The PBT Profiler has undergone rigorous scientific peer
review. The results of the peer review are available
through the Federal Docket Management System
(FDMS) on-line at www.requlations.gov by searching All
Documents for "PBT Profiler".
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~ The PBT Profiler ~
EPA's Sustainable Futures Initiative
http://www.epa.gov/oppt/sf uses the Persistent (P),
Bioaccumulative (B), and Toxic (T) Chemical (PBT)
Profiler, an on-line screening tool that estimates
persistence, bioaccumulation, and chronic fish toxicity.
The opening screen of the PBT Profiler, available at
www.pbtprofiler.net, is shown on the right. Developed
jointly by the chemical industry, NGOs and the Agency,
the PBT Profiler is one of the most widely used chemical
screening tools in the world.
Using tha PBT
Profiler
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Developed by the Environmental Science Center under cataract to the Office of Pollution Prevention and Toxics. U.S.
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Opening screen of the PBT Profiler
Results
Orange or red highlights indicate that the EPA criteria have been exceeded.
Black-and-white version
Bio accumulation Toxicity
| (2) Detailed Results | 95.95.4 Phenol. 2.4.5-tiicldoro- 1(1) Summary Results |
PBT Profiler Estimate = PBT
Half-Life Percent in
P2 Considerations and more information
Sample Summary Results Page
The PBT Profiler model's on-line web site explains
the intended purpose and use of the model, and
information to encourage proper use of the model.
Chemicals can be entered in the model using CAS
Registry Number, SMILES Notation, or by drawing
the structure with the integrated drawing program.
Chemicals that are not appropriate for running in
the PBT Profiler are clearly described, and flags are
incorporated so that if a user enters an
inappropriate chemical (such as a metal, a mixture,
or a chemical with a molecular weight over 1,000)
that chemical is clearly identified to the user as
inappropriate for screening with the PBT Profiler.
Highly praised by industry and environmentalists,
OPPT has seen a dramatic increase in the use of
the PBT Profiler screening tool. The PBT Profiler
was released in September 2002, and since public
have been performed by chemical manufacturers and
The PBT Profiler estimates physical / chemical and
environmental fate properties (Persistence: WS, Kow,
VP, Henry's Law constant, OH* and 03 reaction rates,
MP, MW, and ultimate biodegradation); Bioaccumulation:
Fish BCF; and Toxicity: fish chronic value (ChV) from
ECOSAR. It uses a level 3 multimedia model to estimate
distribution in water, soil, sediment, and air and compares
P, B, and T estimates to EPA criteria and formats results
in color-coded output (Summary Results). As shown on
the sample results page to the left, quantitative estimates
of P, B, and T are provided (Detailed Results - within the
dashed line) and information relevant to Pollution
Prevention (P2) assessments is available by clicking on
the P2 Considerations and more Information link.
Number of Chemicals Evaluated with the PBT Profiler
Since its Public Release in Sept. 2002
Source: PBT Profiler online model www.pbtprofiler.net "What's New" page, click on
Details to get the number of chemicals profiled by date.
release nearly 145,000 chemical-specific PBT analyses
other stakeholders.
For more information contact:
Bill Waugh, 202-564-7657, waugh.bill@epa.gov: Kelly Mayo, 202-564-7662, mavo.kellv@epa.gov.
Maggie Johnson, 202-564-8924, iohnson.maggie@epa.gov
Jan. 2008
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