PEER REVIEW DRAFT DOCUMENT - DO NOT CITE or QUOTE &EPA United States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention Draft Risk Evaluation for Carbon Tetrachloride Systematic Review Supplemental File: Data Quality Evaluation of Physical-Chemical Properties Studies CASRN: 56-23-5 m December 2019 1 ------- Peer Review Draft Document - Do Not Cite or Quote Table of Contents Table 1. Physical Form Study Summary for Carbon Tetrachloride (1 of 2) 3 Table 2. Physical Form Study Summary for Carbon Tetrachloride (2 of 2) 4 Table 3. Melting Point Study Summary for Carbon Tetrachloride 5 Table 4. Boiling Point Study Summary for Carbon Tetrachloride 6 Table 5. Density Study Summary for Carbon Tetrachloride 7 Table 6. Vapor Pressure Study Summary for Carbon Tetrachloride 8 Table 7. Vapor Density Study Summary for Carbon Tetrachloride 9 Table 8. Water Solubility Study Summary for Carbon Tetrachloride 10 Table 9. Octanol-water Partition Coefficient Study Summary for Carbon Tetrachloride 11 Table 10. Henry's Law Constant Study Summary for Carbon Tetrachloride 12 Table 11. Flash Point Study Summary for Carbon Tetrachloride 13 Table 12. Viscosity Study Summary for Carbon Tetrachloride 14 Table 13. Refractive Index Study Summary for Carbon Tetrachloride 15 Table 14. Dielectric Constant Study Summary for Carbon Tetrachloride 16 2 ------- Peer Review Draft Document - Do Not Cite or Quote Table 1. Physical Form Study Summary for Carbon Tetrachloride (1 of 2) Study Reference: CHRIS. (1984). CHRIS hazardous chemical data. US Coast Guard. Vol 2. Washington, DC. HERO ID: 17566 Note: CHRIS (1984) was not available for review. Data from CHRIS (June 1999) was evaluated in its place. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. Low The information or data is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Medium Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level Medium 3 ------- Peer Review Draft Document - Do Not Cite or Quote Table 2. Physical Form Study Summary for Carbon Tetrachloride (2 of 2) Study Reference: O'Neil, M.J., ed. (1996). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 12th ed., Whitehouse Station, NJ: Merck and Co., Inc., p. 1054. HERO ID: 670297 Note: O'Neil (1996) reported the physical form. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High Data cited as found in the literature. Evaluation/Review The information or data reported has reliable review. High The information or data is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 4 ------- Peer Review Draft Document - Do Not Cite or Quote Table 3. Melting Point Study Summary for Carbon Tetrachloride Study Reference: Lide DR. (1999). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. 80th ed. CRC Press, Boca Raton, FL. HERO ID: 3827230 Note: Lide (1999) reported the melting point. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 5 ------- Peer Review Draft Document - Do Not Cite or Quote Table 4. Boiling Point Study Summary for Carbon Tetrachloride Study Reference: Lide DR. (1999). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. 80th ed. CRC Press, Boca Raton, FL. HERO ID: 3827230 Note: Lide (1999) reported the boiling point. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 6 ------- Peer Review Draft Document - Do Not Cite or Quote Table 5. Density Study Summary for Carbon Tetrachloride Study Reference: Lide DR. (1999). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. 80th ed. CRC Press, Boca Raton, FL. HERO ID: 3827230 Note: Lide (1999) reported density. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 7 ------- Peer Review Draft Document - Do Not Cite or Quote Table 6. Vapor Pressure Study Summary for Carbon Tetrachloride Study Reference: Boublik T et al. 1984. The vapor pressures of pure substances: selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region. Vol. 17. Amsterdam, Netherlands: Elsevier Sci. Publ. HERO ID: 194873 Note: Boublik et al. (1984) reported the vapor pressure. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection in which results have been selected by experts based on their quality and availability. References to the original sources are included. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 8 ------- Peer Review Draft Document - Do Not Cite or Quote Table 7. Vapor Density Study Summary for Carbon Tetrachloride Study Reference: Boublik T et al. 1984. The vapor pressures of pure substances: selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low-pressure region. Vol. 17. Amsterdam, Netherlands: Elsevier Sci. Publ. HERO ID: 194873 Note: Vapor density was calculated from Boublik et al. (1984). Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was calculated for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 9 ------- Peer Review Draft Document - Do Not Cite or Quote Table 8. Water Solubi ity Study Summary for Carbon Tetrachloride Study Reference: Horvath AL. (1982) Halogenated hydrocarbons: solubility-miscibility with water. New York, NY: Marcel Dekker, Inc. HERO ID: 194749 Note: Horvath (1982) reported the water solubility. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Original sources are also referenced. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High Methodology for producing the information is designed to answer a specific question, and the methodology's objective is clear. Reliability/Analytic Method The information or data reported is from a reliable method. High Data are obtained by accepted standard analytic methods. Overall Quality Level High 10 ------- Peer Review Draft Document - Do Not Cite or Quote Table 9. Octanol-wa ter Partition Coefficient Study Summary for Carbon Tetrachloride Study Reference: Hansch, C., Leo, A., D. Hoekman. (1995). Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society. HERO ID: 51424 Note: Hansch et al. (1995) reported the log Kow. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection that has been compiled by experts and includes references to the original sources. The original source for this value is a peer-reviewed journal. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 11 ------- Peer Review Draft Document - Do Not Cite or Quote Table 10. Henry's Law Constant Study Summary for Carbon Tetrachloride Study Reference: Leighton DT, Calo JM. (1981). Distribution coefficients of chlorinated hydrocarbons in dilute air-water systems for groundwater contamination applications. J Chem Eng Data. 26 (4): 382-85. HERO ID: 194928 Note: Leighton and Calo (1981) reported the Henry's Law constant as a dimensionless value and it has been converted to atm-m3/mol. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The value was measured for the subject chemical substance. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The source is a peer-reviewed journal. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High The method for producing this value is not biased towards a particular outcome. Reliability/Analytic Method The information or data reported is from a reliable method. High The analytical method used to measure this value is an accepted standard method. Overall Quality Level High 12 ------- Peer Review Draft Document - Do Not Cite or Quote Table 11. Flash Point Study Summary for Carbon Tetrachloride Study Reference: CHRIS. (1984). CHRIS hazardous chemical data. US Coast Guard. Vol 2. Washington, DC. HERO ID: 5348366 Note: CHRIS (1984) was not available; however, a more recent version CHRIS (1999) reporting flash point was reviewed. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information or data is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 13 ------- Peer Review Draft Document - Do Not Cite or Quote Table 12. Viscosity Study Summary for Carbon Tetrachloride Study Reference: Daubert, T.E., R.P. Danner. (1989). Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis. HERO ID: 3827242 Note: Daubert and Danner (1989) reported the viscosity. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High Data are measured for the subject chemical substance. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High Measured data are consistent with the subject chemical substance structural features. Evaluation/Review The information or data reported has reliable review. High The information or data is from a recognized data collection collection/repository where data are peer-reviewed by experts in the field, are broadly available to the public for review and use and include references to the original sources. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High Methodology for producing the information is designed to answer a specific question, and the methodology's objective is clear. Reliability/Analytic Method The information or data reported is from a reliable method. Low Analytical method is not reported. Overall Quality Level High 14 ------- Peer Review Draft Document - Do Not Cite or Quote Table 13. Refractive Index Study Summary for Carbon Tetrachloride Study Reference: O'Neil, M.J., ed. (1996). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 12th ed., Whitehouse Station, NJ: Merck and Co., Inc., p. 1054. HERO ID: 670297 Note: O'Neil (1996) reported the refractive index. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High Data cited as found in the literature. Evaluation/Review The information or data reported has reliable review. High The information or data is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 15 ------- Peer Review Draft Document - Do Not Cite or Quote Table 14. Dielectric Constant Study Summary for Carbon Tetrachloride Study Reference: Norbert, AL; Dean, JA. (1967). Lange's Handbook of Chemistry. McGraw-Hill NY, NY. HERO ID: 3836460 Note: Norbert and Dean (1967) reported the dielectric constant. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High Data are measured for the subject chemical substance. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High Measured data are consistent with the subject chemical substance structural features. Evaluation/Review The information or data reported has reliable review. High The information or data is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High 16 ------- |