UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
T-
I WASHINGTON, D.C. 20460
OCT 2 8 1994
MEMORANDUM
SUBJECT:
FROM:
TO:
THROUGH:
OFFICE OF
PREVENTION, PESTICIDES AND
TOXIC SUBSTANCES
Fenamiphos: Revised Dietary Exposure Analysis in
Support of the Reregistration Eligibility Document.
Jennifer M. Wintersteen
Dietary Risk Evaluation
Science Analysis Branch/
Jane S. Smith, Chemical Manager
Reregistration Section
Chemical Coordination Branch
(7509C)
(7505C)
Elizabeth A. Doyle, Section Head ^ (5( . C\^yy J?Q_
Dietary Risk Evaluation Section '
SAB/Health Effects Division A (/
Action Requested ₯$(j
Provide a revised DRES analysis to estimate the chronic and
acute dietary exposure and risk from fenamiphos food uses that are
either published or being supported through reregistration.
Originally CBRS recommended for new tolerances on poultry and eggs
for reregistration. Metabolism data on poultry has been reviewed
and there appears to be no need for tolerances on these commodities
(C. Olinger personal communication, 10/20/94)
Discussion
Tox-icological Endpoint
The chronic analysis used a Reference Dose (RfD) of 0.0001
mg/kg body weight/day, based on a no observed effect level (NOEL)
of 0.01 mg/kg bwt/day and an uncertainty factor of 100. The-NOEL is
based on results of a two-year feeding study in beagle dogs which
demonstrated plasma cholinesterase inhibition at the next highest
dose.
The HED Carcinogenicity Peer Review Committee classified
fenamiphos as a Group E carcinogen (G. Ghali memo, 11/23/93). The
same memo notes that there was no evidence to suggest that the
chemical was a developmental or reproductive toxicant.
A Toxicology memo indicates that acute cholinesterase
inhibition was of concern for fenamiphos (M. Van Gemert memo,
1/14/94). In order to assess the acute dietary risk for fenamiphos
a NOEL of 0.5 mg/kg bwt/day for maternal toxicity from the rat
developmental study was supplied in the same memo as appropriate
for acute dietary assessment.
/CXy Recycled/Recyclable
7~\ C\ Printed with Soy/Canola Ink on paper that
XHw contains at leaat 50% reeydad flter
-------
Residue Information
Food uses in this analysis include all published tolerancJes
listed in the Tolerance Index System (TIS) and 40 CFR §180.349 and
§180.2950. All published tolerances are being supported in
reregistration except soybeans and cocoa beans. New values for
anticipated residues (ARs) have been prepared by Chemistry Branch-
Reregistration Support (CBRS). ARs are listed in Table 1 of a C.
Olinger memo, Reregistration of Fenamiphos, 12/20/93. Tolerances
exist for feed items such as apple pomace, pineapple bran and
raisin waste which result in secondary residues in meat of cattle,
goats, horse, poultry, hogs and sheep as well as milk and eggs.
In the Reregistration Eligibility Document (C.- Olinger memo,
1/26/94) CBRS recommends for a tolerance reassessment for certain
commodities. CBRS recommends for a crop group tolerance for the
citrus fruits group at 0.5 ppm and the revocation of established
tolerances for grapefruit, lemons, limes, oranges and tangerines of
0.6 ppm. In the analysis the raw agricultural commodities (RACs)
kumquat, citron and tangelo were added at' 0.5 ppm and the other
citrus RAC tolerances were unchanged at 0.6 ppm. CBRS recommends
for the revocation of established tolerances on cocoa beans and
soybeans since there are no registered uses of fenamiphos on these
crops. These RACs were left in the analysis since they are still
published tolerances.
CBRS also recommended the tolerance for peanuts should be
increased from 0.02 to 1.0 ppm for reregistration. The DRES
analysis reflects the higher proposed value. Finally, a food
additive tolerance was proposed by the Registrant on pineapple
juice at 0.5 ppm. This tolerance has been included in the analysis.
No pending tolerances have been included in the revised file.
Percent Crop Treated
Percent crop treated (PCT) information used in the chronic
exposure analysis was supplied by the Biological and Iconomic
Analysis Division (BEAD) in an E. Maurer memo dated 5/20/93. In the
BEAD memo no known usage was indicated for some commodities and
were assumed to be 100% crop treated in the analysis. Bananas and
pineapple were included in the list of commodities with no known
usage from BEAD. These commodities are often imported and in order
to estimate the amount of crop imported the USDA Pesticide Data
Program Report of January-June 1992 was used and estimated 100%
crop imported for bananas and 3 6% for pineapple. The DRES analysis
assumed that all imports were treated, and thus used 100% and 36%
as the percent-crop-treated values for bananas and pineapples
respectively.
The DRES chronic analysis represents an overestimation of
exposure and risk in that it considers risk not only from the
recommended uses through reregistration, but also from uses which
have been recommended for by the Chemistry and Toxicology Branches
of the Health Effects Division but have not been published in the
Federal Register. However, to the extent that it uses Anticipated
Residues and percent-crop-treated information,, it is not "worst-
case". A summary of the residue information used in this analysis
is attached as Table 1.
-------
Results
Chronic Exposure
The DRES chronic analysis used tolerance level residues to
calculate the Theoretical Maximum Residue Contribution (TMRC) for
the overall U.S. population and 22 population subgroups.
Refinements in residue and percent crop treated information
were considered in calculating the Anticipated Residue Contribution
(ARC) for those same population groups. The ARC is considered the
more accurate estimate of dietary exposure. These exposure
estimates were then compared to the RfD for fenamiphos to get
estimates of chronic dietary risk. Summaries of the TMRCs, ARCs,
and their representations as percentages of the RfD are attached as
Tables 2, 3a and 3b.
The ARC for the U.S. population from the published uses of
fenamiphos being recommended through reregistration is 1.0 x 10"5
mg/kg bwt/day, which represents 10% of the RfD. The proposed
tolerances being recommended through reregistration contribute 1.0
x 10"* mg/kg bwt/day, or 1% of the RfD. If all new commodities
proposed in reregistration were published the resulting ARC would
be 1.1 x 10"5 mg/kg bwt/day, representing 11% of the RfD for the
general U.S. population.
The ARC from published uses for the most highly exposed DRES
subgroup, non-nursing infants less than one, is 4.0 x 10s mg/kg
bwt/day (40% of the RfD) . The ARC for new tolerances recommended in
reregistration contributes less than 1,0 x 10"6 mg/kg bwt/day (0.02%
of the RfD). If all new tolerances were published for fenamiphos,
the resulting ARC for non-nursing infants less than one would be
4.0 x 10'5 mg/kg bwt/day, representing 40% of the RfD.
The U.S. population and all the DRES subgroups have ARCs for
chronic dietary risk below the RfD when all published and new
commodities are considered. No pending commodities were considered
in this revised analysis. It appears that chronic dietary risk is
minimal for this chemical for published and recommended new
tolerances.
Acute Exposure
The DRES detailed acute exposure analysis evaluates individual
food consumption as reported by respondents in the USDA 77-78
Nationwide Food Consumption Survey (NFCS) and estimates the
distribution of single day exposures through the diet for the U.S.
population and certain subgroups. The analysis assumes uniform
distribution of fenamiphos in the commodity supply. Since the
toxicological effect to which high end exposure is being compared
in this analysis is cholinesterase inhibition, all standard DRES
subgroups are of concern. The analysis includes the U.S.
population-48 states and four subgroups: Infants (<1 year),
children (1-6 years), females (13+ years) and males (13+ years).
The Margin of Exposure (MOE) is a measure of how closely the
high end exposure comes to the NOEL (the highest dose at which no
effects were observed in the laboratory test), and is calculated as
the ratio of the NOEL to the exposure (NOEL/exposure = MOE). For
-------
cholinesterase inhibition, the Agency is not generally concerned
unless the MOE is below 100.
Two revised analyses were conducted. One analysis used
published tolerances, including soybeans and cocoa beans, with
tolerance level residues. Another analysis included only published
tolerances being recommended through reregistration, that is,
soybeans and cocoa beans were not included in the analysis. The
analyses calculated the exposure of the highest exposed individual
for the U.S. population in the distribution and compared the
exposure to the NOEL of 0.5 mg/kg bwt/day from the rabbit
developmental study (M. Van Gemert memo, 1/14/94). The table below
provides the calculated MOEs for all five subgroups.
ACUTE ANALYSIS USING ALL PUBLISHED TOLERANCES AT TOLERANCE LEVEL
DRES Subgroup
95-96%ile MOE
NOEL/Exposure
99%ile MOE
NOEL/Expoaure ]
U.S. pop. -48 states
56
20 1
Infants (< 1 year)
20
7
Children (1-6 years)
25
10
Females (13+ years)
83
33
Males (13+ years)
100
33
No difference in the calculated MOEs was seen when soybeans
and cocoa beans were removed from the acute analysis; therefore,
these commodities appear not to be driving the acute analysis.
A table of distribution of exposures used in this analysis is
attached as Table 4; this table includes on it the calculation of
the MOEs for all five subgroups. This is the first time that acute
exposure has been calculated for fenamiphos using the DRES system.
The estimates of 95th or 96th percentiles are rough calculations
and should be considered estimates only. The calculated high end
MOEs are of concern for all five subgroups used in the DRES acute
program.
Attachments
cc: DRES, CBRS, Tox II, RD Team 22 (Jim stone), Caswell #453A
-------
Table 1.
ANTICIPATED RESIDUE INFORMATION FOR CASWELL NUMBER 453A
DATE: 10/26/94
PAGE: 1
1
Fenamiphos (Nemacur)
Caswell #453A
CAS No. 22224-92-6
A.I. CODE: 100601
CFR No. 180.349
185.2950
1yr feeding - dog
N0EL= 0.0100 mg/kg
0.50 ppm
LEL= 0.0300 mg/kg
1.00 ppm
ONCO: E (RfD/PR Commitee)
Plasma ChE inhibition
No evidence of oncogenic-
ity in rats or mice.
PADI UF -->100
OPP RfD= 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
WHO last reviewed 1987
HED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
FOOD C00E
FOOD
FOOD FORM
PET.#
TOLERANCE
(ppm)
ANTICIPATED
RESIDUE (ppm)
AR STATISTIC TYPE
X CROP TREATED
RES. VALUE I
IN TAS RUNj
01006AA
RASPBERRIES
10
RAU-FRESH OR NFS
2E2605
P
0.100000
0.009000
FIELD TRIAL
9.00
0.000810
01006AA
RASPBERRIES
15
RAW-FRESH OR CANNED
2E2605
P
0.100000
0.009000
FIELD TRIAL
9.00
0.000810
01006AA
RASPBERRIES
31
COOKED-FRESH OR CANNED
2E2605
P
0.100000
0.009000
FIELD TRIAL
9.00
'0.000810
01006AA
RASPBERRIES
62
COOKED-FRESH OR FROZEN-BAKED
2E2605
P
0.100000
0.009000
FIELD TRIAL
9.00
0.000810
01006AA
RASPBERRIES
70
RAW-FROZEN
2E2605
P
0.100000
0.009000
FIELD TRIAL
9.00
0.000810
01014AA
GRAPES-FRESH
10
RAU-FRESH OR NFS
2F2623
P
0.100000
0.005000
FIELD TRIAL
14.00
0.000700
01014AA
GRAPES-FRESH
21
COOKED-NFS
2F2623
P
0.100000
0.005000
FIELD TRIAL
14.00
0.000700
01014AA
GRAPES-FRESH
31
COOKED-FRESH OR CANNED
2F2623
P
0.100000
0.005000
FIELD TRIAL
14.00
0.000700
01014DA
GRAPES-RAISINS
10
RAU-FRESH OR NFS
2H5361
P
0.300000
0.005500C
FT/PROCESSING
14.00
0.000770
01014DA
GRAPES-RAISINS
21
COOKED-NFS
2H5361
P
0.300000
0.005500C
FT/PROCESSING
14.00
0.000770
01014DA
GRAPES-RAISINS
22
COOKED-FRESH-BAKED
2H5361
P
0.300000
0.005500C
FT/PROCESSING
14.00
0.000770
01014JA
GRAPES-JUICE
10
RAU-FRESH OR NFS
2F2623
P
0.100000
0.005000C
FT/PROCESSING
14.00
0.000700
01014JA
GRAPES-JUICE
15
RAU-FRESH OR CANNED
2F2623
P
0.100000
0.005000C
FT/PROCESSING
14.00
0.000700
01014JA
GRAPE'S-JUICE
21
COOKED-NFS
2F2623
P
0.100000
0.005000C
FT/PROCESSING
14.00
0.000700
01016AA
STRAWBERRIES
10
RAU-FRESH OR NFS
6E3403
P
0.600000
0.015000
MONITORING DATA
100.00
0.015000
01016AA
STRAWBERRIES
21
COOKED-NFS
6E3403
P
0.600000
0.015000
MONITORING DATA
100.00
0.015000
01016AA
STRAWBERRIES
70
RAU-FROZEN
6E3403
P
0.600000
0.015000
MONITORING DATA
100.00
0.015000
02001AA
CITRUS CITRON
22
COOKED-FRESH-BAKED
REREGIS
N
0.500000
0.500000
100.00
0.500000
02002AA
GRAPEFRUIT-UNSP
00
NOT SPECIFIED (NO CONSUMPTION)
6F1865
P
0.600000
0.011000
FIELD TRIAL
20.00
0.002200
02002AB
GRAPEFRUIT-PULP
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.011000
FIELD TRIAL
20.00
0.002200
02002AB
GRAPEFRUIT-PULP
21
COOKED-NFS
6F1865
P
0.600000
0.011000
FIELD TRIAL
20.00
0.002200
02002JA
GRAPEFRUIT-JUICE
15
RAU-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FT/PROCESSING
20.00
0.000400
02002JA
GRAPEFRUIT-JUICE
31
COOKED-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FT/PROCESSING
20.00
0.000400
02003AA
KUMQUATS
10
RAU-FRESH OR NFS
REREGIS
N
0.500000
0.500000
100.00
0.500006
02004AA
LEMONS-UNSPEC
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.011000
FIELD TRIAL
32.00
0.003520
02004AA
LEMONS-UNSPEC
22
COOKED-FRESH-BAKED
6F1865
P
0.600000
0.011000
FIELD TRIAL
32.00
0.003520
02004AB
LEMONS-PULP
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.011000
FIELD TRIAL
32.00
0.003520
02004AB
LEMONS-PULP
31
COOKED-FRESH OR CANNED
6F1865
P
0.600000
0.011000
FIELD TRIAL
32.00
0.003520
02004HA
LEMONS-PEEL
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.109000
FIELD TRIAL
32.00
0.034880
02004HA
LEMONS-PEEL
21
COOKED-NFS
6F1865
P
0.600000
0.109000
FIELD TRIAL
32.00
0.034880
02004JA
LEMONS-JUICE
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.002000C
FIELD TRIAL
32.00
0.000640
02004JA
LEMONS-JUICE
15
RAU-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FIELD TRIAL
32.00
0.000640
02004JA
LEMONS-JUICE
21
COOKED-NFS
6F1865
P
0.600000
0.002000C
FIELD TRIAL
32.00
0.000640
02004JA
LEMONS-JUICE
31
COOKED-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FIELD TRIAL
32.00
0.000640
02005AA
LIMES-UNSPEC
00
NOT SPECIFIED (NO CONSUMPTION)
6F1865
P
0.600000
0.011000
FIELD TRIAL
100.00
0.011000
02005AB
LIMES-PULP
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.011000
FIELD TRIAL
100.00
0.011000
02005HA
LIMES-PEEL
21
COOKED-NFS
6F1865
P
0.600000
0.109000
FIELD TRIAL
100.00
0.109000
02005JA
LIMES-JUICE
10
RAU-FRESH OR NFS
6F1865
P
0.600000
0.002000C
FT/PROCESSING
100.00
0.002000
02005JA
LIMES-JUICE
15
RAU-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FT/PROCESSING
100.00
0.002000
02005JA
LIMES-JUICE
31
COOKED-FRESH OR CANNED
6F1865
P
0.600000
0.002000C
FT/PROCESSING
100.00
0.002000
-------
Table 1.
ANTICIPATED RESIDUE INFORMATION FOR CASWELL NUMBER 453A
DATE: 10/26/94
PAGE: 2
a ...
Fenamiphos (Nemacur)
Caswell #453A
CAS No. 22224-92-6
A.I. CODE: 100601
CFR No. 180.349
185.2950
lyr feeding - dog
NOEL= 0,0100 rag/kg
0.50 ppm
LEL= 0.0300 mg/kg
1.00 ppm
QNCO; E (RfD/PR Commitee)
Plasma ChE inhibition
No evidence of oncogenic-
ity in rats or mice.
PAD! UF -->100
OPP RfD= 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
WHO last reviewed 1987
HID complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
FOOD CODE
FOOD
FOOD FORM
TOLERANCE ANTICIPATED
PET.# (ppn) RESIDUE
-------
Table 1.
ANTICIPATED RESIDUE INFORMATION FOR CASWELL
NUMBER 453A
DATE: 10/26/94
PAGE: 3
» CHEMICAL
STUDY TYPE
EFFECTS
REFERENCE DOSES
DATA GAPS/COMMENTS
STATUS
Fenamiphos (Nemacur)
CaswelI #453A
CAS No. 22224-92-6
A.I. CODE: 100601
CFR No. 180.349
185.2950
1yr feeding - dog
N0EL= 0.0100 mg/kg
0.50 ppm
LEL= 0.0300 mg/kg
1.00 ppm
ONCO: E (RfD/PR Commitee)
Plasma ChE inhibition
No evidence of oncogenic-
ity in rats or mice.
PADI UF -->100
OPP RfD= 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
WHO last reviewed 1987
HED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
TOLERANCE ANTICIPATED RES. VALUE USED
FOOD CODE FOOO FOOO FORM PET.# (ppm) RESIDUE (ppm) AR STATISTIC TYPE X. CROP TREATED IN TAS RUN (ppm)
06013AA
PINEAPPLE-PULP
21
COOKED-NFS
6F1864
P 0.300000
0.024000
FIELD
TRIAL
36.00
0.008640
06013AA
PINEAPPLE-PULP *
31
COOKED-FRESH OR CANNED
6F1864
P 0.300000
0.024000
FIELD
TRIAL
36.00
0.008640
06013DA
PINEAPPLE-DRIED
10
RAW-FRESH OR NFS
6F1864
P 0.300000
0.024000
36.00
b.008640
06013JA
PINEAPPLE-JUICE
10
RAW-FRESH OR NFS
6F1864
P 0.500000
0.029000C
FT/PROCESSING
36.00
0.010440
06013JA
PINEAPPLE-JUICE
15
RAW-FRESH OR CANNED
6F1864
P 0.500000
0.029000C FT/PROCESSING
36.00
0.010440
06013JA
PINEAPPLE-JUICE
21
COOKED-NFS
6F1864
P 0.500000
0.029000C FT/PROCESSING
36.00
0.010440
06013JA
PINEAPPLE-JUICE
31
COOKED-FRESH OR CANNED
6F1864
P 0.500000
0.029000C
FT/PROCESSING
36.00
0.010440
06016AA
PLANTAINS .
21
COOKED-NFS
3F1399
P 0.100000
0.007000
FIELD
TRIAL
100.00
0.007000
06016AA
PLANTAINS
23
COOKED-FRESH-BOILED
3F1399
P 0.100000
0.007000
FIELD
TRIAL
100.00
0.007000
06016AA
PLANTAINS
25
COOKED-FRESH-FRIED
3F1399
P 0.100000
0.007000
FIELD
TRIAL
100.00
0.007000
06018AA
KIWI
10
RAW-FRESH OR NFS
8E3585
P 0.100000
0.033000
FIELD
TRIAL
14.00
0.004620
07001 FA
COCOA BUTTER
21
COOKED-NFS
2E2691
P 0.020000
0.020000
100.00
0.020000
07001SA
CHOCOLATE
10
RAW-FRESH OR NFS
2E2691
P 0.020000
0.020000
100.00
0.020000
0700ISA
CHOCOLATE
21
COOKED-NFS
2E2691
P 0.020000
0.020000
100.00
0.020000
07001SA
CHOCOLATE
22
COOKED-FRESH-BAKED
2E2691
P 0.020000
0.020000
100.00
0.020000
11001AA
EGGPLANT
10
RAW-FRESH OR NFS
8E3650
P 0.100000
0.008000
FIELD
TRIAL
100.00
0.008000
11001AA
EGGPLANT
21
COOKED-NFS
8E3650
P 0.100000
0.008000
FIELD
TRIAL
100.00
0.008000
11001AA
EGGPLANT
25
COOKED-FRESH-FRIED
8E3650
P 0.100000
0.008000
FIELD
TRIAL
100.00
0.008000
11003AB
CHILI PEPPERS
00
NOT SPECIFIED (NO CONSUMPTION)
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11003AD
PEPPERS-OTHER
10
RAW-FRESH OR NFS
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11003AD
PEPPERS-OTHER
21
COOKED-NFS
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11003AD
PEPPERS-OTHER
51
COOKED-CANNED
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11004AA
PIMIENTOS
10
RAW-FRESH OR NFS
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11004AA
PIMIENTOS
21
COOKED-NFS
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
11004AA
PIMIENTOS
31
COOKED-FRESH OR CANNED
7E3559
P 0.600000
0.034000
FIELD
TRIAL
100.00
0.034000
13001AA
BEETS-TOPS
31
COOKED-FRESH OR CANNED
8E3651
P 1.000000
0.180000
FIELD
TRIAL
100.00
0.180000
13001AA
BEETS-TOPS
63
COOKED-FRESH OR FROZEN-BOILED
8E3651
P 1.000000
0.180000
FIELD
TRIAL
100.00
0.180000
13006AA
BRUSSEL SPROUTS
21
COOKED-NFS
3F1399
P 0.100000
0.017000
FIELD
TRIAL
1.00
0.000170
13006AA
BRUSSEL SPROUTS
23
COOKED-FRESH-BOILED
3F1399
P 0.100000
0.017000
FIELD
TRIAL
1.00
0.000170
13007AA
CABBAGE
10
RAW-FRESH OR NFS
3F1399
P 0.100000
0.014000
FIELD
TRIAL
1.00
0.000140
13007AA
CABBAGE
11
RAW-FRESH-PICKLED,CORNED,OR CURED.
3F1399
P 0.100000
. 0.014000
FIELD
TRIAL
1.00
0.000140
13007AA
CABBAGE
21
COOKED-NFS
3F1399
P 0.100000
0.014000
FIELD
TRIAL
1.00
0.000140
13010AA
CABBAGE-CHINESE
10
RAW-FRESH OR NFS
3F1399
P 0.100000
0.230000
FIELD
TRIAL
11.00
0.025300
13010AA
CABBAGE-CHINESE
10
RAW-FRESH OR NFS
OE3845
P 0.400000
0.230000
FIELD
TRIAL
11.00
0.025300
1301OAA
CABBAGE-CHINESE
21
COOKED-NFS '
3F1399
P 0.100000
0.230000
FIELD
TRIAL
11.00
0.025300
13010AA
CABBAGE-CHINESE
21
COOKED-NFS
OE3845
P 0.400000
0.230000
FIELD
TRIAL
11.00
0.025300
14001AA
BEETS-ROOTS
10
RAW-FRESH OR NFS
8E3651
P 1.500000
0.130000
FIELD
TRIAL
100.00
0.130000
14001AA
BEETS-ROOTS
21
COOKED-NFS
8E3651
P 1.500000
0.130000
FIELD
TRIAL
100.00
0.130000
14001AA
BEETS-ROOTS
26
COOKED- FRESH-PICKLED,CORNED,OR CURED
8E3651
P 1.500000
0.130000
FIELD
TRIAL
100.00
0.130000
14001AA
BEETS-ROOTS
31
COOKED-FRESH OR CANNED
8E3651
P 1.500000
0.130000
FIELD
TRIAL
100.00
0.130000
-------
Table 1.
ANTICIPATED RESIDUE INFORMATION FOR CASWELL NUMBER 453A
DATE: 10/26/94
PAGE: 4
» uncniVinL
Fenamiphos (Nemacur)
Caswell #453A
CAS No. 22224-92-6
A.I. CODE: 100601
CFR No. 180.j49
185.2950
1yr feeding - dog
NOEL2 0.0100 mg/kg
0.50 ppm
LEL= 0.0300 mg/kg
1;00 ppm
ONCO: E (RfD/PR Commitee)
Plasma ChE inhibition
No evidence of oncogenic-
ity in rats or mice.
PADI UF -->100
OPP RfD= 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
WHO last reviewed 1987
HED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
FOOD CODE
FOOD
FOOD FORM
PET.#
TOLERANCE
(ppm)
ANTICIPATED
RESIDUE (ppm)
AR STATISTIC TYPE
X CROP TREATED
RES. VALUE I
IN TAS RUN I
14007AA
GARLIC
10
RAW-FRESH OR NFS
2E2691
P
0.500000
0.028000
FIELD TRIAL
100.00
0.028000
14007AA
GARLIC
21
COOKED-NFS
2E2691
P
0.500000
0.028000
FIELD TRIAL
100.00
0.028000
14007AA
GARLIC
32
COOKED-FRESH OR CANNED-BAKED
2E2691
P
0.500000
0.028000
FIELD TRIAL
100.00
b.028000
15006AA
PEANUTS-WHOLE
10
RAW-FRESH OR NFS
3F1399
P
0.020000
0.042000
FIELD TRIAL
2.00
0.000840
15006AA
PEANUTS-WHOLE
10
RAW-FRESH OR NFS
REREG
N
0.980000
0.042000
2.00
0.000840
15006AA
PEANUTS-WHOLE
21
COOKED-NFS
3F1399
P
0.020000
0.042000
FIELD TRIAL
2.00
0.000840
15006AA
PEANUTS-WHOLE
21
COOKED-NFS
REREG
N
0.980000
0.042000
2.00
0.000840
15006AA
PEANUTS-WHOLE
22
COOKED-FRESH-BAKED
3F1399
P
0.020000
0.042000
FIELD TRIAL
2.00
0.000840
15006AA
PEANUTS-WHOLE
22
COOKED-FRESH-BAKED
REREG
N
0.980000
0.042000
2.00
0.000840
15015AA
OKRA
21
COOKED-NFS
2E2724
P
0.300000
0.047000
FIELD TRIAL
100.00
0.047000
15015AA
OKRA
25
COOKED-FRESH-FRIED
2E2724
P
0.300000
. 0.047000
FIELD TRIAL
100.00
0.047000
15029AA
SOYBEAN-SPROUTED
00
NOT SPECIFIED (NO CONSUMPTION)
3F1399
P
0.050000
0.050000
1.00
0.000500
16002AA
ASPARAGUS
21
COOKED-NFS
3E2913
P
0.020000
0.005000
FIELD TRIAL
100.00
0.005000
16002AA
ASPARAGUS
23
COOKED-FRESH-BOILED
3E2913
P
0.020000
0.005000
FIELD TRIAL
100.00
0.005000
270030A
COTTONSEED-OIL
18
PROCESSED OIL
3F1399
P
0.050000
0.009000C
FT/PROCESSING
1.00
0.000090
27003UA
COTTONSEED-MEAL
18
PROCESSED OIL
3F1399
P
0.050000
0.005000
FT/PROCESSING
1.00
0.000050
270070A
PEANUTS-OIL
18
PROCESSED OIL
3F1399
P
0.020000
0.021000
FT/PROCESSING
2.00
0.000420
270070A
PEANUTS-OIL
18
PROCESSED OIL
REREG
N
0.980000
0.021000
2.00
0.000420
270100A
SOYBEANS-OIL
18
PROCESSED OIL
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AA
SOYBEANS-UNSPEC
21
COOKED-NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AB
SOYBEANS-DRY
10
RAW-FRESH OR NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AB
SOYBEANS-DRY
21
COOKED-NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AB
SOYBEANS-DRY
23
COOKED-FRESH-BOILED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AB
SOYBEANS-DRY
25
COOKED-FRESH-FRIED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023AB
SOYBEANS-DRY
31
COOKED-FRESH OR CANNED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UA
SOY-FL, FULL FAT
21
COOKED-NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UA
SOY-FL, FULL FAT
22
COOKED-FRESH-BAKED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023WA
SOY-FL, FULL FAT
31
COOKED-FRESH OR CANNED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UB
SOY-FL, LOW FAT
21
COOKED-NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UC
SOY-FL.DEFAT
10
RAW-FRESH OR NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023WC
SOY-FL.DEFAT
21
COOKED-NFS
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UC
SOY-FL.DEFAT
22 COOKED-FRESH-BAKED
3F1399
P
0.050000
0.050000
1.00
0.000500
28023UC
SOY-FL.DEFAT
51
COOKED-CANNED
3F1399
P
0.050000
0.050000
1.00
0,000500
28023UC
SOY-FL.DEFAT
53
COOKED-CANNED-BOILED ,
3F1399
P
0.050000
0.050000
1.00
0.000500
43058AA
WINE AND SHERRY
10 RAW^FRESH OR NFS
P
0.100000
0.005000C
FT/PROCESSING
14.00
0.000700
43058AA
WINE AND SHERRY
21
COOKED-NFS
P
0.100000
0.005000C
FT/PROCESSING
14.00
0.000700
50000DB
HILK-NON-FAT SOL
10 RAW-FRESH OR NFS
9F2252
P
0.010000
0.000012
FEEDING STUDY
100.00
0.000012
50000DB
MILK-NON-FAT SOL 21
COOKED-NFS
9F2252
P
0.010000
0.000012
FEEDING STUDY
.100.00
0.000012
50000DB
MILK-NON-FAT SOL 51
COOKED-CANNED
9F2252
P
0.010000
0.000012
FEEDING STUDY
100.00
0.000012
50000FA
MILK-FAT SOLIDS
10
RAW-FRESH OR NFS
9F2252
P
0.010000
0.000012
FEEDING STUDY
100.00
0.000012
-------
Table 1.
ANTICIPATED RESIDUE INFORMATION FOR CASUEU NUMBER 453A
DATE: 10/26/94
PAGE:
fenamiphos (Nemacur)
Caswell #453A
CAS No. 22224-92-6
A.I - CODE; 100601
CFR No. 180.349
185.2950
1yr feeding - dog
NOEL= 0.0100 mg/kg
0.50 ppm
LEL= 0.0300 mg/kg
1.00 ppm
ONCO: 6 (RfD/PR Comnitee)
Plasma ChE inhibition
Mo evidence of oncogenic-
ity in rats or mice.
PADI UF -->100
OPP RfD» 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
MHO last reviewed 1987
MED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
FOOD CODE
FOOD
food form
PET.#
TOLERANCE
(ppm)
ANTICIPATED
RESIDUE (ppm)
AR STATISTIC TYPE
X CROP TREATED
RES. VALUE USED
IN TAS RUN (ppm)
50000FA
MILK-FAT SOLIDS
21
COOKED-NFS
9F2252
P
0.010000
0.000012
FEEDING
STUDY
100.00
0.000012
50000FA
MILK-FAT SOLIDS
51
COOKED-CANNED
9F2252
P
0.010000
0.000012
FEEDING
STUDY
100.00
0.000012
50000SA
MILK SUG (LACT)
21
COOKED-NFS
9F2252
P
0.010000
0.000012
FEEDING
STUDY
100.00
¦0.000012
50000SA
MILK SUG (LACT)
51
COOKED-CANNED
9F2252
P
0.010000
0.000012
FEEDING
STUDY
100,00
0.000012
53001BA
BEEF-MEAI BYP
21
COOKEO-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001BA
BEEF-MEAT BYP
26
COOKED-FRESH-PICKLED,CORNED,OR CURED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001BB
BEEF-OTH ORGAN
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001BB
BEEF-OTH ORGAN
51
COOKED-CANNED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001DA
BEEF-DRIED
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001FA
BEEF-FAT
10
RAW-FRESH OR NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001 FA
BEEF-FAT
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001 FA
BEEF-FAT
22
COOKED-FRESH-BAKED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001 FA
BEEF--FAT
23
COOKED-FRESH-BOILED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001 FA
BEEF-FAT
24
COOKED-FRESH-BROILED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001 FA
BEEF-FAT
25
COOKED-FRESH-FRIED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001KA
BEEF-KIDNEY
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001LA
BEEF-LIVER
25
COOKED-FRESH-FRIED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001LA
BEEF-LIVER
31
COOKED-FRESH OR CANNED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001MA
BEEF-LEAN
10
RAW-FRESH OR NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001HA
BEEF-LEAN
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001MA
BEEF-LEAN
22
COOKED-FRESH-BAKED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001MA
BEEF-LEAN
23
COOKED-FRESH-BOILED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53001MA
BEEF-LEA*
2*
COOKED-FRESH-BROILEO
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53002BB
GOAT-OTK ORGAN
00
NOT SPECIFIED (NO CONSUMPTION)
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53002FA
GOAT-FAT
23
COOKED-FRESH-BOILED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53002FA
GOAT-FAT
25
COOKED-FRESH-FRIED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53002KA
GOAT-KIDNEY
00
NOT SPECIFIED (NO CONSUMPTION)
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
530021A
GOAT-LIVER
00
NOT SPECIFIED (HO CONSUMPTION)
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53002MA
GOAT-LEAN
23
COOKED-FRESH-BOt LED
9F2252
P
0.050000
0.000120
FEEDING
STUDY-
100.00
0.000120
53002MA
GOAT-LEAN
25
COOKED-FRESH-FRIED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53003AA
HORSE
00
NOT SPECIFIED (NO CONSUMPTION)
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53005BA
SHEEP-MEAT BYP
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53005BB
SHEEP-OTH ORGAN
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53005FA
SHEEP-FAT
21
COOKED-NFS ,
9F2252
P
0.050000
0.000120
FEED1HG
STUDY
100.00
0.000120
53005KA
SHEEP-KIDNEY
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUOY
100.00
0.000120
530051A
SHEEP-LIVER
00
NOT SPECIFIED (NO CONSUMPTION)
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53005MA
SHEEP-LEAN
21
COOKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53005MA
SHEEP-LEAN
31
COOKED-FRESH OR CANNED
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
53006BA
PORK-MEAT BYP
21
COCKED-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0,000120
53006BB
PORK-OTK ORGAN
21
COOKEO-NFS
9F2252
P
0.050000
0.000120
FEEDING
STUDY
100.00
0.000120
-------
Table 1,
ANTICIPATED RESIDUE INFORMATION FOR CASWELL NUMBER 453A
DATE: 10/26/94
PACE; 6
Fenamiphos (Nemacur)
Caswell #453A
CAS No. 22224-92-6
A.I. CODE: 100601
CFR No. 180.349
185.2950
1yr feeding - dog
NOELs 0.0100 mg/kg
0.50 ppm
LEL= 0.0300 mg/kg
1.00 ppm
ONCO: E {RfD/PR Conmitee)
Plasma ChE inhibition
No evidence of oncogenic-
itv in rats or mice.
PADI UF -->100
OPP RfD* 0.000100
EPA RfD= 0.000250
Chronic feeding-dog
(current study may be up-
graded)
HED complete 03/21/86
EPA verified 12/09/86
WHO last reviewed 198?
HED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
FOOD CODE
FOOD
FOOO FORK
TOLERANCE ANTICIPATED
PIT,# (ppm) RESIDUE (ppm)
AR STATISTIC TYPE X CROP TREATED
RES. VALUE USED
IN TAS RUM .(ppm)
53006BB
PORK-OTH ORGAN
26 COOKED-FRESH-PICKLED,CORNED,OR CURED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006FA
PORK-FAT
10 RAW-FRESH OR NFS
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006FA
PORK-FAT
21 COOKED-NFS
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
to.000120
53006FA
PORK - F>T
23 COOKED-FRESH-BO!LED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53Q06FA
PORK-FAT
25 COOKED-FRESH-FRIED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006FA
PORK-FAT
26 COOKED-FRESH-P1CKLED,CORNED,OR CURED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006KA
PORK-KIDNEY
21 COOKED-NFS
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
530061A
PORK-LIVER
21 COOKED-NFS
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006LA
PORK-LIVER
25 COOKED-FRESH-FRIED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006HA
PORK-LEAN
21 COOKED-NFS
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006HA
PORK-LEAN
25 COOKED-FRESH-FRIED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
53006MA
PORK-LEAN
26 COOKED-FRESH-PICKLED,CORNED,OR CURED
9F2252
P 0.050000
0.000120
FEEDING STUDY
100.00
0.000120
-------
Table 2.
TOLERANCE ASSESSMENT SYSTEM ROUTINE CHRONIC ANALYSIS DATE: 10/26/94 PAGE: 1
CHEMICAL INFORMATION STUDY TYPE EFFECTS REFERENCE DOSES DATA GAPS/COMMENTS STATUS
Fenamiphos (Nemacur)
C^SHelI #45JA
CAS No. 22224-92-6
A.I. CODE; 100601
CFR No. 180.349
185.2950
1yr feeding - dog
N0EL= 0.0100 ng/kg
0.50 ppm
LEL= 0.0300 fng/kg
1.00 ppm
ONCO: E (RfO/PR Comnitee)
Plasma ChE inhibition
No evidence of oncogenic-
ity in rats or mice.
PAOI UF -->100 , I Chronic feeding-dog
OPP RfD= 0.000100 (current study may be up-
EPA RfD= 0.000250 graded)
HE0 complete 03/21/86
EPA verified 12/09/86
MHO last reviewed 1987
HED complete 07/01/88
RfD/PR reviewed 05/20/93
On IRIS.
TOTAL TMRC (MG/KG BODY WEIGHT/DAY)
NEW TMRC
DIFFERENCE
EFFECT OF ANTICIPATED RESIDUES
AS PERCENT
AS PERCENT
POPULATION SUBGROUP
CURRENT TMRC*
NEW TMRC**
OF RFD
OF RFD
ARC
XRFD
U.S. POPULATION - 48 STATES
0.002114
0.002116
2115.731000
1.397000
'0.000011
11.26700
U.S. POPULATION - SPRING SEASON
0.002094
0.002095
2094.765000
0.288000
0.000011
10,69900
U.S. POPULATION - SUMNER SEASON
0.002001
0.002002
2002.063000
0.634000
0.000011
ff .21000
U.S. POPULATION - FALL SEASON
0.002136
0.002138
2137.786000
1.682000
0.000011
10.66800
U.S. POPULATION - WINTER SEASON
0.002215
0.002218
22.18.277000
2.986000
0.000012
11.91500
NORTHEAST REGION
0.002607
0.002609
2609.091000
1.722000
0.000012
12.22400
NORTH CENTRAL REGION
0.002079
0.002080
2079.809000
1.080000
0.000010
10.44100
SOUTHERN REGION -
0.001696
0.001697
1696.676000
0.874000
0.000010
9.66300
WESTERN REGION
0.002214
0.002216
2215.955000
2.327000
0.000013
13.18800
HISPAN ICS
0.002697
0.002698
2697.600000
0.825000
0.000010
9.83800
NON-HISPANIC WHITES
0.002063
0.002065
2064.636000
1.467000
0.000011
11.30600
NON-HISPANIC BLACKS
0.002048
0.002049.
2048,997000
0.738000
0.000009
8.80200
NON-HISPANIC OTHERS
0.003011
0.003016
3016.128000
5.565000
0.000027
27.01800
NURSING INFANTS (< 1 YEAR OLD)
0.003645
0.003645
3644.908000
0.000000
0.000014
14.21400
NON-NURSING INFANTS (< 1 YEAR OLD)
0.007087
0.007087
7086.536000
0.000000
0.000040
40.14300
FEMALES (13+ YEARS, PREGNANT)
0.001670
0.001673
1673.442000
3.128000
0.000010
9.52100
FEMALES 13+ YEARS, NURSING
0.001632
0.001632
1631.621000
0.000000
0.000007
6.92500
CHILDREN (1-6 YEARS OLD)
0,005706
0.005709
5709.493000
3.678000
0.000023
23.10200
CHILDREN (7-12 YEARS OLD)
0.003068
0.003070
3070.107000
2.239000
0.000016
15.88000
MALES (13-19 YEARS OLD)
0.001706
0.001707
1706.816000
0,797000
0.000008
7.58400
FEMALES (13-19 YEARS OLD, NOT PRES. OR NURSING)
0.001618
0.001621
1620.990000
2.541000
0.000010
9.67600
MALES (20 YEARS AND OLDER)
0.001275
0.001276
1275.609000
0.593000
0.000008
7.87600
FEMALES (20 YEARS AND OLDER, NOT PREG. OR NURS)
0.001544
0.001545
1545.216000
1.076000
0.000009
9.11800
Current TMRC does not include new or pending tolerances.
**Neu TMRC includes new, pending, and published tolerances.
-------
Table 3.
TOLERANCE ASSESSMENT SUMMARY FOR Ftnamiphos (Newacur)
USING ANTICIPATED RESIDUES
CASWELL #453A
PATE! 10/26/94
ANALYSIS FOR POPULATION SUB-GROUP: U.S. POPULATION - 68 STATES
EXISTING ANTICIPATED RESIDUES (PUBLISHED ONLY)
RESULT IN AN ARC OF: 0.000010
THE EXISTING ARC IS EQUIVALENT TO: 9.809
PROPOSED NEW ANTICIPATED RESIDUES (CURRENT PETITION ONLY)
RESULT IN AN ARC OF: 0.000001
THESE NEW ANTICIPATED RESIDUES WILL OCCUPY: 1.458
IF THE NEW ANTICIPATED RESIDUES (CURRENT PETITION ONLY)
ARE APPROVED THE RESULTANT ARC WILL BE: 0.000011
THE HEW ARC WILL OCCUPY 11.267
NO OTHER PENDING ANTICIPATED RESIDUES ARE IN THE FILE
ANALYSIS FOR POPULATION SUB-GROUP: NON-NURSING INFANTS (< 1 YEAR OU>)
EXISTING ANTICIPATED RESIDUES (PUBLISHED ONLY)
MG/KG/DAY
X OF THE AD1
MG/KG/DAY
X OF THE ADI
MG/KG/DAY
X OF THE ADI
RESULT IN AN ARC OF:
THE EXISTING ARC IS EQUIVALENT TO:
0.000040
40.118
MG/KG/DAY
X OF THE ADI
PROPOSED NEW ANTICIPATED RESIDUES (CURRENT PETITION ONLY)
RESULT IN AN ARC OF: <0.000001
THESE NEW ANTICIPATED RESIDUES WILL OCCUPY: 0.025
IF THE NEW ANTICIPATED RESIDUES (CURRENT PETITION ONLY)
ARE APPROVED THE RESULTANT ARC WILL BE: 0.000040
THE NEW ARC WILL OCCUPY 40.143
MG/KG/DAY
X OF THE ADI
MG/KG/DAY
X OF THE ADI
NO OTHER PENDING ANTICIPATED RESIDUES ARE IN THE FILE
-------
Acute Analysis for all Kfclished ftACs fur IS
The SAS Sy$t«!i
15:57 Tuesday, October 25, 1994 1
*
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-------
Acute Analysis for all Published RACs for BED
DETAILED ACUTE ANALYSIS INCLUDING AR'S: ALL STATISTICS BASED ON USERS" DAILY CONSUMPTION 15:57 Tuesday, October 25, 1994 43
«««»********»*<»*******«*»****»»»*»«**»***«*«**»*~»«******»******»******»***»************
NAME: FENAK1PHOS (NEMACUR)
STUDY
RDV
NOEL
CASWELL NO: 453A CFR HO: CFR180.349 A 00000.0003 000001.000 000100 Chronic Dog
CAS NO: 22224-92-6 SHAUGHNESSY NO: 100601 B 00000.0150 000003.000 000010 Chronic Rat
~STATUS COOISa C 00000.0150 000030.000 000100 Reprodctn Rat
RDV INFO: The LD value used in this analysis is 0.005 MG/KG of BODY WEIGHT/DAY
FILE INFO: No Tolerance Data Are Used--Without User Modifications.
SF STUDY TYPE SPECIES EFF. LEV. CORE GRADE . DOC. NO.*
Enzymatic
Enzymatic
Systemic
Minimum
Mini#
Minin
0000001314*
0000001314*
0000001314*
#
AR DATA; No User Modifications*
A********************************** ***»*»******************************«****»*
U.S. POP.--48 STATES
ESTIMATES BASED ON
TOLERANCES:
ANTICIPATED RESIDUES:
ESTIMATED X OF POTENTIAL MEAN DAILY RESIDUE CONTRIBUTION PER USER-DAY
PERSON DAYS THAT ARE USER-DAYS MG/KG 800Y WEIGHT/DAY AS PERCENT OF RDV
0,00 . 0.000000 0.00
99.78 0.002200 43.99
ESTIMATED % OF POPULATION USER-DAYS WITH RESIDUE CONTRIBUTION EXCEEDING X TIMES THE RDV, FOR X>
*
0
.2
.4
.6
.8
1
1.2
1.4
1.6
1.8
2
3
4
1 5
10
15
20
TOLERANCES:
0
0
0
0
0
0
0
0
0
0
0
0
ft
I o
6
6
0
ANTICIPATED RESIDUES:
100
43
32
23
17
12
9
7
6
5
4
2
1
1 0
0
0
0
INFANTS(«1 YEAR)
ESTIMATED X OF POTENTIAL
MEAN DAILY RESIDUE CONTRIBUTION PER USER-DAY
ESTIMATES BASED ON PERSON DAYS THAT ARE USER-DAYS MG/KG 800Y WEIGHT/DAY AS PERCENT OF RDV
TOLERANCES: 0.00 0.000000 0.00
ANTICIPATED RESIDUES: 93.94 0.006805 136.10
ESTIMATED X OF POPULATION USER-DAYS WITH RESIDUE CONTRIBUTION EXCEEDING X TIMES THE ROV, FOR X«
0 .2 .4 .6 .8 1 1.2 1.4 1.6 1.8 2 3 4 5 10 15
TOLERANCES:
ANTICIPATED RESIDUES:
0
100
0
76
0
57
0
48
42
0
38
34 31
0
28
0
25
0
23
14
0
0
20
CHILDREN(1-6 YRS)
ESTIMATES BASED ON
TOLERANCES:
ANTICIPATED RESIDUES:
ESTIMATED X OF POTENTIAL
PERSON DAYS THAT ARE USER-DAYS
0,00
99.92
MEAN DAILY RESIDUE CONTRIBUTION PER USER-DAY
MG/KG BODY WEIGHT/DAY
0.000000
. 0.005909
AS PERCENT OF RDV
0.00
118.18
0
.2
.4
.6
,8
1
1.2
M
1.6
1.8
2
3
4
5
/ 10 I
1
15
20
TOLERANCES:
A
6
6
0
ft
ft
ft
ft
ft
0
ft
ft
ft
ft
ft
ft
ft
ANTICIPATED RESIDUES:
100
67
51
44
40
36
33
31
28
25
23
11
6
3
o.
0
0
-------
Malt* Analysis far all PiMfstied MCs for RED
DETAILED ACUTE ANALYSIS INCLUDING AIMS: ALL STATISTICS BASED OH USERS' DAILY CONSUMPTION 15:57 Tuesday, October 25, 1994 45
EFF. LEV. CORE GRADE DOC. NO.*
Enzymatic Nlniwum 0000001314*
Enzymatic Minimum 0000001314*
Systenic Minimm 0000001314*
*
AR DATA: No User Modifications*
*NAM£: FENAMIPHOS (NEMACUR) STUDY RDV NOEL SF STUDY TYPE SPECIES
CASWELL NO: 453A CFR NO: CFR180.349 A 00000.0003 000001.000 000100 Chronic Do#
*CAS NO: 22224-92-6 SKAUGMNESSY NO: t0060t B 00000.0150 000003.000 000010 Chronic Rat
STATUS C00|9k C 00000.0150 000030.000 000100 Reprodctn Rat
*RDV INFO: The LD value used fn this analysis is 0.005 MG/KG of BOOY HEIGHT/DAY
FILE INFO; No Tolerance Data Are UsedWithout User Modff i cat ions.
FEMALES(13* YRS)
ESTIMATED X Of POTENTIAL
MEAN DAILY RESIDUE CONTRIBUTION PER USER-DAY
ESTIMATES BASED ON PERSON BAYS THAT ARE USER-DAYS HG/KG BOOY WEIGHT/DAYAS PERCENT OF RDV
TOLERANCES: 0.00 0.000000 0.00
ANTICIPATED RESIDUES: 99.80 0.001605 32.09
ESTIMATED X OF POPULATION USER-DAYS WITH RESIDUE CONTRIBUTION EXCEEDING X TIMES THE ROV, FOR X«
0 .2 .4 .6 .8 1 1.2 1.4 1.6 1.8 2 ( 3 - 4 5 10 15
TOLERANCES:
ANTICIPATED RESIDUES:
0
100
0
39
0
29
20
13
TF
8
TF
3
0
0
20
MALES(13* YRS)
ESTIMATED X OF POTENTIAL
MEAN DAILY RESIDUE CONTRIBUTION PER USER-DAY
ESTIMATES BASED ON PERSON DAYS THAT ARE USER-DAYS HG/KG BOOY WEIGHT/DAY AS PERCENT OF RDV
TOLERANCES: 0.00 0.000000 0.00
ANTICIPATED RESIDUES: 99.91 0.001417 28.33
ESTIMATED X OF POPULATION USER-DAYS WITH RESIDUE CONTRIBUTION EXCEEDING X.TIKES THE RDV, FOR X"
0 .2 .4 .6 .8 1 1.2 1.4 1.6 1.8 2 I J ' 4 5 10 15
' TOLERANCES; ~ " '
ANTICIPATED RESIDUES:
0
100
3?
0
16
0
10
0
f
TT
3
0
1
20
0
0
0
0
0
0
0
0
------- |