for the formulated product with adjuvant on warm water and cold water species. 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 11. Freshwater invertebrate life-cycle studies for the degradate NOA-447204 and formulated product with adjuvant 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 12. Marine-estuarine shell deposition studies for the degradates NOA-407854 and NOA-447204. 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 13. Freshwater fish early life-stage studies for the degradate NOA-407854, and the degradate NOA-447204 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 14. Freshwater invertebrate life-cycle studies for the degradate NOA-447204, and forthe degradate NOA -407854 to replace a supplemental study. 47293210 Satisfied 11/30/2007 52 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Pinoxaden RD 7/27/2005 15. Seedling emergence and vegetative vigor studies for each of the two main degradates NOA-407854 and NOA- 447204 47293204, 47293205, 47293206 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 16. Tier II Aquatic plant growth studies forthe parent pinoxaden, degradates NOA-407854 and NOA-447204, and for the formulation with adjuvant 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 17. 830 Series subgroup A required for the pinoxaden technical produced on a commerical scale. 46701301 Satisfied 11/30/2007 Prohexadione Calcium RD 4/26/2000 1. Storage stability on the processed commodities of peanuts 4/30/2001 45190501, waiver requested Waived 8/16/2000 Prohexadione Calcium RD 4/26/2000 2. 21-day dermal toxicity study in rabbits 10/31/2001 45430301 Satisfied 6/18/2001 P ro poxy ca rba zo ne- sodium RD 6/30/2004 1. Additional storage stability data for mustard greens and turnips to validate the submitted field rotational crop study 6/30/2006 46874601 Satisfied 6/30/2006 Propoxycarbazone- sodium RD 6/30/2004 2. Study monitoring of "carboxylic acid" degradate to determine if it is accumulating in ponds, lakes and reservoirs near propoxycarbazone use areas 6/30/2006 46365701, waiver request Waived 9/20/2004 Waiver granted 4/26/2005 Prothioconazole RD 3/27/2007 1. Developmental neurotoxicity study, brain morphometric measurements from the mid and low dose animals, also addressing the other deficiencies listed in the DER to allow the reconsideration of the FQPA database uncertainty factor 12/1/2007 47293901 Satisfied 12/3/2007 Prothioconazole RD 3/27/2007 2. Final report of the ongoing storage stability study with prothioconazole and desthioprothioconazole in plant commodities 3/31/2008 47408201 Satisfied 4/21/2008 Prothioconazole RD 3/27/2007 3. Poultry feeding study with prothioconazole 6/30/2008 47492801 Satisfied 7/30/2008 Prothioconazole RD 3/27/2007 4.Data to confirm the degree of stability of the prothioconazole-4-hydroxy in ruminant fat for a duration of 45 days. 12/1/2007 47107801 Satisfied 4/17/2007 53 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Prothioconazole RD 3/27/2007 5. Analytical reference standards for the following compounds: prothioconazole- desthio, prothioconazole sulfonic acid potassium salt, prothioconazole 7/1/2007 N/A Satisfied 4/4/2007 Prothioconazole RD 3/27/2007 6. Raw data from field fortifications in MRID 46246447 (in addition to the percent conversions reported in the study) 12/1/2007 47337401 Satisfied 2/15/2008 Prothioconazole RD 3/27/2007 7. Proposed data collection and enforcement methods for livestock commodities must be be validated for poultry commodities. The EPA labs validated the livestock method for liver and milk. If the poultry method is the same or essentially the same, then the registrant at a minimum must present an argument and confirm (in writing) that the cow liver LOQ covers chicken liver. At a max, the registrant must validate the method for poultry commodities, including a demonstration of the LOQs. 6/30/2008 47492801 Satisfied 7/30/2008 Prothioconazole RD 3/27/2007 8. Repeat sediment toxicity study using chironomids following Agency guidelines in which the chemical is first added to the sediment 12/1/2007 47626901 Satisfied 12/17/2008 PT807-HCI RD 12/30/1999 1. Anaerobic Soil Metabolism 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled PT807-HCI RD 12/30/1999 2. Anaerobic Aquatic Metabolism 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled PT807-HCI RD 12/30/1999 3. Aged Leaching 10/30/2001 N/A Cancelled N/A There are no active registrations. All registrations cancelled PT807-HCI RD 12/30/1999 4. Terrestrial Field Dissipation 6/30/2001 N/A Cancelled N/A There are no active registrations. All registrations cancelled 54 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received PT807-HCI RD 12/30/1999 5. Developmental Rat Neurotoxicity study 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled Pyraclostrobin RD 9/30/2007 1. Annually by December 31 of each year and beginning in 2003, report percent crop treated data for pyraclostrobin for each crop pyraclostrobin is sold for use BASF submitted PCT data in December of each year, beginning in 2003 through 2010 Satisfied EPA informed BASF on March 23,2011 (via email) that PCT data is no longer required Pyraclostrobin RD 9/30/2007 2. 2 year chronic toxicology study in rats must be submitted for female rats. The primary deficiency in the results for female rats in the study previously submitted is that the highest dose was well below the sub-chronic maximum dose and there were no significant treatment-related toxicological effects. 9/30/2006 BASF submitted additional supporting data in 2/1/2002 in advance of the registration decision. 45596201 and 45596202-45596206 (supplemental information) Satisfied 2/1/2002 EPA upgraded study to acceptable for both male and female rats 9/10/2003 Pyraclostrobin RD 9/30/2007 3.18-month carcinogenicity study in mice must be submitted for female rats. The primary deficiency in the results for female mice in the study previously submitted is that the highest administered dose was well below the subchronic maximum tolerated dose and there were no significant systemic treatment-related toxicological effects of the dosine. 9/30/2006 46678201 Satisfied 10/27/2005 EPA report from CARC of 2/15/2007 indicates data requirement has been satisfied Pyraclostrobin RD 9/30/2007 4. 2 generation repro study in rats; primary deficiencies in the study previously submitted are that there were no adverse, treatment-related maternal, reproductive, or offspring effexts at the highest dose tested, and the limit dose was not approached. 9/30/2005 45596210 submitted in advance of the registration decision Satisfied 2/1/2002 Original study upgraded to acceptable in HIARC memo of 2/10/2003 Pyraclostrobin RD 9/30/2007 5. 28-day dermal toxicity study in rats 9/30/2004 45596201 submitted in advance of the registration decision Satisfied 2/1/2002 Original study upgraded to acceptable in HIARC memo Pyraclostrobin RD 9/30/2007 6. 28-day inhalation study in rats 9/30/2004 46638801 Satisfied 9/6/2005 Pyraclostrobin RD 9/30/2007 7. Aerobic aquatic metabolism study 9/30/2005 rebuttal submitted 45826701 Satisfied 12/18/2002 Pyraclostrobin RD 9/30/2007 8. Acute aquatic toxicity of pyraclostrobin degradates BF 500-3 and BF 500-6 to freshwater fish 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed 55 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Pyrachstrobin RD 9/30/2007 9. Acute aquatic toxicity of pyraclostrobin degradates BF 500-3 and BF 500-6 to freshwate invertebrates 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed Pyrachstrobin RD 9/30/2007 10. Acute aquatic toxicity of pyraclostrobin degradates of BF 500-3 and BF 500-6 to freshwater green algae 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed Pyraclostrobin RD 9/30/2007 11. Acute toxicity of pyraclostrobin to sediment-dwelling organisms 9/30/2005 49080401, 49080402, 45826705, 46164003 Satisfied 3/11/13, (12/29/2003) EPA classified the studies that were received in 2003 as supplemental; new studies were received on 3/11/2013 Pyrachstrobin RD 9/30/2007 12. Mysid life-cycle study 46227601 (supplemental), 49302901 Satisfied 01/23/2014,3 /17/2004 Satisfied - 49302901 Supplemental (46227601) Pyrachstrobin RD 9/30/2007 13. Avian acute toxicity study using the formulated product Headline EC 9/30/2005 45826702 Satisfied 12/18/2002 Pyrachstrobin RD 9/30/2007 14. Fish acute toxicity study using the formulated product Headline EC 45826703, 45826704, 46164001/2/3 Satisfied 12/18/2002 Pyrachstrobin RD 9/30/2007 15.Modify tolerance enforcement methods for determination of pyraclostrobin and it desmethoxy metabolite in or on plant commodities - the LC/MS/MS method D9808 and the HPLC/UV method D9904to include any modifications made by the EPA laboratory during the Agency laboratory validation. 46710001 Satisfied 12/7/2005 Pyrachstrobin RD 9/30/2007 16.Modify tolerance enforcement methods for determination of residues of pyraclostrobin in or on ruminant commodities - the HPLC/UV metho 439/0 and the HPLC/UV method 446 to include any modifications made by the EPA laboratory during the Agency laboratory validation. 46710001 Satisfied 12/7/2005 Pyrachstrobin RD 9/30/2007 17.Data to support storage conditions of milk and fat tissue samples from ruminant study 9/30/2004 45765401 Satisfied 9/25/2002 Supported HED memo - 7/26/2004 Pyrachstrobin RD 9/30/2007 18. Study confirming that rotational crop samples were analyzed within the interval represented by the storage stability study must be submitted. 9/30/2004 46469501 Satisfied 2/9/2005 56 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Pyraflufen-ethyl RD 9/27/2002 1. Photolysis in water using pyraflufen- ethyl and all possible transformation products 12/31/2003 46162701, 46162702 Satisfied 12/31/2003 Pyraflufen-ethyl RD 9/27/2002 2. Avian reproduction studies 12/31/2003 46447901 Satisfied 1/18/2005 Pyraflufen-ethyl RD 9/27/2002 3. Phototoxicity fish early life stage study using transformation product E-l and transformation product E2. 12/31/2003 48409701 Satisfied 3/2/2011 Pyraflufen-ethyl RD 9/27/2002 4. 28-day Inhalation study 12/31/2003 48381204 Satisfied 2/10/2011 Pyraflufen-ethyl RD 9/27/2002 5. Preliminary analysis (830.1700) conducted in compliance with the GLP requirements of 40CFR160. 12/31/2003 46162701 Satisfied 12/31/2003 Pyrasulfotole RD 8/9/2007 1. Storage stability and corrosion characteristics studies 8/9/2008 47309101 Satisfied 12/27/2007 Pyrasulfotole RD 8/9/2007 2. In vivo dermal penetration study 8/9/2009 47860001 Satisfied 9/18/109 Pyrasulfotole RD 8/9/2007 3. Revisions to the analytical methods 8/9/2009 47806401 Satisfied 7/17/2009 Pyrasulfotole RD 8/9/2007 4. Analytical reference standard for pyrasulfotole, pyrosulfotole-desmethyl and labeled internal standards to the EPA National Pesticide Standards Repository 8/9/2009 47806401 Satisfied 7/17/2009 Pyrasulfotole RD 8/9/2007 5. Toxicity of residues in sediment to benthic organisms (freshwater and marine) 8/9/2009 47552401 Satisfied 9/29/2008 Pyridalyl RD 4/24/2008 1. Dissociation Constant 47664701 Satisfied 2/3/2009 Pyroxsulam RD 2/27/2008 1. One-year storage stability and corrosion characteristics studies 2/27/2009 47711901 Satisfied 3/25/2009 Quinoxyfen RD 9/30/2003 1. Dermal penetration 10/1/2004 47830401, 47476901 Satisfied 3/2/2010 and 3/11/2009 Quinoxyfen RD 9/30/2003 2. 28-day inhalation (rat) 1/1/2005 Waiver requested Waived 4/1/2004 Quinoxyfen RD 9/30/2003 3. Avian reproduction study with the mallard duck for parent and metabolite 10/1/2005 45360412 Waiver requested for parent, 48991801 study for metabolite. Waiver granted for parent; requirement satisfied for metabolite 3/25/2004, 11/12/2012 Waiver granted for parent; study was held in reserve for the metabolite until a method was developed. Quinoxyfen RD 9/30/2003 4. Chronic Toxicity (Marine/Estuarine Fish and Invertebrates) 48102301, 48102302, 49622601, 49645701 Satisfied 4/27/2015 Quinoxyfen RD 9/30/2003 5. Acute Avian Reproduction 7/1/2004 47783301 waiver requested Waiver granted 4/28/2005 Quinoxyfen RD 9/30/2003 6. Acute Oral (rat) 7/1/2004 46360401 Satisfied 57 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Saflufenacil RD 9/3/2009 1. Fish early life-stage toxicity with N/A Waiver granted N/A This is no longer a modified lighting for LDPH chemicals requirement for this chemical. Three ai's were chosen to submit the study, and this was not in that group. The data received supported EFED's earlier conclusions regarding LDPH phototoxicity, so no further information is needed on this topic for saflufenacil at thic time Saflufenacil RD 9/3/2009 2. Immunotoxicity study 48233701 Satisfied 10/14/2010 Saflufenacil RD 9/3/2009 3. One year storage stability and 47913803 N/A 4/27/2010 corrosion characteristics Saflufenacil RD 9/3/2009 4. 830 series group A data (including a 47913802, 48445701 Satisfied 4/27/2010 revised basic CSF) for the BAS 800H TGAI/MUP when the product is produced on commercial scale Spinetoram RD 9/28/2007 1. Successful PMV of plant and livestock 3/28/2008 48875802 Satisfied 6/29/12 enforcement methods Spinetoram RD 9/28/2007 2. Poultry feeding study 3/28/2009 47396302 Waiver requested Waived 4/9/2008 Spinetoram RD 9/28/2007 3. Processing studies 9/28/2009 47453501 Satisfied 6/20/08 Spinetoram RD 9/28/2007 4. Analytical reference standards 3/28/2008 48875802 Satisfied 6/29/12 Spinetoram RD 9/28/2007 5. Acute freshwater invertebrate 6/28/2008 47359202, 47359203 Satisfied 2/29/2008 Spinetoram RD 9/28/2007 6. Oyster acute toxicity test (shell 6/28/2008 47359201 Satisfied 2/29/2008 deposition) raw data or new study Spinetoram RD 9/28/2007 7. Acute estaurine/marine fish 9/28/2009 47767601 Satisfied 6/3/2009 Spinetoram RD 9/28/2007 8. Acute freshwater fish 9/28/2008 47902003, 47902004 Satisfied 11/3/2009 Spinetoram RD 9/28/2007 9. Mysid chronic toxicity test 2/28/2009 47790501 Satisfied 6/30/2009 Spinetoram RD 9/28/2007 10. Whole sediment acute toxicity 2/28/2009 47689701 Satisfied 2/27/2009 invertebrates, estuarine and freshwater Spinetoram RD 9/28/2007 11. Honey bee toxicity of residues on 2/28/2009 47689702 Satisfied 2/27/2009 foliage 58 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Spinetoram RD 9/28/2007 12. 5-batch preliminary analysis data on this technical product produced on large or commercial scale, along with a revised CSF 12/31/2007 47306602, 47306603, 48085901 Satisfied 12/18/17, 5/5/10-(901) Spirodiclofen RD 6/30/2005 1. Details of the commercial scale production process for the TGAI/MUP for the facility located in Germany 6/30/2007 47024301 Satisfied 1/8/2007 Spirodiclofen RD 6/30/2005 2. 5-batch analysis for the TGAI/MUP batches produced on a commercial scale, also submit a revised basic formulation based on the 5-batches produced on a commercial scale 6/30/2007 47024301 Satisfied 1/8/2007 Spirodiclofen RD 6/30/2005 3. Apple (juice) and grape (juice) processing studies which monitor for residue of spirodiclofen 6/30/2007 47168602, 47168601 Satisfied 7/2/2007 Spirodiclofen RD 6/30/2005 4. Additional morphometric analyses of the caudate putamen, parietal cortex, hippocampal gyrus, and dentate gyrus at the mid and low doses are required for both sexes in the developmental neurotoxicitv studv 6/30/2007 47166501 Satisfied 6/28/2007 Spirodiclofen RD 6/30/2005 5. Repeated freshwater fish acute toxicity study using bluegill sunfish 6/30/2007 Waiver requested Waived N/A Spirodiclofen RD 6/30/2005 6. Repeated freshwater fish acute toxicity study using rainbow trout 6/30/2007 Waiver requested Waived N/A Spirodiclofen RD 6/30/2005 7. Repeated freshwater invertebrate toxicity study using daphnia magna 6/30/2007 Waiver requested Waived N/A Spirodiclofen RD 6/30/2005 8. Repeated estuarine/marine acute toxicity -sheepshead minnow 6/30/2007 Waiver requested Waived N/A Spirodiclofen RD 6/30/2005 9. Repeated estuarine/marine acute toxicity - mysid shrimp 6/30/2007 Waiver requested Waived N/A Spiromesifen RD 5/3/2005 1. Additional storage stability data for rotational crops 11/3/2007 47293301 Satisfied 5/18/2007 Spiromesifen RD 5/3/2005 2. Avian reproduction study using bobwhite quail and mallard duck 5/3/2007 47133101, 47142201 Satisfied 11/30/07, 5/31/07 Spiromesifen RD 5/3/2005 3. Chironomid sediment toxicity test 5/3/2007 47133102, 47133103 Satisfied 5/18/2007 59 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Spiromesifen RD 5/3/2005 4. Chronic field test for pollinators 5/3/2007 47344401 Satisfied 2/12/2008 Requirement satisfied with the supplemental study and pollinator issue has been forwarded to the active Reg Review case for resolution. Spiromesifen RD 5/3/2005 5. Preliminary commercial scale 46825601 Satisfied 9/8/2006 Spirotetramat RD 6/30/2008, 10/15/2010 1. New photodegradation on soil study, conducted on sterile soil 6/30/2009 47576501, 47576502 Satisfied 10/22/2008 Spirotetramat RD 6/30/2008, 10/15/2010 2. Soil taxonomy for the Saskatoon loam soil from Sasketchwan, Canada 12/30/2009 Letter Satisfied 1/09 Spirotetramat RD 6/30/2008, 10/15/2010 3. Avian reproduction study with the mallard duck 6/30/2010 48958801 Satisfied 5/11/2009, 10/11/2012 Spirotetramat RD 6/30/2008, 10/15/2010 4. Field testing for pollinators 6/30/2010 47576401, 47563302, 47563303, 47563304, 47563305, 47563306, 47563307, 47563308, 47563309, 47563310, 47563311, 47563312 Satisfied 10/22/08 (first 2), 10/7/08 (the rest) Further testing may be required pending protocol development. Spirotetramat RD 6/30/2008, 10/15/2010 5. Freshwater fish toxicity with fathead minnows 6/30/2009 47774301 Satisfied 6/10/2009 Spirotetramat RD 6/30/2008, 10/15/2010 6. Avian oral toxicity study with passerine species 6/30/2009 47774302 Satisfied 6/10/2009 Spirotetramat RD 6/30/2008, 10/15/2010 7. One-year storage stability and corrosion characteristic studies 6/30/2009 48002901 Satisfied 3/3/2010 Spirotetramat RD 6/30/2008, 10/15/2010 8. Full scale five-batch preliminary analysis of the technical material 6/30/2009 48525902, 4852903, 48525904 Satisfied 7/1/2011 Spirotetramat RD 6/30/2008, 10/15/2010 9. Avian Reproduction with Mallard Duck (required in 10/15/2010 decision) 5/15/2011 48958801 Satisfied 10/11/2012 Spirotetramat RD 6/30/2008, 10/15/2010 lO.lmmunotoxicity (required in 10/15/2010 decision) 10/15/2011 48525901 Satisfied 7/1/2001 Spirotetramat RD 6/30/2008, 10/15/2010 11. Subchronic neurotoxicity (required in 10/15/2010 decision) 10/15/2011 48958802 Satisfied 10/11/2012 Spiroxamine RD 7/16/2004 1. Modify the confirmatory method to use more than single-ion monitoring or conduct an interference study 7/31/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 2. Storage and stability data for the hops trials which were conducted in Germany 12/31/2004 N/A Cancelled N/A Products cancelled 5/23/2012. 60 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Spiroxamine RD 7/16/2004 2a. Storage stability for bananas frozen for 6 months 12/31/2004 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 3. Two-Generation Reproduction Study- Rat (Additional data to clarify lactation indices and clinical signs of toxicity in the second generation in the submitted study (if data is insufficient to upgrade study, a new two-generation reproduction study must be submitted with any future new uses) 12/30/2004 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 4. Adsorption/Desorption study with soils from hop-growing areas 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 5. Freshwater fish (Bluegill sunfish)-Acute 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 6. Freshwater fish rainbow trout-Acute 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Spiroxamine RD 7/16/2004 7. Aquatic plant growth (conducted at maximum seasonal use rate) 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Tebufenpyrad RD 8/26/2002 1. 90-day inhalation study Cancelled No active registrations. Registration Review also closed in Federal Register notice on March 30, 2015. Tembotrione RD 9/28/2007 1. Analytical reference standard for tembotrione and its M5 metabolite to the EPA National Pesticide Standards Repository 3/28/2008 N/A Satisfied 7/23/2008 Confirmed receipt of standard by Ft. Meade Laboratory (National Pesticide Standards Repository) Tembotrione RD 9/28/2007 2. Revision of enforcement methods LC/MS/Ms Methods AE/03/01 for plant commodities and 00967 for livestock commodities to include a calculation for the conversion of residues of the metabolite(s) to parent equivalents for quantitation 9/28/2008 47552801, 47552802 Satisfied 9/29/2008 Tembotrione RD 9/28/2007 3. Life cycle study of estaurine/marine invertebrates 9/8/2009 47623501 Satisfied 12/15/2008 Tembotrione RD 9/28/2007 4. Chemical-specific dislodgeable foliar residue study 9/28/2009 47305501 Waiver requested Waived 12/19/2007 Waiver granted 10/10/2008 61 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Tepraloxydim RD 8/8/2001 1. 28-day Inhalation Study 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 2. Developmental neurotoxicity study 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 3. Residue data on soybean aspirated grain fractions (grain dust) 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 4. Aerobic aquatic metabolism study 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 5. Leaching adsorption/desorption- mobility of aged residues 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 6. Photolysis in water 8/8/2005 N/A Cancelled N/A Tepraloxydim RD 8/8/2001 7. Terrestrial field dissipation studies 8/8/2005 N/A Cancelled N/A Tetraconazole RD 4/14/2005 1. Single side-by-side sugar beet field trial comparing two and six applications of Eminent 125SI at 0.10 lb ai/acre/application. The retreatment intervals for the plot receiving six applications should be 14 days and the RTI for the plot receiving two applications should be 21 days (the final application and harvest dates for each should be identical; preharvest interval (PHI) of 14 days; 4 samples from each clot should be collected 5/1/2007 47111401 Satisfied 4/23/2007 Tetraconazole RD 4/14/2005 2. 28-day inhalation study based on the current use pattern 2/1/2007 46990301 Satisfied 11/21/2006 Tetraconazole RD 4/14/2005 3. Study determining toxicity to benthic organisms (including chronomid) 1/1/2006 46614304 Satisfied 8/2/2005 Tetraconazole RD 4/14/2005 4. Study determining the toxicity to earthworms 12/1/2006 46614305, 46614306 Satisfied 8/2/2005 Tetraconazole RD 4/14/2005 5. New guideline adsorption/desorption study 11/1/2006 47023201 Satisfied 1/8/2007 Thiacloprid RD 9/26/2003 1. Confirmatory procedure for the livestock tissue analytical enforcement method 3/26/2004 waiver requested Waived 1/14/2004 Waiver granted 12/16/04 Thiacloprid RD 9/26/2003 2. Photodegration in soil 9/26/2004 44927933 Satisfied 4/28/2004 Found to be acceptable 6/16/04 Thiacloprid RD 9/26/2003 3. One year storage stability 9/26/2005 46462301 Satisfied 2/4/2005 Found to be acceptable 9/23/05 Thiacloprid RD 9/26/2003 4. Corrosion characteristics 9/26/2005 46462301 Satisfied 2/4/2005 Found to be acceptable 9/23/05 62 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Thiacloprid RD 9/26/2003 5. Bioaccumulation in fish 9/26/2005 44927602 waiver requested Waived 6/8/2004 MRID submitted supported waiver request which was granted on 8/3/04 Thiacloprid RD 9/26/2003 6. Limited field accumulation studies in rotational crops for wheat and soybeans 9/26/2007 46677901, 46677902 Waived 10/28/2005 A waiver request was submitted along with data on wheat and soybeans. Data not reviewed since 12 month plant back interbal was retained. Thiacloprid RD 9/26/2003 7. Five batch analysis 46677905 Satisfied 10/28/2005 Thiamethoxam RD 12/4/2000 1. Modification of Method AG-675 to add microwave extraction of liver or a new enforcement method for liver, additional radiovalidation data for beef liver 3/4/2002 45659202, 45659203 Satisfied 4/23/2002 Thiamethoxam RD 12/4/2000 2. Storage stability data continued to coverthe conditions and intervals that plant and animal commodity samples were stored (up to 30 months) 3/4/2002 45659204, 45659205 Satisfied 4/23/2002 Thiamethoxam RD 12/4/2000 3. Reanalysis of the cow liver samples from the feeding study using a microwave extraction step 3/4/2002 45659206 Satisfied 4/23/2002 Thiamethoxam RD 12/4/2000 4. Reanalysis of field rotational crop samples for metabolite CGA-265307 and description of storage conditions for future uses 3/4/2002 45659201 Satisfied 4/23/2002 Thiamethoxam RD 12/4/2000 5. Plant metabolism study on a leafy vegetable (Crop group 4 or 5) 3/4/2002 45093714 Satisfied 3/31/2000 Thiamethoxam RD 12/4/2000 6. Poultry metabolism study 3/4/2002 44703526, 44715115 Satisfied 11/19/98, 12/10/98 Thiamethoxam RD 12/4/2000 7. Developmental neurotoxicity study 12/4/2002 46028201, 46028202 Satisfied 7/3/2003 Thiamethoxam RD 12/4/2000 8. Repeated daphnia chronic study 12/4/2002 45500001 Satisfied 9/19/2001 63 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Thiencarbazone-methyl RD 9/30/2008 1. Analytical reference standards: Thiencarbazone-methyl and its metabolites BYH 18636-MMT-glucoside, BYH 18636-MMT and isotopically labeled standards provided to the EPA National Pesticide Standards Repository 9/30/2009 sample(s) received Satisfied sample(s) received Thiencarbazone- methyl RD 9/30/2008 2. Additional storage stability data (sample extraction and analysis dates for all samples) for the wheat crop field trial study 9/30/2010 47715301 49428301 Satisfied 3/27/2009 7/14/14 Thiencarbazone- RD 9/30/2008 3. Immunotoxicity study 9/30/2010 48263001 Satisfied 10/15/2010 Thiencarbazone- methyl RD 9/30/2008 4. Terrestrial field dissipation guideline currently classified as supplemental- upgradable pending review of recently submitted additional soil storage stability data 47525801 Satisfied 9/2/2008 Thiencarbazone- methyl RD 9/30/2008 5. Additional data for the analytical method forthe determination of residues of BYH18636 and its metabolites BYH18636-carboxylic acid, BYH18636- sulfonamide, BYH18636 sulfonamide- carboxylic acid, BYH18636-MMT, and BYH18636-triazolinone carboxamide in soil and sediment using LC-MS/MS 9/30/2010 47070114, 47070043, 47070118, 47070044. Satisfied 10/4/2010 Thiencarbazone- methyl RD 9/30/2008 6. Independent laboratory validation of method GS-004-W06-01 forthe determination of BYH18636 and its metabolites BYH18636-carboxylic acid, BYH18636-sulfonamide, BYH18636- sulfonamide carboxylic acid, BYH18636- MMT and BYH18636- dicarboxysulfonamide in water 9/30/2010 50091601, 50091602. Satisfied 10/24/2016 Thiencarbazone- methyl RD 9/30/2008 7. Storage stability study conducted for a minimum of one year ambient warehouse conditions must be repeated and submitted 9/30/2010 47069902 Waiver requested Waived 9/29/2010 64 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Thiencarbazone- methyl RD 9/30/2008 8. Copy of analytical methods and samples 9/30/2009 47070114, 47070043, 47070118, 47070044. Satisfied 10/4/2010 Samples received in Ft. Meade Lab. Thiencarbazone- methyl RD 9/30/2008 9. 5-batch analysis reflecting commercial scale production 9/30/2009 47918601 Satisfied 11/25/2009 Tolfenpyrad RD 7/28/2010 1. 90-day dermal toxicity study in rat, storage stability, corrosion characteristics 7/28/2011 482334021, 482334022 Satisfied 9/20/2010 Tolfenpyrad RD 7/28/2010 2. For prod. chem. review, submit analytical method as described in MRIDs 47447704 and 47447705, and samples to EPA lab for validation 7/28/2011 48660301 Satisfied 9/20/2010 Topramezone (BAS 670H) RD 8/10/2005 l.Aerobic aquatic metabolism 7/31/2008 47496702 Satisfied/ supplemental 8/1/2008 Topramezone (BAS 670H) RD 8/10/2005 2. Anaerobic Aquatic Metabolism 7/31/2008 47496703, 48600413 Satisfied/ supplemental 8/1/2008 Topramezone (BAS 670H) RD 8/10/2005 3. Mobility in Soils 7/31/2008 45902425, 46242703 Satisfied 3/28/03, 4/6/04 Topramezone (BAS 670H) RD 8/10/2005 4. Frozen Storage Stability 7/31/2008 47496704, 47496705, 47496708 ( non-guideline studies) No further data or reviews required. 8/1/2008 Data will have no significant impact in support of Terrestrial Field Dissipation study. Topramezone (BAS 670H) RD 8/10/2005 5. Avian Subacute Dietary 7/31/2008 47496708, 47496707 Satisfied 8/1/2008 Topramezone (BAS 670H) RD 8/10/2005 6. Avian Reproduction 7/31/2008 47496708, 47496707 Satisfied 8/1/2008 Topramezone (BAS 670H) RD 8/10/2005 7. Aquatic Invertebrate Life-cycle 7/31/2008 47496707 Satisfied 8/1/2008 Topramezone (BAS 670H) RD 8/10/2005 8. Aquatic Plant Growth (Tier II) (Navicula) 7/31/2008 48600403 Satisfied 3/2/2012 Topramezone (BAS 670H) RD 8/10/2005 9. Seedling Emergence (Tier II) 7/31/2008 45902327 Satisfied 3/28/2003 Topramezone (BAS 670H) RD 8/10/2005 10. Vegetative Vigor (Tier II) 7/31/2008 45902328 Satisfied 3/28/2003 Topramezone (BAS 670H) RD 8/10/2005 11. Adequate storage stability data in the plant and livestock metabolism studies by 7/31/2008 7/31/2008 45902410 Satisfied 3/28/2003 Topramezone (BAS 670H) RD 8/10/2005 12. 5-batch analysis 7/31/2008 47496701 Satisfied 8/1/2008 65 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Trifloxysulfuron RD 9/29/2003 1. Independently validated analytical chemistry methods to identify and quantify residues in water. These methods must be sufficiently sensitive to adequately determine NOAEC, EC05, and characterize residues in water resources 9/29/2008 47534701, 47534702 Satisfied 9/9/2008 Trifloxysulfuron RD 9/29/2003 2. Repeat of the Tier II aquatic vascular plant test on Lemma gibba with the technical in the acidic pH range 9/29/2008 47168201 Satisfied 7/2/2007 Trifloxysulfuron RD 9/29/2003 3. Repeat of the Tier II aquatic plant test on the blue-green algae Anabaena flos- algae with the technical. 9/29/2008 47168202 Satisfied 7/2/2007 Trifloxysulfuron RD 9/29/2003 4. Product chemistry deficiencies 9/29/2008 47157600, 47157601 Satisfied 6/12/2007 Triticonazole RD 9/30/2002 1. Dermal sensitization study (870.2600)- submit positive control data conducted within 6 months of the study date for either MRID nos. 448020-34 or -35 or submit a new dermal sensitization study 10/1/2003 46817301 Satisfied 4/17/2006 Triticonazole RD 9/30/2002 2. 28-day (nose only) inhalation toxicity study in rats 10/1/2003 Waiver requested Waived 3/15/2005 Triticonazole RD 9/30/2002 3. Developmental neurotoxicity study 10/1/2004 Waiver requested Waived 5/20/2005 Triticonazole RD 9/30/2002 4. Rat metabolism study 10/1/2004 46503401 Satisfied 10/1/2004 Triticonazole RD 9/30/2002 5. Mechanistic study (to be discussed and designed in collaboration with the registrant) N/A Waived Triticonazole RD 9/30/2002 6. Parital carcinogenicity study in the male rat at higher dose levels 12/1/2006 46552101 Waiver requested Waived 5/23/2005 Triticonazole RD 9/30/2002 7. Additional storage and stability data 10/1/2004 47091801 Satisfied 3/29/2007 Triticonazole RD 9/30/2002 8. Avian Reproduction study in Bobwhite Quail 10/1/2004 48733902 Satisfied 2/1/2012 Triticonazole RD 9/30/2002 9. Acute Freshwater Fish Toxicity Study in Bluegill sunfish and rainbow trout 10/1/2003 46021001 Satisfied 6/30/2003 Triticonazole RD 9/30/2002 10. Freshwater Fish Early Life-Stage Toxicity Study 10/1/2004 46876702 Satisfied 7/3/2006 Triticonazole RD 9/30/2002 11. Freshwater Fish Chronic Life Cycle Toxicity Study 12/1/2004 46876703 Satisfied 7/3/2006 Triticonazole RD 9/30/2002 12. Acute Aquatic Invertebrate Freshwater Toxicity Study 10/1/2003 Satisfied 66 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Triticonazole RD 9/30/2002 13. Daphnia magna Life-Cycle Toxicity Study 12/1/2004 46876701 Satisfied 7/3/2006 Triticonazole RD 9/30/2002 14. Acute Estuarine/Marine Aquatic Animal Toxicity Studies 10/1/2003 Satisfied Triticonazole RD 9/30/2002 15. Fish Early Life-Stage Estuarine/Marine Toxicity Study 10/1/2003 46876702 Satisfied 10/1/2003 Triticonazole RD 9/30/2002 16. Estuarine/Marine Invertebrate Life- Cycle Toxicity Study 10/1/2003 48842801 Satisfied 10/1/2003 Triticonazole RD 9/30/2002 17. Additional aerobic metabolism study 10/1/2003 47296303 - Acceptable 49017701 - Supplemental Satisfied 12/5/2007, 12/13/2012 No additional data/information is required after assessing the latest study and completing reviews for the Interim Registration Review Decision. Triticonazole RD 9/30/2002 18. Aerobic aquatic metabolism study 12/1/2004 47296301 Satisfied 12/5/2007 Triticonazole RD 9/30/2002 19. Additional aqueous photolysis data 10/1/2003 47296302 Satisfied 12/5/2007 Triticonazole RD 9/30/2002 20. Corrected CSF and description of production process 46608801 Satisfied 7/27/2005 Zoxamide RD 4/11/2001 1. TLC scans for initial grape extracts 12/1/2001 454614402, 45461403 Satisfied 7/25/2001 Zoxamide RD 4/11/2001 2. Substitution of derivatizing agent in the residue analytical method 12/1/2001 45437801, 45437802 Satisfied 6/25/2001 Zoxamide RD 4/11/2001 3. Incorporate changes resulting from method review 12/1/2001 Rebuttal to review sumbitted Satisfied Zoxamide RD 4/11/2001 4. Protocol first then pulmonary sensitization study 12/1/2001 45568300 Waiver requested Waived Zoxamide RD 4/11/2001 5. Storage stability data for the grape processing study 12/1/2001 45461402, 45461403 Satisfied 7/25/2001 Zoxamide RD 4/11/2001 6. Product stewardship plan for monitoring and recording incidents related to inhalation and dermal sensitization. Biannual reports required. 12/1/2001 N/A Satisfied N/A Report received. No inicidents reported. No longer required. Zoxamide RD 4/11/2001 7. Full scale production data including 5 batch analysis 12/1/2001 45568301, 45568302 Satisfied 12/20/2001 Zoxamide RD 4/11/2001 8. Resistance monitoring data for potatoes 12/1/2001 45568303, 45568304, 45568305 Satisfied 12/20/2001 Submitted as part of harmonization effort with PMRA. BEAD determined data no longer needed. 67 of 68 ------- New Active Ingredient Registration Status 2000-2022 Chemical Division Rea Notice Conditional Data Reciuirement(s) Due Date MRID for Studv Submitted Review Status Date Data Comments Date Received Zoxamide RD 4/11/2001 9. Proximity information of endangered, threatened freshwater fish and estuaring/marine invertebrates to use sites 12/1/2001 Waiver requested Waived 12/20/2001 Registrant is member of Endangered Species Task Force 68 of 68 ------- |