EPA Research on Antibiotic Resistance and Wastewater: A One Health Approach


*>EPA

EPA Research on Antibiotic
Resistance and Wastewater:
A One Health Approach

E PA/600/S-24/191
K.Azzam OHCT/CEMM

Keely, etal. (2022); Kocurek (2023)

jA'A

Brown et al (2024)

V Antibiotic

Antibiotic-Resistant Gene (ARG)
jggjff' Antibiotic-Resistant Bacteria (ARB)

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Citations listing of "EPA Research on AMR and wastewater: A One Health Approach" - EPA Authors underlined

Start at the bottom left corner of the iSTOCK graphic and follow the citations up the waterways!

1.	Ananda Tiwari, Vicente Gomez-Alvarez, Sallamaari Siponen, Anniina Sarekoski, Anna-Maria Hokajarvi, Ari Kauppinen, Eila Torvinen, llkka T.
Miettinen, Tarja Pitkanen (2022). "Bacterial Genes Encoding Resistance Against Antibiotics and Metals in Well-Maintained Drinking Water
Distribution Systems in Finland". Frontiers in Microbiology, 12(9).

2.	Scott P Keely, Nichole E Brinkman, Emily A Wheaton, Michael A Jahne, Shawn D Siefring, Manju Varma, Ryan A Hill 1. Scott G Leibowitz 1. Roy
W Martin. Jay L Garland. Richard A Haugland (2022). "Geospatial Patterns of Antimicrobial Resistance Genes in the US EPA National Rivers
and Streams Assessment Survey." Environ Sci Technol 56(21): 14960-14971.

3.	Brandon Kocurek, Shawn Behling, Gordon Martin, Padmini Ramachandran, Elizabeth Reed, Christopher Grim, Mark Mammel, Jie Zheng,
Alison Franklin. Jay Garland. Daniel A. Tadesse, Manan Sharma, Gregory H. Tyson, Claudine Kabera, Heather Tate, Patrick F. McDermott, Errol
Strain, Andrea Ottesen (2023). "Metagenomic survey of antimicrobial resistance (AMR) in Maryland surface waters differentiated by high
and low human impact." Microbiol Resour Announc: e0047723.

4.	Laura E. Hubbard, Dana W. Kolpin, Carrie E. Givens, Brett R. Blackwell, Paul M. Bradley, James L. Gray, Rachael F. Lane, Jason R. Masoner,
Richard Blaine McCleskey, Kristin M. Romanok, Mark W. Sandstrom, Kelly L. Smalling, Daniel L. Villeneuve (2022). "Food, Beverage, and
Feedstock Processing Facility Wastewater: a Unique and Underappreciated Source of Contaminants to U.S. Streams." Environ Sci Technol
56(2): 1028-1040.

5.	Corinne Wiesner-Friedman. Rachelle E Beattie, Jill R Stewart, Krassimira R Hristova, Marc L Serre (2023). "Identifying sources of antibiotic
resistance genes in the environment using the microbial Find, Inform, and Test framework." Front Microbiol 14: 1223876.

6.	Sohyun Cho, Lari M. Hiott, Quentin D. Read, Julian Damashek, Jason Westrich, Martinique Edwards, Roland F. Seim, Donna A. Glinski, Jacob
M. Bateman McDonald, Elizabeth A. Ottesen, Erin K. Lipp, William Matthew Henderson. Charlene R. Jackson, and Jonathan G. Frye (2023).
"Distribution of Antibiotic Resistance in a Mixed-Use Watershed and the Impact of Wastewater Treatment Plants on Antibiotic Resistance in
Surface Water." Antibiotics (Basel) 12(11).

7.	Connor L. Brown, Ayella Maile-Moskowitz, Allison J. Lopatkin, Kang Xia, Latania K. Logan, Benjamin C. Davis. Liqing Zhang, Peter J. Vikesland
& Amy Pruden (2024) "Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during
wastewater treatment." Nat Commun 15, 5412.

8.	Laura A. Boczek, Eugene W. Rice. Brian Johnston, James R. Johnson (2007). "Occurrence of antibiotic-resistant uropathogenic Escherichia coli
clonal group A in wastewater effluents." Appl Environ Microbiol 73(13): 4180-41.

9.	Gomez-Alvarez. V. and J. Hoelle (2019). "Draft Genome Sequences of Antibiotic-Resistant Escherichia coli Isolates from U.S. Wastewater
Treatment Plants." Microbiol Resour Announc 8(23).

10.	Jill Hoelle. James R Johnson, Brian D Johnston, Brian Kinkle, Laura Boczek. Hodon Ryu. Sam Haves (2019). "Survey of US wastewater for
carbapenem-resistant Enterobacteriaceae." J Water Health 17(2): 219-226.

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11.	Mamadou Niang, John F. Reichard, Andrew Maier, Glenn Talaska, Jun Ying, Jorge Santo Domingo. Eunice Varughese. Laura Boczek. Emma
Huff &Tiina Reponen (2023). "Ciprofloxacin- and azithromycin-resistant bacteria in a wastewater treatment plant." J Occup Environ Hyg 20(5-
6): 219-225.

12.	Mary E Schoen, Michael A Jahne, Jay Garland. Lucia Ramirez, Allison J Lopatkin, Kerry A Hamilton (2021). "Quantitative Microbial Risk
Assessment of Antimicrobial Resistant and Susceptible Staphylococcus aureus in Reclaimed Wastewaters." Environ Sci Technol 55(22):
15246-15255.

13.	Andrew D McEachran, Melanie L Hedgespeth, Seth R Newton. Rebecca McMahen, Mark Strynar, Damian Shea, Elizabeth Guthrie Nichols
(2018). "Comparison of emerging contaminants in receiving waters downstream of a conventional wastewater treatment plant and a forest-
water reuse system." Environmental Science and Pollution Research 25(13): 12451-12463.

14.	E W Rice. J W Messer, C H Johnson, and D J Reasoner (1995). "Occurrence of high-level aminoglycoside resistance in environmental isolates
of enterococci." Appl Environ Microbiol 61(1): 374-376.

15.	Regina Lamendella, Jorge W Santo Domingo. Shreya Ghosh, John Martinson & Daniel B Oerther (2011). "Comparative fecal metagenomics
unveils unique functional capacity of the swine gut." BMC Microbiol 11: 103.

16.	Susan T Glassmeyer, Emily E Burns, Michael J Focazio, Edward T Furlong, Matthew O Gribble, Michael A Jahne. Scott P Keely, Alison R
Kennicutt, Dana W Kolpin, Elizabeth K Medlock Kakaley, Stacy L Pfaller (2023). Water, Water Everywhere, but Every Drop Unique: Challenges
in the Science to Understand the Role of Contaminants of Emerging Concern in the Management of Drinking Water Supplies. GeoHealth
7(12):e2022GH000716.

17.	Franklin, A. M., Andrews, D.M., Williams, C.F., Watson, J.E. (2022). " Simultaneous Extraction of Four Antibiotic Compounds from Soil and
Water Matrices." Separations. 9(8), 200.

18.	Rachel A. Kaiser, Jason S. Polk, Tania Datta, Scott P. Keely, Nichole E. Brinkman, Rohan R. Parekh, Getahun E. Agga (2023). "Occurrence and
prevalence of antimicrobial resistance in urban karst groundwater systems based on targeted resistome analysis." Sci Total Environ 874:
162571.

19.	R J Meinersmann, M E Berrang, J K Bradshaw, M Molina. D E Cosby, L L Genzlinger, BJ Snyder Meinersmann, R. J., et al. (2020). "Recovery of
thermophilic Campylobacter by three sampling methods from river sites in Northeast Georgia, USA, and their antimicrobial resistance
genes." Letters in Applied Microbiology 71(1): 102-107.

20.	Michael A Jahne. Shane W Rogers. Ivan P Ramler, Edith Holder, Gina Hayes (2015). "Hierarchal clustering yields insight into multidrug-
resistant bacteria isolated from a cattle feedlot wastewater treatment system." Environ Monit Assess 187(1): 4168.

21.	Kostich, M. S. and J. M. Lazorchak (2008). "Risks to aquatic organisms posed by human pharmaceutical use." Science of the Total
Environment 389(2-3): 329-339.

22.	Nicholas J. Ashbolt, Alejandro Amezquita, Thomas Backhaus, Peter Borriello, Kristian K. Brandt, Peter Collignon, Anja Coors, Rita Finley,
William H. Gaze, Thomas Heberer, John R. Lawrence, D.G. Joakim Larsson, Scott A. McEwen, James J. Ryan, Jens Schonfeld, Peter Silley,Jason

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R. Snape, Christel Van den Eede, and Edward Topp (2013). "Human Health Risk Assessment (HHRA) for Environmental Development and
Transfer of Antibiotic Resistance." Environmental Health Perspectives 121(9): 993-1001.

23. Alison M. Franklin. Daniel L Weller, Lisa M Durso, Mark Baglev. Benjamin C. Davis. Jonathan G. Frye, Christopher J. Grim, Abasiofiok M.
Ibekwe, Michael A. Jahne, Scott P. Keely, Autumn L. Kraft, Betty R. McConn, Richard M. Mitchell, Andrea R. Ottesen, Manan Sharma, Errol A.
Strain, Daniel A. Tadesse, Heather Tate, Jim E. Wells, Clinton F. Williams, Kim L. Cook, Claudine Kabera, Patrick F. McDermott, Jay L. Garland.
(2024). "A one health approach for monitoring antimicrobial resistance: developing a national freshwater pilot effort." Front Water 6:
1359109.

NOTE: Wiesner-Friedman reference is listed above #5.

24. Shane W Rogers, Carrie E Shaffer, Tom A Langen, Michael Jahne. Rick Welsh (2018). "Antibiotic-Resistant Genes and Pathogens Shed by Wild
Deer Correlate with Land Application of Residuals." Ecohealth 15(2): 409-425.

25. Alison M. Franklin. Nichole E. Brinkman, Michael A. Jahne. Scott P. Keely (2021). "Twenty-first century molecular methods for analyzing
antimicrobial resistance in surface waters to support One Health assessments." Journal of Microbiological Methods 184: 11.

26. Autumn L. Kraft, Jim E. Wells, Jonathan G. Frye, Abasiofiok M. Ibekwe, Lisa M. Durso, Lari Hiott, Cheryl East, Betty R. McConn, Alison M.
Franklin. Laura A. Boczek, Jay L. Garland. Claudine Kabera, Patrick F. McDermott, Andrea R. Ottesen, Jie Zheng, Kimberly L. Cook, Manan
Sharma (2023). "A comparison of methods to detect low levels of Salmonella enterica in surface waters to support antimicrobial resistance
surveillance efforts performed in multiple laboratories." Sci Total Environ 905: 167189.

27. Streptomycin. Revised Human Health Risk Assessment for the Section 3 Registration for Citrus Fruits Crop Group 10-10 dated November 28,
2018. Available at https://www.regulations.gov/document/EPA-HQ-OPP-2008-0687-0027

-Transmittal of the Preliminary Environmental Fate and Ecological Risk Assessment for the Registration Review of Streptomycin Sulfate dated
May 22, 2018. Available at https://www.regulations.gov/document/EPA-HQ-OPP-2008-0687-0028

-US EPA (2024): "EPA Proposes Framework for Interagency Collaboration on the Review of Potential for Resistance from Antibacterial and
Antifungal Pesticides" https://www.epa.gov/pesticides/epa-proposes-framework-interagencv-collaboration-review-potential-resistance.

28. Keya Sen, Tanner Berglund, Marilia A. Soares, Babak Taheri, Yizheng Ma, Laura Khalil, Megan Fridge, Jingrang Lu. and Robert J. Turner (2019).
"Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC
Containing E. coli." Front Microbiol 10: 1034.

29. Robert A. Sowah, Marirosa Molina. Ourania Georgacopoulos, Blake Snyder, and Mike Cyterski (2022). "Sources and Drivers of ARGs in Urban
Streams in Atlanta, Georgia, USA." Microorganisms 10(9).

30. Angela L Batt. Thomas M Kincaid. Mitchell S Kostich. James M Lazorchak. Anthony R Olsen (2016). "Evaluating the extent of pharmaceuticals
in surface waters of the United States using a National-scale Rivers and Streams Assessment survey." Environ Toxicol Chem 35(4): 874-881.

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31.	Maria J. Soto-Giron, Luis M. Rodriguez-R, Chengwei Luo, Michael Elk, Hodon Ryu. Jill Hoelle. Jorge W. Santo Domingo, and Konstantinos T.
Konstantinidis (2016). "Biofilms on Hospital Shower Hoses: Characterization and Implications for Nosocomial Infections." Appl Environ
Microbiol 82(9): 2872-2883.

32.	Asia Korajkic, Brian R. McMinn, Zachery R. Staley, Warish Ahmed, and Valerie J. Harwood,* (2020). "Antibiotic-Resistant Enterococcus
Species in Marine Habitats: A Review." Curr Opin Environ Sci Health 19: 92-100.

NOTE: Wiesner-Friedman reference is listed above #5.

33.	Kyle D. Brumfield, Joseph A. Cotruvo, Orin C. Shanks . Mano Sivaganesan, Jessica Hey, Nur A. Hasan, Anwar Huq, Rita R. Colwell and Menu B.
Leddy (2021). "Metagenomic Sequencing and Quantitative Real-Time PCRfor Fecal Pollution Assessment in an Urban Watershed." Front
Water 3: 626849.

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