Shaugbnessy No: 129008
Date Out of EPGWB:
TO: Robert J. Taylor/Cynthia Giles
Product Manager #25
Registration Division (H7505C)
FROM: Erail RsgeLman, Supervisory Chemist
Environmental Chemistry Review Section
Environmental Fate and Ground Water (H7507C)
THRU: Henry M. Jacoby, Chief - '
Environmental Fate and Branch/EFED' (H7507C)
y
Attached, please find the EPGWB review of:
Reg./File #: 352-ICU; 352-LGL
Common Name: Nicosulfuron
2 —(((((4,6-Dimethoxypyrimidine-2-yl) aminacartony 1) amino-
Chemical Name:
Type product: Herbicide Field
Product
Company Name: E.I. du Pont de Nemours and
Purpose: Review of data in EPGWB review of
Comment on the rotational intervals in a new label
a) 6/15/90
Date Received: EPGWB #: 90-0639
Action CDde: 101 Total Reviewing Time (decimal days):3.5
Deferrals to: Ecological Effects Branch, EFED
Science Integration & Policy Staff, EFED
Non-Dietary Exposure Branch, HED
Dietary Exposure Branch, HED
Toxicology Branch I , HED
Toxicology Branch II, HED
I
-------
CHEMICAL:
Chemical aroe: 3-Pyridinecarboxamide( (((4,6^imethyl-2-yl)amiixx^u±onyl)
aminosulforryl)) -N,N-dimethyl
2- (((((4,6-Diinethoxypyrimidine-2-y 1) aminocarbonyl)) -
amxnosulfony 1)) -N,N-dimethyl-3-pyridinecartxDxamide
Common name: Nicosulfuron
Companv code: "DPX-V9360"
Chemical Abstracts Registry Number: 11991-09-4
Product name: ACCENT
o
h
Chemical structure: , ^ „cn(Ch3)2
,och3
O N=
II
N so2nhcnh—^ \
N-
OCHj
OPX-V9360
Phvsical/Chemical properties of active ingredient:
Molecular weight: 410.10
Physical characteristics: white solid
Solubility (in buffer solution; 28 C)
pH 5.1 to 5.6 390 ppm
6.3 9000 ppn
pH 7.2 18000 ppn
pH 9.0 > 250,000 ppn
pKgt 4.3
Vapor pressure: 1.2 x 10~16 Torr
Octanol/water partition coefficient:
pH 5 0.44
pH 6 0.017
pH 9 0.01
STUDY/ACTION TYPE:
- Review of additional data submitted in response to EPGWB review of 5/30/90.
- Review new label submitted by du Pont and aanrament on the proposed
rotational crop restrictions.
STUDY IDEtTITFICATION:
- Letter of Tony E. Catka (E.I.du Pont de Nenours and Canpany) dated 6/15/90
accrarpanying the registrant's responses to the deficiencies noted in the
EPGWB review of 5/30/90). These deficiences concerned the following data
requirements:
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a) 161-2: Fhotodegradation in water
b) 162-1: Aerobic soil metabolism
c) 163-1: Mobility in soil
d) 164-1: Terrestrial field dissipation (short term)
e) 165-1: Accumulation in confined rotational crops
- Copy of proposed new label (5/1/90). Copy attached.
REVIEWED BY:
Silvia C. Terroas, Chemist
Review Section #2
OPP/EFED/EPGWB
APPROVED BY:
Emil Regelman
Supervisory Chemist
Review Section #2
OPP/EFED/EPGWB
Signature:
Date:
/7?c?
JUN 2 7 1990
CONCLUSIONS:
a) EPGWB considers that the additional data submitted for the Photodeoradation
in Water (161-2), Aerobic Soil Metabolism (162-1), and Mobility in Soil
(163-1) are acceptable. Therefore, these data requirements can be considered
fulfilled. Except for the Fhotodegradation in Water study (see RECOMMENDATIONS)
no new data are being requested at the present time. Further details on the
data submitted and summaries of data are included in the Data Evaluation
Record for each of these studies. This additional data can be submitted
after registration.
b) EFGWB still believes that a new terrestrial field dissipation study is
warranted. The new study should be designed to address the movement of
nicosulfuron and its degradates/metabolites under "worst-case precipitation/
vulnerable soils conditions". The study should also demonstrate that
mineralization does occur in the field to a significant extent. This study
can be submitted after registration.
EFGWB also believes that, if at an early stage it is demonstrated that
nicosulfuron and its degradates/metabolites do not leach under worst-case
precipitation/irrigation conditions, then the need for more costly and
complex ground-water monitoring studies (either small-scale prospective or
small-scale retrospective) may be avoided in the future. The high solubility,
high mobility, and moderate-to-high persistence of nicosulfuron mark
this herbicide as a potential leacher.
Rainfall events immediately following application can potentially
favor leaching and or horizontal movement by run-off, particularly
if the soils have a high sand constant (submitted mobility in soil
data indicate that, for the two sandy loam and two silty loam soils
-------
studied, there was no correlation between organic matter content
of the soil and values for parent nicosulfuron).
c) Data requirements for Accumulation in Confined Rotational Crops (165-1)
are considered fulfilled. Residue levels for parent and/or Pyridine
Sulfonamide degradate at 10-months have been determined to be of no
concern by the Toxicology Branch II at the present time. Pyridine
Sulfonamide was found in very small quantities (4-6% of the total
radioactivity) in rat metabolism studies and in plant studies.
However, EFGWB has concern about phytotoxic effects to rotational crops.
Studies demonstrate that nicosulfuron residues may exhibit phytotoxic
effects below levels of toxicological concern to rotational crops long
after the 10-month period. This phytotoxic effect could occur particularly
in regions where soil conditions and/or climatic condition could
favor slew degradation/dissipation of parent nicosulfuron.
Based on available data, the minimum rotational crop interval that
can be recummended is 10-months, unless the registrant conducts additional
14C-label studies or applies for tolerances. Therefore, the label
should be modified to reflect EFGWB recommendations about recrop
intervals. The pH of soils for which the use of ACCENT is not reexsnmended
or for which recrop intervals have been specified should also be
revised (see corresponding DER).
d) EFGWB has reviewed the precautionary warning about tailwater from
first irrigation after ACCENT application (if no rainfall has occurred
or if it has been below 1/2 inch) [for flood or furrow-irrigated fields]
and considers it adequate.
Because EPS® is concerned about runoff to nontarget areas it is also
recmnmended that the following be added to the label:
1. Do not apply where/when conditions could favor runoff.
2. Do not apply if rainfall or storm is expected within 24 hours.
e) Spray Drift data was requested in EFGWB review of 2/22/90. The registrant
requested waiver of these studies based on roentoership in the Spray Drift
Task Force. Because of the high probability of phytotoxic effects to
nontarget crops frxm drift, EFGWB did not concur granting the waiver at
the time (Hitch, 5/30/90). EFGWB considers spray drift data as critical
in the assessment of the impact of ACCENT on the environment.
7. REaDMMEMATTONS:
The registrant should be informed of the following:
a) Data requix^rrents for Hydrolysis (161-1); Fhotodegradation in water (161-2) ;
Fhotodegradation on soil (161-3); Aerobic soil metabolism (162-1);
Anaerobic soil/aquatic metabolism (162-2/162-3); Mobility in soil (163-1) ;
and Accumulation in confined rotational crops (165-1) have been fulfilled.
3
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b)
Data requirements for Volatility from soil, laboratory/field (163-2/163-3);
Bioaccumulation in fish (165-4) have been waived for the parent pesticide.
c) The Terrestrial field dissipation study is considered a valuable but
supplemental study. For the reasons expressed in the CONCLUSIONS section,
EPGWB is requesting that a new study be conducted. The study should be
designed to address the concerns pointed out by the Branch.
d) A minimum 10-month rotational interval is recommended.
e) Tah^l TTiodifications:
1) Hie proposed label should be revised to clarify the pH of soils for
which the use of ACCENT is not recommended or for which recrop intervals
have been specified (see corresponding DER).
2) Hie proposed label should reflect the recommended minimum recrop
intervals.
3) Further precautionary statements to prevent runoff should be added to the
label, as indicated in the CONCLUSIONS section, part: d.
4) As a result of spray drift studies, new precautionary statements/
recommendations may be required in the label.
f) EPGWB would appreciate comments on the differences in reaction products
observed in irradiated samples at pH 5 when compared to those kept
under dark conditions.
g) EPGWB acknowledges the registrant's efforts in developing sensitive,
state-of-the-art analytical techniques to identify lew-levels of residues
of nicosulfuron and/or its degradates.
h) Copies of all DERs attached to this review should be made available to
the registrant.
To Registration Division:
EPGWB rerranmends that RD consider classifying sulfonylurea herbicides
as Restricted Use because of their potential to cause adverse environmental
effects and to leach or run off into ground and surface water.
8. BACKGROUND:
E.I. du Pont de Nemours and Conpany is seeking registration of the new
sulfonylurea herbicibe ACCENT, which contains the active ingredient "DPX-V936Q"
(nicosulfuron). The currently proposed use is on corn.
Data for an EUP was reviewed by EPGWB on 5/1/89; responses to additional data
submitted by the registrant appear in 10/20/89 and 11/29/89 reviews. A Science
Chapter for nicosulfuron was completed by EPGWB on 2/22/90 and the review
of the registrant's responses was completed on 5/30/90 and 6/1/90. The reviews
4
5"
-------
to the registrant's responses to the latter two reviews are included here.
ACCENT Herbicide is a water dispersable granule containing 75% of the active
ingredient DPX-V9360 (nicosulfuron) by weight. It is a selective herbicide
developed to control annual and perennial grass weeds and selected broadleaf
weeds when applied postemertrence from the 2-leaf through the 6-leaf stage of
field corn. It is not to be used on popcorn, sweet corn or corn grown for
seed production.
Foliar absorption is the primary means of ACCENT uptake by plants. ACCENT
should always be applied prior to the 10 leaf stage of corn. The application
method recommended is by ground spraying. The pesticide should not be
applied through any type of irrigation system. Maximum single application
rate is 1 oz ai/acre. If split applications are to be made, they should not
exceed a total of 1 1/3 oz ai/acre in any crop per year (split applications
of 2/3 oz are recommended).
9. DISCUSSION OF INDIVIDUAL STUDIES:
No studies were submitted. DERs of original studies appear on EFGWB reviews
of 5/1/89 and 2/22/90. Reviews of additional data are contained in EFGWB
reviews of 10/20/89, 11/29/89, 5/30/90 and 6/1/90.
The reviews of additional data requested on 5/30/90 and 6/1/90 are attached
here.
10. CDMPLCriON OF ONE-LINER:
New information about generated values for the degradates Pyridine
Sulfonamide and Pyrimidine Amine is being incorporated to the one-liner at
this time.
11. CBI APPENDIX: No CBI Appendix.
5
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STATUS OF DATA REQUIREMENTS
"DPX-V9360" (Nicosulfuron)
(Terrestrial food crop uses: corn)
Data requirement Status
Section 158.290. Environmental Fate;
161-1 Hydrolysis Fulfilled
161-2 Ftiotxdfigradation in water Fulfilled
161-3 Photnipgr^dation on soil Fulfilled
161-4 Photodegradation in air Not required
162-1 Soil metabolism- Aerobic Fulfilled
162-2 Soil metabolism- Anaerobic Fulfilled
162-3 Aquatic metabolism- Anaerobic Fulfilled
163-1 Mobility in soil Fulfilled
163-2/3 Volatility frcxn soil Not required
164-1 Terrestrial field dissipation Supplemental
information
New study required
165-1 Accumulation in rotational crops
(confined) Fulfilled
165-2 Acrxmilation in rotational crops
(field) , Reserved
165-4 Bioaccmnulation in fish Waived, but
may be required if concerns
arise about potential
bioaccumilation of degradates
Section 158.440. Sprav Drift:
201-1 Droplet size spectrum Both of these studies
202-1 Drift field evaluation have been requested
(Hitch, 5/30/90)
Section 158.75. Other Data:
Ground water and/or
surface water mcaiitoring studies
Reserved
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"DPX-V9360" (Nicosulfuron)
RESPONSES TO 5/30/90 AND 6/1/90 REVIEWS
Table of Contents
Page
161-1 Riotodegradation in water 1.1
162-1 Metabolism in soil- Aerobic 2.1
163-1 Mobility in soil 3.1
164-1 Terrestrial field dissipation 4.1
165-1 Accumulation in confined rotational crops 5.1
REVIEWER: Silvia C. Tennes, Chemist
Review Section #2 y
EPA/OPP/EFED/EFGWB / /fa
*
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Photodecrradation of rPvrimidine-2-^Cl DPX-V9360 and rPvridine-2—Cl-
DPX-V936Q in Water
Authors: M.T. Scott and R.D. McFetridge
MRID of Original Study: 41082620
Background
The original study was reviewed on 2/22/90. Several deficiencies were noted
in the review, which were responded by the registrant with additional data
sutmitted on 3/28/90 and reviewed by EFGWB en 5/30/90.
In the latter review, EPGWB requested information to clarify if the authors
had any supporting data indicating that the "Pyrimidine Amine" degradate
may be prone to photadejradation. Uiis information was included in the 6/15/90
submission.
EFGWB response to registrant/s part-mission dated 6/15/90:
Hie authors have pointed cut that there was no evidence for photodegradation
when "Pyrimidine Amine" at pH 9 was irradiated for 17.5 hours in a Rayonet
Photochemical Reactor. Hcwever, it was frcro the data at pH 5 that EFGWB
considered that "Pyrimidine Amine" may be prone to photxriegradatian because
"Polar Qjtt^uunds" and "Rx^rrtegradatian Product 1" are present in the
irradiated samples and not in the dark, control samples. EPGWB would like
further clarification of this observation.
Hie registrant has responded satisfactorily to the other to aanroents made
by EPGWB regarding "Polar Qanpsxinds" and "Hiotoproduct 1".
CONCHJSIONS:
The data rpquirproents for Hiotodearadation in Water studies f 162-1) are
considered satisfied. However, EFGWB would appreciate that the registrant
further crnments about the differences in reaction products observed in
irradiated samples at pH 5 when compared to dark samples.
SUMMARY OF DATA:
At pH 9 (pH of TOvimim hydrolytic stability), direct photolysis of DFX-V9360
is not a major degradation pathway. Under natural sunlight (early sunnier,
Wilmington, EE; total cumulative exposure of 207,688 watt-hr/m2 after 30 days),
the estimated half-life of parent DPX-V9360. At pH 7 the estimated half-life
was 200-250 days, but at pH 5 the half-life was ca. 14-15 days.
1.1
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-2-
PHOTODEGRADATION OF CPYREVffl)INE-2-14C-DPX-V9360
AND [PYRIDINE-2-14C-DPX-V9360 IN WATER
Authors: M. T. Scott and R. D. McFetridge
MRID of Original Studv: 41082620
EPA REVIEW
1. The possibility that "Polar Compounds" are formed via a photodegradative
process of the bridge-cleavage product "Pyrimidine Amine". That is, if there
is any indication that "Pyrimidine Amine" is prone to photodegradation.
2. Clarify the percentage of each of the four components of the "Polar
Compounds" at Days 14, 21, and 30, and indicate if there were further
attempts to characterize these components. If attempts were made to identify
these components, the results should be presented and discussed.
3. The possibility that the "Photoproduct 1" (believed to contain the two rings) is
the "Cyclized Ipso Precursor" reported in the additional information
submitted for the Aerobic Soil Metabolism Study.
REGISTRANTS RESPONSE
1. Pyrimidine Amine does not photolyze. Three separate pH 9 (the most
hydrolytically stable pH) 100-ppm solutions of Pyrimidine Amine were
irradiated in a Rayonet Photochemical Reactor for 17.5 hours. The irradiated
solutions were analyzed by HPLC and the results showed no degradation of
the Pyrimidine Amine (Du Pont Notebook E52771, p. 66).
2. The "Polar Compounds" consisted of at least 2-3 components that were not
resolved and percentages of these unresolved components would not be
meaningful. No attempts were made to identify these components since the
pH 5 solution was not the most hydrolytically stable pH value for DPX-V9360.
3. Photoproduct 1 was not the same as the Cyclized Ipso Product. The HPLC
retention time of the Cyclized Ipso Product was -17 minutes while that of
Photoproduct 1 was approximately 7.6 minutes run under the same
conditions.
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Aerobic Soil Metabolic of ^C-DFX-V9360 in a Corn Belt Soil
Author: B.C. Rhodes
MRID Number of Original Sturdy: 41082622
Background
The original study was reviewed by EFGWB on 2//22/90. At that time the
study was considered unacceptable to fulfill data requirements because
the information presented included only eight months instead of the twelve
months required by Subdivision N guidelines.
Data up to twelve months were included in the 3/28/90 submission and reviewed
by EPGWB on 5/30/90. Hie study was considered basically acceptable, but
additional information was requested on 5/30/90 to clarify the apparent
further degradation of the Fyrimidine Amine degradate and to provide further
information on the Cyclized Ipso Precursor degradate. The requested
information was provided in the 6/15/90 submission.
EFX5WB response to registrant's gnhmi^inn dated 6/15/90;
Hie registrant has provided information shewing the distribution of bound
residues in humin, fulvic acid and humic acid fractions for 120-day ••bound
residues" (ca 15% of applied radioactivity), thus demonstrating hew "bound
residues" are distributed among these fractions:
% Bound Residue
Humin 20.7
Fulvic Acid 47.0
Humic Acid 32.3
The registrant has also provided further information about the Cyclized
Ipso Precursor, as requested. The conditions favoring formation of this
degradate are mildly acid or neutral to mildly alkaline. Thus, formation of this
degradate may be expectad in mildly acidic-neutral-mildly alkaline soils.
Acid- or base- catalized cyclization of the Ipso precursor appear to be the
most plausible mertianian for the formation of the Cyclized product. The
registrant has also informed that the Cyclized Ipso Precursor is stable, but
that the stability of the Precursor has not been studied.
CONCLUSIONS;
Data requirements for Aerobic Soil Metabolism (162-1) are now fulfilled.
SUMMARY OF DATA:
DPX-V9360 degraded in ncnsterile siltv clav loam soil frcm Paris, IL (20%
sand, 50% silt, 30% clay; 5.1% CM; pH 6.1; CEC 30.4 meq/100 g; BD disturbed
soil, 1.09 g/an3; PC 1/3 bar, 31.8%) with a half-life of 26 days, in sterile
soils, the half-life of degradation was 6-nunths. These results indicate that
biotic degradation under aerobic conditions is a significant factor in the
breakdown of DPX-V9360.
2.1
-------
The main degradation pathway involves cleavage of the sulfonylurea bridge to
form Pyridine Sulfonamide and Pyrimidine Amine. Maximum Pyridine Sulfonamide
(94%) was detected after 180 days and decreased to ca. 92% by 360 days while
percentage of bound residues increased slightly, but steadily.
Maximum Pyridine Amine was detected after 180 days (ca. 84%), which declined
to ca. 70% after 360 days. This decline was accompanied by an increase in
"bound residues" (ca. 50% of the 15% "bound residues" after 120-days were
present in the fulvic acid fraction).
A degradate identified as Cyclized Ipso Precursor appeared at ca.2% after
between 20 and 30 days and was present to up to 120 days; however, the
concentration of this degradate did not exceed 7% at any time.
No significant amounts (<1%) of 1400o were detected at any time throughout
the 360-duration of the study with either the [pyridine]- or the [pyrimidine] -
labeled material.
2.2
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-3-
AEROBIC SOIL METABOLISM OF 14C-DFX-V93G0 IN A CORN BELT SOIL
Author: B. C. Rhodes
MRID of Original Studv: 41082622
EPA'S REVIEW
However, EFGWB is requesting further clarification of the
following results:
a. The apparent further degradation of the Pyrimidine Amine
degradate/metabolite. Is it a result of actual degradation to products that
become incorporated into the carbon pool of the soil or is it just the results of
stronger adsorption onto soil components?
b. Conditions favoring the cyclization of the "Ipso Precursor" to the "Cyclized
Ipso Precursor" products and comments on the stability of both the "Ipso
Precursor" and the "Cyclized Ipso Precursor".
REGISTRANTS RESPONSE
a. Bound residues from the Day-120 aged sample were characterized by a
modified isolation procedure similar to that described by Ivarson and
Stevenson [Ivarson, K C., and Stevenson, I. L., Canadian Journal of
Microbiology. 10, 677 (1974)]. Day-120 soil treated with [pyrimidine-2-14C]-
DPX-V9360 containing -15% bound total 14C was extracted with 0.5N sodium
hydroxide and water. The combined aqueous extracts were adjusted to pH 1.0
and then centrifuged. 14C was measured in each fraction. Thus, the residual
residues were separated into the humin, fiilvic acid, and humic acid
fractions. The distribution of the bound residues was as follows:
Percent of Bound Residue
Humin 20.7
Fulvic Acid 47.0
Humic Acid 32.3
b. Formation of Cyclized Ipso Product occurred in both the Aerobic Soil
Metabolism Study and under physiological conditions in the Goat Metabolism
Study (MRID No. 410826-27). Thus formation of the Cyclized Ipso Product cin
occur under mildly acidic (soil pH = 6.1) or neutral to mildly alkaline
(physiological pH) conditions. Although DPX-V9360 Ipso Precursor was not
isolated, acid- or base-catalyzed cyclization of the Precursor are the most
plausible mechanisms for this reaction according to our synthetic organic
chemists. Indeed, an intramolecular cyclization would be more
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-4-
thermodynamically favorable than a reaction involving cyclization of two
molecules.
The stability of the Precursor has not been studied; the Cyclized Ipso Product
was found to be stable.
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Batch Equilibrium arri Mobility Studies of DPX-V9360
Author: T.M. Priester
MRID Number of Original .Study; 40924222
Background
Hie Agency had requested (2/22/90; 5/30/90) that batch-equilibrium adsorption/
desorption studies be conducted with the degradates Pyridine Sulfonamide and
Pyridimine Amine. Soil TIC studies had been conducted with these degradates
and reviewed earlier by EPGWB (5/1/90; 10/20/90). Hie purpose of requesting
data on Freundlich sorption coefficients for the degradates was to have a
conplete data set for nicosulfuron and its main degradates which can be used
in any future studies involving modeling.
EPGWB response to registrant/s dated 6/15/90
Hie registrant has used a regression approach to generate Kg^ values from
Rf values. Hie registrant feels confident of this approach because of extensive
work done with the same soils used in the TIC and batch equilibrium studies.
Tbe equations used to predict K values from Rf values for the degradates were
the following:
In K= -4.8Rf +2.0 for the Woadstrwn sandy loam (r= -0.95)
In K= -5.2Rf + 2.1 for the Cecil sandy loam (r= -0.94)
In K= -6.4Rf + 3.1 for the Flanagan silt loam (r= -0.89)
In K= -5.3Rf + 2.3 for the Keyport silt loam (r= -0.68)
The predicted (P) and observed (O) values are summarized below:
DPX-V9360 Tertoacil Diuron Pyridine Pyridimine
Sulfonamide Amine
P
0
/
P
0 / P 0
/
P
/
P
SANDY LOAM SOUS
Wocdstown
0.41
0.16
/
0.33
0.39 / 3.51 4.00
/
0.10
/
2.51
Cecil
0.35
0.28
/
0.81
0.71 / 5.15 6.70
/
0.18
/
3.46
SIUT LOAM SOILS
Flanagan
1.67
1.73
/
1.89
1.30 / 13.5 17.00
/
0.34
/
20.08
Keyport
1.64
0.61
/
2.03
1.20 / 9.62 20.00
/
0.34
/
9.87
EPGWB considers that the registrant's approach is valid, but would like to point
that the correlation betweee observed and predicted f°r parent DFX-V9360
in Keyport silt loam soil was the poorest. The Keyport soil was the most acidic
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of all the soils (pH 4.3) and frcm data incited in the original study it
was seen that some decanpnsition had occurred and that the total amount of
Pyrimidine Amine amine formed was ca.4.6% of the applied radioactivity;
0.98% was present in the aqueous phase and 3.6% was extracted frcm the soil.
Since Pyrimidine Amine is known to adsorb more strongly than parent or Pyridine
Sulfonamide, a plausible reason for a lower value of the observed may
be related to ccmpetitioiydepletion of binding sites by Pyrimidine Amine.
The data included in the original submission also showed that there was not
a strong correlation between organic matter content and adsorption of parent
DPX-V9360 onto the four soils studied. Adsorption appeared to depend more on
other soil characteristics such as pH and cation exchange capacity.
It should also be kept in mind that all of the chemicals used to generate
values frcm Rf may bind to a given soil by different merfianisms
(for example, hydrogen bczidijig, chemisorption, electrostatic attraction, etc)
and, therefore, sane degree of variation is to be expected between predicted
and observed values.
cmcnjsiQNS:
EPGWB accepts the approach used by the registrant to generate values
frcm Rf values for the degradates Eyridine Sulfonamide and Pyrimidine Amine.
Therefore, data requirements for Mobilty in Soil studies (163-1) are now
considered satisfied.
SUMMARY OF DATA
Soil DPX-V9360 Pyridine Sulfonamide Pyrimidine Amine
(pH; %CM; CEC) *a % Kg (predicted) Kg (predicted)
SANDY LOAMS
Wxdstxwn
(6.6; 1.1; 5.3) 0.16 0.49
Cecil
(6.5; 2.1; 6.6) 0.28 0.84
SIUT LOAMS
2.34 0.34 20.00
0.34 9.87
1.28
SOIL % sand % silt % clav Origin
Wcrdstown 60 33 7 Dover, DE
Cecil... 61 21 18 Raleigh, NC
Flanagan 2 81 17 Rochelle, IL
Keyport 11 78 11 Newark, DE
0.10
0.18
2.51
3.46
Flanagan
(5.4; 4.3; 21.1)...1.73
Keyport
(4.3; 4.7; 14.1)...0.61
3.2
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Hie results shew that parent DFX-V9360 and Pyridine Sulfonamide do not adsorb
strongly onto the four soils study, with Pyridine Sulfonamide adsorbing the
weakest. The value belcw 2 indicate that both of these species will
be mobile, particularly in sandy soils and that Pyridine Sulfonamide is
expected to be more mobile than the parent pesticide.
The predicted values for Pyrimidine Amine range from 2.51 to 20,
indicating that Pyrimidine Amine is expected to be less mobile than parent
DFX-V9360 or Pyridine Sulfanamide.
For parent DPX-V9360, no correlation was found between the organic matter
content of the soil and the K^s values and appears that other factors
(such as pH or CEC) may be more iirportant in determining the adsorption of
parent to soils.
3.3
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-5-
RESPONSE TO EPA ENVIRONMENT] FATE REVIEW
OF BATCH EQUILIBRIUM AND MOBILITY STUDIES OF
DPX-V9360 AND DEGRADATES (AMR-842-87; EPAMRID NO. 4092422)
Awthor: T. M. Priester
Original Study MRID No.: 40924222
EPAS REVIEW
As expressed in the review of data submitted with the Section 3
registration package (dated 2/22/90), EFGWB has requested that batch-equilibrium
adsorption/desorption studies be conducted with the degradates Pyridine
Sulfonamide and Pyrimidine Amine and the same soils used in the study
conducted with parent DPX-V9360. Therefore, these studies must be conducted
and submitted to the Agency in order to fulfill data requirement 163-1.
REGISTRANTS RESPONSE
The data requirement for Subdivision N, 163-1 indicates that either
column leaching, batch equilibrium or soil TLC (thin-layer chromatography) is
necessary to determine the potential mobility of a pesticide and its major
degradates. We believe that this requirement has been satisfied since Batch
Equilibrium was done on DPX-V9360 (the pesticide) and Soil TLC was done on
DPX-V9360 (the pesticide) and its major degradates (Pyridine Sulfonamide and
Pyrimidine Amine).
However, because of the extensive comparative work done on the soils
used for this study, we know that a very tight regression between Soil TLC Rf (x)
and Ln Kab (y) can be generated. This regression forms from a set of data with a
Tshebyshev's distribution and can predict Kab accurately from Soil TLC Rf.
Examples of these linear regressions are provided (Figure 1 to 4). The equations
used to predict K from Soil TLC Rf are as follows:
K = e**[Rf*(-4.82)+1.98] for Woodstown Sandy Loam (r = -0.95)
K = e**[Rf*(-5.17)+2.12] for Cecil Sandy Loam (r = -0.94)
K = e**[Rf(-6.40)+3.07] for Flanagan Silt Loam (r = -0.89)
K = e**[Rf(-5.28)+2.66] for Keyport Silt Loam (r = -0.68)
K = e**[Rf(-5.61)+2.57] for catholic case (r = -0.89)
For those compounds that we have both Adsorption and Soil TLC data,
these equations predict Kab-values that are in close agreement with tne observed
Kab-values (see Tables I to IV). Thus, Du Pont feels that the Kab-values generated
in this manner serve the Agency's purpose and an adsorption/desorption study
with the metabolites is therefore not necessary.
if
-------
SOIL-TLC MOBILITY t) VERSUS LN OF FREUNDLICF DSORPTION (LN K)
FOR VARIOUS DU PONT AGRICULTURAL CHEMICALS, AND SELECTED DEGRADATES
THEREOF ON CECIL SANDY LOAM
. "
i
Rf
-------
SOIL-TLC MOBILITY (R VERSUS LN OF FREUNDLICH A ORPTION CONSTANT (K)
FOR VARIOUS DU PONT AGRICULTURAL CHEMICALS, AND ^ELECTED DEGRADATES
THEREOF OF WOODSTOWN SANDY LOAM
i ' ¦, ^
i
o
Rf
-------
SOIL-TLC MOBILITY (Rf /ERSUS LN FREUNDLICH ADSOF ION CONSTANT (LN K)
FOR VARIOUS DU PONT AGRICULTURAL CHEMICALS, AND SELECTED DEGRADATES
THEREOF ON FLANAGAN SILT LOAM
J
Qj *f
-------
SOIL-TLC NOBILITY (Rf) £RSUS LN OF FREUNDLICH ADf PTION CONSTANT (LN K)
FOR VARIOUS DU PONT AGRICULTURAL CHEMICALS, AND SELECTED DEGRADATES
THEREOF ON KEYPORT SILT LOAM
i
i
-------
Kab-Valu«« calculated troa Soil TLr f-Valu«a on Woodatown Sandy Loaa
compound
Rf
Ln K
• croc
Ln K
Tab
Liait
lowar Halt pradictad upper Halt obaarvad
K K K K
DPX-V9360 0.60 -0.9120 0.144 0.643968 0.210985 0.401720 0.764883
Pyridine Sulfonaaide 0.87 -2.2134 0.211 0.943592 0.042554 0.109328 0.280886
Pyriaidine Aaine 0.22 0.9196 0.179 0.800488 1.126496 2.508287 5.585020
Terbacll 0.64 -1.1048 0.150 0.670800 0.169382 0.331277 0.647912
Dlucon 0.15 1.2570 0.200 0.894400 1.437061 3.514861 8.596886
0.16
0.39
4.00
In k • *f•(-4.82)+l.98; Tab ¦ 4.472*error;
11 ¦ •••(Ln K - Tab); ul ¦ •••(Ln K + Tab);
K - •••(Ln K)
ib
-------
Kab-valuaa calculated tcom Soil TLC Rf-Valuaa on Cacll Sandy Loaa
It
Ln K
• trot
Tt.
lowar Halt
pradlctad
uppar .alt
obsarvad
La K
Limit
K
K
K
K
DPX-V9360
0.610
-1.03370
0.1200
0.536640
0.207974
0.355688
0.608316
0.28
Fyrldlaa Sultonaalda
0.740
-1.705(0
0.1530
0.684216
0.091628
0.181627
0.360024
Fyrlaldlaa Aaina
0.170
1.24110
0.1050
0.469560
2.163095
3.459417
5.532612
Tarbacil
0.450
-0.20650
0.0918
0.410530
0.539545
0.813426
1.226334
0.71
Oluron
0.093
1.63919
0.1210
0.541112
2.998398
5.150996
8.848978
6.70
Lb k • Kt*(-5.17)+2.
12; Tab
¦ 4.472*«rror;
11 • •••(to K - Tab); ul « «**(Ln K + Tab);
K • «**
-------
Kab-Valuaa calculated froa Soil T~ ' Rf-Valuai on Flanagan Silt Loaa
II Ln K arror Tab lowar Halt pradlctad uppar lli.< obaarvad
Ln K Limit K K K K
DPX-V9360 0.400 0.5100 a.223 0.997256 0.614310 1.665291 4.514326
Pyridina SulConaalda 0.650 -1.0900 0.391 1.748552 0.058510 0.336216 1.931993
Pyriaidina Aaina 0.011 2.9996 0.26S 1.185080 6.136129 20.077504 65.672462
Tarbacil 0.380 0.6380 0.213 0.952536 0.730128 1.892692 4.906378
Diuron 0.073 2.6028 0.228 1.019616 4.870439 13.501469 37.427884
1.73
1.30
17.00
Ln k - Rf*(-6.401+3.07; Tab - 4.472*attot;
11 - a *•(Ln K - Tab); ul - a**(Ln K + Tab);
K - a * *(Ln K)
su
-------
Kab-Valuoa calculated froa Soil ' Rf-Valuea on Kayport Silt Loaa
If Ln K accoc Tab lower Halt predicted uppac Halt obaervad
Ln K Lialt K K K k
DPX-V9360 0.410 0.4952 0.260 1.162720 0.512979 1.640826 5.248313
Pyridine Sulfonaalde 0.710 -1.0*88 0.497 2.222514 0.036466 0.336620 3.107393
Pyrlaldlne Amino 0.070 2.2904 0.201 0.930176 3.197066 9.178111 25.042541
Terbacil 0.370 0.7064 0.234 1.046448 0.711736 2.026682 5.771015
Diuron 0.075 2.2640 0.206 0.921232 3.829629 9.621498 24.172896
0.61
1.20
20.00
Ln k a If* (-5.28)4-2.66; Tab - 4.472*error;
11 - •••(Ln I-- Tab I; ul - •••(Ln K + Tab);
* - •••(Ln X)
-------
Terrestrial Field Dissipation of rPvrimidine-2-^Cl DPX-V936Q and
rPvridine-2-^ClDPX-V9360 in Newark. DE; Greenville. Mississippi;
and Rochelle. IL
Author: T.M. Priester
MRID Number of Original Study: 41082624
Background
rIhe terrestrial field dissipation study was originally reviewed by EFGWB
on 2/22/90. One of the major concerns at that time was that radioactivity
losses (39-62% for the Pyridine-labeled material; 46-55% for the Pyrimidine-
labeled material) were high. Ihe study author claimed that "these losses
presumably result frcra extensive degradation of the pyridine and pyrimidine
rings to 002 and other volatile degradates".
In the registrant's response (reviewed on 5/30/90) the author recognized
that that statement may have, been excessively bold, but that sane mineralization
still occurs. However, no data has been provided that such is the case.
Another concern has been the lack of irrigation during the studies in situations
where rainfall may have been belcw average. Additional information on 30-year
rainfall average and comparison with rainfall during the one-year period of the
study.
On 5/30/90 concluded that the available terrestrial field dissipation study
did not fulfill data requirements and that the study is to be considered to
provide supplemental information only.
EFGWB response to registrant's submission dated 6/30/90
EFGWB is certainly well aware of the registrant's work in developing sensitive
techniques for nicosulfuron and other sulfonylurea herbicides. Of particular
interest have the following: a) the use of supercritical fluid extraction
coupled with supercritical fluid chromatography and b) the interfacing of
microcolumn liquid chromatography to a magnetic mass spectrometer.
Although the registrant may be right in stating that "the purpose of this
[terrestrial field dissipation] study is to determine the fate of the compound
under actual field conditions", the registrant also recognizes that the
"irrigation-14002-carix>nate/bicarbonate-metabolite questions focus in on
ground-water contamination potential concerns". Ihe registrant should keep in
mind that it is fran terrestrial field dissipation data that ground-water
potential concerns can be more clearly defined. If data from terrestrial field
dissipation studies do indicate the potential for leaching to ground-water, then
ground-water monitoring studies (small-scale prospective) may be then required.
Even though the registrant has stated that no irrigation is practiced in the
areas where ACCENT is to be applied, future uses of ACCENT may involve areas
where irrigation is practiced.
With respect to the "^C02/bicarbonate/cartonate" issue, what the Agency is
requesting is that the registrant demonstrate that mineralization does occur
under field conditions.
4.1
3^7
-------
Therefore, EFGWB still considers that a new study is warranted. It is required
that "worst-case" precipitation conditions in most vulnerable soils within the
soils for the intended use be addressed in the study. Mineralization should also
be demonstrated.
EFGWB believes that, if at an early stage it is demonstrated that nicosulfuron
and its degradates/metabolites do not leach under worst-case precipitation
conditions/most vulnerable soils, then the need for more costly groundwater
monitoring studies (small-scale prospective or small-scale retrospective)
may be avoided in the future.
4.2
-------
-14-
RESPONSE TO EPA ENVIRONMENTAL FATE REVIEW OF
TERRESTRIAL FIELD SOIL DISSIPATION OF
[PYRIMIDENE-2-14C-DPX-V9360 AND [PYRIDINE-2-14C-DPX-V9360
IN NEWARK, DELAWARE; GREENVILLE, MISSISSIPPI;
AND ROCHELLE, IL (AMR343-87; EPA MRJD NO. 4092422)
Author: T. M. Priester
MRID of Original Studv: 41082624
EPA'S REVIEW
Conclusions
The study was considered to provide supplemental information only
(the study does not fulfill data requirements).
Because no irrigation was done in the course of the studies (to
supplement precipitation, as indicated in the SEP December 1989) and because it
has not been demonstrated that mineralization may be an important
degradation/dissipation mechanism in the field, EFGWB is requesting that
another study (two different sites) be conducted and submitted to the Agency.
The Registrant should pay careful attention to the recommendations
given in the December 1989 SEP, particularly sampling regime, reporting of data,
depth of cylinders. Provisions should be made to trap any 14C02 that may evolve
during the course of the study (at least two cylinders, one for each radiolabel)
and/or to identify any 14C carbonates/bicarbonates that may have formed as the
result of mineralization.
It will be highly appreciated if the Registrant presents summary
meteorological data in a consistent and clear manner for each of the sites, which
will facilitate the review process (for example, in a tabulated form report the 30- or
40-year mean precipitation per each month with actual precipitation per month;
same for temperatures). Please also include clear diagrams of test plot and all
the required information regarding the test sites.
REGISTRAR
¦t
The Reviewer references the December 1989 SEP twice in the
conclusions above. It should be noted that this study was begun in Jui
-------
-15-
[z(mean,stdev) = <1] and all fall within 1.96 standard deviations of the mean
[z(mean.stdev) = <1.96].
Although rainfall may have been below historical averages at times
during the course of this study, it is important to note the following:
• Typical agricultural practices in the Illinois and Mississippi regions
do not include irrigation.
• Statistically, the data in Appendix I indicates that if the Z-score is less
than 1.96, the hypothetical population (precipitation for 1987 and 1988)
does not fall significantly outside the 30-year mean.
CONCERNING TRAPPING "CQj
The Reviewer stated that provisions should be made for trapping 14CC>2.
Although this information might be helpful, it is not practical for cylinder
studies. If one were to trap 14CC>2, presumably by some device covering the top of
the cylinder, one would eliminate any environmental effects: irrigation;
photolysis effects; air temperature effects. One would have a sort of "closed
system" which defeats the purpose of a field study.
CONCERNING 14C-CARBONATES/BICARBONATES
Although data on carbonate/bicarbonate formation may be interesting,
Du Pont feels that such information, in and of itself, has little environmental
significance. Certainly, should these compounds form, even in significant
concentrations, there can be no toxicological problem. Du Pont feels that the
underlying concern about carbonates/bicarbonates and 14C02 is really one of
ground water contamination potential.
The Reviewer cited the 14C-distribution data as a function of depth in
Tables I-IV and noted migration into lower depths. It should be noted that
Tables I-IV represent results at only one site (Newark, Del.) and that Tables I and
II represent data from cylinders treated at 10 oz/acre, ten times the proposed
maximum application rate. Even at this exaggerated application rate, from
14-20 inches in depth, total 14C concentrations were either not detected
(<0.005 ppm), 0.01 ppm, or 0.02 ppm between 67 and 79 weeks post-application.
When applied at the proposed maximum use rate, these concentrations were less
than or equal to 0.001 ppm. In Rochelle, 111., total 14C concentrations were less
than 0.0005 ppm at depths of 14-46 inches between 65 and 76 weeks. Furthermore,
14C did not significantly migrate into the 9-14 inch segment at the Newark site
(1 oz/acre application) or Rochelle, 111., (1 oz/acre application rate) kite from
17 weeks through the end of the study, within experimental error (Tables V-VT).
The Reviewer also cited migration of pyridine- and pyrimidine-labeled
moieties into the soil. As stated in Du Pont's response to the concerns in the
2/22/90 Review, the low concentrations of the major metabolites Pyridine
-------
-16-
Sulfonamide and Pyrimidine Amine, their low toxicity, and their lack of
herbicidal, nematicidal, fungicidal or insecticidal activity would indicate
insignificant potential for ground water contamination.
CONCERNING TEST PLOTS AND TEST RITES
This information is provided in Appendix II.
-------
-17-
SUMMARY OF REGISTRANTS RESPONSES TO CONCERNS
ABOUT THE TERRESTRIAL FIELD SOIL DISSIPATION STUDY
The Reviewer concludes that another study at two sites is warranted.
Du Pont feels strongly that a new study would not contribute significant new data
on the environmental impact of DPX-V9360.
The irrigation-14C02-carbonate/bicarbonate-metabolite mobility
questions focus in on ground water contamination potential concerns. Regarding
irrigation/lack of average rainfall during the course of the study, the mean
rainfall statistically did not deviate from 30-year norms. The purpose of this study
is to determine the fate of the compound under actual use conditions. Since
irrigation is not a typical agricultural practice in those regions, irrigation of those
fields would not mimic what is normally done, thus violating the intent of the
study. Concerning 14C02 trapping, this could not be done without eliminating
climatological effects as described earlier. As to metabolite concentrations as a
function of soil depth and time, considering that their concentrations are low, the
low toxicity of the major metabolites and the inherent variability of field studies,
Du Pont strongly feels that a new study would result in the generation of the same
metabolites at concentrations that would not be statistically significant from the
original study. Thus, Du Pont feels that the present study answers the questions
posed in the guidelines. In fact, Du Pont feels that it has shown good faith by
supplying the Agency with data generated using radiolabeled material, a more
sensitive technique, which would not be obtained had this study used unlabeled
material. Had this study been done by this less sensitive technique, CO2 and
mineralization would not have been issues and metabolites would not have been
detected, considering the low levels of metabolites found using 14C-DPX-V9360.
Du Pont respectfully asks the Agency to bear this in mind.
-------
-20-
apprndxx j
METEOROLOGICAL DATA
-------
i 13C
19(0
19(1
1962
19(3
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
• v. )
• v. )
15—JUN-90 5:11 JPag» 1
PRECIPITATION (INCHES) SUMMARIES AT WILMINGTON, DELAWARE
(NEAREST NOAH STATION TO NEWARK, DELAWARE)
January
February March
April
May
jun«
July
-0
-0
86*000
3 .690000
1.710000
840000
3 .740000
5.190000
510000
3.260000
4.300000
050000
2.090000
4.240000
130000
3.370000
2.200000
380000
2.170000
3.200000
820000
4 .900000
0.810000
670000
1.900000
5.450000
290000
1.520000
4.750000
680000
1.760000
1.710000
000000
2.130000
3.610000
220000
6.290000
2.290000
500000
5.430000
2.400000
810000
3.420000
4.020000
920000
1.730000
4.560000
230000
2.950000
4.630000
210000
1.700000
2.250000
180000
1.090000
4.550000
410000
1.770000
5.590000
610000
7.020000
2.610000
440000
0.830000
6.220000
520000
3.230000
1.260000
750000
2.710000
2.870000
980000
3 .550000
6.840000
250000
4.270000
5.400000
560000
2.050000
2.030000
210000
2.770000
1.190000
350000
1.520000
1.160000
460000
4.140000
1.820000
480000
2.750000
3.690000
910667
2.991667
3.411333
871020
2.236187
2.800856
694409
1.495389
1.673576
921069
-0.984137
-1.349406
265973
0.767916
-0.955041
2.930000
4.880000
3.500000
1.120000
5.970000
1.760000
3.100000
2.690000
1.570000
1.580000
5.560000
2.150000
4.470000
6.570000
3.080000
3.030000
1.400000
3.910000
2.160000
4.030000
4.550000
3.540000
5.410000
6 .800000
4.240000
0.350000
2.770000
2.630000
2.590000
2.760000
3.370000
2.655317
1.629514
-0.454123
-0.478670
120000
450000
610000
230000
220000
,410000
350000
790000
780000
210000
940000
510000
850000
560000
960000
5.650000
5.050000
0.960000
6.940000
3.100000
2.400000
5.050000
3.720000
7.380000
5.030000
5.520000
1.690000
3.150000
4.950000
6.570000
3.771667
3.616470
1.901702
-0.326900
0.619620
1.370000
3.100000
3.050000
3.260000
1.020000
1.620000
0.700000
3.010000
2.810000
3.620000
6.160000
2.500000
7.490000
5.190000
3.970000
6.160000
2.140000
4.410000
3 .000000
4.010000
4 .230000
4 .500000
4.700000
3 .940000
.540000
.370000
.050000
.310000
.210000
5.430000
3.462333
2.950294
1.717642
-0.670881
-1.893487
6 .180000
4.840000
1.780000
1.650000
3.700000
.840000
.090000
.450000
.830000
.480000
.030000
.650000
.070000
.820000
1.490000
5.530000
4.330000
1.380000
5.530000
760000
490000
520000
700000
330000
530000
6 .910000
3 . 990000
4.090000
8.290000
12 .630000
4.297000
5.787904
2.405806
-0.086042
1.(59735
August
S«pt«ab«r
Octob* r
5.080000
9.530000
2.850000
3.750000
2.330000
1.880000
1.870000
3 .650000
1.510000
4.030000
3.500000
0.210000
1.830000
2.770000
1.290000
2.040000
2.410000
1.590000
1.420000
8.530000
5 .170000
11.160000
1.160OOO
2.050000
1.170000
1.500000
3.280000
2.340000
6.840000
1.470000
2.310000
0.820000
2.640000
8.380000
6.990000
6.410000
0.250000
1.640000
4.200000
2.440000
3.020000
2.220000
5.110000
5.650000
1.770000
2.550000
6.190000
3.060000
2a. 0 0 0 0 0 0
2.110000
6.120000
4*. 820000
1.290000
3.590000
5.970000
2.180000
1.480000
6.110000
5.940000
3.450000
1.090000
1.440000
3.990000
3.380000
3.820000
2.840000
4.680000
2.300000
1.970000
1.290000
3 .440000
3.870000
1.560000
2.020000
3.310000
2.280000
4 .560000
1.840000
2.880000
2 .750000
4.040000
4 .210000
4.850000
2.310000
3.030000
2.180000
1.940000
1.970000
4.310000
3.920000
3.366667
3.(5733 3
2 .875667
5 .440630
5.102524
2.050729
2.332516
2.258877
1.432037
0.361555
0 .527991
-0 .395009
-0.144336
-0.654012
-0.653382
to
-------
DSP 3SR X 13C
PRECIPITATION (INCHES) SUMMARIES AT WILMINGTON, DELAWARE
(DEAREST NOAH STATION TO NEWARK, DELAWARE)
Yaar Nov*ab«r Dacaabar Annual
1960
2 .040000
2 .670000
46
030000
1961
2.410000
3 .030000
40
440000
1962
4.(70000
2 .500000
34
410000
1963
6.(70000
1.(50000
32
100000
1964
1.620000
4.700000
32
(20000
196S
0.940000
1.540000
24
900000
1966
1.750000
3.(10000
39
450000
1967
2.0(0000
5.240000
44
650000
1968
3.920000
2.330000
31
750000
1969
1.790000
7.900000
40
3(0000
1970
4.090000
3.020000
3(
310000
1971
5.520000
1.330000
52
240000
1972
7 .(40000
5.990000
48
130000
1973
0.670000
7.310000
47
050000
1974
1.190000
4.1(0000
39
610000
1975
2.630000
3.000000
49
610000
1976
0.490000
1 .790000
33
590000
1977
6.140000
5.(10000
40
130000
197S
2 .690000
5.560000
51
2(0000
1979
2.230000
1.440000
52
310000
19(0
2.410000
0.(30000
33
920000
19(1
0.670000
3 .950000
35
2(0000
19(2
3.(70000
2.390000
41
070000
19(3
5.4(0000
6.(00000
54
700000
19(4
1 .630000
1.940000
41
720000
19(5
4.460000
0.(00000
33
730000
19(6
6.420000
6.110000
42
(70000
19(7
3.500000
1.900000
32
9(0000
19((
5.290000
0.900000
37
(00000
19(9
1.990000
1 .270000
49
770000
Httn
3.250000
3.396333
40
767667
Varianc*
4.14(069
4.373(45
56
539501
St. D«v.
2.0366(1
2.091374
7
519275
1(19(7,*td«v. )
0.122749
-0.715479
-1
035694
s <198(,atdav.)
1.001630
-1.193633
-0
394675
U)
15-JUB-90 5:11 Pag* 2
to
to
-------
Group 30 Yea Summaries and Standard Dev tions for
Precipitation (Inches) at Wilmington, uelaware
(Nearest NOAH Station to Newark, Delaware
Error bars overlap if the difference between two means is not significant at
the 5 percent level. If the error bars for the group mean overlap the dashed
line, the group mean is not significantly different from the grand average.
Significant differences are determined using Bonferroni simultaneous
iMconfidence intervals for all comparisons.
-------
i 13C
1960
1961
1962
1963
1964
1965
1966
1967
196 8
1969
1970
1971
1972
1973
1974
1975
1976
1977
1976
1979
I9 60
1981
1982
1983
1984
1985
1986
1987
1988
1989
• v. )
• v. )
15—JUN-90 5:32 P»g« 1
TEMPERATURE (DEGRE..^ F) SUMMARIES AT WILMINGTON, DELAWAk
(NEAREST HOHA STATION TO NEWARK, DELAWARE)
January February March April May Jun* July August S«pt*ab«r October
35.100000
25.600000
31.200000
.28.400000
33.200000
29.000000
29.300000
36 . 200000
28.000000
30.800000
24.500000
27.400000
36.100000
35.600000
36.200000
37.500000
27.700000
20.800000
27.200000
31.400000
32.400000
25.400000
24.200000
35.200000
24.800000
27.500000
32.200000
31.400000
27.400000
36.000000
30.256667
19.746678
4.443723
0.257292
-0.642854
35.900000
34.700000
31.300000
27.500000
31.600000
33.600000
31.900000
29 .400000
30.500000
33.600000
33.500000
35.500000
32.600000
35.500000
33.100000
35.900000
41.200000
33.300000
22.800000
22.100000
29.900000
37.900000
34.200000
35.300000
38.600000
37.400000
31.600000
31.900000
34.800000
34.300000
33.046667
16.488092
4.060553
-0.282392
0.431797
32.600000
42.600000
41.200000
44.100000
43.100000
38.400000
42.900000
39.400000
44.600000
39.600000
38.900000
40.700000
41.300000
49.400000
44.300000
40.600000
46.500000
47.200000
37.600000
45.400000
40.000000
40.200000
41.800000
45.900000
35.600000
47.100000
43.600000
44 .600000
44.200000
42.100000
42.183333
13.195230
3.632524
0.665286
0.555170
56.400000
48.900000
52 .200000
52.600000
49.400000
49.300000
47.900000
51.500000
54.100000
55.100000
51.900000
51.100000
50.000000
57.700000
55.500000
47.500000
54.700000
54.400000
50.300000
50.600000
54.600000
55.000000
50.600000
53.100000
50.700000
58.000000
52.400000
52.300000
50.800000
51.600000
52.340000
7.490069
2.736799
-0.014616
-0.562701
60.600000
58.900000
64.200000
60.300000
64.300000
66.000000
60.300000
55.400000
59.600000
64 .200000
64 .800000
60.400000
62.500000
61.400000
62.400000
65.200000
59.900000
63.900000
60.300000
63.800000
64.900000
62.500000
65.000000
61.000000
61.200000
65.900000
65.700000
63.100000
62.900000
62.100000
62.423333
6.139782
2.477858
0.273085
0.192370
71.000000
70.500000
71.500000
70.800000
72.100000
70.200000
72.500000
71.200000
71.400000
73.400000
71.700000
73.400000
68.600000
75.800000
70.400000
71.500000
72.400000
68.900000
70.600000
67.900000
68.900000
72.300000
69.900000
71.800000
73 .800000
70.600000
12.100000
73.500000
71.600000
74.300000
71.486667
3.101885
1.761217
1.143149
0.064349
73 .100000
75.600000
72 .600000
76.300000
75.800000
74 .500000
77.200000
74 .400000
76.700000
75.700000
76.600000
75.900000
76.900000
78.100000
76.700000
75.700000
74.200000
76.400000
73.400000
75.300000
77.700000
77 .100000
77.300000
77.600000
75.200000
76.600000
77.100000
79.100000
79.400000
75.900000
76.136667
2.589299
1.609130
1.841575
2.028011
74 .900000
74.000000
72.900000
71.700000
71.500000
73.300000
74.800000
72.800000
77.100000
75.400000
76.700000
74 .000000
75.500000
78 .100000
76.100000
76.300000
73.700000
75^ 400000
77.100000
75.000000
78.200000
73.500000
72.000000
77.000000
75.200000
74.400000
72.500000
74 .300000
77.300000
74 .400000
74.836667
3.492747
1.868889
-0.287158
1.318073
68.000000
72.500000
63.600000
63.700000
67.200000
69 .400000
65.300000
65.100000
69.700000
68. 200000
72.100000
71.100000
69.600000
70.400000
66.500000
65.400000
66 .900000
69.300000
66. 700000
68.200000
71.300000
66.900000
67.400000
69 .300000
63.700000
69.100000
67.500000
68.300000
65.800000
68 .400000
67.886667
5.741885
2.396223
0.172494
-0.870815
55.300000
56.900000
56.700000
58 .400000
52 .800000
53.600000
53.600000
54.700000
59.000000
56.000000
60 . 400000
62.900000
53.500000
59.900000
53 .200000
60.000000
52.500000
53.400000
54.100000
55.000000
54.800000
53.000000
56 .000000
56.900000
61.200000
58.300000
57.200000
51.700000
51.000000
57.600000
55.986667
9.205333
3.034029
-1.412863
-1.643579
-------
DET 35R s 13C
TEMPERATURE (DEGREES r) SUMMARIES AT WILMINGTON, DELorfARE
(NEAREST BOHA STATION TO NEWARK, DELAWARE)
Taar
Novaabar Dacaabar
Annual
1960
1961
1962
1963
1964
1965
1966
1967
1961
1969
1970
1971
1972
1973
1974
1975
1976
1977
1971
1979
1910
1911
1912
1913
1914
1915
1916
1917
1911
1919
Ma an
Varianca
St. Dav.
s(1917,atdav.)
s(1911,atdav.)
45.900000
46.700000
42,500000
41.000000
47.600000
45.000000
46.600000
40.700000
47.000000
44.600000
41.500000
45.700000
45.200000
49.100000
46.600000
51.000000
40.400000
46.600000
46.100000
49.600000
43.300000
45.300000
47.500000
46.700000
43.300000
51.000000
44.100000
47.400000
46.700000
44.600000
46.133333
6.527126
2.554124
0.495794
0.221103
21.400000
33.200000
30.300000
21.400000
37.300000
37.700000
34.100000
36.100000
34.200000
32.700000
35.900000
42.100000
41.600000
37.700000
31.900000
36.200000
31.000000
33.400000
37.200000
31.100000
33.100000
34.200000
41.300000
32.100000
42.100000
32.900000
37.300000
31.600000
35.100000
25.000000
35.253333
17.561092
4 .191431
0.791454
-0.036513
53.100000
53.300000
52.500000
52.500000
53.100000
53.300000
53.100000
52.300000
54.300000
54.100000
54.600000
55.000000
54.400000
57.200000
55.000000
55.200000
53.400000
53.600000
52.000000
53.500000
54.100000
53.600000
53.900000
55.200000
53.100000
55.700000
54.400000
54.700000
53.900000
53.900000
53.910000
1.113034
1.017674
0.661963
-0.073551
15—JON—90 5:32 P«ga 2
to
cn
*
-------
ILP 35R X 13C
15-JUN-90 5:11 Pag« 1
PRECIPITATION v_.
-------
ILP JSR ( 1JC
PRECIPITATION (INCHES) SUMMARIES AT ROCKFORD, ILLIR
(NEAREST NOAH STATION TO ROCHELLE, ILLINOIS)
Xa«r Dacaabar
Annual
1960
1961
1962
1963
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
1975
1976
1977
197S
1979
1980
1981
1982
1983
1984
1915
1916
1987
1918
1989
Ha«n
V»ri
St.
K19
t( 19
640000
970000
500000
790000
910000
030000
160000
550000
310000
200000
370000
040000
370000
320000
630000
1.950000
0.370000
870000
760000
240000
710000
770000
650000
310000
290000
300000
660000
030000
750000
510000
998667
421129
192111
703980
-0.208594
44.510000
40.390000
27.700000
30.710000
39.240000
49.450000
32.900000
39.050000
39.990000
43.290000
38.760000
27.800000
55.150000
56.480000
34 .310000
30.780000
23.250000
38.010000
35.350000
36.100000
34 .170000
34.900000
43.590000
34 .450000
33 .840000
40 .110000
34.330000
40.870000
24.770000
28.220000
37.082333
61.731867
7.856963
0.482078
-1.567060
-C"
to
-J
-------
Group eans and Standard Deviati/ *>
for Precipitation (Inches) at Rockford, Illinois
(Nearest NOAH Station to Rochelle Illinois)
Error bars overlap if the difference between two means is not significant at
the 5 percent level. If the error bars for the group mean overlap the dashed
line, the group mean is not significantly different from the grand average.
Significant differences are determined using Bonferroni simultaneous
confidence intervals for all comparisons.
r
-------
ILT 3SR X 13C
15-JUN-90 5:32 Paga 1
TEMPERATURE (DEGREES F) SUMMARIES AT ROCKFORD, ILLINOIS
(NEAREST NOHA STATION TO ROCHELLE, ILLINOIS)
Vaar
January
February March
April
May
Juna
July
August
Saptaabar Octobar
1960
1961
1962
1963 '
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
19 75
1976
1977
1978
1979
1980
1981
1982
198 3
1984
1985
1986
1987
1988
1989
Ma an
Varlanca
St. Dav.
>(1987,stdav.)
>( 1988 ,stdav. )
24.100000
19 .500000
14.500000
9.300000
26.700000
19.500000
13.400000
24.600000
21.200000
17.900000
12.500000
14.800000
17.000000
26.300000
21.200000
23.500000
16.500000
5.900000
11.300000
7.700000
19.300000
21.400000
8.900000
25.300000
16.000000
12.900000
20.900000
23.100000
16.000000
29.900000
18.036667
37.592057
6.131236
0.825826
22 .300000
31.500000
21.400000
16.300000
25.700000
22.100000
23.900000
16.900000
21.200000
28.300000
22.400000
25.000000
20.500000
26.900000
24.000000
23.100000
30.800000
23.500000
12.300000
12.900000
17.100000
25.900000
19.600000
29.500000
31.900000
19.300000
22.500000
32.400000
19.700000
16.100000
22.833333
28.905747
5.376407
1.779379
-0.332179 -0.582793
22.500000
37.400000
31.400000
38 .400000
32.300000
25.900000
37.600000
35.900000
40.400000
31.000000
33.100000
32.300000
32 .400000
43.000000
36.200000
29.200000
38 .500000
42 .200000
29.300000
31.700000
30.100000
37.300000
32.800000
36.800000
28.600000
39.300000
40.000000
39.500000
36.200000
34.000000
34.510000
23.823690
4.880952
1.022342
0.346244
50.800000
43.000000
47.700000
50.700000
48.500000
45.600000
44 .100000
47.800000
49.780000
48.400000
48.500000
48.000000
44.500000
47.600000
50.800000
42.500000
49 .700000
55.100000
47.500000
42.900000
36.400000
51.400000
44 .000000
43.900000
46.900000
54.100000
52.200000
51.100000
47.700000
46.900000
47.602667
15.044213
3.878687
0.901680
0.025094
57.200000
56.300000
64.400000
57.600000
62.600000
61.900000
51 .400000
52.900000
56 .100000
59.400000
60.400000
57.000000
62 .300000
55.800000
56 .600000
62.400000
55.300000
68.200000
58.900000
58.700000
60 .600000
56.300000
65.000000
54.700000
55.400000
62.200000
61.400000
63.900000
62.500000
58 .200000
59.186667
15.122575
3 . 8 88 7 7 5
1 .212035
0.852025
67.100000
68.900000
69.000000
71.100000
68 .600000
67.900000
69.200000
68.400000
69.600000
63.600000
68.500000
74.200000
65.800000
70.600000
66 .100000
70.500000
68 .800000
67.400000
69 .100000
68.400000
66.700000
70.000000
64 .800000
70.500000
70.900000
46 .400000
68.500000
72.500000
71.300000
68 .200000
68.753333
5.041195
2.245261
1.668700
1.134241
71 .400000
72 .300000
6 9.500000
73.800000
72 .800000
72 .900000
75.400000
69.600000
70.900000
72.600000
73 . 600000
70.700000
71.100000
73.500000
75.300000
73.100000
73 .400000
75.400000
72.300000
71.500000
75.400000
72.500000
74 .600000
78.000000
70.800000
71.900000
75.300000
76.300000
76 .600000
74.100000
73.220000
4.478207
2.116177
1.4 554 55
1.597220
72.700000
72.400000
71.700000
69.800000
66.900000
69.700000
69.700000
66.100000
71.400000
71.700000
71.400000
70.700000
71.300000
73 .200000
70.300000
73 .100000
69.400000
68.600000
71.700000
70.000000
73.700000
71.200000
69.000000
77.200000
72.800000
6 8 .300000
67.100000
70.800000
76 .400000
70.100000
70.946667
6.101885
2.470199
-0.059374
2.207649
66.400000
65.100000
60.500000
64.000000
62.700000
62.200000
62.500000
62.400000
63.200000
63.100000
63.600000
68 .100000
63.300000
64.300000
60.100000
58.000000
60.000000
63.400000
68.100000
63.000000
64.200000
62.500000
61.800000
63.300000
61.600000
64 .000000
64.900000
62.800000
65.300000
60 .500000
63.16333
4.89343
2.21211
-0.16424
0.96589
51.800000
53.000000
54 .600000
62 .000000
48.100000
52.400000
51 .400000
51 .300000
53 .200000
49.800000
52.800000
59.200000
48 .900000
46.500000
52.000000
53.100000
45.100000
49.100000
49.900000
50.800000
47.300000
48.800000
53.600000
51.500000
54 .600000
51.800000
51.700000
44 . 700000
45.200000
51.800000
51.200000
14 .073103
3.751414
-1.732680
-1.599397
to
CD
-C
-------
ILT 35R X 13C
TEMPERATURE (DEGREES F) SUMMARIES AT ROCKFORD, ILLINOIS
(NEAREST NOHA STATION TO ROCHELLE, ILLINOIS)
Yaar
Rovaabar
Dacaabar
Annual
1960
196
196
196
196
196
1966
196
196
196
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
Maan
Varianca
St. Oav.
t (1967,atdav.)
t( 1988 ,a tdav.)
39.800000
38.300000
38.800000
43.200000
41 .100000
39 .600000
39.000000
34 .400000
37.800000
36.700000
37.700000
39.100000
36 .600000
39.900000
38.000000
42 .200000
28.100000
36.500000
37.900000
35.900000
38.200000
39.400000
38.100000
40.100000
37.100000
35.300000
33.400000
41.600000
39.600000
35.400000
37.960000
8.481793
2.912352
1.249849
0.563119
21.900000
22.800000
22.100000
13.200000
22.900000
32.300000
24.800000
27.700000
25.300000
24.200000
26 . 600000
31.500000
21.600000
24.100000
26.700000
27.000000
15.000000
19.900000
29.900000
29 .000000
25.400000
22.900000
33.100000
12.700000
29.200000
14.600000
28.100000
29.400000
26.300000
14.200000
24.146667
32.092230
5.665000
0.927331
0.380112
47.300000
48.400000
47.100000
47.400000
48.300000
47.700000
46.900000
46.500000
48.400000
47.200000
47.600000
49 .200000
46.300000
50.200000
48.100000
48 .100000
45.900000
47.900000
45.900000
45.200000
47.000000
48.300000
47.100000
48.600000
48.000000
46.700000
48.800000
50.700000
48.600000
46 .700000
47.670000
1.480793
1.216878
2.489978
0.764251
-«C
-JU1J-90 5:32 P»g« 2
co
o
-------
13C
1960
1961
1962
1963
1964
1965
1966
1967
1966
1969
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
lav .)
lav. )
15-JUN-90 5:11 Peg* 1
PRECIPITATION (INCHES) SUMMARIES AT JACKSON, MISSISSIPPI
(DEAREST NOAH STATION TO GREENVILLE, MISSISSIPPI)
January
February March
April
May
Juna
July
August
Saptaabar Octobar
.290000
.070000
.060000
.330000
.210000
,860000
.230000
.860000
.560000
.860000
.090000
.020000
.940000
.590000
11.000000
4 . 570000
3 .640000
6.180000
5.320000
14.100000
7.530000
. 410000
.480000
.170000
.640000
.050000
.750000
.660000
.250000
.380000
.836667
,537775
.921947
-0.060462
-0.885254
560000
590000
750000
820000
320000
900000
840000
560000
540000
020000
630000
680000
090000
230000
720000
180000
430000
260000
360000
350000
190000
630000
220000
550000
640000
550000
530000
10.280000
890000
520000
494333
481474
341255
471182
-0.258124
5.220000
8.900000
3.610000
1.930000
10.920000
6.660000
.050000
.320000
.830000
.900000
.400000
.680000
.570000
.120000
.500000
. 860000
15.130000
6 .410000
3.370000
4.670000
13 .570000
6.190000
.130000
.000000
.840000
.130000
.340000
.470000
.460000
.350000
.717667
.551136
.090491
-0.080138
0.563772
1 .460000
2.000000
8.550000
2.440000
11.880000
.250000
.760000
.660000
.200000
.590000
. 750000
.860000
.440000
.440000
.740000
.070000
.080000
.980000
.540000
14.380000
14.330000
1.260000
6.590000
15.530000
.960000
.310000
.750000
.210000
.370000
.130000
.517000
17.592946
4.194395
-1.026847
-0.035047
3.950000
2.180000
1.090000
10.230000
2.100000
2.390000
2.960000
7. 490000
8 .550000
3 .960000
1.220000
0.840000
2.590000
1.360000
1.490000
2.910000
2 .340000
1 .700000
1.470000
3.290000
6.280000
1.650000
0 .880000
0 .000000
2.180000
2.450000
5.170000
6.430000
3 .670000
7 .830000
1.360000
2.540000
1.920000
3.610000
9.610000
0.840000
7.960000
1.450000
3.140000
6.650000
4.870000
1 .630000
10.820000
3.760000
4 .050000
3.490000
1.800000
2.780000
7.540000
1.020000
2.240000
3.900000
1.950000
0.280000
1.520000
1.290000
5.460000
3 .350000
0.560000
2 .260000
2.430000
2.540000
2.340000
5.640000
6.480000
9.130000
8.050000
3.400000
6.280000
2.640000
6 .000000
0.090000
4.520000
2.010000
3.310000
2.840000
5.040000
2 .080000
5.960000
0.320000
1.990000
2.380000
4.440000
2.720000
3.010000
3.390000
1.540000
6.170000
5.060000
1.740000
6.530000
7.440000
9 .810000
6.210000
2 .680000
8.250000
8.010000
2.800000
4.960000
5.260000
3.780000
3.520000
0.740000
2.170000
6 .220000
t. 450000
3.930000
2 .790000
10.480000
1.030000
3.650000
1.800000
2.900000
1.210000
5.520000
4.380000
13.250000
7.440000
5 .930000
1.760000
6.600000
1.740000
2.910000
1.4S0000
3 .250000
3.470000
6.640000
3.660000
6.510000
2.810000
3.510000
5.120000
0.770000
6.270000
9.290000
4 .970000
1.050000
6.730000
9.410000
2.930000
1.700000
3.700000
2.700000
1.520000
5.610000
3.180000
3.070000
4.560000
0.930000
7.680000
0.860000
„1.740000
4 .430000
7.060000
3 .940000
7.170000
10.000000
3 .720000
4.780000
2.030000
2.630000
5.100000
4.980000
6.170000
1.040000
4 .030000
1.500000
0 .270000
0.290000
0.100000
2.730000
3.020000
2.280000
6.140000
7.920000
8.170000
4.470000
1.740000
5.400000
0 .230000
5.022667
3 .133000
4 .455667
4 .112667
3 .414333
3.242333
10.434406
4.426739
8.377087
4.495131
4.127619
7 .672867
3 .230233
2.103982
2.894320
2.120172
2.031654
2.769994
-0.013209
1.443454
-1.180128
-0 .038991
-0.942254
-1.073047
-1.465116
-1.441552
-0.596225
-0.515367
-0.558330
1 .046091
co
>
-------
MSP 35R X 13C
PRECIPITATION (INCHES) SUMMARIES AT JACKSON, MISSISSIPPI
(NEAREST NOAH STATION TO GREENVILLE, MISSISSIPPI)
Vaar
Novaabar
Dacaabar
Addad
Annual
1960
1961
1962
1963
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
Maan
Varianca
St. Dav.
1(1987,itdavi)
1(1988,atdav.)
.450000
.330000
.880000
.550000
.440000
.790000
.660000
0.930000
5.550000
.870000
.700000
.540000
.520000
.150000
.120000
.340000
.340000
.980000
.300000
.790000
.110000
.970000
7.430000
8.110000
6.480000
0.510000
9.400000
4.200000
5.660000
6.860000
4.732000
6.677292
2.584046
-0.205879
0.359127
1.
2.
2.
3.
6.
4.
4.
3.
9.
3.
8 .
4.
1.
4.210000
11.160000
3.250000
4.390000
6.950000
3.650000
4.830000
8.680000
5.580000
7.220000
4.230000
9.820000
9.670000
6.710000
7.220000
4.290000
3 .440000
3.470000
8.370000
4.180000
0 .910000
4.900000
17.700000
6.950000
.170000
> 610000
> 980000
> 500000
> 800000
200000
1834667
10.726274
3.275099
-0.712854
-0.315919
45.130000
65.070000
40.490000
35.030000
71.450000
43 .990000
58.070000
45.710000
45.190000
38.900000
48.360000
62.060000
50.030000
55.050000
60.210000
70.230000
57.390000
53.580000
47.330000
92.750000
63.060000
46.610000
75.630000
73.270000
49.760000
47.360000
50.010000
47.310000
43 .990000
52.370000
54.513000
162.280856
12.738950
-0.565431
-0 .826049
-C
15-JUN-90 5:11 Piga 2
CO
to
-------
MST 35R x 13C
15-JUN-90 5:32 Pag* 1
TEMPERATURE (DEGREES F) SUMMARIES AT JACKSON, MISSISSIPPI
(NEAREST NOHA STATION TO GREENVILLE, MISSISSIPPI)
7aa r
Janua ry
February March
April
May
Juna
July
August
Saptaabar Octobar
1960
1961
1962
1963
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
Maan
Varianca
St. Dav.
s (1987,stdav.)
S (1988,stdav.)
45.500000
40.600000
42.700000
40.500000
45.300000
48.500000
40.800000
46.400000
43.400000
48 .000000
41 .200000
4 8.700000
51.500000
44.300000
55.100000
51.800000
44.300000
35.300000
36.500000
38.300000
47.400000
41.800000
47.200000
43.700000
39.900000
38.000000
45.300000
44.400000
41.700000
52.500000
44.353333
23.174989
4.814041
0.009694
-0.551166
43.500000
52 .900000
57.200000
43.500000
44.400000
47.200000
46.300000
44.200000
39.900000
4 8.100000
46.300000
59 .100000
51.200000
46.900000
50.100000
52.900000
56.700000
49.300000
39.600000
46.000000
45.500000
48.700000
48 .800000
47.400000
49.700000
44.800000
52.600000
51.300000
47.500000
48 .200000
48.326667
21.159264
4.599920
0.646388
-0.179713
47.500000
60.500000
52.500000
61.500000
56.300000
50.200000
54.700000
60.500000
53 .900000
49 .300000
54.000000
52.400000
58.800000
62.100000
62.400000
56.800000
60.000000
59.700000
52 .500000
57.400000
54.300000
55.100000
62.100000
53 .900000
56.500000
61.300000
57.000000
55.500000
55.800000
58.800000
56.443333
16.012885
4 .001610
-0.235738
-0.160769
66.100000
61.000000
62.600000
68.100000
68 .100000
67.800000
64.800000
69.300000
65.900000
65.100000
68 .100000
62.200000
66.400000
62 .500000
63 .100000
63.500000
65.400000
66.300000
65.400000
64.800000
61.600000
71.000000
63.800000
60.100000
63.900000
65.200000
64.100000
62.200000
64.600000
63.200000
64 .873333
6.509609
2.551394
-1.047793
-0 .107131
69 .900000
70.400000
75.300000
74 .400000
74.700000
74.000000
70.900000
69 .600000
71.200000
72.300000
72 . 900000
6 7.9 00000
71.900000
70.900000
73 .800000
74.100000
67.900000
75.500000
71.900000
70.300000
72.800000
69.900000
74.700000
70.700000
71.000000
72.200000
72.900000
75.900000
70.800000
72.000000
72.090000
4.598172
2.144335
1.776775
-0.601585
80 .000000
75.500000
78.500000
80.700000
80.700000
77.700000
76 . 100000
78.300000
79 .600000
80.300000
79.100000
79 .900000
79 .600000
81.300000
74.800000
78.300000
76.700000
81.700000
80.000000
76.700000
80.700000
81.800000
79.500000
76.600000
78 .900000
28 .800000
80.4 00000
79 .000000
79.800000
78.400000
78 .980000
3.280276
1 . 81115 3
0.011043
0.452750
83.900000
79.100000
84.300000
81.100000
81.300000
81.500000
82.400000
77.300000
80.700000
83 .500000
80.800000
81.000000
80.400000
83.700000
80.400000
81.200000
80.800000
82.700000
83.400000
80.200000
85.800000
83.600000
82.400000
82.900000
80.600000
80.500000
83.200000
82.000000
82.500000
80.600000
81.793333
3 .028230
1 .740181
0.118762
0.406088
80.500000
79.100000
83.200000
81.900000
81.700000
79 .500000
78 .300000
77.000000
80.900000
79.600000
81.600000
80.500000
82 .800000
80.100000
79.300000
80.600000
80.200000
8 2.000000
82.000000
79.700000
84.700000
82.600000
81.800000
82.700000
79.900000
80.300000
80.500000
82.900000
82 .600000
80.800000
80.976667
2.671506
1.634474
1.176729
0.993184
76.200000
75.900000
77.200000
75.000000
77.100000
76 . 300000
74.400000
69.800000
73 . 300000
75.200000
80.100000
78.300000
81.500000
77.600000
72.000000
72.300000
74.800000
78 .400000
78 .400000
73.800000
82.400000
73.200000
74.100000
74 .100000
74.600000
74.000000
79 .800000
75.200000
77.900000
74.100000
75.900000
8.244828
2.871381
-0 .243785
0.696529
66.700000
64.100000
68.300000
70.000000
62.500000
62.200000
61.100000
61.400000
66 . 200000
66.200000
64.700000
70.100000
68.000000
68 .600000
64.100000
66.200000
59 .900000
62 .000000
63.600000
64 .100000
61.400000
65.400000
65.100000
65.800000
71.200000
68.000000
66.100000
59 .900000
61.600000
63.900000
64 .946667
9 .446023
3.073438
-1 .642026
-1.088900
CO
co
ur
-------
MST 35R x 13C
TEMPERATURE (DEGREES r) SUMMARIES AT JACKSON, MISSISSIPPI
(NEAREST NOHA STATION TO GREENVILLE, MISSISSIPPI)
Taar
Novtabtr
Dacaabar
Annual
1960
1961
1962
1963
1964
1965
1966
1967
1968
1369
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
Maan
Varlanca
St. Dav.
1(1987,atdav.)
1(1988,atdav.)
55.800000
55.500000
.53.600000
56.400000
59.400000
60.100000
56.200000
52.700000
52.700000
52.400000
52.800000
54.700000
52.000000
61.700000
55.600000
56.600000
47.200000
57.100000
60.300000
50.900000
63.200000
58 .600000
56.400000
55.100000
53 .600000
62.500000
60.100000
56.600000
59.300000
57.100000
56.206667
13.414437
3.662572
0.107393
0.844579
44 .500000
48 .200000
46 .500000
38 .600000
50.500000
49.400000
46 .500000
50.100000
45.700000
47 .100000
52.700000
57.900000
50.100000
49.300000
50.400000
47.400000
45.000000
47.500000
48.800000
46.200000
46.200000
46.600000
52.900000
41.800000
58.300000
42.700000
46.600000
52.100000
49.300000
40.400000
47.976667
18.943230
4.352382
0.947374
0.304048
63.300000
68.600000
65.500000
64.300000
65.200000
64.600000
62.700000
63.100000
62.800000
63.900000
64.500000
65.200000
66.200000
65.700000
65.100000
65.100000
63.200000
64.800000
63.600000
62.400000
64 .700000
64.900000
65.700000
62.900000
64.800000
64.000000
65.700000
64.800000
64.500000
64.200000
64.533333
1.617471
1.271798
0.209677
-0.026210
~*n»/
15—JUN-90 5:32 Pag* 2
k
i
*
-------
i
;Group 30 Year Means and Standard L /iations for Precipitation inches) at Jackson, Mississippi
(Nearest NOAH Station to Greenville, Mississippi)
-------
-36-
APPENDIX II
TEST PLOT DIAGRAMS
-------
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-------
Confined Accumulation Study of —C-DPX-V9360 on Rotational Crops
Author: R.F. Dietrich
MRID Number of Original Study: 41082625
Background:
This study was original reviewed en 2/22/90 and the registrant's responses
to EFGWB were reviewed on 5/30/90. The Dietary Exposure Branch (DEB) also
requested a comment from EFGWB regarding the rotational crop intervals
recommended in the proposed label. EFGWB completed the latter review on
6/1/90.
On the 5/30/90 review, EFGWB considered that the registrant's response
regarding the apparent increase in total radiolabeled residues when the
pyridine-labeled parent was used, the information on "Compounds A, B, and C",
concerns about the pesticides used to control disease/insects were all
satisfactorily addressed. The only remaining concern at that point was the
absence of the Pyriniidine Amine degradate in soil extracts.
With respect to rotational crop intervals, EFGWB expressed its concern about
the proposed rotational cop intervals based on potential phytotoxic residues
still remaining at the proposed intervals. Based on residues-in-crop concerns,
EFGWB r^mnertied a minimum rotational crop interval of 10 months, provided
that DEB and the Toxicology Branch II did not have any further concerns for
the residue levels (parent and/or degradates) reported for 10-month rotation
interval. At the time EFGWB canpleted its review, DEB did not have data to
determine whether the level of "Pyridine Sulfonamide" (which were always higher
than those of parent) should also be regulated (that is, if tolerances for
this degradate should also be established). The needed data was received
at a later date and evaluated in DEB's review of 6/13/90.
The data submitted to DEB (received on 5/1/90) also contained a revised label.
Because considerable differences were noted between the proposed rotational crop
intervals in the original label and those in the amended label, DEB forwarded
their review to EFGWB for further evaluation.
Review of registrant's response dated 6/15/90
EFGWB agrees with the registrant that Pyrimidine Amine and its degradates are
likely to be strongly bound to soil and that this is supported frcm the
results of the aerobic soil metabolism study and the values predicted
vising regression methods (see this review).
Therefore, EFGWB considers that this study is nw acceptable and can be used to
fulfill data requirements for Accumulation in Confined Rotational Crops (165-1).
Rotational Crop Tntorvalg
The DEB review dated 6/13/90 considered that all of the previous deficiencies
had been resolved. DEB conclusions were that the only residue to be regulated
is parent DPX-V9360 (that is, the degradate Pyridine Sulfonamide is not to be
-------
regulated), provided the Toxicology Branch II did not have any particular
concerns about the levels of both parent and/or the Pyridine Sulfonamide
degradate.
EPGWB has also consulted the Toxicology Branch and was informed that the
Pyridine Sulfonamide did not present any evident toxicological concern.
However, EPGWB still believes that the minimum rotational crop interval
should be set at 10 months.
EPGWB comments on rotational crop intervals reannroended in the amended
label
Unlike the earlier label in which recranmended recrop intervals are grouped
by states and in which recrop intervals as long as 20 months and/or field
bioassays are recamnendad, the amended label appears as follcws:
Minimum Time in Months Before
Crop Planting the Rotational Crop
Corn (Field) Anytime
Soybeans 9
Wheat 9*
Corn (Pop) 9
Corn (Sweet) 9
Barley 9*
Dry beans 9
Oats 9*
Alfalfa 12
~Rotational crop interval may be reduced to 3 months in soils with pH less
than 7.0
The minimum time interval for sorghum, cotton and all rotational crops is 9-
months on soils with a pH less than or equal to 6.5 or 18 months for all soils
with pH greater than 6.5.
In the earlier label the registrant raoraended against using ACCEr/r in soils
with pH above 7.5 because extended pesticide persistence above that pH could
potentially result in crop injury. Hie way the new label raoranends recrop
intervals for sorghum, cotton and others ("18 months for soils with pH greater
than 6.5) appears to inply that soils with pH greater than 7.5 are no longer
of concern. Therefore, the registrant must revise its reuuiuiendation and add
an upper pH-limit (for example, "pH greater than 6.5 but lower than 7.5" or
"for soil-pH ranging from 6.5 to 7.5").
Although in the new label the registrant indicates hew the variation of residues
remaining in the soil after corn harvest are dependent on the soil pH,
application rate, organic matter content of the soil, climatic and weather factors,
and time elapsed since application, the new label (unlike the old one) does
not make specific remnnendations for geographical areas.
-------
In the registrant's response of 6/15/90, it is also indicated that the
registrant has apparently determined recrop intervals from field studies,
since confined studies tend to accentuate phytotoxicity. From a recropping
data summary provided by the registrant (with no specific data), the
registrant indicate that crop injury was estimated visually and that no
subsequent crop injury was observed when winter wheat was planted from
89 to 203 days after application of DPX-V9360 at rates up and including
4.0 oz a.i./A.
5.3
.55"
-------
RESIDUES IN ROTATION CROPS
Croo/CroD Fraction
Soil acrina time
Total radioactive
residues, Dom-
Pvr.i±C Pvrim.i^C
Parent
Comoosition.
Pvr. Sulf.
PPm
N-Des.
Oth<
Soybean forage/hay
30-day
0.221
0.060
0.002
0.080
0.025
A
120-day
0.191
0.056
0.002
0.071
0.022
B
10 months
0. 075
0.014
nd
0.021
0.002
C
Soybean seed
30-day
0.226
0.043
nd
0.023
0.003
D
120-day
0.157
0.033
nd
0.015
0.002
E
10 months
0.069
0.012
nd
" 0.013
nd
F
Lettuce
120-day
0.050
0.015
0.002
0.019
—
G
10 months
0.011
0.003
nd
0.004
-
H
Wheat forage/hay
120-day
0.112
0.033
ne
ne
—
I
10 months
0.043
0.009
0.001
0.008
—
J
Wheat straw/chaff
120-day
0.246
0.099
0.004
0.056
—
K
10 months
0.185
0.056
0.007
0.038
—
L
Wheat grain
120-day
0.025
0.020
0.005
0.003
—
M
10 months
0.014
0.006
0.005
0.003
—
N
Radish greens
10 months
0. 027
0.004
0.001
0.010
-
0
Radish root
10 months
0.006
0.003
na
na
_
P
aCalculated as DPX-V93 60 equivalents; nd= not detected; ne= not extracted; na= not analyzed
k"polars", "Bound radioactivity", "Other species resolved by chromatography", "Compounds A, B, and C"
(which contain the pyridine ring) and seen in D, E, and F. For details see Tables VII, VII, IX and X
Compounds A, B and C have been identified. Seedling stunting for wheat crop planted at 120-days.
------- |