PEER REVIEW DRAFT - DO NOT CITE OR QUOTE xvEPA United States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention Draft Risk Evaluation for Perchloroethylene Systematic Review Supplemental File: Data Quality Evaluation of Physical-Chemical Properties Studies CASRN: 127-18-4 CI CI CI CI October 2019 ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table of Contents Table 1. Physical Form Study Summary for Perchloroethylene 3 Table 2. Melting Point Study Summary for Perchloroethylene 4 Table 3. Boiling Point Study Summary for Perchloroethylene 5 Table 4. Density Study Summary for Perchloroethylene 6 Table 5. Vapor Pressure Study Summary for Perchloroethylene 7 Table 6. Vapor Density Study Summary for Perchloroethylene 8 Table 7. Water Solubility Study Summary for Perchloroethylene 9 Table 8. Octanol-water Partition Coefficient Study Summary for Perchloroethylene 10 Table 9. Henry's Law Constant Study Summary for Perchloroethylene 11 Table 10. Flash Point Study Summary for Perchloroethylene 12 Table 11. Viscosity Study Summary for Perchloroethylene 13 Table 12. Refractive Index Study Summary for Perchloroethylene 14 Table 13. Dielectric Constant Study Summary for Perchloroethylene 15 ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 1. Physical Form Study Summary for Perchloroethylene Study Reference: Lewis, RJ. Sr. (2007). Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. Hoboken, NJ. HERO ID: 3378175 Note: Lewis (2007) reported the physical form of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The information was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The information agrees with various sources. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Not rated Rating of this factor is not applicable to this kind of information. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 2. Melting Point Study Summary for Perchloroethylene Study Reference: Lide, DR. (2007). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. In DR Lide (Ed.), (88th ed.). Boca Raton, FL: CRC Press. HERO ID: 3827361 Note: Lide (2007) reported multi confidence of the melting pie physical-chemical properties and only the )oint is evaluated here. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 3. Boiling Point Study Summary for Perchloroethylene Study Reference: Lide, DR. (2007). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. In DR Lide (Ed.), (88th ed.). Boca Raton, FL: CRC Press. HERO ID: 3827361 Note: Lide (2007) reported multiple physical-chemical properties and only the confidence of the boiling point is evaluated here. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 4. Density Study Summary for Perchloroethylene Study Reference: Lide, DR. (2007). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. In DR Lide (Ed.), (88th ed.). Boca Raton, FL: CRC Press. HERO ID: 3827361 Note: Lide (2007) reported multiple physical-chemical properties and only the confidence of the density is evaluated here. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 5. Vapor Pressure Study Summary for Perchloroethylene Study Reference: Riddick, J.A., W.B. Bunger, Sakano T.K. (1985). Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons. HERO ID: 3827366 Note: Riddick et al. (1985) reported the vapor pressure of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection in which results have been selected by experts based on their quality and availability. References to the original sources are included. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 6. Vapor Density Study Summary for Perchloroethylene Study Reference: Browning (1965). Toxicity and metabolism of industrial solvents. Amsterdam, The Netherlands: Elsevier Publishing Co. httD://dx.doi.org/10.1002/9780470114735. HERO ID: 29334 Note: Browning (1965) reported the vapor density of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. Medium The value was reported in a known data collection that has been available to the public and was compiled using data from reliable sources. Original sources are not reported; therefore, this metric has been rated medium. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level Medium ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 7. Water Solubility Study Summary for Perchloroethylene Study Reference: Horvath AL. (1982) Halogenated hydrocarbons: solubility-miscibility with water. New York, NY: Marcel Dekker, Inc. HERO ID: 194749 Note: Horvath (1982) reported the water solubility of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Original sources are also referenced. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High Methodology for producing the information is designed to answer a specific question, and the methodology's objective is clear. Reliability/Analytic Method The information or data reported is from a reliable method. High Data are obtained by accepted standard analytic methods. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 8. Octanol-water Partition Coefficient Study Summary for Perchloroethylene Study Reference: Hansch, C., Leo, A., D. Hoekman. (1995). Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society. HERO ID: 51424 Note: Hansch et al. (1995) reported the octanol-water partition-coefficient of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection that has been compiled by experts and includes references to the original sources. The original source for this value is a peer-reviewed journal. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 9. Henry's Law Constant Study Summary for Perchloroethylene Study Reference: Gossett, J. M. (1987). Measurement of Henry's Law constants for CI and C2 chlorinated hydrocarbons. Environmental Science and Technology 21(2): 202-208. HERO ID: 732584 Note: Gossett (1987) reported the Henry's Law constant for perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Original sources are also referenced. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High Methodology for producing the information is designed to answer a specific question, and the methodology's objective is clear. Reliability/Analytic Method The information or data reported is from a reliable method. High Data are obtained by accepted standard analytic methods. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 10. Flash Point Study Summary for Perchloroethylene Study Reference: NFPA. (2010). Fire protection guide to hazardous materials (14th ed.). Quincy, MA. HERO ID: 2991057 Note: NFPA reported the flash point data for perchloroethylene. The confidence of the data has been evaluated using the 13th edition (2002; HERO ID 5882513) since the 14th edition was unavailable, and the data value was unchanged. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment The information or data The data was measured for the substance of interest. Representativeness reflects the data and chemical substance type. High Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. Medium The value was reported in a known data collection that has been available to the public and was compiled using data from reliable sources. Original sources are not reported (although they are available upon request) and peer-review has not been performed, therefore this metric has been rated medium. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. High The value was obtained by an accepted analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 11. Viscosity Study Summary for Perchloroethylene Study Reference: Hickman, JC. (2000). Tetrachloroethylene. In Kirk-Othmer Encyclopedia of Chemical Technology. New York, NY: John Wiley & Sons. httD://dx.doi.org/10.1002/0471238961.2005201808090311.a01. HERO ID: 3827362 Note: Hickman (2000) reported the viscosity of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The value was measured for the subject chemical substance. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The value was similar to measured values for chemicals of similar structure. Evaluation/Review The information or data reported has reliable review. High The value was from a peer- reviewed source. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 12. Refractive Index Study Summary for Perchloroethylene Study Reference: Lide, DR. (2007). CRC handbook of chemistry and physics: A ready- reference book of chemical and physical data. In DR Lide (Ed.), (88th ed.). Boca Raton, FL: CRC Press. HERO ID: 3827361 Note: Lide (2007) reported multiple physical-chemical properties and only the confidence of the refractive index is evaluated here. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Table 13. Dielectric Constant Study Summary for Perchloroethylene Study Reference: Dean, JA. (1985). Lange's Handbook of Chemistry. McGraw-Hill Book Co. New York, NY. HERO ID: 46951 Note: Dean (1985) reported the dielectric constant of perchloroethylene. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance type. High The data was measured for the substance of interest. Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/Review The information or data reported has reliable review. High The information is from a recognized data collection where data are peer-reviewed by experts in the field and are broadly available to the public for review and use. Reliability/Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/Analytic Method The information or data reported is from a reliable method. Low Data source does not provide information regarding the analytical method. Overall Quality Level High ------- |